Clinical trials: Head and Neck Cancer (H&N)
Head and Neck Cancer
MRI for Eval Tumor & Node Response & Normal Tissue Function to Concurrent Chemo & Radiation Therapy in H&N Cancer (GCC1043)
The investigators' goal is to incorporate advanced imaging information into the treatment planning process and assess response in tumor, nodes and non-cancerous tissues in head and neck cancer patients during and after concurrent…
- Trial name
- NCT01768442
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Maryland, Baltimore
Head and Neck Neoplasms, Emergency Department Presentation
Access to Care Pilot for ED-Presenting Head and Neck Cancer Patients (ENRICH-HNC)
Patients diagnosed with head and neck cancer (HNC) after presenting to an emergency department (ED) often face significant delays in diagnosis and treatment.
- Conditions
- Head and Neck Neoplasms, Emergency Department Presentation, Head and Neck Cancer (H&N)
- Trial name
- ENRICH-HNC (NCT07225725)
- Testing
- Community Health Support Specialist (CHSS) Navigation
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- University of Tennessee
Head and Neck Cancer
Quantitative Endoscopy of H&N
The last decade has seen progressive advances in RT delivery, such as intensity modulated radiation therapy (IMRT)and image-guided radiation therapy (IGRT), which now allow highly precise radiation dose delivery.
- Trial name
- NCT02704169
- Testing
- Spatially registered endoscopy
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- University Health Network, Toronto
Locally Recurrent Head and Neck Cancer
Salvage Brachytherapy and Hyperthermia for Recurrent H&N-tumours
The aim of the present trial is to assess the prospective results of protocol-based interstitial pulsed-dose-rate (PDR) brachytherapy with interstitial hyperthermia (iHT) in a group of selected patients where salvage surgery with…
- Trial name
- HyBT-H&N (NCT03238378)
- Testing
- Brachytherapy, Hyperthermia
- Where
- Germany
- Volunteers
- 96 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Cutaneous Squamous Cell Carcinoma of the Head and Neck
Remote Audiometry to Monitor for Treatment-Related Hearing Loss in Patients With H&N SCC Receiving Cisplatin and/or Radiation
This clinical trial tests the impact of offering hearing tests (audiometry) close to home and remotely on participation in monitoring for treatment-related hearing loss in patients with head and neck squamous cell cancer…
- Conditions
- Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Cutaneous Squamous Cell Carcinoma of the Head and Neck, Head and Neck Carcinoma of Unknown Primary, Head and Neck Squamous Cell Carcinoma
- Trial name
- NCT06662058
- Testing
- Audiometric Test, Interview
- Where
- United States
- Volunteers
- 118 people
- Sponsor
- Emory University
Head and Neck Cancer
MRG FU With Radiotherapy for Palliation of H&N Cancer
Head and neck cancer is the sixth most common form of malignancy world-wide. Surgery, chemotherapy and radiation are associated with a high burden of side effects; tumour recurrence within the neck continues to be a major cause…
- Trial name
- NCT03218475
- Testing
- MR Guided Focused Ultrasound
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Sunnybrook Health Sciences Centre
Malnutrition, Esophageal Cancer
INEC Study: Immuno-modulating Enteral Nutrition in Cancer
The aim of this study is to investigate if enteral immunonutrition of head and neck or esophageal cancer patients, using an arginine, omega 3 fatty acid, nucleotides-enhanced diet [Impact (R), Novartis] versus a standard enteral…
- Conditions
- Malnutrition, Esophageal Cancer, Head and Neck Cancer
- Trial name
- NCT00333099
- Testing
- Impact (R) Enteral Nutrition, impact
- Where
- France
- Volunteers
- 250 people
- Sponsor
- University Hospital, Clermont-Ferrand
Radiation Treatment
Trial Comparing Avg. Global Qual of Lifescore in Hypo Frac. RT vs Conv. Frac. in H&N Cancers
Radiotherapy forms an integral part of Head and Neck cancer treatment in both definitive as well as adjuvant setting. This study explores the use of hypofractionated radiotherapy, delivering 55Gy in 20 fractions over 4 weeks in…
- Trial name
- HYPORT-HN (NCT06536699)
- Testing
- Radiotherapy - hypofractionated, Radiotherapy - Conventional
- Where
- India
- Volunteers
- 600 people
- Sponsor
- Tata Medical Center
Head and Neck Cancer (H&N), Oral Mucositis (Ulcerative) Due to Radiation
Oral Care Program for Mouth Side Effects During Head and Neck Radiation Therapy
People having radiation therapy to the head and neck often develop painful mouth problems - mouth sores, dry mouth, mouth pain, trouble eating and drinking, and changes in taste.
- Conditions
- Head and Neck Cancer (H&N), Oral Mucositis (Ulcerative) Due to Radiation, Stomatitis (Oral Mucositis), Xerostomia Due to Radiotherapy
- Trial name
- OSEM (NCT07885033)
- Testing
- ORAL CARE PRODUCT KIT
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- UNCANCER LLC
Immunotherapy, Cancer
Observational Basket Trial to Collect Tissue to Develop and Train a Live Tumor Diagnostic Platform (ELEPHAS-02)
The primary objective of this study is to develop and train the Elephas live tumor diagnostic platform and determine the ex-vivo accuracy of the Elephas Score using in-vivo RECIST 1.1 as the reference method
- Conditions
- Immunotherapy, Cancer, Bladder Cancer, Urothelial Carcinoma Bladder
- Trial name
- ELEPHAS-02 (NCT05520099)
- Testing
- Core Needle Biopsy, Forceps Biopsy, Punch Biopsy
- Where
- 12 sites in United States
- Volunteers
- 416 people
- Sponsor
- Elephas
Squamous Cell Carcinoma of the Head and Neck
Phase 2 Study of Imprime PGG & Pembrolizumab in Subjects With Adv SCCHN Who Failed Pembro Monotherapy or Experiencing SD
Objective: To determine the Overall Response Rate (ORR) to Imprime PGG + pembrolizumab in subjects with advanced Squamous Cell Carcinoma of the Head and Neck (SCCHN) Safety: To characterize the safety of Imprime PGG +…
- Trial name
- NCT03246685
- Testing
- Imprime PGG, Pembrolizumab
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- HiberCell, Inc.
Squamous Cell Carcinoma, Squamous Cell Carcinoma of the Head and Neck
IRX-2 Regimen and Durvalumab, for Incurable H&N Squamous Cell Carcinoma
The purpose of this study is to see if the IRX-2 regimen and Durvalumab, will have a tolerable safety profile and will increase the intratumoral immune profile compared with the pretreatment tumors.
- Conditions
- Squamous Cell Carcinoma, Squamous Cell Carcinoma of the Head and Neck, Metastatic Squamous Cell Carcinoma, Oral Cavity Squamous Cell Carcinoma
- Trial name
- NCT03381183
- Testing
- Durvalumab, IRX-2 Regimen
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Head and Neck Squamous Cell Carcinoma
Evaluation of OE-MRI in Patients With H&N Cancer
Assessment of the use of oxygen enhanced MRI scanning in a cohort of patients with head and neck squamous cell carcinomas to identify areas of hypoxia with tumours and relate this to treatment outcomes.
- Trial name
- NCT04724096
- Testing
- Oxygen Enhanced MRI scan
- Where
- United Kingdom
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Nottingham University Hospitals NHS Trust
Head and Neck Cancer (H&N), Trauma Sequelae
Immunomonitoring of Circulating Immune Cells in Maxillofacial Surgery
The immune response following facial reconstruction may help predict healing time and the date of discharge after maxillofacial surgery.
- Conditions
- Head and Neck Cancer (H&N), Trauma Sequelae, Osteoradionecrosis of Jaws
- Trial name
- IMMUNOFACE (NCT07772063)
- Testing
- Treg
- Volunteers
- 60 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Head and Neck Neoplasms, Survivorship
H&N Cancer; Survivorship and Late Effects
A cross-sectional study on late effects after modern treatment in long-term survivors of head and neck cancer (HNC). Participants fill in questionnaires and participate at a one day visit at the hospital including blood sample…
- Trial name
- NCT04758026
- Where
- Norway
- Volunteers
- 265 people
- Sponsor
- Oslo University Hospital
Head and Neck Cancer (H&N)
eHealth Support Tool to Improve Quality of Life in Head and Neck Cancer Survivors
This study evaluates the development, implementation and effectiveness of a nurse-led eHealth support tool designed to improve quality of life and survivorship outcomes among adults treated for head and neck cancer.
- Trial name
- NCT07426874
- Testing
- eHealth Survivorship Support Tool, Control
- Where
- Ireland
- Volunteers
- 30 people
- Sponsor
- Royal College of Surgeons, Ireland
Head and Neck Cancer (H&Amp;Amp;N), Radiation-induced Oral Mucositis
Mouthwash Temperature and Oral Mucositis in Head and Neck Radiotherapy
This single-center randomized controlled trial evaluates the effects of cold (15-20°C) versus room-temperature (30-35°C) water gargling on oral mucositis severity, pain, and comfort in patients with head and neck cancer…
- Conditions
- Head and Neck Cancer (H&Amp;Amp;N), Radiation-induced Oral Mucositis, Supportive Care, Nursing Interventions
- Trial name
- CoolRinseHNC (NCT07252557)
- Testing
- Water Rinse at Different Temperatures
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- Chung Shan Medical University
Head and Neck Cancer
Using Intensity-Modulated Radiation Therapy to Permit Sparing of Parotid Gland Function
Radiotherapy is the primary treatment modality or an important adjunct treatment for many patients with H\&N carcinoma. Local control is directly related to dose and to the technical accuracy with which the dose is delivered to…
- Trial name
- NCT00137475
- Testing
- Intensity-Modulated Radiation Therapy
- Where
- Canada
- Volunteers
- 130 people
- Sponsor
- AHS Cancer Control Alberta
Head and Neck Cancer (H&N)
Speed of Processing Training to Improve Cognitive Functioning and Driving Performance in Head and Neck Cancer Survivors
The goal of the study is to understand how well cognitive training improves reaction time in people with head and neck cancer (HNC). Aim 1.
- Trial name
- NCT07740616
- Testing
- Speed of Processing Training
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Alabama at Birmingham
Head and Neck Cancer
Cough, Expiratory Training, and Chronic Aspiration After Head and Neck Radiotherapy
The goal of this clinical research study is to learn if exercising the muscles that help you cough and swallow, called expiratory muscle strength training (EMST), can help reduce the risk of pneumonia due to aspiration (inhaling…
- Trial name
- NCT02662907
- Testing
- Barium Swallow, Questionnaires, Expiratory Muscle Strength Training (EMST) Device
- Where
- United States
- Volunteers
- 175 people
- Sponsor
- M.D. Anderson Cancer Center