Clinical trials: Hemodynamic Instability During Anesthesia
Nociceptive Pain, Goal-directed Therapy
Nol-Index Guided Remifentanil Analgesia Versus Standard Analgesia During Moderate-to-High Risk Cardiovascular Surgery
This study will investigate the potential of guiding remifentanil analgesia during cardiac and vascular surgery in moderate to high risk patients requiring general anesthesia.
- Conditions
- Nociceptive Pain, Goal-directed Therapy, Hemodynamic Instability, Nol-Index
- Trial name
- NCT04137991
- Testing
- Nol-Index guided analgesia, Standard Analgesia
- Where
- Belgium
- Volunteers
- 48 people
- Sponsor
- Erasme University Hospital
Hemodynamic Instability
Topical Anesthesia and Intra-arterial Chemotherapy for Retinoblastoma
The objective of this study is to use local topical anesthesia to numb the sensory input, captured by branches of the Trigeminal nerve found on the skin in and around the eye, to decrease a hemodynamic reflex seen during…
- Trial name
- TOPIAC (NCT02955524)
- Testing
- Tetracaine 0.5%, Lidocaine hydrochloride ophthalmic gel 3.5%
- Sponsor
- University of Miami
Hemodynamic Instability
Cardiovascular Effects of Muscle Relaxation During Laparoscopic Surgery
Many surgical procedures are performed using the laparoscopic approach. However, insufflation of the abdomen (pneumoperitoneum) has detrimental hemodynamic effects.
- Trial name
- RELAX-LAP (NCT04076709)
- Testing
- goal directed anaesthesia
- Where
- Netherlands
- Volunteers
- 34 people
- Sponsor
- Leiden University Medical Center
Cesarean Section, Hemodynamic Instability
Low-Doses Of Isobaric Bupivacaine On Intraoperative Hemodynamics In Spinal Anesthesia During Cesarean Section
The primary aim of this study was to compare the effects of two different low-dose bupivacaine used in spinal anesthesia on intraoperative hemodynamics in cesarean section operations.Investigators think that low-dose bupivacaine…
- Trial name
- NCT05136040
- Testing
- Bupivacaine
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Trigemino-Cardiac Reflex, Impacted Third Molar Tooth
The Frequency of Trigeminocardiac Reflex During the Extraction of Impacted Mandibular Wisdom Teeth
The goal of this clinical trial is to investigate trigeminocardiac reflex (TCR) formation during surgical extraction of mandibular impacted wisdom teeth in healthy adults.
- Trial name
- NCT06499532
- Testing
- Monitoring and Surgical removal of mandibular impacted wisdom teeth, using Gow-Gates anesthesia technique, Monitoring and Surgical removal of mandibular impacted wisdom teeth, using inferior alveolar nerve block anesthesia technique
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Kutahya Health Sciences University
Intraoperative Hypotension, Hemodynamic Instability
AI-Assisted Blood Pressure Control During Anesthesia
This proof-of-concept randomized controlled trial evaluates a reinforcement learning (RL)-based clinical decision support system for intraoperative hemodynamic management during non-cardiac surgery.
- Trial name
- RL-PRAIS PoC (NCT07123675)
- Testing
- Device: AI Clinical Decision Support System, Procedure: Standard of Care Anesthesia
- Where
- 2 sites in China
- Volunteers
- 40 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Hemodynamic Instability
Maternal Cardiac Output Response to Rescue Norepinephrine and Phenylephrine Boluses in Patients With Severe Preeclampsia
The purpose of this study is to investigate the maternal cardiac output response to rescue norepinephrine and phenylephrine boluses for postspinal anesthesia hypotension in parturients with preeclampsia undergoing cesarean…
- Trial name
- NCT05035485
- Testing
- Phenylephrine, Norepinephrine
- Where
- China
- Volunteers
- 40 people
- Sponsor
- General Hospital of Ningxia Medical University
Hypotension, Bradycardia
Effects of Ondansetron on Hemodynamic Changes After Spinal Anesthesia in Geriatric Urologic Surgery
Spinal anesthesia is frequently used in urologic surgery in geriatric patients; however, it may cause significant hemodynamic changes such as hypotension and bradycardia.
- Conditions
- Hypotension, Bradycardia, Hypotension During Surgery, Spinal Anesthesia Induced Hemodynamic Change
- Trial name
- NCT07551219
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Ankara City Hospital Bilkent
Post Induction Hypotension
Lower Extremity Elevation to Minimize Hemodynamic Instability During Induction of General Anesthesia
The purpose of this study is to determine if lower extremity elevation (LEE) will reduce the incidence of postinduction hypotension, to compare the utilization of vasoactive medications after induction in patients with LEE and…
- Trial name
- NCT06513169
- Testing
- Group 1: LEE
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- The University of Texas Health Science Center, Houston
Hemodynamics Instability, Anesthesia, General
Hemodynamics During Induction of General Anesthesia With High and Low Propofol Dose.
The study objective is to examine if a high propofol dose is non-inferior to a low dose in respect to hemodynamic stability in healthy patients during induction of general anesthesia with propofol and remifentanil.
- Conditions
- Hemodynamics Instability, Anesthesia, General, Anesthesia, Intravenous
- Trial name
- PH (NCT03861364)
- Testing
- Propofol
- Where
- Norway
- Volunteers
- 68 people
- Sponsor
- Helse Fonna
Hemodynamic Instability
Effect of Remazolam on Hemodynamics During Hepatectomy
There is high incidence of hemodynamic instability in patients undergoing hepatectomy with low central venous pressure, especially in general anesthesia combined with epidural anesthesia.
- Trial name
- NCT06565715
- Testing
- Remimazolam, Propofol
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Jun Zhang
Infertility Female, Hemodynamic Instability
Lidocaine vs Magnesium Sulfate for Hemodynamic Stability During Emergence in Infertility-Related Laparoscopic Surgery"
This study is being conducted to compare two medications, intravenous lidocaine and intravenous magnesium sulfate, and their ability to keep blood pressure and heart rate stable during the period of waking up from general…
- Trial name
- LidoMagGyna (NCT07359560)
- Testing
- Lidocaine (drug), Normal Saline (Intravenous), magnesium sulfate
- Where
- Egypt
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Intraoperative Hypotension, Jugular Veins
Internal Jugular Vein Ultrasound and Acute Kidney Injury After Abdominal Surgery
This observational study aims to learn whether changes in the internal jugular vein during anesthesia induction can help predict low blood pressure and kidney injury after surgery. The main questions it aims to answer are: 1.
- Conditions
- Intraoperative Hypotension, Jugular Veins, Hypotension on Induction, General Anesthesia With Propofol
- Trial name
- PRO-JUGULAR (NCT07638306)
- Testing
- Internal Jugular Vein Ultrasound Assesment
- Where
- Romania
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Tîrgu Mureș Emergency Clinical County Hospital, Romania
Hemodynamic Instability, Anesthesia
Hemodynamic Changes and Propofol Pharmacokinetic Variation During Anesthesia Induction and Knee-chest Positioning
Induction of anesthesia and the knee-chest position are associated with hemodynamic changes that may impact patient outcomes. Changes from baseline in cardiac output and other hemodynamic variables following induction of…
- Conditions
- Hemodynamic Instability, Anesthesia, Surgery
- Trial name
- NCT03961958
- Testing
- Propofol reduction
- Where
- Portugal
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Salamanca
Hemodynamic Instability
Advanced vs Standard Hemodynamic Monitoring During Propofol Sedation for ERCP: A Prospective Study
The aim of this study is to evaluate whether there is a difference in hemodynamic events requiring intervention between patients monitored with advanced hemodynamic monitoring using the MostCare system and those monitored with…
- Trial name
- NCT07538115
- Testing
- Hemodynamic Monitoring, Standard Monitoring
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Hitit University
Amobarbital Sodium, Hemodynamics Instability
Effect of Amobarbital Sodium Combined With Low-dose Propofol on Hemodynamics During Induction and Perioperative Adverse Reactions
At present, there are limited data on perioperative efficacy of barbiturates at home and abroad. The purpose of this clinical trial is to observe the effects of amobarbital sodium combined with low-dose propofol on hemodynamics…
- Trial name
- NCT06385756
- Testing
- Amobarbital, Propofol
- Volunteers
- 96 people
- Sponsor
- Tongji Hospital
Hemodynamic Instability, Hypovolemia
Preoperative Volume Substitution in Elective Surgery Patients
Preoperative fasting can evoke a hypovolemia which may cause a hemodynamic instability during introduction of anesthesia. The purpose of this study is to test the hypothesis that a defined preoperative volume substitution…
- Conditions
- Hemodynamic Instability, Hypovolemia, Anesthesia
- Trial name
- NCT01811966
- Testing
- Volume, Control
- Where
- Germany
- Volunteers
- 220 people
- Sponsor
- Philipps University Marburg
Hemodynamic Instability, Anesthesia, General
Hemodynamics During Induction of General Anesthesia With Medium or Low Remifentanil Doses.
In this trial the investigators want to examine if there is any difference in hemodynamic stability during induction when comparing two low and a medium remifentanil dose and keeping propofol induction dose at about 2.0 mg/kg.
- Conditions
- Hemodynamic Instability, Anesthesia, General, Anesthesia, Intravenous
- Trial name
- RH (NCT03861377)
- Testing
- Remifentanil R2, Remifentanil R4, Remifentanil R8
- Where
- Norway
- Volunteers
- 99 people
- Sponsor
- Helse Fonna
Propofol, Remimazolam
Respiratory Depression of Remimazolam vs. Propofol for Monitored Anesthesia Care
The comparison of incidence of respiratory depression between remimazolam and propofol under monitored anesthesia care for hysteroscopic surgery
- Conditions
- Propofol, Remimazolam, Hysteroscopic Surgery, Respiratory Insufficiency
- Trial name
- NCT07076628
- Testing
- Propofol, Remimazolam
- Where
- South Korea
- Volunteers
- 76 people
- Sponsor
- DongGuk University
Hemodynamic Instability During Anesthesia, Induction Anesthesia
Low-dose Propofol Plus High-dose Alfentanil in Rapid Sequence Induction
This study compares four different anesthesia induction regimens to see which one provides the most stable blood pressure and heart rate during rapid sequence intubation.
- Conditions
- Hemodynamic Instability During Anesthesia, Induction Anesthesia, Intubation
- Trial name
- NCT07730918
- Testing
- propofol, alfentanil, Sufentanil
- Where
- China
- Volunteers
- 172 people
- Sponsor
- Aoyang Hospital Affiliated to Jiangsu University