Clinical trials: Hepatorenal Syndrome
Acute Kidney Injury, Hepatorenal Syndrome
Study of Accuracy of NGAL, a Renal Injury Biomarker, in Patients With Cirrhosis
The purpose of this study is to test the accuracy of urinary neutrophil-gelatinase associated lipocalin (NGAL) and other biomarkers (plasma renin, norepinephrine) to predict acute kidney injury (AKI) development in patients with…
- Trial name
- NCT02049125
- Where
- 4 sites in Brazil
- Volunteers
- 300 people
- Sponsor
- University of Sao Paulo
Hepatorenal Syndrome, Cirrhosis
Angiotensin 2 for Hepatorenal Syndrome
Hepatorenal syndrome (HRS) is a disease in which patients with cirrhosis (end stage liver failure) develop secondary kidney injury and failure.
- Conditions
- Hepatorenal Syndrome, Cirrhosis, Kidney Failure, Acute
- Trial name
- ANTHEM (NCT04048707)
- Testing
- Angiotensin II, Midodrine, Octreotide
- Sponsor
- University of California, Los Angeles
Liver Cirrhosis, Acute Kidney Injury
RAI & HRS: Relationship Between Relative Adrenal Insufficiency and Failure of Treatment in Hepatorenal Syndrome
Hepatorenal syndrome is a life-threatening medical condition and a serious complication of advanced liver scarring (cirrhosis). It consists of a deterioration of the function of the kidneys caused by a severe alteration in the…
- Conditions
- Liver Cirrhosis, Acute Kidney Injury, Hepato-Renal Syndrome
- Trial name
- NCT04273750
- Where
- United Kingdom
- Volunteers
- 26 people
- Sponsor
- University Hospital Plymouth NHS Trust
Hepato-Renal Syndrome, Portal Hypertension
MRI to Assess the Effect of Terlipressin in Patients With Acute Hepatorenal Syndrome (HRS-AKI)
Heptorenal syndrome (HRS) is divided into two types. A non-acute kidney injury (NAKI-HRS), which is predominantly related to end-stage disease and a more acute kidney injury (HRS-AKI).
- Conditions
- Hepato-Renal Syndrome, Portal Hypertension, Acute Kidney Injury, Liver Diseases
- Trial name
- NCT03483272
- Where
- 2 sites in Denmark
- Volunteers
- 11 people
- Sponsor
- Hvidovre University Hospital
Hepatorenal Syndrome Type I and Type II
A Phase 1 Study of LJPC-501 in Patients With Hepatorenal Syndrome
Hepatorenal syndrome (HRS) is a life-threatening condition marked by rapid decline in kidney function in patients with liver cirrhosis or fulminant liver failure.
- Trial name
- NCT01906307
- Testing
- LJPC-501
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- La Jolla Pharmaceutical Company
Liver Cirrhosis
Faecal Microbiota Transplantation for Liver Cirrhosis
The purpose is to investigate the effect of faecal microbiota transplantation (FMT) on complications, progression, and mortality of patients with liver cirrhosis.
- Trial name
- CHiFT (NCT04932577)
- Testing
- Faecal microbiota transplantation
- Where
- Denmark
- Volunteers
- 220 people
- Sponsor
- University of Aarhus
Kidney Failure, Acute
Non-invasive Evaluation of the Predictive Value of CEUS and SWE in ACLF, Renal Failure and Hepatorenal Syndrome
Evaluation of non-invasive prognostic parameters in patients developing ACLF and renal failure in patients receiving and not receiving transjugular intrahepatic portosystemic shunt (TIPS).
- Trial name
- NECTAR (NCT04446858)
- Where
- Germany
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Bonn
Cirrhosis, Liver, Hepatorenal Syndrome
HRS-AKI Treatment With TIPS in Patients With Cirrhosis
The study compares the effectiveness and safety of TIPS implantation in patients with HRS-AKI (stage1, 2 and 3) and liver cirrhosis with standard therapy (drug therapy with terlipressin + albumin).
- Conditions
- Cirrhosis, Liver, Hepatorenal Syndrome, Acute Kidney Injury, Ascites Hepatic
- Trial name
- Liver-HERO (NCT05346393)
- Testing
- TIPS, Standard of Care
- Where
- 14 sites in Germany
- Volunteers
- 124 people
- Sponsor
- Jena University Hospital
Sepsis, Acute Kidney Injury Due to Sepsis
Microbiome and Enteric Signatures in Sepsis-associated Hepatorenal Injury
Sepsis is a major cause of morbidity and mortality in intensive care units. Sepsis-associated liver injury (SALI) and sepsis-associated acute kidney injury (S-AKI) are common complications associated with adverse clinical…
- Conditions
- Sepsis, Acute Kidney Injury Due to Sepsis, Gastrointestinal Microbiome, Sepsis-Associated Liver Injury
- Trial name
- MESH (NCT07735182)
- Where
- 6 sites in China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Zhejiang University
Cirrhosis With Ascites
Adrenal Insufficiency in Cirrhotics With Ascites. Effects of Hydrocortisone on Renal and Haemodynamic Function
Relative adrenal insufficiency (RAI) is an well known condition in patients with septic shock. Liver failure (including chronic liver failure)and sepsis are both characterized by hyperdynamic circulatory failure (with low…
- Trial name
- AILD (NCT00657306)
- Testing
- hydrocortisone, dextrose solution 5%
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- University of Turin, Italy
Acute on Chronic Liver Failure
To Compare the Response Rate of Noradrenaline vs. Terlipressin in Hepatorenal Syndrome in Patients With Acute on Chronic Liver Failure
Continous infusion of nor adrenaline + albumin Continous infusion of terlipressin + albumin Response will assessed at every 48 hour (i) Complete response: Regression of acute kidney injury stage with reduction of S.
- Trial name
- NCT02573727
- Testing
- Nor adrenaline + albumin, Terlipressin + albumin
- Where
- India
- Volunteers
- 120 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Hepato-Renal Syndrome
Nor-epinephrine Versus Midodrine/Octreotide in Patients With Hepatorenal Syndrome
Hepatorenal syndrome is a functional renal impairment occurring in cirrhotic patients . It develops secondary to splanchnic arterial vasodilatation which decreases the effective blood volume, activate the…
- Trial name
- NCT04522297
- Testing
- Midodrine/Octreotide, Nor-epinephrine
- Where
- Egypt
- Volunteers
- 91 people
- Sponsor
- National Hepatology & Tropical Medicine Research Institute
Hepatorenal Syndrome, Liver Regeneration, AKI - Acute Kidney Injury
Renal Histopathology and Transcriptomic Analysis in Hepatorenal Syndrome During Liver Transplantation
Hepatorenal Syndrome (HRS) is a serious complication that can occur in patients with liver cirrhosis, characterised by kidney dysfunction, or acute kidney failure (AKI).
- Conditions
- Hepatorenal Syndrome, Liver Regeneration, AKI - Acute Kidney Injury, Liver Transplant
- Trial name
- NCT07300709
- Testing
- renal biopsy
- Where
- Hong Kong
- Volunteers
- 42 people
- Sponsor
- The University of Hong Kong
Ascites Infection
Rifaximin Prophylaxis for Spontaneous Bacterial Peritonitis and Hepatorenal Syndrome in Cirrhotic Patients
Norfloxacin is the most commonly used drug for the prophylaxis against spontaneous bacterial peritonitis (SBP) in patients with liver cirrhosis.
- Trial name
- NCT05621005
- Testing
- Rifaximin 550 milligram Oral Tablet [XIFAXAN]
- Where
- Egypt
- Volunteers
- 104 people
- Sponsor
- Samar Atef Sebaweh Mohammed
Hepatorenal Syndrome
Study To Confirm Efficacy and Safety of Terlipressin in Hepatorenal Syndrome (HRS) Type 1
This study is to treat adult patients with hepatorenal syndrome (HRS) Type 1. Out of every three participants, two will receive terlipressin and one will receive placebo. Assignments will be made randomly.
- Trial name
- NCT02770716
- Testing
- Terlipressin
- Where
- 64 sites in United States, Canada
- Volunteers
- 300 people
- Sponsor
- Mallinckrodt
Glycogen Storage Disease Type IA, Glycogen Storage Disease Type I
Accuracy of Home Lactate Meter and Accu-chek Glucometer in Patients With Glycogen Storage Disease
The goal of this study is to determine if the Lactate Plus meter is accurate compared to lab lactate levels, and to determine if the Accu chek guide glucometer is accurate compared to lab serum glucose levels in patients with…
- Conditions
- Glycogen Storage Disease Type IA, Glycogen Storage Disease Type I, Glycogen Storage Disease Type IB, Glycogen Storage Disease Xi
- Trial name
- NCT07459582
- Testing
- Lactate Meter, Accu Chek
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Connecticut Children's Medical Center
Hepatorenal Syndrome, Acute Kidney Injury
Study to Evaluate R2R01 Plus Terlipressin Versus Terlipressin Alone in Patients With Hepatorenal Syndrome
This study aims to evaluate the safety, tolerability and efficacy of R2R01 combined with terlipressin as compared to terlipressin alone in the treatment of patients with HRS-AKI
- Trial name
- NCT05875948
- Testing
- R2R01, Terlipressin
- Where
- 7 sites in United States
- Volunteers
- 95 people
- Sponsor
- River 2 Renal Corp.
Hepatorenal Syndrome, Liver Cirrhosis
Endothelin Receptor Antagonism With Ambrisentan to Treat Hepatorenal Syndrome
Patients with advanced cirrhosis of the liver develop kidney problems occasionally. This condition is called Hepatorenal Syndrome, requires hospitalization and frequently results in death.
- Conditions
- Hepatorenal Syndrome, Liver Cirrhosis, Acute Kidney Injury, Ascites Hepatic
- Trial name
- NCT06256432
- Testing
- Ambrisentan, Terlipressin
- Where
- 6 sites in India
- Volunteers
- 54 people
- Sponsor
- Noorik Biopharmaceuticals AG
Hepatorenal Syndrome
Terlipressin for HRS-AKI in Liver Transplant Candidates (INFUSE)
Hepatorenal syndrome-acute kidney injury (HRS-AKI), a potentially reversible renal failure, is a serious, rapidly progressing, often fatal, complication of decompensated cirrhosis.
- Trial name
- INFUSE (NCT04460560)
- Testing
- Terlipressin
- Where
- 7 sites in United States
- Volunteers
- 50 people
- Sponsor
- University of Pennsylvania
Cirrhosis, Hepatorenal Syndrome Type I
Treatment of Hepatorenal Syndrome With Terlipressin Infusion Adjusted to Hemodynamic Response
Observe the effect of terlipressin on renal function in patients with SHR type I adjusting the dose based on hemodynamic response.
- Trial name
- AMELIORATE (NCT01530711)
- Testing
- Terlipressin and albumin
- Where
- 6 sites in Spain
- Volunteers
- 40 people
- Sponsor
- Pere Gines