Clinical trials: Hearing Loss, Sensorineural
Intratympanic Steroid Injection, Idiopathic Sudden Sensorineural Hearing Loss
Comparing Topical Tetracaine Drops to Topical Focal Phenol for Local Anesthesia During Intratympanic Steroid Injection
Intratympanic steroid injections are an accepted treatment for Meniere's disease and idiopathic sudden sensorineural hearing loss. This treatment is typically performed using local topical anesthesia.
- Conditions
- Intratympanic Steroid Injection, Idiopathic Sudden Sensorineural Hearing Loss, Meniere Disease
- Trial name
- NCT04794842
- Testing
- Tetracaine 5% drops, Phenol 90% concentration
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Our Lady of the Lake Hospital
Hearing Loss, Sensorineural
Benefit of Assistive Listening Device for Lateralization
Speech intelligibility in noise will be evaluated in adults with moderate to moderate-severe sensorineural hearing loss using a Phonak Roger microphone and hearing aid with compatible Phonak Roger receiver.
- Trial name
- NCT05072457
- Testing
- Roger On microphone, Roger Select microphone
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Sonova AG
Hearing Loss, Sensorineural, Cystic Fibrosis
A Study of Web and Tablet-based Interactive Audiometry in Adults With CF
Adults with CF regularly receive anti-infective therapy that can result in impaired hearing. Recent studies have identified that up to 50% of adults with CF have hearing loss with resulting significant impact on quality of life.
- Trial name
- NCT04400955
- Testing
- Audiometry tablet diagnostic tool and web-based test
- Where
- United Kingdom
- Volunteers
- 156 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Noise-Induced Hearing Loss
Intervention for Hearing Health Among Native Americans
The purpose of the study is to understand the cultural impact on hearing loss among Native American populations who traditionally rely on oral communication.
- Trial name
- IHHANA (NCT07534098)
- Testing
- Talking Circle, Diabetes prevention program & delayed TC
- Where
- 2 sites in United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Hearing Loss, Sensorineural Hearing Loss
Non-significant Risk Study of a Cochlear Implant Headpiece
This study aims to evaluate a cochlear implant headpiece.
- Trial name
- NCT05488535
- Testing
- cochlear implant headpiece
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- Advanced Bionics
Bone Conduction, Hearing Loss, Conductive
Post-market Evaluation of the Transition From the Baha Connect System to the Osia System in Adult Bone Conduction Implant Recipients
The goal of this interventional study is to confirm the safety and performance of the latest generation Osia System and to examine its benefits compared to the Baha Connect System in adults with mixed or conductive hearing loss…
- Conditions
- Bone Conduction, Hearing Loss, Conductive, Hearing Loss, Mixed
- Trial name
- OSIRIS (NCT07130136)
- Testing
- Cochlear™ Osia® System, Cochlear™ Baha® System
- Where
- 3 sites in United Kingdom
- Volunteers
- 20 people
- Sponsor
- Cochlear
Sudden Sensorineural Hearing Loss (SSNHL)
Acupuncture Therapy for Sudden Sensorineural Hearing Loss
The goal of this multicenter, prospective, randomized controlled trial is to evaluate the efficacy and safety of acupuncture combined with corticosteroid therapy in treating sudden sensorineural hearing loss (SSNHL).
- Trial name
- SSNHL-Acu (NCT07575334)
- Testing
- Acupuncture
- Where
- China
- Volunteers
- 256 people
- Sponsor
- Eye & ENT Hospital of Fudan University
Sensorineural Hearing Loss, Hearing Loss
Quantification of Visually Evoked Cortical Potentials in Individuals With Hearing Loss
This research is being done to determine whether a test that measures a "Visual Evoked Potential" can be used in a new way for individuals that have hearing loss.
- Trial name
- NCT05107466
- Testing
- P300 Visually evoked potential
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Idiopathic Sudden Sensorineural Hearing Loss
Mechanism and Application of Vitamin D in Idiopathic Sudden Sensorineural Hearing Loss
Clinical Trial Protocol: Investigating the Therapeutic Efficacy of Vitamin D in ISSNHL。Core Research Questions Can vitamin D supplementation improve the prognosis of Idiopathic Sudden Sensorineural Hearing Loss (ISSNHL)? What…
- Trial name
- N (NCT07045883)
- Testing
- Vitamin D Supplementation+ standard treatment, standard treatment
- Where
- China
- Volunteers
- 197 people, healthy volunteers welcome
- Sponsor
- Zhongshan Hospital Xiamen University
Congenital Hearing Loss Secondary to Biallelic Mutations in the Otoferlin Gene (OTOF), Biallelic Mutations in the Gap Junction Beta 2 (GJB2) Gene
A Natural History Study in Pediatric Participants With Hearing Loss Due to OTOF, GJB2, or GJB2/GJB6 Mutations
This is an observational study to examine the characteristics of gene-related hearing loss in pediatric participants with biallelic otoferlin (OTOF) Mutations, Gap Junction Beta 2 (GJB2) Mutations, or Digenic GJB2/Gap Junction…
- Conditions
- Congenital Hearing Loss Secondary to Biallelic Mutations in the Otoferlin Gene (OTOF), Biallelic Mutations in the Gap Junction Beta 2 (GJB2) Gene, Digenic Mutations in GJB2/Gap Junction Beta 6 (GJB6) Genes
- Trial name
- ENSEMBLE (NCT06019481)
- Where
- 2 sites in United States
- Sponsor
- Regeneron Pharmaceuticals
Bilateral Sensorineural Hearing Loss, Cochlear Implant
Binaural Cue Sensitivity in Children and Adults With Combined Electric and Acoustic Stimulation
There is a rapidly growing population of adult and pediatric cochlear implant (CI) recipients with acoustic hearing preservation in the implanted ear(s) allowing for combined Electric and binaural Acoustic Stimulation (EAS).
- Conditions
- Bilateral Sensorineural Hearing Loss, Cochlear Implant, Hearing Preservation, Electric and Acoustic Simulation
- Trial name
- NCT07356128
- Testing
- binaural processing over time, binaural processing over time for children and adults with normal hearing
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Hearts for Hearing
Hearing Loss, Sensorineural
Mi2000 Totally Implantable Cochlear Implant (Mi2000 TICI)
The goal of this clinical trial is to test the Mi2000 Totally Implantable Cochlear Implant in a population of candidates for a cochlear implant.
- Trial name
- NCT06459765
- Testing
- Mi2000 TICI
- Where
- 6 sites in Austria, Belgium and 2 more
- Volunteers
- 30 people
- Sponsor
- MED-EL Elektromedizinische Geräte GmbH
Sudden Hearing Loss, Extracellular Vesicles
Study on the Safety and Efficacy of Intratympanic Injection of Small Extracellular Vesicles Derived From Mesenchymal Stem Cells in Severe and Profound Sudden Sensorineural Hearing Loss
The goal of this clinical trial is to learn if small extracellular vesicles derived from mesenchymal stem cells work to treat severe and above sudden sensorineural hearing loss.
- Trial name
- NCT07404709
- Testing
- Tympanic injection of hUC-MSC-sEV-003 (small extracellular vesicles) at low doses, Tympanic injection of hUC-MSC-sEV-003 (small extracellular vesicles) at moderate doses, Tympanic injection of hUC-MSC-sEV-003 (small extracellular vesicles) at high doses
- Where
- 5 sites in China
- Volunteers
- 9 people
- Sponsor
- The Affiliated Hospital of Qingdao University
Hearing Loss, Presbycusis
Variability In Hearing Aid Outcomes In Older Adults
The goal of this project is to find out if the way a hearing aid processes a sound signal should be determined in part by an individual's cognitive characteristics.
- Trial name
- NCT02448706
- Testing
- Hearing Aid Fitting A, Hearing Aid Fitting B
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Northwestern University
Hearing Loss, Hearing Loss, Sensorineural
Single-sided Deafness and Cochlear Implantation
This observational study evaluates the effects of cochlear implantation in patients with deafness in one ear.
- Conditions
- Hearing Loss, Hearing Loss, Sensorineural, Hearing Loss, Unilateral, Hearing Loss, Sudden
- Trial name
- NCT05052944
- Testing
- Cochlear implantation
- Where
- 5 sites in United States
- Volunteers
- 78 people
- Sponsor
- Johns Hopkins University
Siderosis, Neurological Disorder
Audiovestibular Function in Infratentorial Superficial Siderosis
One in six people in the United Kingdom and over 400 million people worldwide have disabling hearing loss. This figure will double by 2050 as predicted by the World Health Organisation.
- Conditions
- Siderosis, Neurological Disorder, Rare Diseases, Age Related Hearing Loss
- Trial name
- AViSS (NCT04200664)
- Testing
- Hearing assessment, Vestibular/balance assessment, Quality of life assessment
- Where
- 2 sites in United Kingdom
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University College, London
Hearing Loss, Cochlear
Improved Speech Recognition Performance in Noise by Encoding Binaural Spatial Cues to the Cochlear Implant User.
The aim of the study is to evaluate the interaural time difference (ITD) benefit in patients with bilateral cochlear implants and to assess speech performance in noisy conditions compared to normal hearing listeners.
- Trial name
- APPIC (NCT04357704)
- Testing
- S0N0, S0N500, S-500N500
- Volunteers
- healthy volunteers welcome
- Sponsor
- Oticon Medical
Hearing Loss, Sensorineural, Hearing Loss, Cochlear
The Neuro Zti Cochlear Implant System Efficacy and Safety in Adults
The purpose of the study is to assess the efficacy and the safety profile of the Neuro Cochlear Implant System (CIS) in adults with severe-to-profound hearing loss.
- Conditions
- Hearing Loss, Sensorineural, Hearing Loss, Cochlear, Deafness
- Trial name
- NCT02941627
- Testing
- Neuro Zti, Neuro One
- Where
- 6 sites in Canada, Denmark
- Volunteers
- 53 people
- Sponsor
- Oticon Medical
Hearing Loss, Bilateral or Unilateral, Hearing Loss, Conductive
Sentio Systematic Evaluation
The study is designed as an international, multi-center, single-armed, non-interventional/observational study including subjects who has received or are planned to receive the Sentio system as part of normal clinical practice.
- Conditions
- Hearing Loss, Bilateral or Unilateral, Hearing Loss, Conductive, Hearing Loss, Mixed Conductive-Sensorineural, Single Sided Deafness
- Trial name
- SENSE (NCT07161154)
- Testing
- Transcutaneous bone conduction hearing system
- Volunteers
- 100 people
- Sponsor
- Oticon Medical
Hearing Loss, Sensorineural, Hearing Loss, Sudden
Verification of the Efficacy/Safety of the Mixed Drug Injectable Delivery Vehicle for Treating Intractable Hearing Loss
This study is a prospective, randomized pilot study. To verify an efficacy/safety of the mixed drug injectable delivery vehicle for treating intractable hearing loss.
- Conditions
- Hearing Loss, Sensorineural, Hearing Loss, Sudden, Intratympanic Injection
- Trial name
- NCT06437054
- Testing
- Dexamethasone, Hyaluronic acid, Indocyanine green(ICG)
- Sponsor
- Seoul National University Hospital