Clinical trials: Hyaluronic Acid
Colorectal Polyps
Clinical Trial to Evaluate the Efficacy and Safety of SUBMO® as a Submucosal Injection Agent in Endoscopic Resection of Superficial Gastrointestinal Lesions.
The SUBMO-PIC01-2025 study evaluates whether SUBMO®, a submucosal injection hydrogel composed of high-molecular weight hyaluronic acid and methylene blue, is as effective and safe as normal saline for endoscopic resection of…
- Trial name
- NCT07448129
- Testing
- SUBMO® Submucosal Injection, Normal Saline (0.9% Sodium Chloride) with Surface Dye Injection
- Where
- 4 sites in Spain
- Volunteers
- 300 people
- Sponsor
- i+Med S.Coop.
Pulmonary Hypertension
Investigation of H01 in Adults With Pulmonary Hypertension Including Interstitial Lung Disease (The SATURN Study).
This study is a prospective, randomized, double-blind, study of H01 (Hymecromone) in adults with pulmonary hypertension (PH). The primary objective of this study is to evaluate the safety and tolerability of oral H01 and the…
- Trial name
- SATURN (NCT05128929)
- Testing
- Hymecromone (H01)
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Stanford University
Brow Ptosis, Skin Aging
Single-Session Microfocused Ultrasound, AbobotulinumtoxinA and Temporal Hyaluronic Acid Filler for Non-Surgical Brow Lifting
This observational study describes the results of a routine aesthetic treatment for mild to moderate eyebrow drooping (brow ptosis).
- Conditions
- Brow Ptosis, Skin Aging, Facial Aging
- Trial name
- NCT07894822
- Testing
- Microfocused ultrasound with visualization, AbobotulinumtoxinA, Hyaluronic acid filler
- Where
- Russia
- Volunteers
- 36 people
- Sponsor
- Estelab Clinic
Osteoarthritis
Efficacy Study of "Go On" in Magnetic Resonance Imaging (MRI) Improvement in Osteoarthritis (OA) Knee
OA knee is a common degenerative diseases of the joint. There are many methods to treat this condition. Hyaluronic acid is one of the recomended treatment of OA knee.
- Trial name
- GoOn MRI (NCT00750724)
- Testing
- 25 mg sodium hyaluronate "GO ON", normal saline,2 ml., intraarticular weekly for 5 weeks
- Where
- Thailand
- Volunteers
- 60 people
- Sponsor
- Khon Kaen University
Arthroscopic Surgery
Functional Outcomes After Hyaluronic Acid Injections Following Arthroscopy
The goal of this study is to investigate the effect of hyaluronic acid injection on functional recovery and pain control in patients following knee or shoulder arthroscopy.
- Trial name
- NCT07468045
- Testing
- CG Synovia (Hyaluronic Acid 0.5%)
- Where
- 2 sites in Indonesia
- Volunteers
- 9 people
- Sponsor
- Daewoong Group Indonesia
Wrinkle
Soluble Hyaluronic Acid Microneedle VS. Non-ablative Fractional Laser on Infraorbital Wrinkles.
This study is a prospective half-face controlled study, aiming to evaluate the therapeutic effects and adverse reactions of soluble hyaluronic acid microneedle and non-ablative fractional laser on infraorbital wrinkles and…
- Trial name
- NCT04989361
- Testing
- Soluble Hyaluronic Acid Microneedle, Non-fractional laser
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Shanghai Dermatology Hospital
Osteoarthritis, Knee, Knee Osteoarthritis
2 Weekly Intra-articular Hyaluronan Knee Injections, Given 1 wk. Apart, of HYMOVIS Combined With Physical Exercise Program (PEP) Compared to PEP Alone, in Relatively Young, Active Population of Subjects With Patellofemoral Osteoarthritis (PFOA) and/or Tibiofemoral Osteoarthritis (TFOA)
Knee osteoarthritis (OA) is among the most common causes of musculoskeletal pain and disability. At present, there is no cure for OA.
- Conditions
- Osteoarthritis, Knee, Knee Osteoarthritis, Patellofemoral Osteoarthritis
- Trial name
- NCT03281837
- Testing
- HYMOVIS plus Physical Exercise Program (PEP), Physical Exercise Program (PEP) alone
- Where
- 10 sites in United States
- Volunteers
- 148 people
- Sponsor
- Fidia Pharma USA Inc.
Aging
Effectiveness and Safety of STYLAGE® HYDRO in the Treatment of Face, Neckline Area and Neck
FLASH Study is a Post-Market Follow-Up PCMF designed to evaluate the tolerance and efficacy of STYLAGE Hydro by using a satisfaction questionnaire.
- Trial name
- FLASH (NCT05809739)
- Testing
- STYLAGE Hydro
- Where
- 2 sites in France
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Laboratoires Vivacy
Myomas, Ovary Cysts
The Efficacy and Safety Study of a New Cross-linked Hyaluronan Hydrogel in the Reduction of Postsurgical Peritoneal Adhesions
The purpose of this study was to determine whether the new crosslinked hyaluronan hydrogel was safe to use, and was effective for the prevention/reduction of adhesion formation following gynecological surgery
- Conditions
- Myomas, Ovary Cysts, Endometriotic Cysts, Adhesions
- Trial name
- BAP (NCT02166554)
- Testing
- Saline, Cross-linked Hyaluronan Hydrogel
- Where
- 7 sites in China
- Volunteers
- 216 people
- Sponsor
- BioRegen Biomedical (Changzhou) Co., Ltd
Genitourinary Syndrome of Menopause
Comparison of Vaginal Hyaluronic Acid Treatment Over Autologous Platelet Rich Plasma Treatment for Genitourinary Syndrome of Menopause
Genitourinary syndrome of menopause (GSM) is a collection of symptoms and signs caused by hypoestrogenic changes to the labia majora/minora, clitoris, vestibule/introitus, vagina, urethra, and bladder that occur in menopausal…
- Trial name
- NCT05571527
- Testing
- Platelet Rich Plasma treatment, Vaginal Hyaluronic Acid supplement
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Ocular Redness
A Study Comparing the Efficacy and Safety of Brimonidine Tartrate Ophthalmic Solution 0.025% With Sodium Hyaluronate Relative to Lumify in Adult Subjects With Ocular Redness
To demonstrate the efficacy of BTOS-HA as non inferior to Lumify for treating ocular redness in a population of adult subjects.
- Trial name
- NCT06803654
- Testing
- BTOS-HA, Lumify®
- Where
- 11 sites in United States
- Volunteers
- 578 people
- Sponsor
- Bausch & Lomb Incorporated
Hyaluronic Acid, Open Flap Debridement
Adjunctive 0.8% Hyaluronic Acid Gel in Open-Flap Surgery for Thin Gingival Phenotype in Patients With Periodontitis
The aim of this study is to evaluate the clinical effectiveness of 0.8% hyaluronic acid (HA) gel as an adjunct to open flap debridement (OFD) in periodontitis patients with a thin gingival phenotype.
- Conditions
- Hyaluronic Acid, Open Flap Debridement, Periodontitis, Gingival Phenotype
- Trial name
- NCT07130266
- Testing
- Procedure/Surgery: Hyaluronic acid gel application, giving an impression of the application
- Where
- Turkey (Türkiye)
- Volunteers
- 37 people
- Sponsor
- Bezmialem Vakif University
Knee Osteoarthritis
The Comparison of Efficacy and Safety of the Mesenchymal Stem Cells From Adipose and Hyaluronic Acid
The aim of this study was to evaluate the efficacy and safety of Mesenchymal Stem Cells (MSCs) from adipose anticular injection in comparison with hyaluronic acid anticular injection in the treatment of human knee…
- Trial name
- NCT03357575
- Testing
- Mesenchymal Stem Cells from adipose, Hyaluronic Acid
- Volunteers
- 14 people
- Sponsor
- Peking University People's Hospital
Patients With an Indication for Myomectomy or Polymyomectomy
Hyaluronic Acid for the Prevention of Endocavitary Synechiae After Myomectomy
PREVENDO is a prospective, multicenter, pilot, and randomized study in 2 parallel arms and single blind, evaluating the proportion of endometrial synechiae 6 weeks after surgery in patients undergoing abdominal myomectomy or…
- Trial name
- PREVENDO (NCT04702399)
- Testing
- GEL GROUP
- Volunteers
- 76 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cicatrix, Post-Surgical Complication
Class I Medical Device on Post-surgical Scars
To compare the effect of a class I pullulan based medical device containing Allium cepa \& HA versus a class I medical device silicone gel on new post-surgical wounds
- Conditions
- Cicatrix, Post-Surgical Complication, Scar Itching, Keloid
- Trial name
- NCT05412745
- Testing
- Kaloidon Plus, silicone gel
- Where
- 2 sites in Italy
- Volunteers
- 64 people
- Sponsor
- University of Rome Tor Vergata
Periodontitis (Stage 3), Periodontitis
Testing Sodium Hypochlorite and Hyaluronic Acid as an Adjunct to Non-Invasive Therapy for Stage III Periodontitis Management
The study was designed to evaluate the concept of the clean \& seal, using sodium hypochlorite gel and hyaluronic acid as adjunctive to non-surgical therapy for management of Stage III Periodontitis.
- Trial name
- NCT07071467
- Testing
- Scaling and root planing with sodium hypochlorite and hyaluronic acid, Scaling and root planing
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Karim Ismail
Esophageal Neoplasms, Endoscopic Mucosal Resection
Comparison of 0.4% Hyaluronic Acid Solution Versus Hydroxyethylamide Solution in Submucosal Endoscopic Resections
This is a randomized, single-center clinical trial that will compare the efficacy of two substances used in the submucosal cushion formation stage of endoscopic submucosal resections of early esophageal malignant neoplasms.
- Conditions
- Esophageal Neoplasms, Endoscopic Mucosal Resection, Hyaluronic Acid
- Trial name
- NCT06077981
- Testing
- Submucous Endoscopic Dissection with hydroxyethylamide, Submucous Endoscopic Dissection with Hyaluronic acid (TS-905 Blue Eye)
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Instituto do Cancer do Estado de São Paulo
Osteoarthritis of Knee
Clinical Efficacy and Safety of NEOIAL HC for Intra-articular Use in the Treatment of Severe Knee Osteoarthritis
Osteoarthritis (OA) is one of the most frequent causes of pain and disability in adults. According to the Osteoarthritis Research Society International (OARSI), at least 40% of people over the age of 65 suffer from symptomatic…
- Trial name
- NCT05936762
- Testing
- Neoial HC
- Where
- Italy
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Nextrasearch S.r.l.s.
Melasma
Tranexamic Acid With Microneedling in Melasma
Topical tranexamic, a hydrophilic molecule, can't pass the lipid barriers of the stratum corneum and it's also not retained in adequate amount in the epidermis to enter the melanocytes, so there's a difficulty in the effective…
- Trial name
- NCT05909072
- Testing
- Hyaluronic acid combined with tranexamic acid microneedling, tranexamic acid microneedling
- Volunteers
- 27 people
- Sponsor
- Zagazig University
Acute Radiation Proctitis, Acute Radiation Enteritis
Efficacy of Hyaluronic Acid in Prevention of Acute Radiation Proctitis
A randomized placebo-controlled clinical trial to evaluate efficacy of hyaluronic acid in prevention of acute radiation proctitis among oncology patient population especially who are diagnosed with abdomeno-pelvic tumors and…
- Trial name
- NCT06469216
- Testing
- Hyaluronic Acid
- Where
- 2 sites in Egypt
- Volunteers
- 44 people
- Sponsor
- Assiut University
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