Clinical trials: HIV/AIDS, active
HIV/AIDS, HPV Infection
ORCHID: An Online Intervention for Persons With HIV (Miami)
The purpose of this research is to test ORCHID (Optimizing Resilience \& Coping with HIV through Internet Delivery), a skills-building intervention that improves mental health status for persons with HIV, who are at-risk for…
- Trial name
- ORCHID-Miami (NCT05935644)
- Testing
- ORCHID
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Miami
HIV/AIDS
Enhancing the Organizational Social Context to Improve Viral Suppression and Retention in HIV Care
Despite the widespread use of effective antiretroviral therapy (ART), the HIV epidemic continues to impact racial and ethnic minority populations disproportionately.
- Trial name
- NCT06462807
- Testing
- ARC
- Where
- United States
- Volunteers
- 1,500 people
- Sponsor
- University of Pennsylvania
HIV Associated Neurocognitive Disorder, HIV Dementia
SV2A & TSPO PET Imaging Measures to Reveal Mechanisms of HIV Neuropathogenesis During Antiretroviral Therapy
The purpose of this study is to longitudinally characterize and evaluate changes in synaptic density in the brain using novel positron-emission tomography (PET) scans; magnetic resonance imaging (MRI), and clinical laboratory…
- Conditions
- HIV Associated Neurocognitive Disorder, HIV Dementia, HIV Encephalitis, Healthy
- Trial name
- ART (NCT05586581)
- Testing
- SV2A PET, TSPO PET
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Yale University
HIV/AIDS, HIV/AIDS Prevention
Peer-led Dynamic Choice HIV Prevention for Women: The Peer-led DCP Randomized Trial
This Hybrid Type 1 cluster randomized trial will test the Peer-led Dynamic Choice HIV Prevention (DCP) intervention compared to standard of care.
- Trial name
- NCT07787988
- Testing
- Peer-led Dynamic Choice HIV Prevention (DCP) intervention
- Where
- Uganda
- Volunteers
- 560 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
AIDS-Related Anal Carcinoma, Anal Margin Squamous Cell Carcinoma
Therapy Adapted for High Risk and Low Risk HIV-Associated Anal Cancer
This phase II trial studies the side effects of chemotherapy and intensity modulated radiation therapy in treating patients with low-risk HIV-associated anal cancer, and nivolumab after standard of care chemotherapy and radiation…
- Conditions
- AIDS-Related Anal Carcinoma, Anal Margin Squamous Cell Carcinoma, Anal Non-Keratinizing Squamous Cell Carcinoma, Anal Squamous Cell Carcinoma
- Trial name
- NCT04929028
- Testing
- Anoscopy, Biospecimen Collection, Capecitabine
- Where
- 14 sites in United States
- Volunteers
- 40 people
- Sponsor
- National Cancer Institute (NCI)
AIDS-Related Burkitt Lymphoma, AIDS-Related Diffuse Large B-cell Lymphoma
Gene Therapy and Combination Chemotherapy in Treating Patients With AIDS-Related Non-Hodgkin Lymphoma
This pilot clinical trial studies gene therapy following combination chemotherapy in treating patients with acquired immune deficiency syndrome (AIDS)-related non-Hodgkin lymphoma.
- Conditions
- AIDS-Related Burkitt Lymphoma, AIDS-Related Diffuse Large B-cell Lymphoma, AIDS-Related Plasmablastic Lymphoma, AIDS-Related Primary Effusion Lymphoma
- Trial name
- NCT02337985
- Testing
- Prednisone, Rituximab, Etoposide
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- City of Hope Medical Center
HIV/AIDS
ADELANTE: A Randomized Controlled Trial to Improve Engagement in Care for Latinos With HIV
The goal of this study is to test the effectiveness of ADELANTE on viral suppression among Latinos with HIV and viral non-suppression.
- Trial name
- NCT06274632
- Testing
- ADELANTE
- Where
- 2 sites in United States
- Volunteers
- 250 people
- Sponsor
- Massachusetts General Hospital
Depression, HIV
Implementing Depression and Adherence Treatment
The goal of this clinical trial is to compare a core set and enhanced set of implementation strategies in increasing the reach of evidence-based treatments to patients with HIV and depression.
- Conditions
- Depression, HIV, Adherence, Treatment, AIDS
- Trial name
- NCT07032363
- Testing
- Core Implementation Strategies, Enhanced Implementation Strategies
- Where
- South Africa
- Volunteers
- 10 people
- Sponsor
- University of Miami
Chronic Disease, HIV/AIDS
Observational Pharmaco-Epidemiology Research & Analysis
Greater advances are needed in two separate but related areas in healthcare: 1) the Clinical Decision Support Systems that complement the EHR use in support of routine patient care, population management and disease management…
- Conditions
- Chronic Disease, HIV/AIDS, Liver Diseases, Inflammatory Bowel Diseases
- Trial name
- OPERA (NCT03813862)
- Testing
- Non-interventional (observational only)
- Where
- United States
- Volunteers
- 2,000,000 people, healthy volunteers welcome
- Sponsor
- Epividian
HIV/AIDS, Nicotine Dependence
Optimizing Tobacco Use Treatment for PLWHA
The advent of anti-retroviral therapy (ART) for people living with HIV/AIDS (PLWHA) substantially improved life expectancy but has also led to the critical need to address modifiable risk factors associated with cancer and…
- Trial name
- HTO (NCT04176172)
- Testing
- Varenicline, Nicotine patch, Standard treatment
- Where
- 2 sites in United States
- Volunteers
- 340 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
HIV/AIDS
Efficacy, Acceptability and Safety of Event-driven HIV PrEP Using TAF/FTC in MSM in Thailand and France.
The purpose of this study is to evaluate the efficacy, acceptability, and safety of a simplified event-driven pre-exposure prophylaxis of HIV based on oral TAF/FTC in HIV-uninfected cisgender men who have sex with men (MSM).
- Trial name
- SimpPrEP (NCT05813964)
- Testing
- TDF/FTC 300mg/200mg fixed-dose combination tablets, TAF/FTC 25mg/200mg fixed-dose combination tablets
- Where
- 6 sites in France, Thailand
- Volunteers
- 524 people, healthy volunteers welcome
- Sponsor
- ANRS, Emerging Infectious Diseases
AIDS-related Non-Hodgkin Lymphoma, AIDS-related Plasmablastic Lymphoma
Gene Therapy After Frontline Chemotherapy in Treating Patients With AIDS-Related Non-Hodgkin Lymphoma
This pilot clinical trial studies gene therapy after frontline chemotherapy in treating patients with acquired immune deficiency syndrome (AIDS)-related non-Hodgkin lymphoma (NHL).
- Conditions
- AIDS-related Non-Hodgkin Lymphoma, AIDS-related Plasmablastic Lymphoma, AIDS-related Primary Effusion Lymphoma, HIV Infection
- Trial name
- NCT01961063
- Testing
- busulfan, lentivirus vector rHIV7-shI-TAR-CCR5RZ-transduced hematopoietic progenitor cells, pharmacological study
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- City of Hope Medical Center
HIV/AIDS
An mHealth Intervention to Improve Outcomes for Women With HIV/AIDS
The purpose of this study is: 1. To develop a new mobile health (mHealth) system that will send text messages to remind both pregnant and non-pregnant women with HIV to adhere to their treatment plan (like keeping appointments…
- Trial name
- NCT03738410
- Testing
- Mobile Health Messaging application, Standard of Care Treatment
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Miami
HIV/AIDS, Pregnancy Related
Measuring Adverse Pregnancy and Newborn Congenital Outcomes
The purpose of this study is to develop a pharmacovigilance (PV) surveillance program to monitor adverse pregnancy and infant outcomes, including the presence of congenital abnormalities, among HIV-positive and HIV-negative women…
- Conditions
- HIV/AIDS, Pregnancy Related, Congenital Disorders, Newborn Morbidity
- Trial name
- MANGO (NCT04405700)
- Testing
- Pharmacovigilance surveillance program
- Where
- Kenya
- Volunteers
- 2,800 people, healthy volunteers welcome
- Sponsor
- Indiana University
AIDS-Related Anal Carcinoma, AIDS-Related Cervical Carcinoma
Screening Algorithms for Cervical and Anal High-Grade Squamous Intraepithelial Lesions in People With HIV in Mexico and Puerto Rico
This clinical trial aims to find what different tests work best to find high-grade squamous intraepithelial lesions (HSIL) in the cervix or anus in patients living with human immunodeficiency virus (HIV).
- Conditions
- AIDS-Related Anal Carcinoma, AIDS-Related Cervical Carcinoma, High Grade Anal Intraepithelial Neoplasia, High Grade Cervical Intraepithelial Neoplasia
- Trial name
- CAMPO-101 (NCT05074264)
- Testing
- Biopsy, Biospecimen Collection - Anal, Biospecimen Collection - Cervical
- Where
- 4 sites in Mexico, Puerto Rico
- Volunteers
- 1,586 people
- Sponsor
- University of California, San Francisco
HIV/AIDS, Stroke
Robot-Assisted Rehabilitation After HIV-Associated Stroke: Botswana
Today, nearly 37 million people are living with HIV (PLHIV) worldwide and 30 to 40% of them will have neurologic complications leading to disability.
- Trial name
- NCT04488250
- Testing
- Robot Therapy
- Where
- 2 sites in United States, Botswana
- Volunteers
- 30 people
- Sponsor
- University of Pennsylvania
HIV/AIDS, Sexually Transmitted Diseases
Sustaining Innovative Tools to Expand Youth-Friendly HIV Self-Testing
Sustaining Innovative Tools to Expand Youth-Friendly HIV Self-Testing (S-ITEST), locally known as 4 Youth by Youth (4YBY) in Nigeria, builds on the investigator's previous efforts, which are detailed in ClinicalTrial ID#…
- Trial name
- S-ITEST (NCT07072481)
- Testing
- Activities, Benefits, Capacity
- Where
- Nigeria
- Volunteers
- 1,401 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
HIV/AIDS, Hepatitis C
Project I Test: Implementing HIV Testing in Opioid Treatment Programs
This study will test two active evidence-based "practice coaching" (PC) interventions to improve opioid treatment programs' (OTPs') provision and sustained implementation of on-site 1) HIV testing and linkage to care and 2)…
- Conditions
- HIV/AIDS, Hepatitis C, Substance Use Disorders, Opioid-use Disorder
- Trial name
- NCT03135886
- Testing
- Information Control, HIV and HCV Testing Practice Coaching Intervention, HIV Testing Practice Coaching Intervention
- Where
- United States
- Volunteers
- 418 people, healthy volunteers welcome
- Sponsor
- Columbia University
HIV-1-infection, Human Immunodeficiency Virus
Impact of HIV-1 and Aging on Mucosal Vaccine Responses
The purpose of this study is to learn more about both HIV-1 infection and advancing age, and their association with increased risk of serious infection and impaired response to the Prevnar 13 vaccine.
- Conditions
- HIV-1-infection, Human Immunodeficiency Virus, HIV/AIDS, HIV Infections
- Trial name
- NCT03729778
- Testing
- Prevnar-13
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- VA Eastern Colorado Health Care System
HIV/AIDS
Community Health Workers And MHealth to ImProve Viral Suppression Plus (CHAMPS+)
Although global efforts have been made to end the HIV epidemic, there are still some gaps in HIV testing, antiretroviral therapy (ART) adherence, and viral suppression (VS) among people with HIV (PWH).
- Trial name
- CHAMPS+ (NCT06472206)
- Testing
- CHW Sessions, CleverCap
- Where
- 5 sites in United States
- Volunteers
- 420 people
- Sponsor
- Columbia University