Clinical trials: Heart Murmurs
Heart Failure With Normal Ejection Fraction
Interleukin-1 Blockade in HF With Preserved EF
Heart Failure with Preserved Ejection Fraction (HFpEF) is a common form of heart failure Standard treatment for heart failure, show less than ideal results in HFpEF Evidence of systemic inflammation is common in all forms of…
- Trial name
- D-HART2 (NCT02173548)
- Testing
- Anakinra
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Virginia Commonwealth University
Congestive Heart Failure, Diastole
Aldosterone Antagonism in Diastolic Heart Failure
The primary purpose of this study is to determine whether eplerenone has a beneficial effect on improving exercise ability in patients with diastolic heart failure.
- Trial name
- NCT00108251
- Testing
- Eplerenone
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- US Department of Veterans Affairs
Murmur, Heart, Innocent Murmurs
Real-World Evaluation of Eko Algorithms in a Point of Care Setting
The purpose of this research is to prospectively test and validate the utility of Eko artificial intelligence (AI) plus Eko Murmur Analysis Software (EMAS) murmur characterization in algorithm in a real world, point-of-care…
- Conditions
- Murmur, Heart, Innocent Murmurs, Heart Murmurs, Pathologic Murmur
- Trial name
- NCT05459545
- Testing
- Use of Eko CORE and Eko CORE 500 electronic stethoscope
- Where
- 5 sites in United States
- Volunteers
- 371 people, healthy volunteers welcome
- Sponsor
- Eko Devices, Inc.
Left Ventricular Dysfunction, Heart Failure
Detection of Heart Conditions Using Artificial Intelligence
The purpose of this study is to evaluate how Eko AI performs in the real world, front-line setting where the availability of sophisticated, expensive diagnostic tools is limited, and where there is a premium on detecting VHD…
- Trial name
- NCT04933890
- Testing
- Use of Eko DUO electronic stethoscope
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Eko Devices, Inc.
Heart Murmurs, Mitral Valve Prolapse
Automated Algorithm Based Analysis of Phonocardiograms of Newborns
The purpose of this double-blind pivotal clinical utility study is to determine on a large patient population whether heart murmurs can be reliably detected with high sensitivity and specificity using a locked, automated…
- Conditions
- Heart Murmurs, Mitral Valve Prolapse, Systolic Murmurs
- Trial name
- NCT02105480
- Testing
- Computer aided auscultation (CAA)
- Where
- Austria
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- CSD Labs GmbH
Heart Failure, Cardiovascular Disease
Rhode Island Diastolic Dysfunction - Heart Failure
To study the hypothesis that treating patients with underlying diastolic dysfunction with oral Kuvan® (BH4, also known as tetrahydrobiopterin) in addition to current best practices will improve metabolic and echocardiographic…
- Trial name
- RIDD-HF (NCT02353312)
- Testing
- Kuvan
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Providence VA Medical Center
Systolic and Diastolic Blood Pressure Levels, Uric Acid Levels
Hyperuricemia on Hypertension and Metabolic Syndrome
The purpose of this study is to evaluate the influence of hyperuricemia treatment compared with placebo on participants with high risk of hypertension and metabolic syndrome.
- Conditions
- Systolic and Diastolic Blood Pressure Levels, Uric Acid Levels, Metabolic Syndrome Parameters, Hepatic Enzymes
- Trial name
- NCT01157936
- Testing
- Allopurinol
- Where
- Mexico
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Instituto Nacional de Cardiologia Ignacio Chavez
Diastolic Dysfunction, Coronary Artery Disease
Study of the Effect of Inhaled Anesthetics on Diastolic Heart Function Using a Doppler-derived Efficiency Index
The purpose of this study is to determine the effect of inhaled anesthetic drugs upon diastolic heart function (heart suction and filling performance) in patients who are undergoing coronary bypass surgery.
- Conditions
- Diastolic Dysfunction, Coronary Artery Disease, General Anesthesia
- Trial name
- NCT00907439
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Washington University School of Medicine
Chest Pathology
Auscultate Obese Patients Using Electronic and Traditional Stethoscopes
Auscultating Obese patients using the 3M Littmann Electronic Model 3200 Stethoscope is more effective in identifying referrable murmurs than using a traditional stethoscope.
- Trial name
- NCT01665820
- Testing
- Auscultate with electronic or mechanical stethoscope (3M Littmann)
- Where
- Lithuania
- Volunteers
- 30 people
- Sponsor
- Solventum US LLC
Hypertension
Systolic Blood Pressure Intervention Trial
Elevated blood pressure (BP) is an important public health concern. It is highly prevalent, the prevalence may be increasing, and it is a risk factor for several adverse health outcomes, especially coronary heart disease, stroke…
- Trial name
- SPRINT (NCT01206062)
- Testing
- Intensive control of SBP, Standard control of SBP
- Where
- United States
- Volunteers
- 9,361 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Prehypertension
Potassium Supplementation to Reduce Blood Pressure
The aim of this study is to conduct a definitive trial to assess the efficacy of consuming 1L/day of water rich in potassium to reduce blood pressure in mild to moderately hypertensive adults.
- Trial name
- NCT05412654
- Testing
- High potassium water, Control low potassium water
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Oxford Brookes University
Heart Failure, Diastolic (HFpEF)
Pogejiuxin Decoction Combination of Conventional Western Medicine for the Treatment of Heart Failure With Preserved Ejection Fraction
The objective of this study is to investigate the potential of Pogejiuxin Decoction to enhance the efficacy and mitigate the adverse effects associated with conventional treatment in patients with heart failure and preserved…
- Trial name
- NCT06629246
- Testing
- Conventional heart failure treatment, Pogejiuxin decoction combined with conventional heart failure treatment
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Chongqing Traditional Chinese Medicine Hospital
Hypertension
Safety/Efficacy of Combo Therapy With Aliskiren & Hydrochlorothiazide vs Therapy With Hydrochlorothiazide Alone in Patients With Hypertension
The purpose of this trial is to evaluate the safety and efficacy of combination therapy of aliskiren/hydrochlorothiazide (HCTZ) 150/25 mg and 300/25 mg compared with HCTZ 25 mg in patients with hypertension who do not show…
- Trial name
- NCT00387517
- Testing
- Aliskiren/HCTZ
- Where
- 2 sites in United States, Germany
- Volunteers
- 726 people
- Sponsor
- Novartis
Murmur, Heart, Innocent Murmurs
Real-World Evaluation of Eko Murmur Analysis Software in a Point of Care Setting
The purpose of this research is to evaluate the impact of Eko AI plus EMAS (Eko Murmur Analysis Software) on a clinician's referral decision in a real-world primary care setting.
- Conditions
- Murmur, Heart, Innocent Murmurs, Heart Murmurs, Pathologic Murmur
- Trial name
- NCT05176899
- Testing
- Use of Eko CORE electronic stethoscope
- Where
- United States
- Volunteers
- 103 people
- Sponsor
- Eko Devices, Inc.
Atrial Fibrillation, Atrial Fibrillation Recurrent
Effect of Dronedarone on Atrial Fibrosis Progression and Atrial Fibrillation Recurrence
Patients who have undergone cardiac ablation will be randomized and blinded to one of two groups; one group will receive dronedarone while the other group will receive a placebo.
- Trial name
- EDORA (NCT04704050)
- Testing
- dronedarone 400 mg Oral Tablet
- Where
- 4 sites in United States
- Volunteers
- 22 people
- Sponsor
- Tulane University School of Medicine
Murmur, Heart, Aortic Valve Stenosis
Development of an Algorithm to Differentiate Heart Murmurs Using Electronic Stethoscopes
The Eko CORE and DUO stethoscopes are FDA-approved electronic devices that have the capacity to record heart sounds. The study seeks to expand murmur detection to include VHD classification through the development of novel ML…
- Conditions
- Murmur, Heart, Aortic Valve Stenosis, Tricuspid Regurgitation, Mitral Regurgitation
- Trial name
- NCT04400513
- Testing
- Use of Eko CORE and Eko DUO electronic stethoscopes
- Where
- United States
- Volunteers
- 1,145 people
- Sponsor
- Eko Devices, Inc.
Hypertension
Efficacy & Safety of Orally Administered Valsartan/Amlodipine Combo Therapy vs Amlodipine Monotherapy in Black Patients With Stage II Hypertension
The purpose of this study is to evaluate the blood pressure lowering effects of a valsartan/amlodipine combination treatment and amlodipine monotherapy for the treatment of Black stage II hypertensive patients (MSSBP ≥ 160 mmHg).
- Trial name
- NCT00353912
- Testing
- valsartan + amlodipine
- Where
- United States
- Volunteers
- 571 people
- Sponsor
- Novartis
Chest Pain
Understanding Pediatric Chest Pain and Other Symptoms
The causes of pediatric pain are often not the same for every child. Most children who visit a cardiology specialist with complaints of chest or other somatic pain have no known medical diagnosis to explain their symptoms.
- Trial name
- NCT00166231
- Where
- 2 sites in United States
- Volunteers
- 156 people
- Sponsor
- Emory University
Valvular Heart Disease, Heart Murmurs
Can a Smartphone Listen to Your Heart? A Performance Study on Detecting Abnormalities in Your Heart Sounds
This observational study aims to assess the performance of the software called ausculto™. ausculto™ is a collection of computer algorithms that intend to analyse heart sounds recorded from the built-in microphone of a smartphone…
- Conditions
- Valvular Heart Disease, Heart Murmurs, Cardiovascular Abnormalities
- Trial name
- AUSC1 (NCT06070298)
- Testing
- Computer algorithms
- Where
- China
- Volunteers
- 577 people
- Sponsor
- Wong Chun Ka
Heart Murmurs
EKO SENSORA: Detecting Clinically Significant Murmurs
The Eko Artificial Intelligence (AI) has primarily been evaluated in the primary care setting. The digital stethoscope records a phonocardiogram of heart sounds of the patient and uses machine learning artificial intelligence to…
- Trial name
- EkoNM (NCT06155643)
- Testing
- Eko Sensora
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Corewell Health South