Clinical trials: High Cardiac Output
Athletic Performance, Exercise Training
High-Intensity Intermittent Training and Sport-Specific Performance in Youth Amateur Boxers
Boxing is an intermittent combat sport that requires repeated high-intensity actions, sustained punching output, and rapid post-exercise recovery.
- Conditions
- Athletic Performance, Exercise Training, Physical Fitness
- Trial name
- BOX-HIIT (NCT07571070)
- Testing
- Nine-session high-intensity intermittent boxing training
- Where
- Colombia
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Federal University of Vicosa
Cardiac Output, High
Rescuer Fatigue Using Two Thumb Versus Two Finger Method During Simulated Neonatal Cardiopulomnary Resuscitation
The majority of newborns transition successfully from intrauterine to extrauterine life without any assistance. Less than 1% of all newborns will require extensive neonatal resuscitation involving chest compressions (CC) and…
- Trial name
- NCT04111237
- Testing
- Two Finger technique, Two Thumb Technique
- Where
- Ireland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University College Cork
Death, Stroke
Remote Ischemic Preconditioning in High Risk Cardiovascular Surgery Patients
Remote ischemic preconditioning (RIPC) occurs when a tissue (ex. heart) becomes less vulnerable to an ischemic insult if a remote tissue (ex. arm) has had previous exposure to a period of ischemia and reperfusion.
- Conditions
- Death, Stroke, Low Cardiac Output Syndrome, Myocardial Infarction
- Trial name
- NCT01328912
- Testing
- Remote ischemic preconditioning stimulus, control
- Where
- Canada
- Volunteers
- 429 people
- Sponsor
- Queen's University
Hemodynamic Instability, Cardiac Output, High
Individualized Perioperative Hemodynamic Goal-directed Therapy in Major Abdominal Surgery (iPEGASUS-trial)
To evaluate the impact of perioperative, algorithm driven, hemodynamic therapy based on individualized fluid and cardiac output optimization on postoperative moderate and severe complications in patients undergoing major…
- Conditions
- Hemodynamic Instability, Cardiac Output, High, Peroperative Complication
- Trial name
- iPEGASUS (NCT03021525)
- Testing
- Individualized Goal Directed Therapy, Control Group
- Where
- 7 sites in Germany, Italy and 1 more
- Volunteers
- 380 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Hypoxia, Hypercapnia
The Effect of Hypercapnia on Physiological Parameters During Short-term Breathing
The aim of the project is to evaluate the effect of hypercapnia on physiological parameters in a healthy person during short-term hypoxia and hypercapnia.
- Conditions
- Hypoxia, Hypercapnia, Cardiac Output, High
- Trial name
- HYPERCO (NCT05441007)
- Testing
- Hypoxic, Hypercapnic, Hypoxic and Hypercapnic
- Where
- Czechia
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Czech Technical University in Prague
Anemia, Liver Disease
Phase 2 Study of PEG-Intron in Hereditary Hemorrhagic Telangiectasia
The purpose of the study is to evaluate the safety and tolerability of pegylated interferon alpha-2b (PEG-Intron) in patients with severe complications related to Hereditary hemorrhagic telangiectasia (HHT).
- Conditions
- Anemia, Liver Disease, Hypoxemia
- Trial name
- NCT00588146
- Testing
- Pegylated Interferon Alpha2b, Standard care
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Mayo Clinic
Cardiac Disease, Cardiac Failure
Preoperative Infusion of Levosimendan in Patients Undergoing Cardiac Surgery
The aim of this retrospective study will be to investigate the effect of the preoperative administration of levosimendan on the outcome of patients with compromised cardiac function undergoing cardiac surgery
- Conditions
- Cardiac Disease, Cardiac Failure, Cardiac Surgery, Inotropes
- Trial name
- NCT04635293
- Testing
- preoperative infusion of levosimendan, no preoperative infusion of levosimendan
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- Aretaieion University Hospital
Systolic Hypertension, Pregnancy Related
Effect of Labetalol, Atenolol, and Nifedipine on Maternal Hemodynamics Measured by ICG in Early Pregnancy
The purpose of the research is to characterize the effect of labetalol, atenolol, and nifedipine on maternal hemodynamics early in pregnancy.
- Conditions
- Systolic Hypertension, Pregnancy Related, Diastolic Hypertension, Cardiac Output, Low
- Trial name
- NCT04755764
- Testing
- Labetalol, Atenolol, Nifedipine
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Marshall University
Pulmonary Hypertension
Acute Exposure of High Altitude on Cardiac Output
Randomized crossover trial in patients with Pulmonary Hypertension (PAH, CTEPH) to assess the acute response High Altitude (Säntis; 2500m above sea level) on non-invasive cardiac output assessments by Finapres® NOVA Technology at…
- Trial name
- NCT03637218
- Testing
- Assessment at Low Altitude (470m above sea level), Exposure to High Altitude (2500m above sea level)
- Where
- Switzerland
- Volunteers
- 28 people
- Sponsor
- University of Zurich
Hypovolemia, Cardiac Output, High
Validation of Capnography as a Predictor of Cardiac Output Change as Measured by FloTrac
The aim of this study is to evaluate the correlation of capnography with non-invasive measurement of cardiac output with the FloTrac/EV1000 following a reversible fluid challenge, a passive leg raising maneuver, using…
- Conditions
- Hypovolemia, Cardiac Output, High, Cardiac Output, Low
- Trial name
- NCT01880684
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Montreal Heart Institute
Pregnancy Related, Cardiac Output, High
Non-invasive Haemodynamic Monitoring in Pregnancy
This prospective and observational trial over 55 pregnant women (third trimester) compares non invasive haemodynamic monitoring using Nexfin technology and ultrasonography technic
- Conditions
- Pregnancy Related, Cardiac Output, High, Haemodynamic Instability
- Trial name
- NCT03046784
- Testing
- haemodynamic evaluation
- Where
- France
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Hospital Nord
Major Abdominal Surgery, Colorectal Surgery
Automated Versus Manual Fluid Management for High Risk Abdominal Surgical Patient. A Prospective, Randomized Trial
Dynamic parameters like pulse pressure variation have been shown to be accurate predictors of fluid responsiveness. Hemodynamic optimization based on fluid management and stroke volume optimization have been shown to improve…
- Conditions
- Major Abdominal Surgery, Colorectal Surgery, Hepatectomy, Pancreatectomy
- Trial name
- CL vs CP (NCT01950845)
- Testing
- Closed loop automated System (LIR®: learning intravenous resuscitator), manual current practice by anesthesiologist team
- Where
- France
- Volunteers
- 46 people
- Sponsor
- Hospices Civils de Lyon
Cardiac Output, Low, Cardiac Output, High
The Effect of Epinephrine, Norepinephrine and Phenylephrine on Intraoperative Hemodynamic Performance
The use of catecholamines for blood pressure and hemodynamic management is essential during undergoing surgery. The type of the catecholamine with the most clinical meaningful effect is still unknown.
- Conditions
- Cardiac Output, Low, Cardiac Output, High, Perfusion; Complications
- Trial name
- RACE (NCT05492968)
- Testing
- Epinephrin, Norepinephrine, Phenylephrine
- Where
- Austria
- Volunteers
- 225 people
- Sponsor
- Medical University of Vienna
Low Cardiac Output Syndrome
Levosimendan in High Risk Patients Undergoing Cardiac Surgery
Low cardiac output syndrome (LCOs) is a serious complication in critically ill patients or those undergoing major surgery, resulting in multiple organ damage with significant in-hospital and long-term morbidity and mortality, as…
- Trial name
- CHEETAH (NCT00994825)
- Testing
- Levosimendan
- Where
- 18 sites in Brazil, Italy and 1 more
- Volunteers
- 1,000 people
- Sponsor
- Università Vita-Salute San Raffaele
Hip Fractures
Non Invasive Cardiac Output Monitoring to Guide Goal Directed Fluid Therapy in High Risk Patients Undergoing Urgent Surgical Repair of Proximal Femoral Fractures
Improving or maximising cardiac output in the perioperative setting through the use of goal directed fluid therapy has been shown to reduce complications and length of hospital stay in patients undergoing major abdominal surgery.
- Trial name
- ClearNOF (NCT02382185)
- Testing
- Fluid optimisation, Optimisation of blood pressure, Application of clearsight monitor
- Where
- 2 sites in United Kingdom
- Volunteers
- 240 people
- Sponsor
- York Teaching Hospitals NHS Foundation Trust
Postoperative Complications
Personalized Hemodynamic Therapy in Patients Undergoing High-risk Surgery
The purpose of this study is to evaluate the effectiveness of using the personal preoperatively assessed cardiac output in high-risk patients to guide perioperative administration of fluids and vasoactive drugs on predefined…
- Trial name
- TAPIR (NCT02834377)
- Testing
- Treatment algorithm targeting individual cardiac output
- Where
- Germany
- Volunteers
- 188 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
ICU, Pulmonary Artery Catheter (PAC)
The HIgh-fidelity Hydraulic couPling Upper-arm Cuff Assessment of Limits, Safety, and Effectiveness (HIPULSE) Trial (Cardiac Output Study)
The purpose of this study is to compare cardiac output (CO), fluid responsiveness, and related measurements between the Philips AMC and PAC (Swan-Ganz) in ICU or surgical patients.
- Conditions
- ICU, Pulmonary Artery Catheter (PAC), Swan-Ganz Catheter
- Trial name
- CO (NCT06895603)
- Testing
- Philips Advanced Monitoring Cuff (AMC)
- Where
- 2 sites in United States, Germany
- Volunteers
- 75 people
- Sponsor
- Philips Clinical & Medical Affairs Global
Cardiac Output, Low, Cardiac Output, High
Non-invasive Continuous Cardiac Output Monitoring in Preterm Infants Study
This is an observational study in newborn term and preterm infants. The study will validate if non-invasive continuous cardiac output monitoring is feasible in newborn infants, if normative values can be constructed and what is…
- Conditions
- Cardiac Output, Low, Cardiac Output, High, Blood Pressure
- Trial name
- NICCOM (NCT04064177)
- Testing
- NICAS cardiac output monitor
- Where
- United Kingdom
- Volunteers
- 148 people
- Sponsor
- Imperial College Healthcare NHS Trust
Hereditary Hemorrhagic Telangiectasia (HHT), Rendu Osler Disease
IV Bevacizumab Treatment of Patients With Hereditary Hemorrhagic Telangiectasia (HHT) or Rendu-Osler (RO) Disease: A Retrospective Analysis of French Cohort Data From 2009 to 2024
Rendu-Osler disease (RO), also known as Hereditary Haemorrhagic Telangiectasia (HHT), is an autosomal dominant genetic disorder. Its pathophysiology is associated with an imbalance in angiogenic balance.
- Trial name
- CoBé (NCT07772050)
- Testing
- Real World data study.
- Where
- France
- Volunteers
- 244 people
- Sponsor
- Hospices Civils de Lyon
Pre-Eclampsia, Pregnancy
Goal-Directed Therapy in Pregnant Women at High Risk of Developing Preeclampsia
Preeclampsia is associated with significant maternal and fetal morbidity and mortality. Early identification and subsequent management of patients at risk of developing preeclampsia presents an ongoing challenge in prenatal care.
- Conditions
- Pre-Eclampsia, Pregnancy, Hypertension
- Trial name
- NCT01351428
- Testing
- Nifedipine
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital