Clinical trials: Hydrocephalus
Hydrocephalus, Cerebral Ventricle
Impact of Cerebral Ventricular Dilatations and Cerebrospinal Fluid Pulsations on Periventricular White Matter in Hydrocephalic Patients
Hydrocephalus is characterized by excessive accumulation of cerebrospinal fluid (CSF) in the ventricles of the brain. One of the forms of hydrocephalus is called "normal pressure", although one of the main signs is precisely an…
- Conditions
- Hydrocephalus, Cerebral Ventricle, Cerebrospinal Fluid, White Matter Fiber
- Trial name
- HYDRODIFF (NCT05825521)
- Testing
- MRI
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Normal Pressure Hydrocephalus
CPT-3 in Normal Pressure Hydrocephalus
The study will collect prospective cohort data of individuals that are undergoing routine clinical care for suspected idiopathic Normal Pressure Hydrocephalus (NPH).
- Trial name
- NCT03521518
- Testing
- Conner's Continuous Performance Test-3
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Vanderbilt University Medical Center
Hydrocephalus, Normal Pressure, Biochemical Lesions Head Region
Role of Brain Specific Biomarkers in Hydrocephalus
Normal pressure hydrocephalus (NPH) is a neurodegenerative disease of unclear etiology characterized by a clinical trias named after the neurosurgeon Hakim.
- Conditions
- Hydrocephalus, Normal Pressure, Biochemical Lesions Head Region, Brain Damage
- Trial name
- NCT06083233
- Testing
- Lumbar puncture, External lumbar drainage, Ventriculo-peritoneal shunt placement
- Where
- Czechia
- Volunteers
- 32 people
- Sponsor
- University Hospital Hradec Kralove
Idiopathic Normal Pressure Hydrocephalus
Improved Analysis Methods for Infusion Tests
Objective: Patients with Idiopathic Normal Pressure Hydrocephalus are improved with shunt surgery. To increase the accuracy of the diagnosis, supplementary tests that characterize the cerebrospinal fluid (CSF) dynamics are used.
- Trial name
- NCT01319136
- Where
- 2 sites in Sweden
- Volunteers
- 48 people
- Sponsor
- Umeå University
Hydrocephalus, Normal Pressure Hydrocephalus
The Role of the Glymphatic System Avaluated Thourgh mr Imaging in the Diagnosis and Management of NPH
The goal of this observational study is to evaluate the role of DTI-ALPS in the diagnostic and therapeutic management of NPH The main questions it aims to answer are: Whether the glymphatic system (GS) is actually impaired in NPH…
- Trial name
- GLINFANPH_2021 (NCT06857136)
- Where
- Italy
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Cerebral Ventriculomegaly
Prospective Follow-up of a Multicentric Cohort of Children With Prenatal Discovery of Mild Isolated Cerebral Ventriculomegaly. Evaluation at 2 and 5 Years.
Isolated uni or bilateral mild cerebral ventriculomegaly represents the most frequent "minor" cerebral anomalies discovered by antenatal echography.
- Trial name
- NCT00421772
- Where
- 2 sites in France
- Volunteers
- 245 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Normal Pressure Hydrocephalus
ShuntCheck Accuracy in Detecting Shunt Obstruction Normal Pressure Hydrocephalus (NPH) Patients
The purpose of this study is to examine the role of ShuntCheck and MR Imaging in evaluating the presence or absence of Shunt Obstruction in the patients of Hydrocephalus or Idiopathic Intracranial Hypertension (IIH) undergoing…
- Trial name
- NCT00793416
- Testing
- Shunt flow detection
- Where
- United States
- Sponsor
- NeuroDx Development
Hydrocephalus, Ventriculomegally
Late Post Traumatic Ventriculomegally Does it Requires CSF Diversion ?
Aim of the study is : 1. prevelance of ventriculomegally in post traumatic patients after head trauma 2. To determine the incidence of surgically treated ventriculomegally within 6 months from head injury in a series of…
- Trial name
- NCT06703164
- Volunteers
- 34 people
- Sponsor
- Assiut University
Aneurysms, Arteriovenous Malformations
Neurosurgical Outcome Network
The evaluation of neurosurgical outcomes varies from center to center, and the predictive factors that determine these outcomes are not fully known or shared.
- Conditions
- Aneurysms, Arteriovenous Malformations, Cavernomas, Skull Base Tumors
- Trial name
- NEON (NCT06724029)
- Where
- 27 sites in Italy
- Volunteers
- 4,500 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Head Injury, Intracerebral Hemorrhage
The Prediction of Intracranial Pressure and Clinical Outcome by Transcranial Doppler in Neurocritical Patients
The purpose of this study is to use transcranial Doppler (TCD) to predict intracranial pressure (ICP) and clinical outcome of neurocritical patients.
- Conditions
- Head Injury, Intracerebral Hemorrhage, Ischemic Stroke, Subarachnoid Hemorrhage
- Trial name
- NCT00886054
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- National Taiwan University Hospital
Disorder of Consciousness, Hydrocephalus
Prediction Model of Improvement of Disturbance of Consciousness in Patients With Hydrocephalus After Shunt Operation
Patients with hydrocephalus are usually treated with cerebrospinal fluid (CFS) shunt to deal with excess cerebrospinal fluid in the brain.
- Trial name
- NCT05237102
- Testing
- Cerebrospinal fluid shunt
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Zhuohang Wang
Obstructive Hydrocephalus, Subarachnoid Hemorrhage
VisAR Augmented Reality Navigation of Ventriculostomy
This study is intended to evaluate the feasibility of using VisAR augmented reality surgical navigation during placement of an external ventricular drain (EVD).
- Conditions
- Obstructive Hydrocephalus, Subarachnoid Hemorrhage, Brain Trauma
- Trial name
- NCT06132139
- Testing
- VisAR
- Volunteers
- 50 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Neonatal Post-Hemorrhagic Hydrocephalus
Contrast Enhanced Ultrasound Evaluation of Brain Perfusion in Neonatal Post-Hemorrhagic Hydrocephalus
The aim of the proposed project is therefore to utilize the CEUS technique to assess cerebral perfusion changes before and after ventricular shunting in neonatal cases of PHH.
- Trial name
- NCT03061045
- Testing
- Sulfur Hexafluoride Lipid Type A Microspheres 25 MG Intravenous Powder for Suspension [LUMASON]
- Sponsor
- Johns Hopkins University
Hydrocephalus
Randomized Controlled Trial of Shunt vs ETV/CPC for PIH in Ugandan Infants
Two treatment options exist for infant patients with hydrocephalus. Most patients are treated with a surgical procedure in which a shunt is inserted into the brain and abdomen.
- Trial name
- NCT01936272
- Testing
- Chhabra Shunt Placement, ETV/CPC
- Where
- Uganda
- Volunteers
- 100 people
- Sponsor
- Boston Children's Hospital
Arnold Chiari Deformity, Hydrocephalus
Establishing the Physiology of Syringomyelia
The brain and spinal cord are surrounded by fluid called cerebrospinal fluid (CSF). The CSF flows through channels in the brain and around the spinal cord. Occasionally, people are born with malformations of these channels.
- Conditions
- Arnold Chiari Deformity, Hydrocephalus, Syringomyelia
- Trial name
- NCT00001327
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Idiopathic Normal Pressure Hydrocephalus (INPH)
A Placebo-Controlled Effectiveness in INPH Shunting (PENS) Trial
The Placebo-Controlled Effectiveness in Idiopathic Normal Pressure Hydrocephalus (iNPH) Shunting (PENS) trial is a multi-center blinded, randomized, placebo-controlled design investigation of cerebrospinal fluid (CSF) shunt…
- Trial name
- PENS (NCT03350750)
- Testing
- programmable CSF shunt valve
- Where
- 7 sites in United States, Canada and 1 more
- Volunteers
- 18 people
- Sponsor
- Johns Hopkins University
Hydrocephalus
Noninvasive Intracranial Pressure and Hydrocephalus Patients
Using a pulse oximeter, we have developed an algorithm that estimates intracranial pressure (ICP) based on patients who have had traumatic brain injuries.
- Trial name
- NCT02404740
- Testing
- Pulse oximetry
- Volunteers
- 163 people
- Sponsor
- University of Colorado, Denver
Hydrocephalus, Normal Pressure Hydrocephalus
The Usage of Telemetric Prechamber Sensor Reservoir in Management of Normal Pressure Hydrocephalus. Comparisson of Benefit for Patients with Implanted Telemetric Prechamber Sensor Reservoir.
Normal pressure hydrocephalus (NPH) is a preventable and treatable cause of dementia. However, as a nosological entity, it is significantly underdiagnosed, often being mistakenly classified as presenile or senile dementia without…
- Conditions
- Hydrocephalus, Normal Pressure Hydrocephalus, Normal Pressure Hydrocephalus Patients
- Trial name
- NCT06629168
- Testing
- lumbar puncture, External lumbar drainage, Ventriculo-peritoneal shunt placement
- Where
- Czechia
- Volunteers
- 33 people
- Sponsor
- University Hospital Hradec Kralove
Subarachnoid Hemorrhage, Aneurysmal, Cerebrocardiac Syndrome
Mechanisms of Brain-Heart Injury of Post-Intracranial Hemorrhage
Intracranial hemorrhage is a condition characterized by high mortality rates and suboptimal functional outcomes. It precipitates both direct brain injury and subsequent secondary injuries, including delayed cerebral ischemia…
- Conditions
- Subarachnoid Hemorrhage, Aneurysmal, Cerebrocardiac Syndrome, Mass Spectrometry, Heart Failure
- Trial name
- NCT06906432
- Testing
- Multi-disciplinary assessment
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Hydrocephaly
Quantitative Characterization of Safe Irrigation for Ventricular Shunt Catheters
The objective of this pilot study is to perform a set of pressure and flow rate measurements in order to quantitatively characterize safe irrigation or "flushing" of a ventricular shunt catheter, a routine maneuver performed by a…
- Trial name
- NCT02651337
- Testing
- Cerebrospinal Fluid (CSF) Drainage
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Alcyone Therapeutics, Inc