Clinical trials: HIV Testing
Foreskin HIV Susceptibility
Effect of Antibiotics on Penile Microbiome and HIV Susceptibility Study in Ugandan Men
This pilot study will assess the impact of four antimicrobial products (3 topical, one systemic) on the foreskin microbiome and HIV susceptibility of foreskin-derived CD4+ T cells.
- Trial name
- NCT03412071
- Testing
- Oral Tinidazole, Topical metronidazole, Topical Clindamycin
- Where
- Uganda
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Undiagnosed HIV Infection, Populations That Are Reluctant to Test for HIV
Expanded Social Network Recruitment to HIV Testing (E-SNRHT) Intervention to Locate Undiagnosed Cases and Reduce HIV-related Stigma
In South Africa's large generalized HIV epidemic, male-to-female transmission comprises a large proportion of transmission events, but men are much less likely to seek HIV testing, and disproportionately remain undiagnosed.
- Conditions
- Undiagnosed HIV Infection, Populations That Are Reluctant to Test for HIV, Long-term Undiagnosed HIV Infection, Individuals With Newly-diagnosed HIV Infection
- Trial name
- E-SNRHT (NCT06857071)
- Testing
- Expanded Social Network Recruitment to HIV Testing (E-SNRHT) Intervention
- Where
- South Africa
- Volunteers
- 2,480 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Chicago
HIV Infections
Evaluation of the Performance of Chembio Diagnostics Systems, Inc. DPP® HIV 1/2 Rapid Test
This study has been designed to evaluate the performance of the Chembio Diagnostics Systems, Inc. DPP® HIV 1/2 rapid test. The device is intended to qualitatively detect the presence of antibodies against HIV-1/2 in oral fluid…
- Trial name
- NCT01032902
- Testing
- In Vitro Diagnostic Device
- Where
- 5 sites in United States
- Volunteers
- 2,808 people, healthy volunteers welcome
- Sponsor
- Chembio Diagnostic Systems, Inc.
HIV
A Cognitive Behavioral Therapy Group Intervention to Increase HIV Testing and PrEP Use Among Latinx Sexual Minority Men
This study consists of a randomized controlled trial (RCT) of a multi-session cognitive behavior therapy (CBT) group intervention that aims to improve HIV outcomes by increasing adaptive, effective coping responses to stigma from…
- Trial name
- NCT04225832
- Testing
- CBT Coping Intervention
- Where
- United States
- Volunteers
- 289 people, healthy volunteers welcome
- Sponsor
- RAND
HIV Infections
AmbassADDOrs for Health Study
The goal of the study is to evaluate Malkia Klabu ("Queen Club") in Tanzania, a loyalty program intervention that creates adolescent girls and young women (AGYW)-friendly drug shops where AGYW can access HIV prevention services…
- Trial name
- ADDO (NCT05357144)
- Testing
- Loyalty card program at drug shops & supply of HIVST and SRH products, Comparison drug shops
- Where
- 2 sites in Tanzania
- Volunteers
- 157 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
HIV
POC HIV Testing and Early DTG Use for Infants
This study is being conducted to explore the feasibility of implementing targeted birth HIV testing of high-risk neonates using facility-based point-of-care (POC) HIV diagnostics, and to improve the ability to implement the best…
- Trial name
- NCT05393193
- Testing
- Point-of-Care Cepheid Xpert HIV-1, DTG/ABC/3TC
- Where
- Botswana
- Volunteers
- 900 people
- Sponsor
- Harvard School of Public Health (HSPH)
HIV-1-infection
A Study to Test Three Experimental HIV Vaccines in Healthy Adults.
HIV-CORE 006 is a Phase 1 double-blind placebo-controlled trial, in which the mosaic immunogens are delivered by a prime-boost regimen of non-replicating simian adenovirus followed by non-replicating poxvirus MVA.
- Trial name
- HIV-CORE 006 (NCT04553016)
- Testing
- Vaccine
- Where
- 4 sites in Kenya, Uganda and 1 more
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Malaria Infection, Pregnancy
Diagnostic Access to Self-Care and Health Services in Low and Middle Income Countries (DASH) - Phase II
Our primary goal is to determine if on-demand, home-based rapid testing, or rapid testing done by a community health worker (CHW) results in people testing for diseases more frequently and getting care more quickly.
- Conditions
- Malaria Infection, Pregnancy, HIV, Diabetes
- Trial name
- DASH (NCT06588790)
- Testing
- Home-based rapid testing, Community health worker rapid testing
- Where
- 3 sites in Kenya, South Africa and 1 more
- Volunteers
- 2,250 people, healthy volunteers welcome
- Sponsor
- University of Washington
HIV, Linkage to Care
Kingasa Pilot Study
In the Kingasa study, the investigators will use a factorial design in order to evaluate both an intervention to increase male partner HIV testing and an intervention for pregnant and postpartum women living with HIV to provide…
- Conditions
- HIV, Linkage to Care, PMTCT, PrEP
- Trial name
- NCT05092997
- Testing
- POC viral load testing, Wellness visit services for male partners
- Where
- Uganda
- Volunteers
- 151 people, healthy volunteers welcome
- Sponsor
- University of Washington
Diagnosis of Tuberculosis in People Living With HIV
FujiLAM Prospective Evaluation Trial
This is a prospective, multicentre cohort study in which the accuracy and the diagnostic yield of the FujiLAM test will be assessed using a microbiological reference standard, an extended microbiological reference standard and a…
- Trial name
- NCT04089423
- Testing
- Fujifilm SILVAMP TB LAM
- Where
- 7 sites in Malawi, South Africa and 5 more
- Volunteers
- 1,731 people
- Sponsor
- Foundation for Innovative New Diagnostics, Switzerland
HIV Infections
Missed Opportunities for HIV Screening in General Practice
The number of new HIV diagnoses in France in 2022 is estimated to be between 4,200 and 5,700. Of these diagnoses, 43% of infections were detected at a late stage.
- Trial name
- DepVIH (NCT07303114)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Strasbourg, France
Growth and Development
Infant Peri-Exposure Prophylaxis to Prevent HIV-1 Transmission by Breastfeeding: Mechanisms & Safety
General objective To assess the long-term safety and efficacy of one-year infant prophylaxis using lamivudine (3TC) or lopinavir/ritonavir (LPV/r) to prevent post-natal transmission through breastfeeding.
- Trial name
- NCT03519503
- Where
- 4 sites in Burkina Faso, South Africa and 2 more
- Volunteers
- 562 people
- Sponsor
- ANRS, Emerging Infectious Diseases
HIV/AIDS
PrEP Communication Intervention for Female Clients of a Needle Exchange
This study will identify perceptions of PrEP in women who inject drugs (WWIDs) and develop and pilot test a targeted intervention that will be embedded in a large, urban syringe exchange program through an extensive formative…
- Trial name
- NCT03541642
- Testing
- Enhanced Intervention, Basic Intervention
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Temple University
HIV/AIDS, Tuberculosis
Targeted Universal TB Testing With Simultaneous TPT Prescribing Among People Living With HIV in South Africa
Background: In 2023, the South African Department of Health introduced targeted universal TB testing (TUTT) at antiretroviral therapy (ART) initiation (irrespective of the presence of TB symptoms).
- Trial name
- TUTT-PT (NCT06739915)
- Testing
- TUTT-PT Intervention
- Where
- South Africa
- Volunteers
- 364 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
HIV Infections
HIV - Monotherapy in Switzerland (MOST-ch)
The investigators plan to conduct a two arm study, to compare failure rates in the central nervous system (CNS) and genital compartment in virologically fully suppressed patients continuing a highly active antiretroviral therapy…
- Trial name
- MOST (NCT00531986)
- Testing
- Lopinavir-Monotherapy, HAART
- Where
- 6 sites in Switzerland
- Volunteers
- 60 people
- Sponsor
- Cantonal Hospital of St. Gallen
HIV Seropositivity
The Value of HPV Testing for Cervical Cancer Screening in Women Living With HIV (PAPILLO-VIH)
The main objective of this study is to evaluate the interest of a screening strategy based on the HPV test in patients living with HIV, compared to the cell smear alone in the same population.
- Trial name
- PAPILLO-VIH (NCT05968183)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Centre Hospitalier de Saint-Denis
HIV Infection
Comparison of HIV Testing Algorithms
The primary objective of the study is to assess whether an improved MSF HIV diagnostic algorithm which includes a simple and easy to perform confirmation test has significantly better positive predictive value than WHO…
- Trial name
- NCT01716299
- Testing
- application of a confirmation test
- Where
- 2 sites in Ethiopia
- Volunteers
- 495 people, healthy volunteers welcome
- Sponsor
- Medecins Sans Frontieres, Netherlands
HIV Infections
Negative Serology by Immunoenzymatic Test (EIA) in HIV-infected Children Treated Early With Antiretroviral in the ANRS-Pediacam Study: Pathophysiological Mechanisms
The objective of the study is to identify the pathophysiological mechanisms responsible for the induction and maintenance of negative serologies by EIA tests in HIV-infected children treated early with HAART in the ANRS…
- Trial name
- PediacamNEG (NCT06302933)
- Testing
- Blood sampling
- Where
- 3 sites in Cameroon
- Volunteers
- 451 people, healthy volunteers welcome
- Sponsor
- ANRS, Emerging Infectious Diseases
HIV/AIDS
LetSync: Pilot Test of Mobile Health (mHealth) Intervention
The Pilot Test (AKA Study B) will entail a pilot randomized, controlled trial (RCT) of an mHealth behavioral intervention, LetSync, with 80 couples (N=160) to assess its acceptability, feasibility, and preliminary impact on…
- Trial name
- NCT04951544
- Testing
- LetSync app
- Where
- United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
HIV Prevention
Scalable Interventions to Increase PrEP Adherence: Value Affirmation and Future Selves
Pre-exposure prophylaxis, or PrEP, is a relatively new HIV prevention method where individuals who are at risk for HIV but do not currently have it take a daily pill (Truvada).
- Trial name
- SIIPA (NCT03278990)
- Testing
- Value Affirmation and Future Selves Combination, Control writing exercise
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Stuart Fisk