Clinical trials: HNPCC
Decision Aid
Using Visual Arrays to Support Understanding of Genetic Risk
The goal of this study is to understand how people understand risk from genetic testing. The investigators want to understand what visual aid best helps people accurately assess risk.
- Trial name
- NCT06994832
- Testing
- Visual Array, Narrative Visual Array, Choice
- Where
- United States
- Volunteers
- 1,045 people, healthy volunteers welcome
- Sponsor
- Stephanie B. Seminara, MD
Colon Cancer, Rectal Cancer
Adherence to Colon Cancer Screening (ACCS)
This randomized clinical trial studies website access or genetic counseling with or without patient navigators on adherence to colorectal cancer screening recommendations in patients with newly diagnosed colorectal cancer and…
- Trial name
- NCT02112747
- Testing
- Patient Navigator
- Where
- United States
- Volunteers
- 1,900 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Lynch Syndrome, Hereditary Colonic Polyposis Syndromes
Metagenomic Evaluation of the Gut Microbiome in Patients With Lynch Syndrome and Other Hereditary Colonic Polyposis Syndromes
The purpose of this study is to understand the role bacteria that normally live in the colon may play in colorectal cancer risk, in addition to the hereditary risk to colorectal cancer.
- Trial name
- NCT02371135
- Testing
- colonic biopsies, questionnaires
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Colorectal Cancer, Lynch Syndrome
Molecular Screening for Lynch Syndrome in Denmark
A clinically applicably strategy for molecular screening for Lynch Syndrome is being implemented in Denmark. Based on sequential analysis with immunohistochemistry and methylation analysis, patients with possible hereditary…
- Conditions
- Colorectal Cancer, Lynch Syndrome, HNPCC
- Trial name
- NCT01845753
- Testing
- Observation
- Where
- 11 sites in Denmark
- Volunteers
- 5,000 people
- Sponsor
- Vejle Hospital
Constitutional Mismatch Repair Deficiency Syndrome, Hematopoietic and Lymphoid Cell Neoplasm
Testing the Combination of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) in Children, Adolescent, and Young Adult Patients With Relapsed/Refractory Cancers That Have an Increased Number of Genetic Changes, The 3CI Study
This phase Ib trial investigates the side effects of the combination of nivolumab and ipilimumab, and to see how well they work in treating patients with cancers that have come back (relapsed) or does not respond to treatment…
- Conditions
- Constitutional Mismatch Repair Deficiency Syndrome, Hematopoietic and Lymphoid Cell Neoplasm, Lynch Syndrome, Recurrent Lymphoma
- Trial name
- NCT04500548
- Testing
- Biospecimen Collection, Ipilimumab, Nivolumab
- Where
- 9 sites in United States, Canada
- Sponsor
- National Cancer Institute (NCI)
Lynch Syndrome, Endometrial Cancer
Frequency of Endometrial Cancer Precursors Associated with Lynch Syndrome
Given that there is a significant prevalence of Lynch syndrome among patients with endometrial cancer (about 5% of patients with endometrial cancer), and given there is a known risk of endometrial cancer among patients with…
- Conditions
- Lynch Syndrome, Endometrial Cancer, Endometrial Hyperplasia, Mismatch Repair Deficiency
- Trial name
- NCT05257057
- Testing
- Immunohistochemical staining
- Where
- United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- WellSpan Health
BRCA1 Mutation, POLD1 Gene Mutation
An Intervention to Increase Genetic Testing in Families Who May Share a Gene Mutation Related to Cancer Risk and An Intervention to Help Patients and Their Primary Care Providers Stay Up-to-date About Uncertain Genetic Test Results
The purpose of this study is to examine the impact of new cancer genetic counseling models that aim to increase patient engagement with the genetics team.
- Conditions
- BRCA1 Mutation, POLD1 Gene Mutation, CDKN2A Mutation, BRCA2 Mutation
- Trial name
- NCT05420064
- Testing
- Intervention Arm At-risk Relative/ARR Contacts, MyGene Portal, Standard of Care
- Where
- 8 sites in United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Lynch Syndrome
Evaluation of Capsule Colonoscopy in Patients With Lynch Syndrome
Lynch syndrome is the most common hereditary cancer syndrome and is caused by pathogenic variants in DNA mismatch repair genes, resulting in a markedly increased lifetime risk of colorectal cancer.
- Trial name
- Lynch syndrome (NCT07445828)
- Testing
- colon capsule endoscopy
- Where
- Sweden
- Volunteers
- 78 people
- Sponsor
- Region Skane
Hereditary Cancer Syndromes, BRCA1 Hereditary Breast and Ovarian Cancer Syndrome
Strategy for Management of Patients With Hereditary Cancer Syndromes (HCS) in a Rural Environment
This study aims to improve cancer prevention and surveillance adherence in patients with Hereditary Cancer Syndromes (HCS), particularly those living in rural areas.
- Conditions
- Hereditary Cancer Syndromes, BRCA1 Hereditary Breast and Ovarian Cancer Syndrome, Lynch Syndrome
- Trial name
- LINC (NCT07381985)
- Testing
- Longitudinal Cancer Genetics Follow-Up Program
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Vermont Medical Center
Cancer, Breast Cancer
Liquid Biopsy Evaluation and Repository Development at Princess Margaret
The objective of this protocol is to develop an institution-wide liquid biopsy protocol that will establish a common process for collecting blood and corresponding archived tumor specimens for future research studies at the…
- Conditions
- Cancer, Breast Cancer, Lung Cancer, Colon Cancer
- Trial name
- LIBERATE (NCT03702309)
- Where
- Canada
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Hereditary Non-polyposis Colon Carcinoma, HNPCC
I-Scan For Colon Polyp Detection In HNPCC
Hereditary non-polyposis colon carcinoma (HNPCC or Lynch-Syndrome) is a rare cause of colorectal cancer caused by a gene defect in the so -called mismatch repair genes.
- Conditions
- Hereditary Non-polyposis Colon Carcinoma, HNPCC, Lynch Syndrome
- Trial name
- NCT01823471
- Testing
- The use of I-scan in the detection of polyps in HNPCC
- Where
- Belgium
- Volunteers
- 70 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Colon Cancer, Lynch Syndrome
Integrating Genetic Testing for Lynch Syndrome in a Managed Care Setting
The investigators research mobilizes the resources of an integrated health-delivery system with extensive electronic clinical data to implement and evaluate a new strategy to maximize screening of Colorectal Cancer (CRC) patients…
- Trial name
- HNPCC (NCT01582841)
- Testing
- MSI screening test
- Where
- United States
- Volunteers
- 247 people
- Sponsor
- Kaiser Permanente
High-Frequency Microsatellite Instability, Mismatch Repair Gene Mutation
Cycling in Preventing Colorectal Cancer in Participants With Lynch Syndrome
This trial studies how well cycling works in preventing colorectal cancer in participants with Lynch syndrome. Exercise such as cycling may reduce colorectal cancer risk in participants with Lynch syndrome.
- Conditions
- High-Frequency Microsatellite Instability, Mismatch Repair Gene Mutation, Mutation-Negative Lynch Syndrome, Mutation-Positive Lynch Syndrome
- Trial name
- NCT03495674
- Testing
- Exercise Intervention, Informational Intervention, Monitoring Device
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- M.D. Anderson Cancer Center
Ovarian Cancer, Breast Cancer
Clinical Validation of Sophia Genetics Assay
Next-generation sequencing (NGS) technologies have revolutionized the field of genomics, enabling rapid and cost-effective analysis of DNA and RNA .
- Conditions
- Ovarian Cancer, Breast Cancer, Lynch Syndrome, Intestinal Polyposis
- Trial name
- COSMOS (NCT07160010)
- Testing
- Sophia Herditary Cancer Solution
- Volunteers
- 248 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Colorectal Cancer, Lynch Syndrome
Omega 3 Fatty Acids in Colorectal Cancer (CRC) Prevention in Patients With Lynch Syndrome (COLYNE)
This is a pilot study aimed at assessing the effects of moderate dose omega-3-acid ethyl esters capsules (generic Lovaza) on molecular, and intestinal microbiota changes in participants at high risk for colorectal cancer.
- Trial name
- NCT03831698
- Testing
- Omega-3 fatty acid ethyl esters (2 gram)
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Kansas Medical Center
Colorectal Cancer, Familial Adenomatous Polyposis
DNA Adductomics for Colorectal Cancer Investigation
This project seeks to identify DNA-adducts in colon tissue from different groups of patients with CRC scheduled for complete or partial colon resections. Other patients scheduled for resection of the colon serve as controls.
- Conditions
- Colorectal Cancer, Familial Adenomatous Polyposis, Hereditary Non-polyposis Colon Cancer, Lynch Syndrome
- Trial name
- adductomics (NCT04865601)
- Testing
- resectomy of the colon
- Where
- Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Colorectal Cancer
Mesalamine for Colorectal Cancer Prevention Program in Lynch Syndrome
Multicenter, multinational, randomized, 3-arm, double-blind, phase II clinical study with 2400mg mesalamine, 1200mg mesalamine or placebo for prevention of colorectal neoplasia in Lynch Syndrome patients for 2 years.
- Trial name
- MesaCAPP (NCT03070574)
- Testing
- mesalamine 2400 MG (5-ASA), mesalamine 1200 MG
- Where
- 6 sites in Austria, Germany and 4 more
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Christoph Gasche
Lynch Syndrome
Chromoendoscopy to Decrease the Risk of Colorectal Neoplasia in Lynch Syndrome
Lynch syndrome (LS), or hereditary nonpolyposis colorectal cancer (HNPCC), is a hereditary disorder predisposing for colorectal cancer. To reduce the risk of colorectal cancer, patients undergo colonoscopy every 1-2 years.
- Trial name
- ChromoLynch (NCT00905710)
- Testing
- Chromoendoscopy
- Where
- Netherlands
- Volunteers
- 240 people
- Sponsor
- University Medical Center Groningen
Cancer Gene Mutation, Lynch Syndrome
Lynch Syndrome Can be Diagnosed Just From Somatic Mismatch Repair Mutation
The objective of the study is the provide proof of high correlation between somatic and germline mismatch repair instability. This correlation is specifically researched in an area where patients have less access to cancer…
- Conditions
- Cancer Gene Mutation, Lynch Syndrome, Endometrial Cancer, Somatic Mutation
- Trial name
- NCT04516083
- Testing
- Mismatch repair instability somatic and germline testing
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- RWJ Barnabas Health at Jersey City Medical Center
Colorectal Cancer
Study of the Results of Education and Counseling for Persons Undergoing Genetic Testing for Hereditary Nonpolyposis Colon Cancer
RATIONALE: Identifying family and individual characteristics may help plan education and counseling for patients who are considering genetic testing.
- Trial name
- NCT00004210
- Testing
- loss of heterozygosity analysis, microsatellite instability analysis, mutation analysis
- Where
- 2 sites in United States
- Volunteers
- 900 people
- Sponsor
- National Human Genome Research Institute (NHGRI)