Clinical trials: Hyperalgesia, Secondary
Healthy Subjects
Effect of High-dose Target-controlled Naloxone Infusion on Pain and Hyperalgesia During a Burn Injury
In several rodent studies, it has been demonstrated that very high doses of opioid antagonists (i.e., naloxone 3-10 mg/kg) administered after weeks after recovery from an inflammatory injury may lead to a reinstatement of…
- Trial name
- TCI-NX-BI (NCT02684669)
- Testing
- Naloxone, Normal saline
- Where
- Denmark
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- mads u werner
Healthy Subjects
Activation of A-delta-fibres and C-fibres in a First Degree Thermal Injury in Volunteers
The aim of this study is to measure reaction times and thermal detection thresholds to CO2 laser stimulation of the skin, before and after a first degree thermal injury, in the primary and secondary hyperalgesia area, in order to…
- Trial name
- BI-Laser (NCT02442726)
- Testing
- CO2-Laser stimulation (Laser Stimulation Device, SIFEC)
- Where
- Denmark
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Primary Hyperalgesia
Sensory Function After Wound Instillation of Capsaicin
The use of capsaicin as a potential analgesic drug for postoperative pain relies on the ability of capsaicin to induce membrane lysis of c-nerve fibers.
- Trial name
- NCT00583180
- Testing
- Capsaicin
- Where
- Denmark
- Volunteers
- 42 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Hyperalgesia, Pain Perception
Session-Order Sensitivity of TS and OA in a Capsaicin Crossover Model
Temporal summation (TS) and offset analgesia (OA) are widely used psychophysical endpoints in pain research that index different components of central nociceptive processing.
- Conditions
- Hyperalgesia, Pain Perception, Central Nervous System Sensitization, Pain Threshold
- Trial name
- TS-OA-Cap (NCT07625475)
- Testing
- Topical 0.075% capsaicin cream (Zostrix), Topical vehicle lotion (Lubriderm)
- Where
- Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Guelph
Secondary Hyperalgesia, Inflammation
The Effect of Hyperbaric Oxygen Therapy on Inflammatory Parameters Induced by a Heat Injury Model
Hyperbaric oxygen may reduce neurophatic pain and promote wound healing. Established anti inflammatory effects of HBO may contribute to this effect.
- Trial name
- HBO-SHA (NCT02397343)
- Testing
- Hyperbaric oxygen
- Where
- Denmark
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Measurements of Areas of Secondary Hyperalgesia
Delineating Areas of Secondary Hyperalgesia: Influence of the Assessment Method
Assessments of mechanical skin sensitivity include psychophysical responses to stimulation with calibrated polyamide monofilaments.
- Trial name
- NCT02286037
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Experimental Pain in Healthy Males
Characterization of Secondary Hyperalgesia in Healthy Volunteers
In this prospective trial we aim to investigate the intra-individual and inter-individual variance in secondary hyperalgesia following pain elicited by the experimental pain model: Brief Thermal Sensitization.
- Trial name
- NCT02166164
- Testing
- Brief thermal sensitization, Long thermal stimulation, Heat-pain-detection threshold
- Where
- Denmark
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Hyperalgesia, Secondary
Modulation of Remifentanil-induced Postinfusion Hyperalgesia
In addition to alleviate pain there is growing evidence that µ-opioids enhance pain. This problem is known as opioid induced hyperalgesia(OIH).The NMDA receptor is involved in opioid induced hyperalgesia it may be possible to…
- Trial name
- NCT00785863
- Testing
- Remifentanil, Ketorolac and remifentanil, Parecoxib and remifentanil
- Where
- Norway
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Ullevaal University Hospital
Hyperalgesia, Secondary
Transversus Abdominis Plane (TAP) Block for Cesarean Section
The purpose of this study is to determine whether a transversus abdominis plane (TAP) block with Clonidine added to the injectate (Clo-TAP) performed approximately 2hrs after the cesarean section (CS) will decrease the amount of…
- Trial name
- CLOTAP (NCT01015807)
- Testing
- Bupivacaine, Clonidine
- Where
- 2 sites in United States, Brazil
- Volunteers
- 90 people
- Sponsor
- University of Washington
Central Sensitisation
Differences in Pain Processing Between Men and Women
Many chronic pain conditions show clear differences between between men and women, such as reported pain intensities or treatment effects, with chronic pain conditions being generally more frequent in women.
- Trial name
- NCT05031286
- Testing
- Cutaneous thermal stimuli
- Where
- Switzerland
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Balgrist University Hospital
Spinal Cord Injury, Hyperalgesia, Secondary
MR Spectroscopy as a Diagnostic and Outcome Measure in Pain and SCI
The goal of this study is to compare the changes that occur in sensation and chemical properties of the brain following SCI between individuals that experience chronic pain and those that do not, and between those with SCI and…
- Conditions
- Spinal Cord Injury, Hyperalgesia, Secondary, Hyperalgesic Sensations
- Trial name
- MRS (NCT00561782)
- Where
- United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Postoperative Hyperalgesia
Intraoperative S-ketamine to Prevent Postoperative Hyperalgesia in Patients Undergoing Video-assisted Thoracic Surgery
Postoperative hyperalgesia (POH) is a paradoxical clinical state of increased sensation of pain or increased sensitivity to non-painful stimuli at the site of surgery or at a surrounding area that was not directly injured.
- Trial name
- NCT05016128
- Testing
- S-ketamine, saline
- Where
- China
- Volunteers
- 92 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Hyperalgesia, Pain
Effect of High Dose Naloxone on Secondary Hyperalgesia
Recent studies have focused on the role of endogenous opioids on central sensitization. Central sensitization is known to be impaired or altered in chronic pain conditions, as fibromyalgia or chronic tension headache.
- Conditions
- Hyperalgesia, Pain, Naloxone, Opioid Antagonist
- Trial name
- NCT01935206
- Testing
- Naloxone (2 mg/kg)
- Where
- 2 sites in Denmark
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Analgesia
The Central Analgesic Effects of Paracetamol on Serotonergic Pathways
1. Introduction Paracetamol, an analgesic prescribed daily, has been in use for more than 50 years. Surprisingly, its mode of action is still unclear.
- Trial name
- NCT00970450
- Testing
- Paracetamol, Tropisetron
- Where
- Switzerland
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Pain
Analgesic and Antihyperalgesic Effects of Morphine and Buprenorphine
Tissue injury is associated with pain from the injured site (primary hyperalgesia) and pain from non-injured tissue in the vicinity of the trauma (secondary hyperalgesia).
- Trial name
- PASORII (NCT01296334)
- Testing
- morphine LO, Morphine Hi, Buprenorphine LO
- Where
- Denmark
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- mads u werner
Healthy Subjects, Hyperalgesia
Effect of High-dose Naloxone Following Third Molar Extraction
Recent studies have focused on the role of endogenous opioids on central sensitization. Central sensitization is known to be impaired or altered in chronic pain conditions, as fibromyalgia or chronic tension headache.
- Conditions
- Healthy Subjects, Hyperalgesia, Inflammations, Endodontic, Pain, Acute
- Trial name
- TME (NCT02976337)
- Testing
- Naloxone, Normal Saline
- Where
- Denmark
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- mads u werner
Phantom Limb Pain (PLP), Primary/Secondary Scar Hyperalgesia
A Trial of Lidocaine Patch for Lower Limb Amputation Pain
Phantom limb pain (PLP) and scar hyperalgesia (SH) are frequent problems after amputation; in particular most persons who undergo limb amputation will experience phantom pain.
- Trial name
- NCT02696720
- Testing
- Lidocaine
- Where
- 2 sites in Belgium
- Sponsor
- Brugmann University Hospital
Chronic Pain, HIV
An Observational Study of Distress, Immune Function, and Pain in HIV.
This case-control study focuses on pain in HIV, which is common despite antiretroviral therapy and compromises quality of life, mental health and daily functioning.
- Conditions
- Chronic Pain, HIV, Distress, Emotional, Immune System and Related Disorders
- Trial name
- NCT04757987
- Testing
- Pain
- Where
- South Africa
- Volunteers
- 107 people
- Sponsor
- University of Cape Town
Pain Perception, Secondary Hyperalgesia
Electrical Intra-cutaneous Half-sine Stimulation for Optimized Preferential C-fiber Activation
This exploratory study is to improve an established pain model by a new stimulation profile that allows preferential activation of C fibers that are of main clinical interest in chronic pain and also to generate a stable…
- Trial name
- NCT05440266
- Testing
- Study Intervention: 25 ms half-sine wave stimulation, Control Intervention: 500 µs rectangular shaped stimulation
- Where
- Switzerland
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Hyperalgesia
Effect of Gabapentin on Pain of the Second Cataract Surgery
Gabapentin pretreatment may reduce hyperalgesia occurring at the second surgery in serial, bilateral cataract surgery.
- Trial name
- NCT02127853
- Testing
- gabapentin
- Where
- South Korea
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital