Clinical trials: HPV, open to volunteers
Human Papillomavirus-Negative Neck Squamous Cell Carcinoma, Resectable Head and Neck Squamous Cell Carcinoma
Decitabine in Combination With Standard of Care Therapy for the Treatment of Surgically Resectable HPV-Negative Head and Neck Cancer
This phase I trial tests the safety, side effects, and best dose of decitabine in combination with standard of care surgery, radiation, and/or chemotherapy and the effectiveness of the combination in treating patients with head…
- Conditions
- Human Papillomavirus-Negative Neck Squamous Cell Carcinoma, Resectable Head and Neck Squamous Cell Carcinoma, Resectable Human Papillomavirus-Independent Head and Neck Mucosal Squamous Cell Carcinoma, HPV-Negative Squamous Cell Carcinoma
- Trial name
- NCT06997094
- Testing
- Biospecimen Collection, Chemotherapy, Decitabine
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Mayo Clinic
HIV-infected Individuals
Safety and Immunogenicity of HPV Vaccine in HIV-infected
HPV can cause various cancers, including cervical cancer. HIV-infected individuals, due to immune deficiency or long-term immunosuppressive therapy, have significantly higher rates of HPV infection and associated lesion risks…
- Trial name
- NCT07797894
- Testing
- HPV vaccination
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Beijing 302 Hospital
Cervix Cancer, HIV Infections
Clinic vs Clinic+Community Outreach HPV Self-Collection to Increase Cervical Screening in Women With HIV
This Clinical Trials Network for Human Immunodeficiency Virus (HIV)-Associated Cervical Cancer Screening and Treatment Optimization (CASCADE) C3001-A trial aims to assess how the introduction of a…
- Conditions
- Cervix Cancer, HIV Infections, HPV Infection
- Trial name
- CASCADE3001A (NCT07428330)
- Testing
- Model 1- Screening in Clinic Only, Model 2 - Screening in Clinic and Community
- Where
- Uganda
- Volunteers
- 7,597 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
HPV, Cervical Cancer
Multimodality Treatments of HPV-related Lesions of the Female Genital Tract
Cervical cancer is one of the most preventable types of cancer, as it develops over an extended period, and its causative agent is well-known.
- Conditions
- HPV, Cervical Cancer, Cervix Lesion, Vagina Disease
- Trial name
- NCT05938192
- Testing
- vaccination
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Head and Neck Cancer
Study of De_Intensified Postoperative Radiation Therapy for HPV Associated Oropharyngeal Squamous Cell Carcinoma
This research study is studying lowering the standard dose of radiation and chemotherapy after surgery, to minimize the side effects and improve the quality of life.
- Trial name
- NCT03875716
- Testing
- Radiation therapy
- Where
- United States
- Volunteers
- 111 people
- Sponsor
- Dana-Farber Cancer Institute
Precancerous Cervical Lesion
Efficacy and Safety of Photodynamic Therapy for Cervical and Vaginal Intraepithelial Neoplasia
To investigate the efficacy and safety of photodynamic therapy (20% 5-amino-ketovalerate 630nm red light) in the treatment of cervical and vaginal intraepithelial neoplasia in women in the real world.
- Trial name
- NCT06982976
- Testing
- ALA-PDT
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Peking University Third Hospital
Human Papillomavirus
Evaluation of a Novel Point-of-Care Diagnostic Test for Human Papillomavirus (HPV)
To learn if new HPV tests can provide the same results as standard HPV tests. The findings from this study may aid in the development of new HPV tests that require less equipment and are more accessible.
- Trial name
- NCT06434337
- Testing
- Novel point-of-care diagnostic test for detecting HPV ("Rice HPV test")
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- M.D. Anderson Cancer Center
HPV Infection
The Effect of the Association EGCG, Folic Acid and Vitamin B12 in Preventing the Persistence of HPV Infection.
The purpose of the study is to test the effect of the administration of a dietary supplement consisting of epigallocatechin gallate (EGCG), vitamin B12 and folic acid in the treatment of infections with papilloma virus of the…
- Trial name
- NCT06285357
- Testing
- EGCG + folic acid + B12
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Lo.Li.Pharma s.r.l
HPV Infection, HIV Infections
Feasibility of HPV Testing With Mail-delivered Sample Collection Kits
People living with human immunodeficiency virus (PLWH) have an estimated 1.6-6.0 times increased risk of developing oropharyngeal cancer (OPC) compared with individuals in the general population.
- Conditions
- HPV Infection, HIV Infections, HPV-Related Malignancy
- Trial name
- NCT07087145
- Testing
- Mail-based Saliva Sample Kit, Study-related Surveys
- Where
- United States
- Volunteers
- 135 people
- Sponsor
- University of California, San Francisco
HPV-Associated Oropharyngeal Squamous Cell Carcinoma, HPV Positive Oropharyngeal Squamous Cell Carcinoma
Risk-adapted Therapy in HPV+ Oropharyngeal Cancer Using Circulating Tumor (ct)HPV DNA Profile - The ReACT Study
This research is being conducted to understand if treatment can be tailored for participants with HPV-related oropharynx cancers using both clinical features (stage of the tumor, smoking status) combined with an investigational…
- Conditions
- HPV-Associated Oropharyngeal Squamous Cell Carcinoma, HPV Positive Oropharyngeal Squamous Cell Carcinoma, HPV-Mediated (P16-Positive) Oropharyngeal Carcinoma by AJCC V8 Stage, HPV-Related Squamous Cell Carcinoma
- Trial name
- NCT04900623
- Testing
- NavDx HPV ctDNA Testing, Radiotherapy, Chemotherapy drug
- Where
- 2 sites in United States
- Volunteers
- 145 people
- Sponsor
- Jonathan Schoenfeld, MD, MPH
Human Papillomavirus
Natural History, Epidemiology and Pathogenesis of Severe HPV-Related Diseases (Neptune)
Background: Most symptoms of human papillomaviruses (HPV) infection, do not cause serious health problems, but some do. As HPV can cause uncontrolled growth of infected cells, some people can develop benign skin lesions, larger…
- Trial name
- NCT05026138
- Where
- United States
- Volunteers
- 850 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV (Human Immunodeficiency Virus), HPV
Feasibility Study Comparing One vs Two Probes for Thermal Ablation Among Cervical Cancer Screen Positive Women Living With HIV in C1001P-CS7 Zimbabwe
Cervical cancer disproportionately affects women in low- and middle-income countries (LMICs), particularly women living with HIV (WLWH) who have a 6-fold increased risk of cervical cancer compared to women in the general…
- Conditions
- HIV (Human Immunodeficiency Virus), HPV, Cervical Precancer, Cervical Neoplasia
- Trial name
- NCT07645352
- Testing
- Thermal ablation (TA) with 1 probe, Thermal ablation (TA) with 2 probes
- Where
- Zimbabwe
- Volunteers
- 300 people
- Sponsor
- Fred Hutchinson Cancer Center
Anal High-grade Squamous Intraepithelial Lesion, Anal HSIL
Artesunate Ointment for the Treatment of Anal HSIL in HIV-negative Participants
This is a phase II double blind, placebo-controlled, randomized study of artesunate ointment for the treatment of HIV-negative men and women who have anal high grade squamous intraepithelial lesions (anal HSIL)
- Conditions
- Anal High-grade Squamous Intraepithelial Lesion, Anal HSIL, Anal HPV Infection, AIN
- Trial name
- ART-AIN IIB-2 (NCT06206564)
- Testing
- Artesunate ointment
- Where
- 2 sites in United States
- Volunteers
- 48 people
- Sponsor
- Frantz Viral Therapeutics, LLC
HPV-unrelated Head and Neck Squamous Cell Carcinoma
Induction PD-1 Inhibitor and Chemotherapy Followed by Chemoradiotherapy in Unresectable or Inoperable HPV-negative LA-HNSCC
The goal of this clinical trial is to evaluate if adding chemotherapy and immunotherapy as induction treatment prior to definitive chemoradiotherapy could improve the outcomes of locally advanced HPV-negative head and neck…
- Trial name
- NCT07776340
- Testing
- Tislelizumab, Paclitaxel, Cisplatin (75 mg/m2)
- Where
- China
- Volunteers
- 104 people
- Sponsor
- Fudan University
Head and Neck Cancer
A Study Comparing Two Immunotherapy Options for Human Papillomavirus Positive HPV-Positive Head and Neck Cancer After Treatment
The goal of this clinical trial is to learn if the combination of cemiplimab and fianlimab can improve outcomes compared to cemiplimab alone in adults with Human Papillomavirus Positive HPV-positive head and neck cancer who have…
- Trial name
- NCT07179315
- Testing
- cemiplimab+fianlimab, Cemiplimab
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- University of Chicago
Cervical Carcinoma, Human Papilloma Virus (HPV)
Leveraging Project ECHO for Improved Cervical Cancer Screening in Ethiopia
Project TICHILALECH ("she can" in Amharic), a five-year, implementation science study, is focused on improving cervical cancer screening, triage, and treatment and integration with human immunodeficiency virus (HIV) care at five…
- Trial name
- NCT07678047
- Testing
- TICHILALECH ECHO
- Where
- Ethiopia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Albert Einstein College of Medicine
HPV Disease, Cervical Intraepithelial Neoplasia Grade I
HIFU vs Observation for LSIL of Cervix: A Randomized Controlled Trial
The majority of low-grade pre-invasive lesions of cervix (low-grade squamous intraepithelial lesions, LSIL).will regress spontaneously over 2 years and immediate treatment may not be necessary.
- Trial name
- HIFU Colpo (NCT07461064)
- Testing
- HIFU treatment
- Volunteers
- 180 people
- Sponsor
- Queen Mary Hospital, Hong Kong
Human Papillomavirus Type 16, Cervical Intraepithelial Neoplasia Grade II
HPV DNA Vaccine Via Electroporation for HPV16 Positive Cervical Neoplasia
The primary goal of this phase I open label study is to determine the safety and tolerability of pNGVL4aCRTE6E7L2 DNA vaccine, as administered by intramuscular (IM) injection with TriGrid™ electroporation to both HIV- or HIV+…
- Conditions
- Human Papillomavirus Type 16, Cervical Intraepithelial Neoplasia Grade II, Cervical Intraepithelial Neoplasia, Grade III
- Trial name
- NCT04131413
- Testing
- pNGVL4aCRTE6E7L2
- Where
- 2 sites in United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins