Clinical trials: High Blood Sugar
Hyperglycemia, Diabetes
Insulin Balanced Infusion System
The purpose of this study is to study the use of a counterbalancing system of glucose and insulin infusion with frequent blood glucose monitoring and combined adaptive algorithm can produce tight glycemic control without…
- Trial name
- NCT01291719
- Testing
- glucose and insulin infusions
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Admetsys Corporation
Diabetes Mellitus, Type II
Evaluate HM-002-1005 in Subjects With Type 2 Diabetes Mellitus
The purposes of this study are to: Evaluate the safety and tolerability of the study drug. Measure how much of the study drug (HM-002-1005) and its breakdown product get into the bloodstream, and how long it takes the body to get…
- Trial name
- NCT06498284
- Testing
- HM-002-1005
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Hua Medicine Limited
Type 2 Diabetes Mellitus, Hyperglycemia
Ex Vivo Immunotherapy for Hyperglycemia in Type 2 Diabetes Mellitus
Diabetes mellitus type 2 is a long-term metabolic disorder that is primarily characterized by insulin resistance, relative insulin deficiency and hyperglycemia.
- Trial name
- DISC (NCT02169531)
- Testing
- ex vivo Activated Immune Cells
- Where
- 2 sites in China
- Volunteers
- 25 people
- Sponsor
- B & Y Technologies
Diabetes Mellitus
Prevention of Postprandial Hyperglycemia by Acarbose May be a Promising Therapeutic Strategy for Reducing the Increased Risk for Cardiovascular Disease
The use of acarbose in impaired glucose tolerance (IGT) and type 2 diabetic subjects has been associated with a significant reduction of cardiovascular events.
- Trial name
- ABDOMEN (NCT01167231)
- Testing
- Acarbose (Glucobay, BAYG5421)
- Where
- Poland
- Volunteers
- 3,310 people
- Sponsor
- Bayer
Brittle Type 1 Diabetes Mellitus
Safety, Tolerability, and Efficacy of Immunomodulation With AT-1501 in Combination With Transplanted Islet Cells in Adults With Brittle T1D
This study will evaluate the safety, tolerability and efficacy of AT-1501 in an immunomodulation regimen in adult patients with T1D undergoing an islet cell transplant.
- Trial name
- NCT05480657
- Testing
- AT-1501 IV Infusion, Isolated cadaveric islet cells
- Where
- United States
- Sponsor
- Eledon Pharmaceuticals
Type 1 Diabetes Mellitus
Comparison of Technosphere Insulin Inhalation Powder & Subcutaneous Rapid-Acting Analog in Subjects With Type 1 Diabetes
This is an Open-label, randomized study in Type 1 diabetics looking at exposure and response (PK/PD) of TI using GEN2C Inhaler versus rapid acting analog.
- Trial name
- NCT01544881
- Testing
- Technosphere Insulin Inhalation Powder, Rapid Acting Analog
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Mannkind Corporation
Low Glycemic Index (GI) Food, Pre Diabetes
Determination of the Glycemic Index Values of 10 Cereal-based Products
To determine the Glycemic index values for 10 cereal-based products
- Conditions
- Low Glycemic Index (GI) Food, Pre Diabetes, Diabetes
- Trial name
- NCT06710743
- Testing
- Glucose solution Day 1, Day 8, and Day 15, Food (cereal). Ten different cereals served once each
- Where
- Australia
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- PepsiCo Global R&D
Diabetes Mellitus Type 2
GLP-1 Receptor Agonist Lixisenatide in Patients With Type 2 Diabetes for Glycemic Control and Safety Evaluation, on Top of Pioglitazone
The purpose of this study is to evaluate the benefits and risks of lixisenatide (AVE0010), in comparison to placebo, as an add-on treatment to pioglitazone with or without metformin, over a period of 24 weeks of treatment…
- Trial name
- GETGOAL-P (NCT00763815)
- Testing
- Lixisenatide (AVE0010), Pen auto-injector, Pioglitazone
- Where
- 150 sites in United States, Austria and 11 more
- Volunteers
- 484 people
- Sponsor
- Sanofi
Dyslipidemias, Pre-diabetes
Dietary Supplementation on Body Fat Composition
The purpose of the current study is to examine the effects of a dietary supplement containing plant derived phenolics at two different dose levels in otherwise generally healthy adults with risk factors (high BMI at dyslipidemia…
- Trial name
- NCT06296251
- Testing
- Plant derived phenolics
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Brightseed
Hypertension, Impaired Glucose Tolerance
Evaluation of Soluble Epoxide Hydrolase (s-EH) Inhibitor in Patients With Mild to Moderate Hypertension and Impaired Glucose Tolerance
The purpose of this study is to determine the safety and efficacy of AR9281, a novel s-EH enzyme inhibitor, in improving glucose metabolism and blood pressure in patients with impaired glucose tolerance and mild to moderate…
- Trial name
- NCT00847899
- Testing
- AR9281
- Where
- 30 sites in United States
- Volunteers
- 150 people
- Sponsor
- Arete Therapeutics
Diabetes Mellitus, Type 2
GLP-1 Receptor Agonist Lixisenatide in Patients With Type 2 Diabetes for Glycemic Control and Safety Evaluation, on Top of Metformin
The purpose of this study is to evaluate the benefits and risks of lixisenatide (AVE0010), in comparison to placebo, as an add-on treatment to metformin, over a period of 24 weeks of treatment, followed by an extension.
- Trial name
- GETGOAL-F1 (NCT00763451)
- Testing
- Lixisenatide (AVE0010), Pen auto-injector, Metformin
- Where
- 15 sites in United States, Brazil and 13 more
- Volunteers
- 484 people
- Sponsor
- Sanofi
Diabetes Mellitus, Type 2
Evaluation of Glucose Lowering Effect, Safety and Tolerability of CS-917
This study will compare glucose lowering with CS-917 compared to placebo after 3 months of treatment
- Trial name
- NCT00290940
- Testing
- CS-917, metformin hydrochloride, pioglitazone
- Where
- 66 sites in United States
- Volunteers
- 400 people
- Sponsor
- Daiichi Sankyo
Type 2 Diabetes Mellitus
Safety and Efficacy of Autologous Adipose-Derived Stem Cell Transplantation in Type 2 Diabetics
The purpose of this study is to determine whether intravenous administration of autologous adipose-derived stem cells is of benefit in the management of types 2 diabetics.
- Trial name
- NCT00703612
- Testing
- Autologous Adipose-derived Stem cells
- Where
- 2 sites in Philippines
- Volunteers
- 34 people
- Sponsor
- Adistem Ltd
Pre Diabetes, Vascular Stiffness
Dietary Exchanges With Avocado and Mango in Pre-diabetes
The research is designed as a randomized, 2-arm, parallel, controlled, human clinical trial to investigate the effects of avocado and mango consumption for 8 weeks on indices of macro- and micro- vascular function in individuals…
- Conditions
- Pre Diabetes, Vascular Stiffness, Vascular Dilation, Cognitive Change
- Trial name
- AVMa (NCT05353790)
- Testing
- Meals + snacks: control, Meals + snacks: Avocado mango
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Clinical Nutrition Research Center, Illinois Institute of Technology
Hyperglycemia
Efficacy of a Brown Seaweed Extract Rich in Polyphenols on Glycemic Response to Sucrose in Human
The primary endpoint of this trial will be to evaluate if a single administration in human of a lemon ice tea containing 500 mg of a polyphenol-rich algal powder is able to reduce postprandial glycemia and insulinemia.
- Trial name
- NCT01384110
- Testing
- Reduction of glycemic index of ingested foods
- Where
- Canada
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- innoVactiv Inc.