Clinical trials: Hydrothorax
Portal Hypertension, Liver Diseases
Achieving Portal Access With Scorpion Post-Approval Study 2
Creation of the parenchymal tract between the portal vein and the hepatic vein is the most difficult and time consuming step in a TIPS procedure.
- Conditions
- Portal Hypertension, Liver Diseases, Ascites Hepatic, Hydrothorax
- Trial name
- APASS2 (NCT06856655)
- Testing
- Scorpion Portal Vein Access Kit
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- Argon Medical Devices
Peritoneal Dialysis, Peritoneal Dialysis (PD)
Iodine Starch Test Use in Pleuroperitoneal Leak
This is a study to see how a simple test can be used to check if fluid in the chest cavity contains starch. Some people with kidney failure have dialysis treatment by putting fluid in the tummy cavity, and sometimes the fluid can…
- Conditions
- Peritoneal Dialysis, Peritoneal Dialysis (PD), Pleural Cavity Effusion, Hydrothorax
- Trial name
- PIT-PLPD (NCT07857564)
- Testing
- Iodine tincture
- Volunteers
- 30 people
- Sponsor
- Nottingham University Hospitals NHS Trust
Lung Cancer, Breast Cancer
Exploratory Study of Precise Therapy for Advanced Tumor Patients With Malignant Hydrothorax or Ascites by Using PTC Drug Sensitivity Testing
To explore the consistency between result of PTC drug screening tests and actual clinical outcome for patients with advanced malignancy.
- Conditions
- Lung Cancer, Breast Cancer, Gastric Cancer, Colorectal Cancer
- Trial name
- NCT06413212
- Testing
- Patient-derived tumor-like cell clusters (PTC) drug sensitivity testing.
- Where
- China
- Volunteers
- 55 people
- Sponsor
- Liu Huang
Pleural Effusion
Catheter Placement for Hepatic Hydrothorax
The purpose of this study is to evaluate the effectiveness of an indwelling tunneled pleural catheter (ITPC) in the management of hepatic hydrothorax that is not responsive to conventional medical therapy.
- Trial name
- NCT02595567
- Testing
- Indwelling tunneled pleural catheter (ITPC)
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Washington University School of Medicine
Congestive Heart Failure, Transudative Pleural Effusion
Therapeutic Thoracentesis for Patients With Congestive Heart Failure and Large Pleural Effusion
Transudative pleural effusions are a common manifestation of patients with congestive heart failure. Severe dyspnea and respiratory failure may develop in those with large effusions, which in general show poor response to medical…
- Trial name
- NCT00629538
- Testing
- Therapeutic thoracentesis
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- Taipei Medical University Hospital
Breast Cancer Metastatic, Hydrothorax
Drug Sensitivity of Hydrothorax and Ascite Organoids from Breast Cancer
Malignant hydrothorax and ascitic fluid in advanced breast cancer often arise from metastasis to the lungs, pleura, or liver. Patients with this condition experience rapid disease progression and multidrug resistance, facing…
- Conditions
- Breast Cancer Metastatic, Hydrothorax, Ascites, Organoids
- Trial name
- NCT06658080
- Testing
- organoid drug test
- Where
- 3 sites in China
- Volunteers
- 90 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Hepatic Hydrothorax
Efficacy & Safety of Pigtail Catheter Drainage Versus Need Based Thoracocentesis for Recurrent Hepatic Hydrothorax.
In cirrhotic patients with recurrent hepatic hydrothorax liver transplantation is a definitive treatment. But a significant number of individual are ineligible for liver transplantation.
- Trial name
- NCT06007820
- Testing
- Large Volume Thoracocentesis, Pigtail Catheter
- Where
- India
- Volunteers
- 70 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Pneumothorax, Hydrothorax
KatGuide Method Versus Conventional Method at Insertion of Chest Tube
The purpose of this study is to investigate whether if KatGuide (a new developed medical device) improves the placing of a large bore chest tube in the pleural cavity compared to the conventional method.
- Conditions
- Pneumothorax, Hydrothorax, Hemothorax, Empyema
- Trial name
- KatGuide (NCT01522885)
- Testing
- KatGuide versus conventional method (forceps), Chest tube insertion
- Where
- 4 sites in Denmark
- Volunteers
- 109 people
- Sponsor
- Niels Katballe
Hydrothorax, Pneumothorax
Improvement and Application of New Closed Drainage Device
According to the problems of traditional closed thoracic drainage in clinical work, this study aims to further improve and improve the new closed thoracic drainage system by changing the material of drainage tube, increasing the…
- Trial name
- IAAONCDD (NCT04143360)
- Testing
- New Closed Drainage Device, Traditional closed drainage device
- Volunteers
- 100 people
- Sponsor
- Yongxin Zhou
Malignant Hydrothorax, Non Small Cell Lung Cancer
Systemic Chemotherapy Combined With Recombinant Human Adenovirus Type 5 and Endostatin Injections for Treatment Malignant Hydrothorax in NSCLC Patients
The purpose of this multi-center clinical trial is to verify more effective on local control of malignant pleural effusions in NSCLC patients by thoracic cavity perfusion of recombinant human adenovirus type 5 injection and…
- Trial name
- NCT02579564
- Testing
- Gemcitabine, Vinorelbine, Paclitaxel
- Volunteers
- 134 people
- Sponsor
- Xinqiao Hospital of Chongqing
Portal Hypertension, TIPS
The BD Liverty™ TIPS Stent Graft Study
The objective of the study is to assess the safety and effectiveness of the BD Liverty™ TIPS Stent Graft for the treatment of the complications of portal hypertension from cirrhosis.
- Trial name
- ARCH (NCT05711316)
- Testing
- BD Liverty™ TIPS Stent Graft
- Where
- 26 sites in United States, France and 1 more
- Volunteers
- 177 people
- Sponsor
- C. R. Bard
Portal Hypertension, Liver Diseases
Achieving Portal Access With Scorpion Post-Approval Study (APASS)
Creation of the parenchymal tract between the portal vein and the hepatic vein is the most difficult and time consuming step in a TIPS procedure.
- Conditions
- Portal Hypertension, Liver Diseases, Ascites Hepatic, Hydrothorax
- Trial name
- NCT05765253
- Testing
- Scorpion Portal Vein Access Kit, Cook Transjugular Liver Access Set, Transjugular Intrahepatic Portosystemic Shunt (TIPS)
- Where
- 3 sites in United States
- Volunteers
- 3 people
- Sponsor
- Argon Medical Devices
Hepatic Hydrothorax
To Study the Safety and Efficacy of Midodrine With Albumin Versus Albumin Alone in Hepatic Hydrothorax
Hepatic hydrothorax is defined with accumulation of transudate fluid (500 ml) in the pleural cavity in patients with decompensated liver cirrhosis but without cardiopulmonary and pleural diseases.
- Trial name
- NCT03645642
- Testing
- Midodrine, Albumin, Diuretics
- Where
- India
- Volunteers
- 8 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Liver Cirrhosis
Thoracoscopic Mesh Repair of Diaphragmatic Defects for Hepatic Hydrothorax
The management of refractory hepatic hydrothorax is challenging and usually unsuccessful. The study will discuss the perioperative treatment, effectiveness, and morphology of diaphragmatic defects of hepatic hydrothorax in…
- Trial name
- NCT02508688
- Testing
- thoracoscopic diaphragmatic repair
- Volunteers
- 63 people
- Sponsor
- National Taiwan University Hospital
Malignant Hydrothorax, NSCLC
A Prospective Study to Evaluate the Consistency of Next-Generation Sequencing(NGS)-Panels by Using Malignant Hydrothorax Form NSCLC
A prospective study to evaluate consistency of different NGS-panel. Cell free DNA is purified from each malignant hydrothorax from NSCLC .Different NGS-panels are applied to perform in vitro diagnosis to detect Single Nucleotide…
- Trial name
- NCT03546452
- Testing
- in vitro NGS-panel
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Shanghai Chest Hospital
Refractory Ascites, Hepatic Hydrothorax
Glutamine Challenge as Predictor of Hepatic Encephalopathy After Transjugular Intrahepatic Portosystemic Shunt (TIPS)
Transjugular intrahepatic portosystemic shunt (TIPS) is the first-line therapy for patients with cirrhosis and refractory ascites. However, mental changes known as hepatic encephalopathy (HE) frequently occur after TIPS.
- Conditions
- Refractory Ascites, Hepatic Hydrothorax, Hepatic Encephalopathy, Cirrhosis
- Trial name
- NCT02026609
- Testing
- Oral glutamine challenge, Psychometric Tests
- Where
- 3 sites in United States, Canada and 1 more
- Volunteers
- 3 people
- Sponsor
- University of Arkansas
Pleural Effusion, Transudative Pleural Effusion
Evaluation of Transthoracic Ultrasonography in Differentiating Pleural Effusions
Pleural effusion is a condition where excess fluid builds up in the space between the lungs and the chest wall. To properly treat this condition, doctors must determine if the fluid is a "transudate" (usually resulting from…
- Conditions
- Pleural Effusion, Transudative Pleural Effusion, Exudative Pleural Effusion
- Trial name
- NCT07513909
- Volunteers
- 90 people
- Sponsor
- Assiut University
Pleural Effusion
Pigtail Catheter: a Less Invasive Option for Pleural Drainage of Recurrent Hepatic Hydrothorax
The effectiveness of pigtail catheter as a less invasive option for pleural drainage in patients with resistant hepatic hydrothorax.
- Trial name
- HH (NCT02119169)
- Testing
- Pigtail catheter
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Sherief Abd-Elsalam
Hepatic Hydrothorax
Comparing Outcome of Thoracocentesis and Pigtail Catheter Drainage in Treatment of Patients With Hepatic Hydrothorax
Hepatic hydrothorax (HH) is a pleural effusion that develops in a patient with cirrhosis and portal hypertension in the absence of cardiopulmonary disease (Lv et al., 2018).
- Trial name
- NCT06319547
- Testing
- Thoracocentasis
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sohag University
Refractory Ascites
Evaluation of Hemodynamic Parameters Following Transjugular Intrahepatic Portosystemic Shunt (TIPS)
During a TIPS procedure, a shunt or stent (mesh tube) is passed down the jugular vein (the vein above the collarbone in the neck) using fluoroscopy (real time x-rays) guidance.
- Trial name
- NCT04050683
- Testing
- Study - Transjugular Intrahepatic Portosystemic Shunt (TIPS), Control - Transjugular Intrahepatic Portosystemic Shunt (TIPS)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Medical College of Wisconsin