Clinical trials: Hope, open to volunteers
Laughter Yoga
The Effect of Laughter Yoga on Hope and Well-Being Levels of Earthquake Victim Mothers
In Turkey, on February 6, 2023, an earthquake measuring 7.7 in magnitude centered in the Pazarcık district of Kahramanmaraş Province, followed by a second earthquake measuring 7.6 in magnitude centered in Elbistan, caused the…
- Trial name
- NCT06757036
- Testing
- Laughter Yoga
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Firat University
Serious Mental Illness, Older Adults
A Pilot Randomized Controlled Trial of the Hopeful and Healthy Living Program
The goal of this clinical trial is to learn if a novel psychosocial intervention is effective in helping adults over 50 with serious mental illness (SMI) increase their social connections and participate in more healthy lifestyle…
- Trial name
- (HHL) (NCT06940843)
- Testing
- Hopeful and Healthy Living (HHL)
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Boston University Charles River Campus
Brain Death, Respiration, Artificial
Miniature In-line Respirator
This first-in-human pilot study will test an investigational miniature breathing device called the Hope inVent. The device is a small, single-use, in-line respirator that connects to a breathing tube and uses compressed oxygen to…
- Trial name
- NCT07768215
- Testing
- Hope inVent
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
HIV
Liver Transplantation From Donors With HIV: Impact on Opportunistic Infections, Cancer, and Long-Term Outcomes (Expanding HOPE Liver)
This research is being done to better understand opportunistic infections and cancer in transplant recipients with HIV who receive livers from a donor with HIV compared to livers from donors without HIV.
- Trial name
- NCT07665372
- Testing
- HIV D+/R+, HIV D-/R+
- Where
- 19 sites in United States
- Volunteers
- 80 people
- Sponsor
- Johns Hopkins University
Lung Cancer
Pathways, a Hope Intervention to Support Personal Goal Pursuit, Mental Health, and Quality of Life During Advanced Lung Cancer Treatment
This study will compare the effects of a brief supportive intervention, called Pathways, against enhanced usual care on the mental health and quality of life of people undergoing treatment for advanced lung cancer.
- Trial name
- NCT06047301
- Testing
- Pathways, Enhanced Usual Care
- Where
- United States
- Volunteers
- 234 people
- Sponsor
- Laurie McLouth
Adults, Overweight , Obesity
High Phenolic Olive Oil for Enhancing Metabolic Health: a Randomized-controlled Trial in Patients With cEntral Obesity (HOPE)
Olive oil is a fundamental component of the Mediterranean diet and a major source of monounsaturated fatty acids with well-established cardioprotective properties.
- Conditions
- Adults, Overweight , Obesity, Metabolic Abnormalities, Consented to Participate in the Trial and Signed an ICF
- Trial name
- HOPE (NCT07445503)
- Testing
- Low phenolic olive oil, High phenolic olive oil
- Where
- Greece
- Volunteers
- 80 people
- Sponsor
- University of Peloponnese
Sepsis and Septic Shock
HOPE-Sepsis: Hemoadsorption Therapy for Sepsis
This is a single-center, prospective, single-arm, open-label study that will enroll 30 adult patients with sepsis at Zhongshan Hospital, Fudan University.
- Trial name
- NCT07865585
- Testing
- Hemoperfusion with CA330 Cytokine Adsorption Column
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shanghai Zhongshan Hospital
Plaque Psoriasis, Metabolic Dysfunction-Associated Steatotic Liver Disease
A Study to Estimate Secukinumab Retention Rate in Psoriasis Patients With MASLD
This study aims to examine the retention rate of secukinumab in adult patients with plaque psoriasis (with or without psoriatic arthritis [PsA]) and metabolic dysfunction-associated steatotic liver disease (MASLD) in routine…
- Trial name
- SEC-HOPE (NCT07683065)
- Where
- 7 sites in Spain
- Volunteers
- 150 people
- Sponsor
- Novartis Pharmaceuticals
Liver Transplantation, HCC
HOPE Against Cancer Recurrence in HCC
Liver transplantation is often performed to treat liver cancer, or hepatocellular carcinoma (HCC), in patients with impaired liver function due to cirrhosis. A shortcoming, however, is tumor recurrence after transplantation.
- Conditions
- Liver Transplantation, HCC, Oncological Outcomes
- Trial name
- HOPE4Cancer (NCT06717919)
- Testing
- Hypothermic oxygenated perfusion, Conventional cold storage
- Where
- 37 sites in United States, Austria and 15 more
- Volunteers
- 220 people
- Sponsor
- Philipp Dutkowski
End Stage Liver DIsease, Liver Failure
VitaSmart HOPE System: Bridge to HOPE Registry
This is a post-market, multicenter, single-arm, observational registry evaluating real-world use of the VitaSmart HOPE System under standard of care conditions.
- Trial name
- NCT07578441
- Testing
- hypothermic oxygenated perfusion therapy of a donor liver under standard of care conditions
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- Bridge to Life Ltd.
GASTROINTESTINAL NEOPLASMS
Longitudinal Study on the Evolution Trend and Influencing Factors of Postoperative Reflux of Esophageal Cancer Based on PEPTEST Technique
The goal of this observational study intends to explore the evolution trend and related factors of postoperative reflux of esophageal cancer based on PEPTEST detection, in order to identify postoperative reflux The main question…
- Trial name
- NCT06509022
- Testing
- PEPTEST test
- Where
- China
- Volunteers
- 138 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Ovarian Carcinoma, Psychiatric Disorder
Adapted Helping Ovarian Cancer Patients Cope Intervention to Address Burnout for Gynecologic Oncology Clinicians
This clinical trial tests an adapted version of the Helping Ovarian Cancer Patients Cope (HOPE) intervention to address burnout among gynecologic oncology clinicians.
- Trial name
- NCT07282158
- Testing
- Behavioral Intervention, Interview, Survey Administration
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Fred Hutchinson Cancer Center
Depression
Efficacy of Narrative Therapy for Older People With Depression
The research aims to investigate the efficacy of a narrative therapy group in reducing depressive symptoms among older people. This study adopts a mixed methods research design, involving both quantitative and qualitative…
- Trial name
- NTOPD (NCT07371988)
- Testing
- Narrative therapy group, Treatment as usual (TAU)
- Where
- Hong Kong
- Volunteers
- 110 people
- Sponsor
- City University of Hong Kong
Mental Health, Violence Against Children
Hope Groups: Parenting and Mental Health Among Refugees in the Middle East
This research is testing if 'Hope Groups' -- a psychosocial, mental health, parenting strengthening, and violence prevention support group program -- work to help Palestinian caregivers displaced by war.
- Trial name
- NCT07506421
- Testing
- Hope Groups
- Where
- Jordan
- Volunteers
- 490 people
- Sponsor
- University of Oxford
Oral Feeding Outcomes, Neurodevelopment Outcome
Impact of Hospital to Home: Optimizing Preterm Infant Environment for Surgical Neonates and Their Parents (H-HOPE)
Infants born with congenital defects may require major surgery in the neonatal period. These infants are at risk for neurodevelopmental impairments.
- Trial name
- H-HOPE (NCT07372898)
- Testing
- H-HOPE
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Chronic Pelvic Pain, Pudendal Neuralgia
Targeting the Conus Medullaris With ECAP-Controlled Closed-Loop SCS for Treatment of Chronic Pelvic Pain: HOPE Trial
The aim of the study is to evaluate the effectiveness of using ECAP (electrically evoked compound action potential)-controlled CL (closed-loop) SCS (spinal cord stimulation) to treat chronic pelvic pain by stimulating an area in…
- Trial name
- NCT06413277
- Testing
- Saluda Evoke Smart SCS System
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Ainsworth Institute of Pain Management
CLIFAHDD, Congenital Contractures of the Limbs and Face, Hypotonia, and Developmental Delay
Aprepitant for the Treatment of CLIFAHDD
There are no drug treatments for individuals with Congenital Contractures of the Limb and Face, Hypotonia, and Developmental Delay (CLIFAHDD), an ultra-rare and severe neurodevelopmental disease.
- Conditions
- CLIFAHDD, Congenital Contractures of the Limbs and Face, Hypotonia, and Developmental Delay, NALCN Channelopathy, Ataxia - Other
- Trial name
- NCT07845825
- Testing
- Aprepitant Powder for Oral Suspension
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Tracheostomized Patients, Decanulation
Effects of a Perma-h Model Mobile-based Rehabilitation Support Program on Hope, Self-efficacy, Perceived Social Support and Rehabilitation Outcomes in Post- Tracheostomy Oral Cancer Patients
The goal of this study (exploratory sequential design; mixed-methods study) is to evaluate whether a PERMA-H model mobile-based rehabilitation support program delivered to post-tracheostomy oral cancer patients can improve…
- Conditions
- Tracheostomized Patients, Decanulation, Oral Cancer , Oral Squamous Cell Carcinoma, Oral Cavity Cancer, Rehabilitation Outcome
- Trial name
- NCT07714967
- Testing
- PERMA-H model mobile-based rehabilitation support program
- Where
- 2 sites in China, Malaysia
- Volunteers
- 100 people
- Sponsor
- Hainan Medical College
Malnutrition, Child
Hens Hatching Hope
The study is a prospective community-cluster non-randomized trial that will evaluate the effectiveness of a program that will provide 30-day egg vouchers to mothers of 6 to 24 month-old children living in rural areas of Intibucá…
- Trial name
- NCT04721197
- Testing
- Egg vouchers, Standard of Care
- Where
- Honduras
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Georgia Southern University
Depression
Sound Bite-- a Therapeutic Song-writing Program
The research aims to investigate the effectiveness of the therapeutic song-writing program on young people with depressive symptoms. This study adopts a multicentre randomized control trial two arms research design.
- Trial name
- Sound Bite (NCT07371962)
- Testing
- therapeutic song-writing program, Waitlist control group
- Where
- Hong Kong
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- City University of Hong Kong