Clinical trials: Hemodynamic Effects of General Anesthesia
General Anesthesia
Effect of Dobutamine on Hepatic Blood Flow During Goal-directed Hemodynamic Therapy
Maintaining adequate perfusion pressure and oxygen supply is essential for organ survival. Splanchnic hypoperfusion during the perioperative period in abdominal surgery may result in mucosal ischemia with increased permeability…
- Trial name
- DOBU whipple (NCT04893655)
- Testing
- Dobutamine Hydrochloride
- Where
- Belgium
- Volunteers
- 58 people
- Sponsor
- University Hospital, Ghent
Hemodynamic Instability
Role of Nebulized Dexmedetomidine in Blunting the Effects of Direct Laryngoscopy and Endotracheal Tube on Heart Rate and Blood Pressure.
The goal of this interventional study is to check the effectiveness of nebulized Dexmedetomidine in preventing the rise in blood pressure and heart rate in patients undergoing General Anesthesia.
- Trial name
- NCT06103721
- Testing
- Dexmedetomidine Injection [Precedex], Normal Saline
- Where
- Pakistan
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Muhammad Haroon Anwar
The Effect of Ketamine - Dexmedetomidine Admixture (Ketodex) on Hemodynamic Stability
The Effect of Ketamine - Dexmedetomidine Admixture (Ketodex) on Hemodynamic Stability During Anesthesia Induction in Adults.
The aim of our study to compare two different doses of Dexmedetomidine added to anesthetic dose of ketamine in the induction of general anesthesia in adult patients regarding the hemodynamic profile, adequacy of hypnosis…
- Trial name
- NCT05948267
- Testing
- ketamine- dexmeditomidine admixure, Propofol, Lidocaine and fentanyl
- Where
- 2 sites in Egypt
- Volunteers
- 120 people
- Sponsor
- Kasr El Aini Hospital
Hemodynamic Instability
Effect of Remimazolam and Propofol on Hemodynamic Stability in Prone Position
Most of the major spinal surgeries are performed in the supine position, which causes a decrease in stroke volume and cardiac index, which leads to the occurrence of hypotension during surgery.
- Trial name
- NCT05644483
- Testing
- Remimazolam, Propofol
- Where
- South Korea
- Volunteers
- 94 people
- Sponsor
- Asan Medical Center
Cesarean Section, Anesthesia, General
Comparing Inhalational Anesthesia and TIVA on Maternal and Neonatal Hemodynamics in Elective Cesarean Section
This prospective, double-blind, randomized controlled trial compares the effects of total intravenous anesthesia (TIVA) versus sevoflurane-based inhalational anesthesia on maternal hemodynamics, depth of anesthesia, and early…
- Conditions
- Cesarean Section, Anesthesia, General, Anesthesia, Intravenous
- Trial name
- NCT07513870
- Testing
- Propofol, Sevoflurane
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Medipol University
Induction of General Anesthesia
Propofol Versus Sevoflurane for Induction of GA in Infants
This comparative study aims to investigate the haemodynamic safety profile for induction of general anesthesia in infants 3 months or less guided by electrical cardiometry parameters versus sevoflurane.
- Trial name
- NCT05105022
- Testing
- Propofol
- Where
- Egypt
- Volunteers
- 122 people
- Sponsor
- Cairo University
Residual Neuromuscular Block, Cardiovascular Diseases
Effects of Low-pressure Pneumoperitoneum Associated With Deep Pipecuronium-induced Neuromuscular Blockade on Hemodynamic Parameters for High Cardiovascular Risk Patient Undergoing General Anesthesia
Deep neuromuscular block (DNMB) during laparoscopy induces less haemodynamic stress by facilitating low-pressure pneumoperitoneum.
- Conditions
- Residual Neuromuscular Block, Cardiovascular Diseases, Neuromuscular Blockade Monitoring
- Trial name
- NCT06517524
- Where
- Hungary
- Volunteers
- 10 people
- Sponsor
- Tamas Vegh, MD
Hypertension
Effect of Treatment of Pre-induction Hypertension on Hemodynamic Stability During Induction of General Anesthesia
The purpose of this study is to determine if treatment of pre-induction hypertension with an intravenous short acting calcium channel antagonist will (1) reduce the magnitude and duration of blood pressure excursions outside of a…
- Trial name
- INGRESS (NCT06063772)
- Testing
- Clevidipine, Lactated Ringers, Intravenous
- Volunteers
- 64 people
- Sponsor
- University of California, San Diego
Post-induction Hypotension (PIH), Geriatric Patient
Incidence and Risk Factors of Post-Induction Hypotension in Geriatric Cancer Patients
This observational clinical study aims to investigate the incidence and risk factors of post-induction hypotension (PIH) in geriatric cancer patients undergoing surgery under general anesthesia.
- Conditions
- Post-induction Hypotension (PIH), Geriatric Patient, Oncologic Disease, Hemodynamic Effects of General Anesthesia
- Trial name
- NCT07294040
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Dolunay ARIK
Immediate Severe Postoperative Pain, Perioperative Hemodynamic
GOAL-Directed ANalgesia (GOALDAN)
The primary purpose of GOALDAN study is to demonstrate the superiority of a targeted perioperative analgesic strategy by the ANI over the usual practice on the incidence of immediate postoperative pain.
- Trial name
- GOALDAN (NCT03618082)
- Testing
- Anesthesic agent guided by ANI (Interventional Group), Administration of the lowest effective concentration of desflurane (Interventional Group)
- Where
- France
- Volunteers
- 380 people
- Sponsor
- University Hospital, Clermont-Ferrand
Anesthesia, Cerebral Blood Flow
Hypertension and Cerebrovascular Hemodynamics in General Anaesthesia
During anesthesia, blood pressure-raising medications are often required to achieve an adequate blood pressure level. However, there is limited knowledge about what constitutes an adequate blood pressure to ensure sufficient…
- Conditions
- Anesthesia, Cerebral Blood Flow, Regional Cerebral Oxygen Saturation, Blood Pressure
- Trial name
- NCT06855407
- Testing
- Blood pressure elevation
- Where
- Sweden
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Umeå University
Anesthesia, General
The Effect of BIS-guided Propofol Induction on Hemodynamic Response in Patients With Cardiac Risk.
Anesthesia induction will be started by monitoring ECG, non-invasive artery monitoring, peripheral oxygen saturation and BIS for all patients who are taken to the operating room without sedation.
- Trial name
- NCT04729465
- Testing
- Propofol, Bispectral Index Monitor
- Volunteers
- 60 people
- Sponsor
- Istanbul University - Cerrahpasa
Delirium, Postoperative Complications
Acceptable Hemodynamic Changes in Dexmedetomidine for Single Intravenous Bolus Injection
Dexmedetomidine（DEX）is a potent and highly selective α 2 adrenergic receptor agonist. It has the pharmacological effects of sedation, hypnosis, analgesia, anti-sympathetic and neuroprotective.
- Conditions
- Delirium, Postoperative Complications, Pathologic Processes, Neurocognitive Disorders
- Trial name
- NCT03655847
- Testing
- Dexmedetomidine
- Where
- China
- Volunteers
- 42 people
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Sepsis, Hypotension
Pre-induction Norepinephrine in Septic Patients Undergoing Surgery
This randomized controlled trial aims to evaluate the effect of early pre-induction norepinephrine infusion on perioperative hemodynamic stability in septic patients with SOFA score ≥2 undergoing surgery under general anesthesia.
- Trial name
- NCT07869693
- Testing
- Norepinephrine, Standard Care
- Volunteers
- 90 people
- Sponsor
- Assiut University
Pain Due to Propofol Injection, Hemodynamic Changes Due to Propofol Injection
The Effect of Combined Ephedrine and Lidocaine Pretreatment on Pain and Hemodynamic Changes Due to Propofol Injection
Objectives: Injection pain and hypotension are two main adverse effects of propofol which distresses patient. The aim of this prospective double blind study was to compare the effect of ephedrine -lidocaine combination with…
- Trial name
- NCT01186549
- Testing
- Ephedrine 30microgram/kg, lidocaine0.5mg/kg -ephedrine30 micrograms/kg, ephedrine 70 microgram/kg
- Where
- Iran
- Volunteers
- 165 people
- Sponsor
- Qazvin University Of Medical Sciences
Carotid Endarterectomy
Effects of Vasopressors on Cerebral Hemodynamics in Patients With Carotid Endarterectomy (MRI Part)
This study was a single-center, exploratory, randomized controlled trial. First, the effects of ephedrine, phenylephrine, or norepinephrine on cerebral blood flow hemodynamics in CEA patients were evaluated using DSC-MRI to…
- Trial name
- NCT05414877
- Testing
- Ephedrine, Phenylephrine, Norepinephrine
- Volunteers
- 60 people
- Sponsor
- Beijing Tiantan Hospital
Anesthesia, Conduction, Pain Management
The Effects of Ultrasound-guided Serratus Plane Block During Video-assisted Thoracoscopic Lobectomy
This study evaluates the effects of serratus plane block on intraoperative opioid consumption, emergence time and hemodynamic stability in patients undergoing video-assisted thoracic surgery.
- Trial name
- NCT03718377
- Testing
- Serratus plane block, General anesthesia only
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Kyungpook National University Hospital
Hip Fractures, Hip Disease
Safety Study of Dexmedetomidine in Elderly Under General Anesthesia
The purpose of this study is to find out appropriate dose range of dexmedetomidine to provide the elderly patients satisfactory sedation and analgesia with stable hemodynamics during perioperative period of hip replacement under…
- Trial name
- NCT05567523
- Testing
- Dexmedetomidine, Normal saline, Midazolam
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Zhenjiang First People's Hospital
Circadian Rhythm, Ciprofol
Effect of Circadian Rhythm on the Sedative Efficacy and Recovery Quality of Ciprofol General Anesthesia: A Multi-Center Observational Study
The goal of this multi-center observational study is to learn about the effect of circadian rhythm (morning vs. afternoon surgery) on the sedative efficacy, hemodynamic stability (especially induction-associated hypotension), and…
- Conditions
- Circadian Rhythm, Ciprofol, Hemodynamic Instability, Anesthetics Adverse Reaction
- Trial name
- NCT07686432
- Testing
- Surgery commences in the morning., Surgery commences in the afternoon.
- Volunteers
- 480 people
- Sponsor
- Jie Chen
General Anesthesia, Elective Surgery
Effect of Pre-injection of Rocuronium on Neuromuscular Blockade Onset Time and Hemodynamics During General Anesthesia Induction
This is a single-center, prospective, randomized, controlled trial comparing pre-injection versus standard bolus administration of rocuronium bromide for general anesthesia induction.
- Trial name
- NCT07716891
- Testing
- Rocuronium Bromide (Pretreatment Injection), Rocuronium Bromide (Conventional Injection)
- Where
- China
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- General Hospital of Ningxia Medical University