Clinical trials: Heat Stress, Exertional
Heat Stroke
Study of Risk Factors for the Occurrence and Severity of Exertional Heatstroke in the Military Environment
Although the circumstances of onset and management of exertional heatstroke have been identified for several years, its pathophysiology remains imperfectly understood. Exertional heatstroke is the result of both extrinsic (i.e.
- Trial name
- EXPLO-CCE (NCT04593316)
- Testing
- Saliva collection, Questionnaires, Ingestible core temperature capsule intake
- Where
- 3 sites in France
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Direction Centrale du Service de Santé des Armées
Exertional Heat Illness
Risk Factors for Exertional Heat Illness
The arduous nature of military training and operations require personnel to encounter high heat load, e.g., during intense physical exertion, particularly in the heat.
- Trial name
- NCT04979455
- Testing
- Core temperature monitoring, Questionnaires, Heart rate monitoring
- Where
- United Kingdom
- Volunteers
- 790 people, healthy volunteers welcome
- Sponsor
- Liverpool John Moores University
Core Temperature, Heat Stress, Exertional
Initial Stay Times and Heat Mitigation Controls for Uncompensable Occupational Heat Stress - Part I
Workplaces rely on upper heat stress limits provided by the American Conference of Governmental Industrial Hygienists (ACGIH) to manage the health and safety of workers in hot environments.
- Conditions
- Core Temperature, Heat Stress, Exertional, Heat Fatigue, Exercise
- Trial name
- NCT05847712
- Testing
- Simulated work in the heat
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Core Temperature, Heat Stress, Exertional
Initial Stay Times and Heat Mitigation Controls for Uncompensable Occupational Heat Stress - Part II
Workplaces rely on upper heat stress limits provided by the American Conference of Governmental Industrial Hygienists (ACGIH) to manage the health and safety of workers in hot environments.
- Conditions
- Core Temperature, Heat Stress, Exertional, Heat Fatigue, Exercise
- Trial name
- NCT06543719
- Testing
- Simulated work in the heat
- Where
- Canada
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Physiological Stress, Heat Stress
Validation of Heat Stress Limit Values for the Athletic Performance
Three male and three female semi-professional athletes, ranging in age from 22 to 27, participated in a study that was done at Lund University in Sweden to examine their physiological responses.
- Conditions
- Physiological Stress, Heat Stress, Sports Injury, Heat Stress, Exertional
- Trial name
- HSL-AP (NCT06084494)
- Testing
- analytical determination and interpretation of heat stress using calculation of the Predicted Heat Strain and Wet Bulb Globe Temperature
- Where
- Pakistan
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of the Punjab
Exertional Heat Illness
Comparing Exertional Heat Illness Risk Factors Between Patients and Controls
The arduous nature of military training and operations require personnel to encounter high heat load, e.g., during intense physical exertion, particularly in the heat.
- Trial name
- NCT05303142
- Testing
- Heat Tolerance Assessment
- Where
- United Kingdom
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- University of Portsmouth
Hyperthermia
Cryo Pack Cooling After Exercise-induced Hyperthermia
This research study aims to examine whether Cryo Cooling packs reduce thermal and cardiovascular strain after exercise-induced hyperthermia compared to a commercially available ice pack.
- Trial name
- NCT04257266
- Testing
- Ice Pack Cooling
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Connecticut
Exertional Heat Illness, Hydration Status
Comparing Risk of Heat Illness Based on Peak Core Temps During Preseason Football Camp Across 3 Different Age Levels
To collect field data in professional, collegiate, and high school football players to determine how they respond physiologically to the rigors of preseason training environment.
- Trial name
- NCT01954537
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Heat Stress, Exertional
Influences of Female Sex and Reproductive Hormones on Physiological Aspects of Heat Acclimation
Women are often understudied in thermal physiology research, leaving recommendations for Soldier safety and performance in hot conditions based largely on data collected in men.
- Trial name
- NCT05292170
- Testing
- Heat acclimation
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Heat Stress, Exertional, Heat Acclimation and Thermotolerance
Acute Exercise With Overdressing
The purpose of this study is to determine if exercise with extra clothing in a gym-like environment can increase body temperatures appropriately to help people adapt to the heat.
- Trial name
- Acute-XO (NCT07080853)
- Testing
- Exercise with Overdressing, Control Exercise
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Heat Stroke Exertional, Heat Illness
Treatment of Exertional Heatstroke witH icE wAter Soaked Towels
Exertional heat stroke (EHS) is the most serious form of heat-illness that can occur during sports and exercise. If not recognized and treated immediately mortality rate of EHS is high.
- Conditions
- Heat Stroke Exertional, Heat Illness, Heat Exhaustion
- Trial name
- THE HEAT (NCT05717777)
- Testing
- There is no intervention, only observational study
- Where
- Netherlands
- Volunteers
- 55 people
- Sponsor
- Erasmus Medical Center
Acute Kidney Injury, Exertional Heat Illness
Effects of Creatine Supplementation on Cognitive Measures and Markers of Acute Kidney Injury After Exercise in the Heat
The goal of this clinical trial is to learn if one week of creatine monohydrate supplementation alters inflammation, markers of acute kidney injury (AKI) risk, and cognitive performance in active, young, healthy volunteers.
- Trial name
- NCT07472426
- Testing
- Creatine Monohydrate
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Northern Iowa
Healthy, Heat Stress, Exertional
Impact of Heat on Dual Task Performance
This study looks at how people response performing single and dual tasks (cognitive and motor) prior to and after a rapid heat stress that increased core temperature to 39C.
- Trial name
- NCT07629414
- Testing
- heat stress
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Louisiana State University Health Sciences Center Shreveport
Heat Acclimation and Thermotolerance
Effect of Combined Exercise, Heat, and Quercetin Supplementation on Whole Body Stress Response
The purpose of this study is to determine whether dietary quercetin supplementation effects thermotolerance and heat acclimation in human subjects exposed to exercise/heat stress. Specific Aim I.
- Trial name
- NCT01168739
- Testing
- Quercetin
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Heat Stress, Exertional, Inflammatory Response
Role of Desloratadine in Reducing Inflammation From Occupational Heat Strain
The aim of this initial investigational study is to compare the effect of desloratadine on the inflammatory responses to heat stress in firefighters exercising in their personal protective equipment.
- Conditions
- Heat Stress, Exertional, Inflammatory Response, Firefighter Personal Protective Equipment
- Trial name
- NCT05446480
- Testing
- Desloratadine, No Intervention
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Victoria
Heat Stroke
Efficacy and Safety of Ryanodex® (EGL-4104) as Adjuvant Treatment in Subjects With Exertional Heat Stroke (EHS)
Study EGL-4104-C-1502 is a phase 2, single-site, open-label, randomized, 2-arm parallel study of Ryanodex for the adjuvant treatment of exertional heat stroke (EHS) administered intravenously (IV), to current standard of care…
- Trial name
- NCT02513095
- Testing
- Dantrolene sodium for injectable suspension
- Where
- Saudi Arabia
- Volunteers
- 34 people
- Sponsor
- Eagle Pharmaceuticals, Inc.
Heat Illness
Exertional Heat Illness: Biomarkers for Prediction and Return to Duty
The investigators goal is to monitor and quantify the differential physiologic and biomarker responses of controls to standardized exercise under thermoneutral and thermally challenged conditions and responses of exertional heat…
- Trial name
- Heat3 (NCT01434979)
- Where
- 2 sites in United States, Israel
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine