Clinical trials: Heart Disease Structural Disorder
Fabry Disease
Fabry Cardiomyopathy: Identification of Early Myocardial Structural and Tissue Abnormalities Using Multiparametric MRI
This study will evaluate whether cardiac MRI T1 and T2 mapping improves our ability to detect early abnormalities in the heart in patients with Fabry disease and identify patients at increase risk of adverse events.
- Trial name
- FIESTA-MRI (NCT04856059)
- Testing
- Cardiac MRI, ECG/Holter and Blood Biomarkers
- Where
- Canada
- Volunteers
- 300 people
- Sponsor
- University Health Network, Toronto
Ventricular Tachycardia
Inducibility and Stability of Ventricular Tachycardia Inpatients Undergoing VT Ablation Under General Anesthesia
This research study is being done to see whether general anesthesia (GA) affects our ability to start ventricular tachycardia (VT) during an VT ablation procedure.
- Trial name
- NCT02419547
- Testing
- Versed, Fentanyl, Propofol
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Brigham and Women's Hospital
Congenital Heart Disease
Study of RV Remodeling in Congenital Heart Disease
The primary aims of this study are to 1. Develop an automated method of quantitation of RV remodeling in terms of regional RV surface curvature and area strain and assess the feasibility, repeatability and accuracy in normal…
- Trial name
- RVShape (NCT02791061)
- Testing
- Cardiovascular Magnetic Resonance Imagine (MRI), Cardiopulmonary exercise testing (CPET), Echocardiography
- Where
- Singapore
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- National Heart Centre Singapore
Cardiomyopathy, Hypertrophic
The Impact of Exercise-Induced Cardiac Remodeling on Myocardial Efficiency
This research study is being conducted to find out how heart function and energy use differ among healthy endurance athletes, individuals who do not exercise regularly, and patients with hypertrophic cardiomyopathy.
- Trial name
- NCT04580693
- Testing
- PET Scan
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- Massachusetts General Hospital
Rheumatic Heart Disease, Heart Diseases
Mobile Health in Structural Heart Disease
The primary objective of this investigation was to assess the impact of new mobile health devices on health outcomes among patients with rheumatic and structural heart disease in a resource limited area.
- Trial name
- ASEF-VALUES (NCT02881398)
- Testing
- mHealth, Standard-Care
- Volunteers
- 253 people
- Sponsor
- Sri Sathya Sai Institute of Higher Medical Sciences
Isolated Aortic Stenosis, Mitral Regurgitation
A Study to Evaluate a Computerized Stethoscope Called ©Voqx to Diagnose Heart Disease
The purpose of this study is to determine whether recording heart sounds with an acoustic stethoscope, combined with artificial intelligence (computer information), will show similar abnormalities to an echocardiogram or cardiac…
- Trial name
- NCT04960280
- Testing
- ©VoqX stethoscope
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Mayo Clinic
Mitral Valve Disease, Heart Valve Diseases
Autonomous Robotics for Transcatheter Cardiac Procedures
Cardiovascular diseases represent the most common cause of death worldwide. Percutaneous approaches with intravascular catheters are pivotal, since they allow to treat patients with high perioperative risks.
- Conditions
- Mitral Valve Disease, Heart Valve Diseases, Structural Heart Abnormality
- Trial name
- ARTERY (NCT04787757)
- Testing
- Percutaneous cardiac procedure
- Where
- Italy
- Volunteers
- 401 people
- Sponsor
- Università Vita-Salute San Raffaele
Transthyretin Amyloidosis Cardiomyopathy (ATTR-CM), Amyloidosis
Cardiac Magnetic Resonance and Echocardiography Study With Acoramidis
The study aims to evaluate the effect of acoramidis on cardiac functional and structural improvement in participants with ATTR-CM.
- Conditions
- Transthyretin Amyloidosis Cardiomyopathy (ATTR-CM), Amyloidosis, Amyloid Cardiomyopathy, Transthyretin Amyloidosis
- Trial name
- ASCEND-ATTR (NCT07695701)
- Testing
- Acoramidis (AG10) oral tablet
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Eidos Therapeutics, a BridgeBio company
Patients Receiving Animal-derived Bioprosthetic Heart Valves
TRANSLINK: Defining the Role of Xeno-directed and Immune Events (SVD) in Patients Receiving Animal-derived Bioprosthetic Heart Valves
Cardiac valve disorders are widely spread in the general population and represents the third most frequent cardiovascular illness after coronary disease and arterial hypertension.
- Trial name
- TRANSLINK (NCT02023970)
- Testing
- Patients receiving animal-derived bioprosthetic heart valves., Echocardiography (1), Echocardiography (2)
- Where
- 5 sites in Canada, France and 2 more
- Volunteers
- 1,668 people
- Sponsor
- Nantes University Hospital
Aortic Valve Stenosis, Heart Valve Diseases
ENVISION IDE Trial: Safety and Effectiveness of NAVITOR in Transcatheter Aortic Valve Implantation
The objective of ENVISION is to evaluate the safety and effectiveness of the Navitor Transcatheter Aortic Valve Implantation (TAVI) System for treating patients with symptomatic, severe native aortic stenosis who are considered…
- Conditions
- Aortic Valve Stenosis, Heart Valve Diseases, Aortic Valve Disease, Heart Disease Structural Disorder
- Trial name
- ENVISION (NCT05932615)
- Testing
- Navitor Transcatheter Aortic Valve Implantation (TAVI) System, Any Commercially Available Transcatheter Aortic Valve (CAV) System
- Where
- 107 sites in United States, Australia and 11 more
- Volunteers
- 1,500 people
- Sponsor
- Abbott Medical Devices
Type 2 Diabetes Mellitus, Cardiovascular Disease
Effects of Liraglutide in Young Adults With Type 2 DIAbetes (LYDIA)
There are recent advances in therapies for the treatment of Type 2 Diabetes Mellitus (T2DM) which include the GLP1 analogues and the DPP IV inhibitors.
- Trial name
- LYDIA (NCT02043054)
- Testing
- Liraglutide, Sitagliptin
- Where
- United Kingdom
- Volunteers
- 90 people
- Sponsor
- University of Leicester
Coronary Artery Disease, Ischemic Heart Disease
Coronary and Structural Interventions Ulm - Bioresorbable Vascular Scaffold
To evaluate the safety, performance and efficacy of the bioresorbable vascular scaffold (BVS) system in patients with coronary artery disease
- Conditions
- Coronary Artery Disease, Ischemic Heart Disease, Stable Angina, Unstable Angina
- Trial name
- CSI-Ulm-BVS (NCT02162056)
- Testing
- use of bioresorbable vascular scaffolds
- Where
- Germany
- Volunteers
- 326 people
- Sponsor
- University of Ulm
Cardiac Disease
A Study of a Multi-Modal Sensor Patch for Real-Time Physiological Monitoring and Inference
The purpose of this research is to validate the prototype AI-Flex device. Researchers at Mayo Clinic developed a new a flexible multi-modal bio-sensing device, AI-Flex, with integrated artificial intelligence (AI) capability.
- Trial name
- NCT05581290
- Testing
- AI-Flex
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Mayo Clinic
Valvular Heart Disease, Nurse's Role
Impact in Quality of Care of the "STructural heARt NURSE" as New Interventional Cardiology Nursing Role in Spain.
The hypothesis is that patients with structural heart disease who are treated by STructural heARt nurses obtain better results in indicators of quality of care, compared with the usual practice (or not assisted) by this type of…
- Conditions
- Valvular Heart Disease, Nurse's Role, Competence, Cardiac Disease
- Trial name
- STAR-Nurse (NCT04301648)
- Testing
- STAR Nurse, Common Practice
- Where
- Spain
- Volunteers
- 86 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Atrial Fibrillation
Role of Eplerenone in Reducing Recurrence of Atrial Fibrillation in Patients With Structural Heart Disease
This is a prospective comparative study, conducted at Cardiology Department, Aswan University Hospital on AF patients with structural heart disease.
- Trial name
- NCT06556732
- Testing
- Eplereone
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
Cardiomyopathies, Ventricular Dysfunction
Measuring Electrical Resistance of Different Tissues on the Outer Surface of the Heart
This is a research study to evaluate the electrical properties of heart tissue. The purpose of this study is to determine the impedance (electrical resistance) of different tissues on the outer surface of the heart.
- Conditions
- Cardiomyopathies, Ventricular Dysfunction, Myocardial Infarction, Arrhythmia
- Trial name
- NCT00291174
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Pennsylvania
Heart Diseases, ASD - Atrial Septal Defect
Abbott Structural Heart Device Registry
The Abbott Structural Heart (SH) Registry is being conducted to confirm the safety and performance of Abbott's SH devices in a post-market, real-world setting.
- Conditions
- Heart Diseases, ASD - Atrial Septal Defect, VSD - Muscular Ventricular Septal Defect, PFO - Patent Foramen Ovale
- Trial name
- SH-Registry (NCT06590467)
- Testing
- Amplatzer™ Occlusion Devices, Epic™ Surgical Tissue Heart Valve devices
- Where
- 36 sites in United States, Denmark and 8 more
- Volunteers
- 2,500 people
- Sponsor
- Abbott Medical Devices
Obesity, Metabolic Dysfunction-associated Steatotic Liver Disease
ELEVATE-LIVER: A Study to Test Whether Survodutide Helps Improve Heart Structure and Function in People With Overweight or Obesity and Fatty Liver Disease
This study is for adults aged 18 years and older who have a type of fatty liver disease called metabolic dysfunction-associated steatotic liver disease (MASLD).
- Trial name
- NCT07850063
- Testing
- Survodutide
- Where
- 25 sites in United States, China and 3 more
- Volunteers
- 600 people
- Sponsor
- Boehringer Ingelheim
Severe Aortic Valve Stenosis
A Clinical Study Using FAPI-PET Imaging to Assess the Postoperative Effects of TAVI in Patients With Aortic Stenosis
This study will include patients with severe degenerative aortic stenosis (AS) who meet the inclusion criteria and voluntarily participate (planned to undergo TAVI), as well as patients with aortic stenosis who have not undergone…
- Trial name
- NCT07335900
- Testing
- Transcatheter Aortic Valve Implantation, Optimal medication treatment
- Where
- China
- Volunteers
- 25 people
- Sponsor
- RenJi Hospital
Radiotherapy; Complications, Ventricular Tachycardia
Stereotactic Ablative Radiotherapy for the Treatment of Refractory Ventricular Tachycardia
Ventricular tachycardia (VT) is an abnormal rhythm arising from the bottom chambers (ventricles) of the heart. The hearts of most patients who develop VT have been previously damaged by a myocardial infarction (heart attack) or…
- Conditions
- Radiotherapy; Complications, Ventricular Tachycardia, Structural Heart Abnormality, Heart Failure
- Trial name
- SABRE-VT (NCT05696522)
- Testing
- Stereotactic ablative radiotherapy
- Where
- United Kingdom
- Volunteers
- 4 people
- Sponsor
- Barts & The London NHS Trust