Clinical trials: Host and Microbiome, open to volunteers
Intrauterine Hyperglycemia, Pregnancy Outcomes
The Born in Guangzhou Cohort Study (BIGCS)
The Born in Guangzhou Cohort Study (BIGCS) was established to investigate the short- and long-term effects of exposure in early life on health consequences in Guangzhou, China.
- Conditions
- Intrauterine Hyperglycemia, Pregnancy Outcomes, Neurodevelopment, Immune Development
- Trial name
- BIGCS (NCT02526901)
- Testing
- No intervention
- Where
- China
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- Guangzhou Women and Children's Medical Center
Diffuse Large B Cell Lymphoma (DLBCL), Follicular Lymphoma (FL)
The Microbiome in Blood Cancer and HLH
The bacteria and viruses in the bowel (gut microbiota; GM) have powerful effects on the immune system. GM changes are seen in patients with auto-immune diseases, where the immune system attacks normal tissues, and cancer, and for…
- Conditions
- Diffuse Large B Cell Lymphoma (DLBCL), Follicular Lymphoma (FL), Haemophagocytic Lymphohistiocytosis
- Trial name
- NCT06734624
- Where
- United Kingdom
- Volunteers
- 750 people
- Sponsor
- University of Nottingham
Gut Microbiome, Liver Diseases
Assessment of Microorganisms and Host Response In Liver Diseases
The normal human gut is home to millions of microbes including bacteria, fungi, and viruses, collectively forming the gut microbiota, which exists in harmony within us.
- Trial name
- MILD (NCT06291571)
- Where
- United Kingdom
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Aberdeen
Choledochal Cyst
Host-Microbe Interactions in Biliary Dilatation
This study is an observational cohort study aimed at continuously enrolling patients with biliary dilatation and healthy controls.
- Trial name
- NCT07152496
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Vulvovaginal Candidiasis
Effect of a Multi-strain Probiotic on Recurrent Vulvovaginal Candidiasis
This study evaluates the effect of a multi-strain probiotic on the risk of recurrence and severity of symptoms in females with recurrent vulvovaginal candidiasis (R-VVC).
- Trial name
- PROVELIA (NCT06480604)
- Testing
- Probiotic
- Where
- 6 sites in India
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- The Archer-Daniels-Midland Company
Vascular Graft Infection, Infectious Aortitis
China Aortic Infection and Graft Infection Study: An Ambispective Cohort
Vascular infections are uncommon but severe infections involving the arterial wall, vascular grafts, or endografts, and their diagnosis and management remain challenging.
- Conditions
- Vascular Graft Infection, Infectious Aortitis, Aortoenteric Fistula
- Trial name
- CAIGIS (NCT07847346)
- Where
- China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Shanghai Zhongshan Hospital
Hereditary Transmission, Immune Development
Maternal Grandmothers in the Born in Guangzhou Cohort Study
The MGBIG is a study exploring cross-generational effects in 5000 women and their children and grandchildren located in Guangzhou, China.
- Conditions
- Hereditary Transmission, Immune Development, Childhood Obesity, Host and Microbiome
- Trial name
- MGBIG (NCT03633162)
- Where
- China
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Guangzhou Women and Children's Medical Center
Heart Failure With Reduced Ejection Fraction, Nonischemic Cardiomyopathy
Gut Microbiome Profiling in Patients With Chronic Heart Failure
The goal of this observational study is to learn about the composition and function of the gut microbiome in adults with chronic heart failure with reduced ejection fraction. The main questions the study aims to answer are: 1.
- Trial name
- NCT06361524
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Stanford University
Endodontic Disease, Periodontitis
Endo-perio Disease - Treatment Outcomes Using Conventional and Hydraulic Calcium Silicate Sealer With or Without LPRF
The endodontic periodontal-disease is characterized by the involvement of the pulp and periodontal disease in the same tooth. The anatomic connections between the dental pulp and the periodontium provide a pathway for perio-endo…
- Trial name
- NCT05681754
- Testing
- Experimental: RCT using hydraulic calcium silicate sealer and L-PRF + GTR, Experimental: RCT using conventional sealer and L-PRF + GTR, Experimental: RCT using hydraulic calcium silicate sealer and GTR
- Where
- United Kingdom
- Volunteers
- 115 people
- Sponsor
- King's College London
ART, Offspring, Adult
IVF Offspring Born in Guangzhou
The IVF Offspring Born in Guangzhou Cohort Study (IVF-BIG) was established to investigate the short- and long-term effects of exposure in early life on the health of mothers and offspring in Guangzhou, China.
- Conditions
- ART, Offspring, Adult, Genetics, Host and Microbiome
- Trial name
- IVF-BIG (NCT03650829)
- Where
- China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Guangzhou Women and Children's Medical Center
Endometritis; Chronic, Subfertility
The FLORA-project: in Search for the Microbial Cause of Chronic Endometritis and the Most Appropriate Treatment to Obtain a Successful Pregnancy IVF/ICSI
Chronic endometritis is an inflammatory condition of the endometrium. This inflammation can negatively affect fertility and pregnancy. The pathology is frequently (+-10%) observed in women with fertility problems.
- Trial name
- FLORA (NCT05337072)
- Testing
- Microbiome study
- Where
- Belgium
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Hospital Acquired Pneumonia (HAP), Cardiovascular and Respiratory Disease
Long-term Alterations of Host-microbiome Interactions and Cardiovascular and Respiratory Diseases Progression After Pneumonia
The HOMI-LUNG - HAP study is part of the HOMI-LUNG project, funded by the Horizon Europe program. The "HOMI-LUNG" project is an international, interdisciplinary project that aims to better understand the causal links between…
- Trial name
- HOMI-LUNG-HAP (NCT06602934)
- Testing
- Blood samples, Oropharyngeal swabs, ECG
- Where
- 5 sites in France
- Volunteers
- 300 people
- Sponsor
- Nantes University Hospital
Clostridioides Difficile Infection
Clostridioides Difficile: Understanding Responses and Treatment Effects
The goal of this observational study is to learn how different treatments for Clostridioides difficile infection (CDI) work, and which biological mechanisms are involved in recovery.
- Trial name
- CURE-CDI (NCT07374094)
- Testing
- Antibiotic treatment, Fecal microbiota transplantation (FMT)
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Umeå University
Protracted Bacterial Bronchitis
Airway Microbiome of Patients With Protracted Bacterial Bronchitis
This project aims to assess the relationship between the microbiome and virome composition, the immune responses, and the respiratory health of children with protracted bacterial bronchitis (PBB).
- Trial name
- NCT07255430
- Where
- Belgium
- Volunteers
- 160 people
- Sponsor
- University Hospital, Antwerp
Twin Diseases, Immune Development
Twins Born in Guangzhou
The 2-BIG is a twin birth cohort study located in Guangzhou, China.Its initial aim is to facilitate research on understanding the interplay between genes and environmental factors on disease etiology.
- Conditions
- Twin Diseases, Immune Development, Childhood Obesity, Host and Microbiome
- Trial name
- 2-BIG (NCT03331133)
- Testing
- No intervention
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Guangzhou Women and Children's Medical Center
Severe Pneumonia
Microbiome and Host Susceptibility in Severe Pneumonia, a Prospective, Multicenter, Cohort Study
This study was a prospective multicenter cohort of severe pneumonia. And by collecting clinical samples to clarify the correlation between lung microbiome, intestinal microbiome, host susceptibility, and prognosis of severe…
- Trial name
- MASS (NCT06114784)
- Testing
- Metagenomics
- Where
- 15 sites in China
- Volunteers
- 2,000 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Preterm Birth, Neurodevelopment
Preterm Birth Cohort Study in Guangzhou
The Preterm Birth Cohort Study in Guangzhou (PBCSG) aims to explore the impact of genetic and environmental factors including life styles on preterm birth, to examine the interaction effect between these factors, and to follow up…
- Conditions
- Preterm Birth, Neurodevelopment, Immune Development, Host and Microbiome
- Trial name
- PBCSG (NCT03668327)
- Where
- China
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Guangzhou Women and Children's Medical Center
Hematopoietic Stem Cell Transplantation (HSCT), aGVHD
GMPA Versus PPI for Gastric Protection and aGVHD Risk
The goal of this clinical trial is to observe whether different gastric protection strategies affect the incidence of acute graft-versus-host disease (aGVHD) in patients undergoing allogeneic hematopoietic stem cell…
- Conditions
- Hematopoietic Stem Cell Transplantation (HSCT), aGVHD, Infection, Mortality
- Trial name
- NCT07791849
- Testing
- Teprenone, Esomeprazole
- Where
- China
- Volunteers
- 198 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Type 2 Diabetes
Dissecting Host-microbiome Modifiers of Type 2 Diabetes Risk
It is now well documented that changes in gut microbiota composition accompany obesity and type 2 diabetes (T2D) and contribute to low-grade inflammation, insulin resistance,and glucose intolerance.
- Trial name
- DBBIOTE (NCT04579900)
- Testing
- Endoscopy and duodenal biopsy and sampling
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Laval University
Gestational Diabetes Mellitus, Pregnancy Outcome
GDM and Its Consequences in Mothers and Offsprings
Gestational diabetes mellitus (GDM) is one of the most common disorders which occured during pregnancy. GDM is not only associated with short-term maternal and fetal adverse outcomes, but also related to a wide range of long-term…
- Conditions
- Gestational Diabetes Mellitus, Pregnancy Outcome, Neurodevelopment, Immune Development
- Trial name
- GDMCMO (NCT04529889)
- Where
- China
- Volunteers
- 7,000 people, healthy volunteers welcome
- Sponsor
- Guangzhou Women and Children's Medical Center