Hereditary TransmissionMGBIGNCT03633162
Maternal Grandmothers in the Born in Guangzhou Cohort Study
An observational study of Hereditary Transmission and Immune Development, run by Guangzhou Women and Children's Medical Center at 1 site in China.
Trial summary
The MGBIG is a study exploring cross-generational effects in 5000 women and their children and grandchildren located in Guangzhou, China. Its initial aim is to facilitate research on understanding the interplay between genes and environmental factors on disease etiology and on explaining the cause of the disease from… Read more about this study
- Who is it for?
- Ages 36 to 100 years, women onlyHealthy volunteers can take part
- Conditions the study is for
- Hereditary Transmission, Immune Development, Childhood Obesity
- How many people
- 5,000 participants
- Where
- 1 siteChina
- Study dates
- 21 May 2018to 31 Dec 2038
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 36 to 100 years
- Women only
- Healthy volunteers accepted
- Adult, Older adult
Study population: All maternal grandmothers of the children in the Born in Guangzhou Cohort Study (BIGCS) would be recruited.
Who may be able to join
- Maternal Grandmother' grandchildren delivered in Guangzhou Women and Children's Medical Center
- Baseline information of maternal grandmother's daughter during pregnancy available
Who cannot join
- Significant cardiovascular abnormalities
- Intelligent obstacle, intellectual disabilities or gawkish condition
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
China1 site, 1 recruiting
- Recruiting
Guangzhou Women and Children's Medical Center
Guangzhou, Guangdong, 510623
Xiu Qiu, Doctor, +862038076001, qxiu0161@163.com
About this study
The MGBIG is a study exploring cross-generational effects in 5000 women and their children and grandchildren located in Guangzhou, China. Its initial aim is to facilitate research on understanding the interplay between genes and environmental factors on disease etiology and on explaining the cause of the disease from the perspective of "grandmother-mother-child" heredity. Data are collected regarding environmental exposures, lifestyle, and social support on grandmother from birth to old age. Biological samples including blood and tissue samples are collected.
Read the detailed description
It was previously believed that heredity strictly follows Mendel's laws, but recent studies have found that through placental material exchange, mammals may transfer maternal immune-related factors vertically, thus promoting the protection of "non-heredited maternal antigenic traits". Thus, the transmission of reproductive information across generations is realized. Since the unusual genetic pattern of the X chromosome, grandmother's influence may be gender specific. Since grandchildren were usually took care by grandparents in China, it could be achievable to attach and recruit maternal grandmother together with mother and children. Cohort including three generations of women is rare in Asia at present. In the MGBIG, extensive information including demographic characteristics, lifestyle, history of diseases, mental health, and behaviors is collected from the participants. Longitudinal follow up and surveillance of common chronic diseases are also to be conducted. The MGBIG intends to recruit maternal grandmothers to study the effects of maternal genetic and environmental exposure on the health of their children and grandchildren.
- Conditions
- Hereditary Transmission, Immune Development, Childhood Obesity, Host and Microbiome, Neurodevelopment
- Keywords
- Maternal Grandmother, Genes, Immune, Cohort, Child development
- Medical subject headings
- Pediatric Obesity
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Other
What is being measured
The primary outcome is the main question the study is designed to answer.
Haplotypes transfered by non-inherited maternal antigens from maternal grandmother to female offspring
Assessed by analyses of MHC haplotypes, HLA haplotypes, and levels of non-inherited maternal antigens of mother and offspring, and pregnancy complication of maternal grandmothers and mothers
Measured: From the date of her daughter get pregnant until the date her grandchild/grandchildren is/are given birth
Secondary outcomes (7)
Serum levels of Inflammatory factors at grandchildren's birth and early neonatal life
Assessed by analyses of IL-1, IL-6, IL-10, IL-12, etc.
Measured: At the birth date of her grandchild/grandchildren, at the date 42 days after the birth of the certain grandchild/grandchildren
The prevalence of eczema of grandchildren
Assessed by self-reported time of onset and electronic medical record
Measured: At the age of 6 weeks, 6 months, 1year, 3 years, 6 years, 12years and 18years of grandchildren
The incidence of asthma of grandchildren
Assessed by self-reported time of onset and electronic medical record
Measured: At the age of 6 months, 1year, 3 years, 6 years, 12years and 18years of grandchildren
The prevalence of Allergic rhinitis of grandchildren
Assessed by self-reported time of onset and electronic medical record
Measured: At the age of 6 months, 1year, 3 years, 6 years, 12years and 18years of grandchildren
The prevalence of Food allergy of children and grandchildren
Assessed by self-reported time of onset and electronic medical record
Measured: At the age of 6 months, 1year, 3 years, 6 years, 12years and 18years of grandchildren
Changes of body composition of grandchildren
Body composition is assessed using Dual Energy X-Ray Absorptiometry
Measured: At age of 3 years,6 years, 12years and 18years
Changes of bone density of grandchildren
Bone density is assessed using Dual Energy X-Ray Absorptiometry
Measured: At age of 3 years,6 years, 12years and 18years
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted16 Aug 2018
- Study start21 May 2018
- Primary completion31 Dec 2038 (estimated)
- Study completion31 Dec 2038 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (2)Papers the sponsor has linked to this study.
- Other trials for Hereditary TransmissionStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Retrospective
- Enrolment
- 5,000 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Guangzhou Women and Children's Medical Center
- Sponsor type
- University, hospital or other
- Collaborators
- Children's Hospital Medical Center, Cincinnati, University of Birmingham
- Responsible party
- Principal investigator, Xiu Qiu, Guangzhou Women and Children's Medical Center
- Investigators
- Xiu Qiu, PhD, Principal investigator, Guangzhou Women and Children's Medical Center, China
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT03633162
- Sponsor's protocol ID
- 2018041801
- Other IDs
- 81673181, 201508030037
- Acronym
- MGBIG
- Status last verified
- Sep 2026
- First submitted
- 23 Jul 2018
- Last updated
- 16 Sep 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Qiu X, Lu JH, He JR, Lam KH, Shen SY, Guo Y, Kuang YS, Yuan MY, Qiu L, Chen NN, Lu MS, Li WD, Xing YF, Zhou FJ, Bartington S, Cheng KK, Xia HM. The Born in Guangzhou Cohort Study (BIGCS). Eur J Epidemiol. 2017 Apr;32(4):337-346. doi: 10.1007/s10654-017-0239-x. Epub 2017 Mar 20.
PubMed 28321694Kinder JM, Jiang TT, Ertelt JM, Xin L, Strong BS, Shaaban AF, Way SS. Cross-Generational Reproductive Fitness Enforced by Microchimeric Maternal Cells. Cell. 2015 Jul 30;162(3):505-15. doi: 10.1016/j.cell.2015.07.006. Epub 2015 Jul 23.
PubMed 26213383
Study at a glance
From the registry record, last updated by the sponsor on 16 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Maternal Grandmothers in the Born in Guangzhou Cohort Study
- ClinicalTrials.gov ID
- NCT03633162
- Acronym / sponsor ID
- MGBIG / 2018041801
- Conditions
- Hereditary Transmission, Immune Development, Childhood Obesity, Host and Microbiome, Neurodevelopment
- Keywords
- Maternal Grandmother, Genes, Immune, Cohort, Child development
- Study type
- Observational
- Recruitment status
- Recruiting
- Enrolment
- 5,000 participants (estimated)
- Lead sponsor
- Guangzhou Women and Children's Medical CenterUniversity, hospital or other
- Collaborators
- Children's Hospital Medical Center, Cincinnati, University of Birmingham
- Study start
- 21 May 2018 (actual)
- Primary completion
- 31 Dec 2038 (estimated)
- Study completion
- 31 Dec 2038 (estimated)
- First posted
- 16 Aug 2018 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The MGBIG is a study exploring cross-generational effects in 5000 women and their children and grandchildren located in Guangzhou, China. Its initial aim is to facilitate research on understanding the interplay between genes and environmental factors on disease etiology and on explaining the cause of the disease from the perspective of "grandmother-mother-child" heredity. Data are collected regarding environmental exposures, lifestyle, and social support on grandmother from birth to old age. Biological samples including blood and tissue samples are collected.
Detailed description
It was previously believed that heredity strictly follows Mendel's laws, but recent studies have found that through placental material exchange, mammals may transfer maternal immune-related factors vertically, thus promoting the protection of "non-heredited maternal antigenic traits". Thus, the transmission of reproductive information across generations is realized. Since the unusual genetic pattern of the X chromosome, grandmother's influence may be gender specific. Since grandchildren were usually took care by grandparents in China, it could be achievable to attach and recruit maternal grandmother together with mother and children. Cohort including three generations of women is rare in Asia at present. In the MGBIG, extensive information including demographic characteristics, lifestyle, history of diseases, mental health, and behaviors is collected from the participants. Longitudinal follow up and surveillance of common chronic diseases are also to be conducted. The MGBIG intends to recruit maternal grandmothers to study the effects of maternal genetic and environmental exposure on the health of their children and grandchildren.
Study design
- Observational model
- Cohort
- Time perspective
- Retrospective
Who may qualify
- Ages
- 36 to 100 years
- Sex
- Female only
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
- Study population
- All maternal grandmothers of the children in the Born in Guangzhou Cohort Study (BIGCS) would be recruited.
Key inclusion criteria (2 listed)
- Maternal Grandmother' grandchildren delivered in Guangzhou Women and Children's Medical Center
- Baseline information of maternal grandmother's daughter during pregnancy available
Key exclusion criteria (2 listed)
- Significant cardiovascular abnormalities
- Intelligent obstacle, intellectual disabilities or gawkish condition
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Other | – |
Primary outcome
Haplotypes transfered by non-inherited maternal antigens from maternal grandmother to female offspring
Time frame: From the date of her daughter get pregnant until the date her grandchild/grandchildren is/are given birth
Assessed by analyses of MHC haplotypes, HLA haplotypes, and levels of non-inherited maternal antigens of mother and offspring, and pregnancy complication of maternal grandmothers and mothers
7 secondary outcomes
Serum levels of Inflammatory factors at grandchildren's birth and early neonatal life
Time frame: At the birth date of her grandchild/grandchildren, at the date 42 days after the birth of the certain grandchild/grandchildren
The prevalence of eczema of grandchildren
Time frame: At the age of 6 weeks, 6 months, 1year, 3 years, 6 years, 12years and 18years of grandchildren
The incidence of asthma of grandchildren
Time frame: At the age of 6 months, 1year, 3 years, 6 years, 12years and 18years of grandchildren
The prevalence of Allergic rhinitis of grandchildren
Time frame: At the age of 6 months, 1year, 3 years, 6 years, 12years and 18years of grandchildren
The prevalence of Food allergy of children and grandchildren
Time frame: At the age of 6 months, 1year, 3 years, 6 years, 12years and 18years of grandchildren
Changes of body composition of grandchildren
Time frame: At age of 3 years,6 years, 12years and 18years
Changes of bone density of grandchildren
Time frame: At age of 3 years,6 years, 12years and 18years
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 16 Sep 2026.
- Background: PubMed 28321694Qiu X, Lu JH, He JR, Lam KH, Shen SY, Guo Y, Kuang YS, Yuan MY, Qiu L, Chen NN, Lu MS, Li WD, Xing YF, Zhou FJ, Bartington S, Cheng KK, Xia HM. The Born in Guangzhou Cohort Study (BIGCS). Eur J Epidemiol. 2017 Apr;32(4):337-346. doi: 10.1007/s10654-017-0239-x. Epub 2017 Mar 20.
- Background: PubMed 26213383Kinder JM, Jiang TT, Ertelt JM, Xin L, Strong BS, Shaaban AF, Way SS. Cross-Generational Reproductive Fitness Enforced by Microchimeric Maternal Cells. Cell. 2015 Jul 30;162(3):505-15. doi: 10.1016/j.cell.2015.07.006. Epub 2015 Jul 23.
- Individual participant dataSharing planned: No
Related trials for Hereditary Transmission
Enrolling by invitationObservational study
Prospective Healthcare-Associated Links in Transmission of Nontuberculous Mycobacteria
Cystic Fibrosis, Nontuberculous Mycobacterial Pulmonary Infection
Enrolling by invitationObservational study
Comparative Autoantibody and Immunologic Cell Marker Study
Autoimmune Diseases, Lupus Erythematosus, Systemic
RecruitingPhase 2
Microbiome Metabolites and Alcohol in HIV to Reduce CVD RCT
Microtia, Dysbiosis
RecruitingObservational study
Measuring Adverse Pregnancy and Newborn Congenital Outcomes
HIV/AIDS, Pregnancy Related
Not yet recruitingObservational study
Congenital and Maternal Point of Care Rapid Testing for Syphilis Study, Uganda
Syphilis, Syphilis, Congenital
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Xiu Qiu, PhD principal investigator
Guangzhou Women and Children's Medical Center, China
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Hereditary Transmission and Immune Development, run by Guangzhou Women and Children's Medical Center at 1 site in China.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 16 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in China. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Xiu Qiu, PhD (0086 20 38367160, qxiu0161@163.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Haplotypes transfered by non-inherited maternal antigens from maternal grandmother to female offspring (time frame: From the date of her daughter get pregnant until the date her grandchild/grandchildren is/are given birth). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT03633162, which also lists 2 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 16 Sep 2026.