Clinical trials: Hemodynamic Changes
Congenital Heart Disease, Cardiopulmonary Bypass
Influence of Personalized Lung Volume Optimization Maneuver on Lung Function and Cardiac Performance in Children
The goal of this randomized interventional clinical trial is to learn if a standardized lung volume optimization maneuver (LVOM) is beneficial in 1.
- Conditions
- Congenital Heart Disease, Cardiopulmonary Bypass, Cardiac Surgery, Mechanical Ventilation
- Trial name
- ILOCO (NCT07193719)
- Testing
- End-expiratory lung volume optimization maneuver with PEEP titration, Standard Care (in control arm)
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- Charite University, Berlin, Germany
Congenital Heart Disease, Cardiopulmonary Bypass
Influence of Lung Volume Optimization Maneuver on Cardiac Output and Lung Compliance in Ventilated Children With Congenital Heart Disease Undergoing Surgical Repair
The aim of this randomized interventional multi-center clinical trial is to determine whether a standardized lung volume optimization maneuver (LVOM), including PEEP titration, improves outcomes in children undergoing…
- Conditions
- Congenital Heart Disease, Cardiopulmonary Bypass, Mechanical Ventilation, Peep Titration in Lung Protective Ventilation
- Trial name
- ILOCO-CHD (NCT07486167)
- Testing
- End-expiratory lung volume optimization maneuver with PEEP titration, Standard Care (in control arm)
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- Charite University, Berlin, Germany
High Altitude, Healthy Adult
Assessment of Total Pulmonary Resistance sPAP/CO Between High Altitude HA vs. Sea Level LA in Healthy Individuals H
To study the effect of relocation from high altitude (Quito Ecuador: 2850m) to sea level on pulmonary resistance (sPAP/CO) and other hemodynamic outcomes in healthy individuals, who live permanently >2600m.
- Conditions
- High Altitude, Healthy Adult, Echocardiography, Pulmonary Resistance
- Trial name
- NCT07804485
- Testing
- Descent from 2850m to sea level
- Where
- Switzerland
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Silvia Ulrich Somaini
Pulmonary Arterial Hypertension (PAH), Pulmonary Vascular Disease
Assessment of Total Pulmonary Resistance sPAP/CO Between High Altitude HA vs. Sea Level LA in Patients With Pulmonary Arterial Hypertension PAH
To study the effect of relocation from high altitude (Quito Ecuador: 2850m) to sea level on pulmonary resistance (sPAP/CO) and other hemodynamic outcomes in patients with pulmonary arterial hypertension PAH, who live permanently…
- Conditions
- Pulmonary Arterial Hypertension (PAH), Pulmonary Vascular Disease, High Altitude, Echocardiography
- Trial name
- NCT07804524
- Testing
- Descent from 2850m to sea level
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Silvia Ulrich Somaini
High Altitude, Healthy
Assessment of Total Pulmonary Resistance sPAP/CO Between Sea Level LA vs. High Altitude HA After Re-ascent in Healthy Individuals
To study the effect of a re-ascent after a one-week stay at sea level (after prior descent from 2850m) to high altitude (Quito Ecuador: 2850m) on pulmonary resistance (sPAP/CO) and other hemodynamic outcomes in healthy…
- Conditions
- High Altitude, Healthy, Healthy Adult, High Altitude Effects
- Trial name
- NCT07804589
- Testing
- Re-Ascent from sea level to 2850m
- Where
- Switzerland
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Silvia Ulrich Somaini
Spinal Anesthesia, Hemodynamic Changes
Hemodynamic Effects of Bilateral and Unilateral Spinal Anesthesia Using the Continuous Pressure Recording Analytical Method.
This randomized controlled study aims to compare the intraoperative hemodynamic effects of unilateral and bilateral spinal anesthesia in elderly patients undergoing elective total hip arthroplasty.
- Trial name
- NCT07789795
- Testing
- Unilateral Spinal Anesthesia, Bilateral Spinal Anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 74 people
- Sponsor
- Kayseri City Hospital
Pain, Hemodynamic Changes
Effect of Stress Ball During Chest Tube Removal After Open Heart Surgery
15 minutes before the procedure, nurses (FEÖ and NT) will explain and demonstrate how to use the stress ball. The stress ball will be applied for approximately five minutes, including the chest tube removal procedure.
- Conditions
- Pain, Hemodynamic Changes, Anxiety
- Trial name
- Stress ball (NCT07251270)
- Testing
- Stress ball
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Mersin University
Comparing 2 Techniques of iv Oxytocin Causing Hemodynamic Changes
Compare Hemodynamic Effect of Oxytocin Bolus and Infusion During Cesarean Section Under Spinal Anesthesia
Oxytocin is routinely used during a cesarean section to promote uterine contraction and prevent postpartum hemorrhage. It is typically administered immediately after delivery of the baby, either as a slow intravenous bolus…
- Trial name
- NCT07687355
- Testing
- Oxytocin bolus
- Volunteers
- 262 people, healthy volunteers welcome
- Sponsor
- Hayatabad Medical Complex
Respiratory Acidosis in ICU Patients, Right Ventricular (RV) Dysfunction
Right Ventricular Function and Respiratory Acidosis After Cardiac Surgery
Right heart dysfunction remains a frequent cause of morbidity and mortality after cardiac surgery. Respiratory acidosis, particularly when accompanied by hypoxemia, plays a significant role in right heart failure, primarily by…
- Conditions
- Respiratory Acidosis in ICU Patients, Right Ventricular (RV) Dysfunction, Hemodynamic Changes, Mechanical Ventilation
- Trial name
- NCT07619274
- Testing
- Not applicable- observational study
- Where
- Canada
- Volunteers
- 220 people
- Sponsor
- Laval University
Sedation, Cataract
Dexmedetomidine and Propofol for Sedation in Cataract Surgery.
The goal of this prospective, randomized, single-blinded is to learn if there is an ideal sedation protocol in cataract surgery in adults.
- Conditions
- Sedation, Cataract, Hemodynamic, Hemodynamic Changes
- Trial name
- NCT07556133
- Testing
- Dexmedetomidine (DEX), Propofol (PRO), Fentanyl (FEN)
- Where
- Lebanon
- Volunteers
- 1,000 people
- Sponsor
- Saint-Joseph University
Hypotension, Bradycardia
Effects of Ondansetron on Hemodynamic Changes After Spinal Anesthesia in Geriatric Urologic Surgery
Spinal anesthesia is frequently used in urologic surgery in geriatric patients; however, it may cause significant hemodynamic changes such as hypotension and bradycardia.
- Conditions
- Hypotension, Bradycardia, Hypotension During Surgery, Spinal Anesthesia Induced Hemodynamic Change
- Trial name
- NCT07551219
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Ankara City Hospital Bilkent
Lumbar Spine Surgery, Hemodynamic Changes
IVC Collapsibility Index in Lumbar Stabilization Surgery
This study aims to evaluate perioperative hemodynamic changes using the inferior vena cava (IVC) collapsibility index in patients undergoing lumbar stabilization surgery under general anesthesia.
- Conditions
- Lumbar Spine Surgery, Hemodynamic Changes, Intravascular Volume Status
- Trial name
- NCT07549165
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 128 people
- Sponsor
- Trabzon Kanuni Education and Research Hospital
Trigeminocardiac Reflex, Hemodynamic Changes
Association Between Lingual Retraction and Hemodynamic Changes in Patients Receiving Dental Treatment Under General Anesthesia
This study aims to investigate the association between sudden decreases in heart rate and blood pressure during dental procedures requiring lingual retraction-such as fillings, root canal treatments, tooth extractions, and cyst…
- Conditions
- Trigeminocardiac Reflex, Hemodynamic Changes, Dental Procedures
- Trial name
- NCT07240688
- Where
- Turkey (Türkiye)
- Volunteers
- 85 people
- Sponsor
- Kırıkkale University
Hemodynamic Changes
Assessment of Venous Return During Volume Expansion: a Prospective Observational Study
According to Guyton's model of venous return, the fluids that effectively increase cardiac output are those that, once administered, increase the vascular stressed volume, thereby increasing the mean systemic filling pressure…
- Trial name
- PSM-PVC-RITVEN (NCT07499388)
- Testing
- Fluid challenge of 500ml of crystalloid
- Where
- Italy
- Volunteers
- 45 people
- Sponsor
- Università Politecnica delle Marche
Laryngoscopy, Hemodynamic Changes
Effect of Nalbuphine Versus Fentanyl on Hemdoynamic Effects of Laryngoscopy
Participants will undergo routine pre-operative evaluation. An intravenous line will be placed in the recovery area. On arrival in the operating room, standard monitoring (blood pressure, heart rate, oxygen saturation, ECG…
- Trial name
- NCT07435337
- Testing
- Nalbuphine, Fentanyl
- Where
- Pakistan
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Rawalpindi Institute of Cardiology
Hemodynamic Changes, Music Therapy
Effects of Music Therapy on Anesthetic Requirements and Hemodynamic Parameters
Music therapy has been reported to reduce analgesic and anesthetic requirements, but evidence in thoracic surgery remains limited.
- Conditions
- Hemodynamic Changes, Music Therapy, Thoracic Surgery, Anesthetic Consumption
- Trial name
- NCT07322562
- Testing
- music therapy during surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- Cukurova University
Maternity, Pregnancy
Passive Leg Raising in Term Pregnancy on Hemodynamic Monitoring - Validating With Transthoracic ECHO (LG-ECHO)
This prospective observational validation study aims to evaluate the agreement and diagnostic accuracy of ClearSight™ compared with transthoracic echocardiography (TTE) during PLR in term pregnant women.
- Conditions
- Maternity, Pregnancy, Labor and Delivery, Hemodynamic Changes
- Trial name
- (LG-ECHO) (NCT07253818)
- Testing
- ClearSight™ System, Transthoracic Echocardiography, Passive Leg Raising (PLR) Maneuver
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Ayse Zeynep Turan Civraz
Spinal Anesthesia, Hemodynamic Changes
Effect of Patient Position on Bupivacaine Dose Requirement and Hemodynamic Stability in Spinal Anesthesia
This study compares different combinations of local anesthetic doses and patient positions during spinal anesthesia for urogenital surgery.
- Conditions
- Spinal Anesthesia, Hemodynamic Changes, Patient Positions, Bupivacaine
- Trial name
- NCT07376798
- Testing
- Bupivacaine %0.5 (hyperbaric)
- Volunteers
- 100 people
- Sponsor
- University of Health Sciences Balikesir Hospital Eduation and Research
Cardiac Autonomic Function, Hemodynamic Changes
Effects of Post-Match Foam Rolling, Static Stretching, and Passive Rest on Acute Cardiac-Autonomic, Hemodynamic, and Neuromuscular Recovery in National Wrestlers
This study looks at three common ways athletes recover after a wrestling match: foam rolling, static stretching, and resting. We want to learn which method helps the body recover better in the short time that athletes often have…
- Conditions
- Cardiac Autonomic Function, Hemodynamic Changes, Neuromuscular Adaptations, Exercise and Recovery
- Trial name
- NCT07305506
- Testing
- Foam Rolling, Static Stretching
- Where
- Turkey (Türkiye)
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Ali Kamil GÜNGÖR
Nebulization, Dexmedetomidine
Efficacy of Nebulized Dexmedetomidine on Blunting Hemodynamic Changes During Intubation and Pneumoperitoneum in Morbid Obese Patients During Laparoscopic Bariatric Surgery
This study aims to evaluate the effect of preoperative dexmedetomidine nebulization on blunting hemodynamic response for laryngoscope, intubation, pneumoperitoneum, and opioid consumption in morbidly obese patients undergoing…
- Conditions
- Nebulization, Dexmedetomidine, Hemodynamic Changes, Intubation
- Trial name
- NCT07054138
- Testing
- Dexmedetomidine, Normal Saline
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Tanta University