Clinical trials: Human Microbiome
Human Gut Microbiota
Diet Interactions With Human Gut Microbiota. The Potential Role of Mediterranean Diet Adherence. DIAGRAM, a Pilot Study
Despite the strong evidence on health benefits of traditional MeD, not many studies have broadly and systematically been made for the potential role and relationship of the MeD in the composition of the gut microbiota.
- Trial name
- DIAGRAM (NCT03080532)
- Testing
- dietary habits
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Intestinal Bacteria Flora Disturbance
The Effect of Fruit/Vegetable Drinks on the Human Intestine
This is a 4 ½ week study with 20 healthy subjects (including a 2 week run-in ) . Subjects will be taking vegetable/fruit juice supplementation for 3 days.
- Trial name
- NCT02377063
- Testing
- Pressed Juice
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
IBD (Inflammatory Bowel Disease)
Human and Microbial Determinants of the Onset of IBD Flares
This study will collect longitudinal biological samples and survey data to identify the triggers of IBD flares.
- Trial name
- NCT06967311
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- Viome
Microbiome, Glucose Metabolism
Westlake Sailing Cohort
Little is known about the dynamic change of human microbiome in different body sites including skin, mouth and gut during sailing.
- Conditions
- Microbiome, Glucose Metabolism, Mood, Environment
- Trial name
- NCT04611945
- Where
- China
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Westlake University
Obesity, Inflammation
Combining HIIT and n-3 PUFA to Reduce Inflammation and Improve Metabolic Health
The goal of this project is to understand the combined effects of fish oil and exercise in obesity-associated inflammation. The investigators hypothesize that fish oil will improve gut bacteria profiles, which will in turn…
- Conditions
- Obesity, Inflammation, Human Microbiome, Insulin Resistance
- Trial name
- HIIT&PUFA (NCT05295719)
- Testing
- Omega-3 polyunsaturated fatty acid, High-Intensity Interval Training, Safflower oil
- Where
- United States
- Volunteers
- 129 people
- Sponsor
- Texas Tech University
Vaginal Microbiome
Vaginal Microbiota and Its Association with Pap Smear Results, Human Papillomavirus, Vitamins, and Metabolic Mark
The human microbiome, comprising bacteria, fungi, and viruses, plays a crucial role in host physiology, immune function, and disease susceptibility.
- Trial name
- NCT06897800
- Where
- Taiwan
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Cheng-Hsin General Hospital
Pilot Study
How Differences in the Composition of Microorganisms in the Soil Affect the Microorganisms in the Human Gut, Through the Vegetables That Grow in it: a Process Pilot Study With Healthy Participants
There are two objectives for this clinical trial. The first is to test whether, with the current logistics and study setup it is possible to perform the study well and see where there might be bottlenecks we couldn't predict.
- Trial name
- HUMANITAS (NCT07742319)
- Testing
- Low diversity vegetable smoothie, High diversity vegetable smoothie
- Where
- Netherlands
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Dysbiosis, Clostridium Difficile
REMBRANDT: REcovery of the MicroBiome fRom Antibiotics for Dental implanTs
Antimicrobial therapy can lead to disruption of the gut microbiome and infection with Clostridioides difficile, a disease associated with high morbidity and mortality, particularly among the elderly.
- Conditions
- Dysbiosis, Clostridium Difficile, Pet-Human Bonding, Antibiotic-Associated Colitis
- Trial name
- NCT05622721
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Pennsylvania
Diet Modification
Effect of Phytin on Human Gut Microbiome (EPoM)
Within many plants, such as seeds, nuts and cereals, there is a compound called phytic acid. Phytic acid has many beneficial properties, including producing molecules which slows down the damage that can be caused to other…
- Trial name
- EPoM (NCT03917693)
- Testing
- Phytin, rice extract
- Where
- 2 sites in United Kingdom
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Quadram Institute Bioscience
Diabetes Mellitus Type 2 in Obese
Cochlear-Vestibular Ganglion (CVG) in Newly Diagnosed Type 2 Diabetes Patients
The proposed study is an integrative scientific undertaking, reflecting the input of experts in the behavioral sciences, mHealth technology, computational biology, endocrinology, biochemistry, and nutrition.
- Trial name
- NCT02668328
- Testing
- Social Cognitive Theory Tailored Behavioral Intervention
- Sponsor
- NYU Langone Health
Colitis, Ulcerative, Inflammatory Bowel Diseases
CAsein GLycomacropeptide in Ulcerative Colitis - Anti-Inflammatory and Microbiome Modulating Effects (CAGLUCIM)
Casein glycomacropeptide (CGMP) has anti-inflammatory properties in experimental rodent colitis and using human in vitro inflammation models. Its use as a food ingredient has proven safe and with no influence on dietary intake.
- Trial name
- CAGLUCIM (NCT02825914)
- Testing
- Casein glycomacropeptide (CGMP)
- Where
- Denmark
- Volunteers
- 80 people
- Sponsor
- University of Aarhus
Bacterial Communities
Sources of Bacterial Contamination in Human Milk Samples From the MiLC Trial
This observational study is a sub-study of the MiLC Trial (ClinicalTrials.gov Identifier: NCT03123874). Our objective is to characterize the bacterial communities of women's breasts, hands, their pump and milk collection kit, and…
- Trial name
- NCT03371511
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Cornell University
Autoimmune
The Human Microbiome in Immune-Mediated Diseases
The immune system is influenced by the commensal microbes that live in the gut and on the skin. This study aims to characterize the microbiota of subjects with autoimmune disease in order to determine whether certain microbial…
- Trial name
- NCT02394964
- Testing
- Sample Collection
- Where
- 2 sites in United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Yale University
Dysbacteriosis
Longitudinal Study of the Human Intestinal Microbiome
The purpose of this study is to identify the human intestinal microbiota (microbes that live inside and on human bodies) in healthy adults over a 6-month period and to study the effect of an antibiotic on the intestinal…
- Trial name
- NCT00832286
- Testing
- Ciprofloxacin
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Gestational Diabetes Mellitus (GDM), Microbiome, Human
A Probiotic Based Intervention in Pregnancies Complicated by GDM
This study is a single center randomized control trial of a probiotic based intervention in pregnancies complicated by gestational diabetes.
- Trial name
- ProbioGDM (NCT06794723)
- Testing
- 5-strain probiotic plus prebiotic natural health product
- Where
- Canada
- Volunteers
- 173 people
- Sponsor
- Queen's University
Inflammation Gastrointestinal Tract
Identifying the Microbial Metabolome: The Missing Link Between Diet and Human Health
There is a lot of evidence to suggest that the bacteria in our gut play a major role in maintaining our health, but very little is known about the way in which this is achieved.
- Trial name
- NCT07591961
- Testing
- Food
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University of Aberdeen
Dietary Fibers, Intermediate Fasting
The Role of the Microbiome in the Response to Dietary Fibers Intake During Intermittent Fasting
Dietary fibers are generally not degraded by the endogenous digestive enzymes, but rather by the complex ensemble of microorganisms that reside in the human gut [1].
- Trial name
- NCT04633369
- Testing
- dietary fibers, Intermediate fasting
- Where
- Israel
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Weizmann Institute of Science
Colorectal Polyp, Inflammation
Impact of Dietary Intervention on Inflammation and Microbiome Composition Post-Colonoscopy
This study aims to investigate the impact of various healthy diets, specifically a modified plant-based Mediterranean diet, on the gut microbiome and overall well-being post-colonoscopy.
- Conditions
- Colorectal Polyp, Inflammation, Dietary Intervention, Microbiota
- Trial name
- NCT06603519
- Testing
- Modified Plant-Based Mediterranean Diet
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Healthy
Trimethylamine-N-oxide Production and Metabolism
The purpose of this study was to understand the production of trimethylamine-N-oxide (TMAO) and its metabolites from dietary precursors found in fish, eggs and beef.
- Trial name
- NCT02558673
- Testing
- TMAO dietary precursors, Control (or active comparator)
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cornell University
Gut Microbiome
Effect of The Substitution of Animal Protein by Soya-Based Fermented Product on Human Gut Microbiome
There is a growing understanding of the functioning and interconnectedness of microbiomes in the food system which offers great potential for enabling the development of new solutions contributing to achieving important food and…
- Trial name
- NCT06304480
- Testing
- 100g fermented Tofu
- Where
- Ireland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University College Cork