Clinical trials: Hepatic Complication
Liver Cirrhosis
Faecal Microbiota Transplantation for Liver Cirrhosis
The purpose is to investigate the effect of faecal microbiota transplantation (FMT) on complications, progression, and mortality of patients with liver cirrhosis.
- Trial name
- CHiFT (NCT04932577)
- Testing
- Faecal microbiota transplantation
- Where
- Denmark
- Volunteers
- 220 people
- Sponsor
- University of Aarhus
Liver Transplant; Complications
Dexmedetomidine to Prevent Hepatic Ischemia-reperfusion Injury-induced Glycocalyx Degradation and Early Allograft Dysfunction in Liver Transplantation
the aim of the study is to approve the hypothesis that dexmedetomidine can protect against glycocalyx degradation induced by hepatic ischemia-reperfusion injury and hence can reduce the subsequent complications as early allograft…
- Trial name
- NCT05031026
- Testing
- Dexmedetomidine, Normal Saline
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Cirrhosis
"Anticipant"-TIPS After a First Portal-hypertension-related Complication in Cirrhosis
Further decompensation (FD) in cirrhosis represents a prognostic stage associated with an even higher mortality than that associated with the first decompensation.
- Trial name
- Ant-TIPS (NCT07889726)
- Testing
- TIPS, Standard of Care (SOC)
- Where
- 8 sites in France
- Volunteers
- 266 people
- Sponsor
- University Hospital, Toulouse
Liver Neoplasm, Kidney Injury, Acute
Perioperative Myocardial and Renal Injury in Patients Undergoing Hepatic Resection
Liver surgeries are high risk surgeries that might result in injuries in kidneys and heart. This study was planned to investigate the frequency of these injuries as well as the risk factors for their devolopment and its effect on…
- Conditions
- Liver Neoplasm, Kidney Injury, Acute, Myocardial Injury After Non-Cardiac Surgery
- Trial name
- NCT06775158
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people
- Sponsor
- Istanbul Saglik Bilimleri University
Ascites, Blunt Abdominal Trauma
Telesonography Adaptation and Use to Improve the Standard of Patient Care Within a Dominican Community
The role of teleradiology has far reaching implications for the health of remote and underserved populations. The ability to coordinate radiographic evaluation and diagnosis from a distance has the potential to raise the standard…
- Conditions
- Ascites, Blunt Abdominal Trauma, Cholelithiasis, Cholecystitis
- Trial name
- NCT00591968
- Testing
- SonoSite Titan portable ultrasound coupled with email telediagnosis
- Where
- Dominican Republic
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Edward Via Virginia College of Osteopathic Medicine
Liver Injury
Liver Ischemia-reperfusion Injury and Clinical Data Analysis
Searching for new targets for the diagnosis and treatment of liver ischemia-reperfusion injury.
- Trial name
- NCT06080308
- Testing
- No intervention
- Where
- China
- Volunteers
- 270 people
- Sponsor
- Qin Zhang
Cirrhosis, Hepatic Encephalopathy
Allopurinol Versus Atorvastatin to Prevent Complications of Liver Cirrhosis
The study aims to compare the potential benefit of allopurinol versus atorvastatin in reducing the risk of developing cirrhosis-related complications, delaying the onset of hepatocellular carcinoma, and improving survival.
- Conditions
- Cirrhosis, Hepatic Encephalopathy, Ascites, Varices
- Trial name
- NCT05511766
- Testing
- Allopurinol 300 MG, Atorvastatin 20mg
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Tanta University
Antibiotic Toxicity, Liver Cirrhosis
A Study to Determine Pharmacokinetic Changes of Ceftriaxone in Patients With Liver Cirrhosis
The investigators designed an observational multicenter explorative in vivo study to investigate the changes in ceftriaxone pharmacokinetics in blood and ascites.
- Conditions
- Antibiotic Toxicity, Liver Cirrhosis, Renal Insufficiency, Ceftriaxone Overdose
- Trial name
- TACTILE (NCT05960006)
- Testing
- No intervention (observational study)
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Hepatorenal Syndrome
Noradrenalin vs Terlipressin in Hepatorenal Syndrome
The purpose of this study is to determine whether noradrenalin is as effective and safe as terlipressin in the treatment of hepatorenal syndrome
- Trial name
- NCT00370253
- Testing
- Terlipressin, Noradrenalin
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- University of Turin, Italy
Colon Cancer Liver Metastasis, Inflammatory Response
Argipressin's Influence on Blood Loss During Hepatic Resection
Infusion of Argipressin during hepatic resection surgery may reduce blood loss. It may also reduce transfusion requirements, and mitigate the perioperative inflammatory response compared to placebo.
- Conditions
- Colon Cancer Liver Metastasis, Inflammatory Response, Vasopressin Causing Adverse Effects in Therapeutic Use
- Trial name
- ARG-01 (NCT05293041)
- Testing
- Argipressin
- Where
- Sweden
- Volunteers
- 248 people
- Sponsor
- Kristina Svennerholm
Hepatectomy, Cancer, Metastatic
Efficacy and Tolerability of Hemopatch After Hepatic Resection
Previous in vitro and in vivo studies detected the Hemopatch Sealing Hemostat® to be a new versatile, self-adhering hemostatic sealing pad consisting of a polyethylene glycol-coated collagen.
- Conditions
- Hepatectomy, Cancer, Metastatic, Hemostasis
- Trial name
- NCT03323359
- Testing
- Hemopatch, Common Surgical Techniques
- Where
- Italy
- Volunteers
- 98 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
BRAF Gene Mutation, Hepatic Complication
Dabrafenib in Treating Patients With Solid Tumors and Kidney or Liver Dysfunction
This phase I trial studies the side effects and best dose of dabrafenib in treating patients with solid tumors and kidney or liver dysfunction.
- Conditions
- BRAF Gene Mutation, Hepatic Complication, Renal Failure, Solid Neoplasm
- Trial name
- NCT01907802
- Testing
- Dabrafenib, Laboratory Biomarker Analysis, Pharmacogenomic Study
- Where
- 18 sites in United States, Canada
- Volunteers
- 8 people
- Sponsor
- National Cancer Institute (NCI)
Kidney Transplant; Complications, Patient Empowerment
Duke Transplant University
The purpose of this research study is to determine the effectiveness of educational videos for patients who have just had kidney transplant compared to usual patient education practices.
- Conditions
- Kidney Transplant; Complications, Patient Empowerment, Medication Adherence, Patient Satisfaction
- Trial name
- NCT04219839
- Testing
- SOC + Educational Videos Designed Especially for post-transplant patients
- Where
- United States
- Volunteers
- 83 people
- Sponsor
- Duke University
Hepatitis C, Chronic, Sustained Virological Response
Prediction of Liver-related Outcomes After HCV Cure
Objectives: To develop and validate a predictive model, applicable to daily practice, of liver complications emergence in hepatitis C virus (HCV)-infected patients and advanced fibrosis, who have achieved sustained viral response…
- Conditions
- Hepatitis C, Chronic, Sustained Virological Response, Direct-acting Antivirals, Hepatocellular Carcinoma
- Trial name
- NCT04460157
- Where
- Spain
- Volunteers
- 1,035 people
- Sponsor
- Hospital Universitario de Valme
Solid Tumors, Soft Tissue Sarcoma
A Pilot Study of Thermodox and MR-HIFU for Treatment of Relapsed Solid Tumors
This is a pilot study of LTLD with MR-HIFU hyperthermia followed by ablation in subjects with refractory/relapsed solid tumors.
- Conditions
- Solid Tumors, Soft Tissue Sarcoma, Ewing Sarcoma, Malignant Epithelial Neoplasm
- Trial name
- NCT04791228
- Testing
- Magnetic Resonance-Guided High Intensity Focused Ultrasound, Lyso-thermosensitive Liposomal Doxorubicin
- Where
- United States
- Sponsor
- Children's National Research Institute
Indocyanine Green, Postoperative Complications
One Way to Diagnose Hepatic Insufficiency the First Postoperative Day After Resection: Prospective Cohort Study
Introduction: Hepatic insufficiency is a complication that puts the life of the patient undergoing resective surgery at risk. Thus, the diagnosis should be made early.
- Conditions
- Indocyanine Green, Postoperative Complications, Acute Liver Failure
- Trial name
- IGHI (NCT04570800)
- Volunteers
- 44 people
- Sponsor
- Castilla-La Mancha Health Service
Biliary Complications, Graft Function, Delayed
Antegrade Arterial and Portal Flushing Versus Portal Flushing Only in LDLT
Arterial flushing is a standard recommendation in deceased donor liver transplantation but not in living donor liver transplantation due to the risk of arterial intimal injury and short cold ischaemia time.
- Trial name
- NCT03048318
- Testing
- Arterial Flushing, Portal Flushing
- Volunteers
- 85 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Liver Failure, Liver Transplant; Complications
Telemedicine Based Remote Home Monitoring After Liver Transplantation
A significant opportunity exists to involve patients and their caregivers in more effective perioperative care and transition to home for transplant patients.
- Trial name
- TelehealthOLT (NCT03878329)
- Testing
- remote home monitoring
- Volunteers
- 50 people
- Sponsor
- University of Cincinnati
Worsening Chronic Heart Failure, Diabetic Nephropathy
A Study to Learn How Finerenone (BAY94-8862) Moves Into, Through and Out of the Body, How it Affects the Body, and How Safe it is in Adult Participants With Different Degrees of Reduced Liver Function and in Healthy Participants With Similar Age, Weight and Gender Distribution
Researchers are looking for a better way to treat people who have worsening of chronic heart failure, a long-term condition where the heart does not pump blood as well as it should, as well as to treat patients who have diabetic…
- Trial name
- NCT04881994
- Testing
- Finerenone (BAY94-8862)
- Where
- Germany
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Bayer
Liver Failure, End Stage Liver Disease
Dual Hypothermic Oxygenated Perfusion of DCD Liver Grafts in Preventing Biliary Complications After Transplantation
Rationale: Recent publications report good results of controlled donation after circulatory death (DCD) Maastricht category III liver transplantation when strict donor-recipient matching is applied and ischemia times are kept to…
- Conditions
- Liver Failure, End Stage Liver Disease, Biliary Tract Diseases
- Trial name
- DHOPE-DCD (NCT02584283)
- Testing
- Dual hypothermic oxygenated perfusion, Liver Assist®, Perfusion fluid
- Where
- 6 sites in Belgium, Netherlands and 1 more
- Volunteers
- 157 people
- Sponsor
- Robert J. Porte