Clinical trials: Heart Arrest
Cardiac Arrest
Target-directed Management of Cerebral Oxygenation in Patients After Receiving ECPR
Neurological injury remains an important cause of morbidity and mortality in patients with ECPR. At present, the results of three prospective randomized controlled studies on ECPR are inconsistent, and it is inconclusive whether…
- Trial name
- TDMCO-ECPR (NCT06711016)
- Testing
- if rSO2 < 58%, if rSO2 58%-68%, rSO2>68%
- Where
- 2 sites in China
- Volunteers
- 654 people
- Sponsor
- Qilu Hospital of Shandong University
Non Shockable Out of Hospital Cardiac Arrest
Cyclosporine A in Cardiac Arrest
The investigators hypothesised that cyclosporine A administration at the onset of cardiopulmonary resuscitation, by inhibiting the mitochondrial permeability transition pore, could prevent the post cardiac arrest syndrome and…
- Trial name
- CYRUS (NCT01595958)
- Testing
- Cyclosporine A, cardio-pulmonary resuscitation
- Where
- France
- Volunteers
- 796 people
- Sponsor
- Hospices Civils de Lyon
Cardiac Arrest
Corticosteroid Therapy in Refractory Shock Following Cardiac Arrest
The major goal of this project is to determine whether the use of physiologic doses of corticosteroids will decrease time to shock reversal, alters the inflammatory cascade, and alters microcirculatory flow in post-cardiac arrest…
- Trial name
- NCT00676585
- Testing
- Normal Saline, Hydrocortisone
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Beth Israel Deaconess Medical Center
Hypoxic Brain Damage, Hypoxic Ischaemic Encephalopathy (HIE)
Intranasal AAV9-PHP.eB Gene Therapy in Cerebral Palsy (CP) & Hypoxic Ischemic Encephalopathy (HIE)
This international study, organized by Healing Hope International, is an observational registry designed to collect real-world data on participants living with chronic hypoxic ischemic encephalopathy (HIE) who receive an emerging…
- Conditions
- Hypoxic Brain Damage, Hypoxic Ischaemic Encephalopathy (HIE), Hypoxic Ischaemic Encephalopathy Due to Cardiac Arrest, Hypoxic Ischemic Encephalopathy of Newborn
- Trial name
- GEN-HOPE (NCT07264166)
- Where
- Mexico
- Volunteers
- 25 people
- Sponsor
- Healing Hope International
Cardiac Arrest, Coma
Out-of-Hospital Intubation With Metal Single Use Laryngoscope Blades
New single use laryngoscope metal blades are available for intubation. This type of blade is safer than the reusable ones concerning the interhuman cross infection risk.
- Conditions
- Cardiac Arrest, Coma, Major Trauma, Respiratory Distress
- Trial name
- LAMETA (NCT00644722)
- Testing
- MacIntosh Green Lite (metal single use laryngoscope blades), MacIntosh Green Spec II (metal reusable laryngoscope blades)
- Where
- France
- Volunteers
- 800 people
- Sponsor
- Henri Mondor University Hospital
Cardiogenic Shock, Cardiac Arrest
Outcomes of Patients With Venoarterial Extracorporeal Membrane Oxygenation
Venoarterial extracorporeal membrane oxygenation (VA ECMO)-also referred to as extracorporeal life support-is a form of temporary mechanical circulatory support and simultaneous extracorporeal gas exchange.
- Trial name
- NCT04039594
- Testing
- VA ECMO
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Beijing Anzhen Hospital
Cardiac Arrest
Prediction of Outcome in Out-of-Hospital Cardiac Arrest
In the course of prehospital respiratory and circulatory arrest, approximately 1000 persons are resuscitated by cardiopulmonary resuscitation in Upper Austria every year.
- Trial name
- PREDOHCA (NCT06030986)
- Testing
- ILCOR Utstein OHCA Core Outcome
- Where
- Austria
- Volunteers
- 10,000 people
- Sponsor
- Kepler University Hospital
Heart Arrest
Naloxone for In-Hospital Cardiac Arrest
The goal of this clinical trial is to learn if the drug naloxone in addition to cardiopulmonary resuscitation improves outcomes of in-hospital cardiac arrets.
- Trial name
- naloxone-IHCA (NCT07806565)
- Testing
- naloxone
- Volunteers
- 850 people
- Sponsor
- Region Skane
Heart Arrest
Oxidative Stress and Cardiac Arrest
Cardiac arrest is a major health problem reaching 375000 cases in Europe each year. Only 5 to 31 % survive after an out of hospital cardiac arrest (OHCA). The main complication after OHCA is the anoxic encephalopathy.
- Trial name
- NCT00888966
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Institut d'Anesthesiologie des Alpes Maritimes
Sudden Cardiac Death
Exercise and Cardiac Measures in Dialysis Patients
Background: The impact of the known non-invasive cardiac indices for identification of hemodialysis (HD) patients at high-risk for sudden cardiac death (SCD) has not been evaluated.
- Trial name
- NCT00944775
- Testing
- Exercise training
- Where
- Greece
- Volunteers
- 63 people
- Sponsor
- Aristotle University Of Thessaloniki
Cardiac Arrest, Reperfusion Injury
Intestinal Ischemia as a Stimulus for Systemic Inflammatory Response After Cardiac Arrest
Out-of-hospital cardiac arrest (CA) is a leading public health problem causing nearly one third of a million deaths annually in the US, accounting for half of all cardiovascular deaths and surpassing deaths from stroke, heart…
- Trial name
- TICA (NCT01944605)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Virginia Commonwealth University
Heart Arrest, Cardiac Arrest
An Intervention for Cardiac Arrest Survivors With Chronic Fatigue
The primary aim was to examine the feasibility of an Energy Conservation + Problem Solving Therapy (EC+PST) intervention delivered over the telephone and to evaluate the preliminary intervention effect on fatigue impact in daily…
- Conditions
- Heart Arrest, Cardiac Arrest, Fatigue
- Trial name
- CAF (NCT02864719)
- Testing
- Energy Conservation+Problem Solving Therapy
- Volunteers
- 18 people
- Sponsor
- University of Pittsburgh
Cardiac Arrhythmias, Sudden Cardiac Death
REal World Assessment for Patients Implanted With Implantable CardioverTer DefibrIllatOr Using Bluetooth Technology
The objective of this observational study is to assess clinical benefits of innovative features (e.g. Bluetooth technology and smartphone patient applications) in a patient population that is implanted with standard indication…
- Conditions
- Cardiac Arrhythmias, Sudden Cardiac Death, Heart Failure
- Trial name
- REACTION (NCT05175937)
- Testing
- smartphone APP based remote monitoring, bedside transmitter based remote monitoring
- Where
- Italy
- Volunteers
- 1,104 people
- Sponsor
- Federico II University
Heart Arrest
Automated Respiration Rate to Improve Accuracy of the Electronic Cardiac Arrest Risk Triage Score (eCART) Algorithm
Currently, breathing rate and heart rate are checked by nursing staff manually every few hours and entered into a patient's medical record.
- Trial name
- NCT02399930
- Testing
- Respiratory & Heart Rate Data Collection
- Where
- United States
- Volunteers
- 133 people
- Sponsor
- University of Chicago
Spinocerebellar Ataxia
Functional and Structural Imaging and Motor Control in Spinocerebellar Ataxia
The purpose of this research study is to investigate how the brain and motor behavior changes both in individuals with spinocerebellar ataxia and healthy individuals, and to assess whether a therapeutic intervention reduces…
- Trial name
- SCA (NCT02488031)
- Testing
- Error-reduction, International Cooperative Ataxia Rating Scale, Scale for the Assessment and Rating of Ataxia
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Florida
Cardiac Arrest
Implementation of LUCAS 2 in Helicopter Rescue in South Tyrol
Cardiopulmonary resuscitation (CPR) is used to maintain adequate perfusion of vital organs in cardiac arrest patients and is fundamental for the neurological outcome and survival of these individuals.
- Trial name
- NCT01745926
- Testing
- MECHANICAL CHEST COMPRESSION
- Where
- Italy
- Volunteers
- 18 people
- Sponsor
- Institute of Mountain Emergency Medicine
Out-of-Hospital Cardiac Arrest
Survival Study After Out-of-hospital Cardiac Arrest
The purpose of this study is to determine if dual dispatch of ambulance, fire fighters and/or police in out-of-hospital cardiac arrest (OHCA), can reduce the time to cardiopulmonary resuscitation (CPR) and defibrillation, thus…
- Trial name
- SAMS (NCT02184468)
- Testing
- Simultaneously dispatch of firefighters and/or police in case of OHCA
- Where
- Sweden
- Volunteers
- 6,000 people
- Sponsor
- Karolinska Institutet
Hypertrophic Cardiomyopathy
Efficacy of Risk Assessment for Sudden Cardiac Death in Patients With Hypertrophic Cardiomyopathy
Hypertrophic cardiomyopathy (HCM) is a heart disease characterized by hypertrophy of the left ventricular myocardium and is most often caused by mutations in sarcomere genes.
- Trial name
- NCT04402268
- Testing
- Cardioverter-defibrillator
- Where
- Poland
- Volunteers
- 252 people
- Sponsor
- Poznan University of Medical Sciences
Cardiac Arrest
Survey of Attitudes and Factors Associated With CPR in an Older Population
The goal of this study is to conduct a survey to better understand the factors associated with undertaking cardiopulmonary resuscitation (CPR) training and performing CPR in an emergency situation.
- Trial name
- NCT00665288
- Where
- Canada
- Volunteers
- 412 people, healthy volunteers welcome
- Sponsor
- Ottawa Hospital Research Institute
Cardiac Arrest
Transorbital Ultrasound and Other Markers for Prognosis Prediction After Cardiac Arrest
In sudden cardiac arrest patients with return of spontaneous circulation, brain damage is one of the main determinants of short-term mortality and poor prognosis (CPC 3-5).
- Trial name
- TOMCAT (NCT04838418)
- Testing
- Optic nerve sheath diameter measured by transorbital ultrasound
- Where
- Czechia
- Volunteers
- 80 people
- Sponsor
- University Hospital Pilsen
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