Clinical trials: HOMA-IR
Polycystic Ovary Syndrome (PCOS) Women
Metformin Effects on Metabolic, Vitamin B12, Iron, Erythropoietin, and Hematological Parameters in Women With PCOS
This double-blind, placebo-controlled, parallel-group randomized controlled trial evaluated changes in metabolic, vitamin B12, iron-status, erythropoietic, and hematological parameters among women with polycystic ovary syndrome…
- Trial name
- MET-PCOS (NCT07793838)
- Testing
- Metformin
- Where
- Jordan
- Volunteers
- 400 people
- Sponsor
- Jerash Private University
Insulin Resistance, Obesity Type 2 Diabetes Mellitus
Triglyceride-Glucose and TGI-BMI Indices Compared With HOMA-IR
Insulin resistance plays a key role in the development of type 2 diabetes, metabolic syndrome, and heart disease. The most common way to measure insulin resistance is the HOMA-IR index, but it requires fasting insulin tests…
- Trial name
- NCT07260201
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Hisar Intercontinental Hospital
Polycystic Ovary Syndrome (PCOS)
Myo-Inositol Alone Versus Myo-Inositol Plus Alpha-Lactalbumin in Women With Polycystic Ovary Syndrome
Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting reproductive-aged women and is associated with menstrual irregularities, infertility, hyperandrogenism, obesity, and insulin resistance.
- Trial name
- MIALA-PCOS (NCT07629895)
- Testing
- Myo-inositol, Alpha-Lactalbumin
- Where
- Pakistan
- Volunteers
- 82 people
- Sponsor
- Quaid-e-Azam Medical College
Gestational Diabetes
Myo-inositol in Obese Pregnant Women
Myo-Inositol is classified as a member of the vitamin B complex. It is a constituent of living cells and is widespread in many food.
- Trial name
- NCT01047982
- Testing
- myo-inositol, folic acid 400 mcg
- Where
- Italy
- Volunteers
- 220 people
- Sponsor
- University of Messina
Visceral Obesity, Insulin Resistance
The Effects of Water-only Fasting and Refeeding on Body Composition
This observational pilot study will assess the effects of water-only fasting on body composition and insulin resistance
- Trial name
- NCT04514146
- Testing
- Water-only fasting
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- TrueNorth Health Foundation
Cardiac Surgery, Insulin Resistance
Impact of Preoperative Oral Carbohydrate Loading on Insulin Resistance in Adult Cardiac Surgery Patients
The goal of this clinical trial is to investigate the effect of preoperative oral carbohydrate on insulin resistance in adult cardiac surgery patients with a cardiopulmonary bypass machine.
- Trial name
- NCT07212153
- Testing
- Oral Carbohydrate Drink (Maltodextrin)
- Where
- Indonesia
- Volunteers
- 50 people
- Sponsor
- Rifdhani Fakhrudin Nur
Polycystic Ovary Syndrome (PCOS), Insulin Resistance Syndrome
Evaluation of MG53 (TRIM72) Levels in Women With Polycystic Ovary Syndrome: An Observational Study
Purpose of the Study: This study is being conducted to examine a protein called MG53 (also known as TRIM72) in women with polycystic ovary syndrome (PCOS).
- Trial name
- PCOSMG53 (NCT07094776)
- Testing
- No intervention (observational study)
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Havva Betül Bacak
Secondary Hypogonadism
The Effect of Testosterone Replacement on the High Density Lipoprotein Cholesterol Subgroups
The study is designed to answer the following questions: 1. Is there any difference between the compositions of the HDL cholesterol subpopulations of patients with hypogonadism and the healthy controls. 2.
- Trial name
- NCT01454011
- Testing
- Testosteron 250mg injection, Testosterone 50mg transdermal application
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Gulhane School of Medicine
Metabolic Syndrome, Lipid Profile
Gluten Free Diet on Metabolic Syndrome
This study benefits the community by highlighting the potential of a gluten-free diet as a non-pharmacological, effective approach to managing obesity and type 2 diabetes.
- Conditions
- Metabolic Syndrome, Lipid Profile, HOMA-IR, Weight Change, Body
- Trial name
- NCT07127055
- Testing
- No intervention, gluten free diet
- Where
- Pakistan
- Volunteers
- 108 people
- Sponsor
- University of Lahore
Insulin Resistance
Carbohydrate Loading in Lowering Perioperative Insulin Resistance in Pediatric Surgery
It is a double blinded randomized controlled trial interventional study, examining the effect of carb loading given prior to surgery on preventing post operative insulin resistance in pediatric patients undergoing elective surgery
- Trial name
- NCT07545538
- Testing
- Carbohydrate loading
- Where
- Indonesia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Gadjah Mada University
Pancreatogenic Diabetes Mellitus
Prediction of Pancreatogenic Diabetes After Partial Resection of the Pancreas
The primary aim of the study is to identify clinical, laboratory, imaging, and pathohistological risk factors for the development of pancreatogenic diabetes after partial resection of the pancreas (PRP) and, based on these, to…
- Trial name
- NCT07665710
- Where
- Slovenia
- Volunteers
- 150 people
- Sponsor
- University Medical Centre Ljubljana
Insulin Resistance, Blood Pressure
Denervation of the REnal Artery in Metabolic Syndrome
The current prevalence of hypertension as part of the metabolic syndrome is substantial and is increasing with the rise of obesity worldwide.
- Trial name
- DREAMS (NCT01465724)
- Testing
- Renal denervation
- Where
- Netherlands
- Volunteers
- 29 people
- Sponsor
- UMC Utrecht
Intermittent Fasting, Weight Loss
The Effectiveness of Intermittent Fasting and Behavioral Economics Intervention on Weight Control in Obese Patients
This study is a parallel randomized controlled trial (RCT). To determine the effect of intermittent fasting, intermittent fasting with behavioral economics, and intensive lifestyle modification on nutritional status; the…
- Conditions
- Intermittent Fasting, Weight Loss, Behavioral Economic, Obese
- Trial name
- NCT06261229
- Testing
- Intermittent fasting, Intermittent fasting + Behavioral economic, Intensive Lifestyle Modification
- Where
- Thailand
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Anovulation
Predictors of Ovarian Response During Clomiphene Citrate Ovulation Induction in Patients With Polycystic Ovary Syndrome
The purpose of this study is to determine whether Visceral fat area and other criteria assessed during initial screening could predict the response to ovulation induction with clomiphene citrate (CC) in patients with polycystic…
- Trial name
- NCT02269306
- Testing
- clomiphen citrate
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Menoufia Obstetrics and Gynecology Group
Insulin Resistance
Cacao Consumption in Patients With Insulin Resistance
Metabolic syndrome (MS) is a clinical entity that includes several disorders that predispose to imbalance in lipid metabolism: hypertension, insulin resistance, hypertriglyceridemia, obesity and low levels of high density…
- Trial name
- NCT03034291
- Testing
- Cacao 70%, White chocolate
- Volunteers
- 92 people
- Sponsor
- Universidad de Antioquia
Deficiency, Vitamin D, Insulin Resistance
Vitamin D Supplementation and and Glycemic Indexes
Age affect insulin sensitivity and the metabolism, and vitamin D status was shown to have a correlation with markers of insulin resistance.
- Trial name
- NCT03478475
- Testing
- cholecalciferol (Euro-Pharm International, Canada)
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Université d'Auvergne
Obesity & Overweight, Mobility Disability
Proof-of-Concept Study Evaluating Total Body Weight, Physical Function & Safety of Enobosarm in Patients Treated With GLP-1 Receptor Agonist, for Weight Loss
The primary objective of this study is to assess the effect of enobosarm on total body weight
- Conditions
- Obesity & Overweight, Mobility Disability, HOMA-IR
- Trial name
- PLATEAU (NCT07446998)
- Testing
- Enobosarm, Semaglutide (Wegovy) weekly injection
- Where
- 13 sites in United States
- Volunteers
- 239 people
- Sponsor
- Veru Inc.
Obesity, Insulin Resistance
Synbiotic Therapy on Intestinal Microbiota and Insulin Resistance in Obesity
Background : There is a plausible relationship between microbial gut and insulin resistance. Intervention to prevent insulin resistance by modifying the microbial gut has been proposed but limited studies demonstrates the…
- Trial name
- NCT04642482
- Testing
- Synbiotic (Rillus)
- Where
- Indonesia
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Hasanuddin University
Obesity, Metabolic Syndrome
The Predictive Role of Preoperative Pentraxin-3 (PTX3) in Metabolic and Inflammatory Outcomes After Roux-en-Y Gastric Bypass
This study evaluated the prognostic value of preoperative pentraxin-3 (PTX3) levels in predicting weight loss, inflammatory resolution (CRP, IL-6), and metabolic improvements (HOMA-IR) following Roux-en-Y gastric bypass in…
- Conditions
- Obesity, Metabolic Syndrome, Insulin Resistance, Inflammation
- Trial name
- PTX3-BYPASS (NCT07241741)
- Testing
- Biomarker Stratification by PTX3
- Volunteers
- 23 people
- Sponsor
- Istanbul University
Polycystic Ovarian Syndrome, Pelvic Endometriosis
Prevalence of HbA1C in Women With PCOS
Women with PCOS have been observed to be potential diabetics.Recently,American Diabetes Association has suggested screening of women with PCOS for HbA1C.
- Conditions
- Polycystic Ovarian Syndrome, Pelvic Endometriosis, Insulin Resistance, Non-insulin Dependent Diabetes Mellitus
- Trial name
- WHI (NCT01838122)
- Where
- India
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Southern Cross Fertility Centre