Clinical trials: H Pylori Eradication
Helicobacter Pylori Eradication Antibiotic
Efficacy and Safety of Ilaprazole Based Bismuth-containing Quadruple Regimen for the First-line Treatment of Helicobacter Pylori Infection
This study compared efficacy and safety of Ilaprazole based bismuth-containing quadruple regimen therapy including Ilaprazole 5mg, Bismuth Potassium Citrate 220mg, Clarithromycin 500mg and Amoxicillin Cap (Amoxicillin) 1000mg BID…
- Trial name
- NCT02835560
- Testing
- Ilaprazole antisecretory drug of each quadruple therapy the Ilaprazole -based quadruple therapy, Esoprazole antisecretory drug of each quadruple therapy Esoprazole-based quadruple therapy
- Volunteers
- 100 people
- Sponsor
- Livzon Pharmaceutical Group Inc.
Helicobacter Pylori
Personalized vs Standard of Care Treatment for Helicobacter Pylori Eradication Among Veterans
The primary objective of this study is to compare the Helicobacter pylori (H. pylori) eradication rate following empiric bismuth-based quadruple therapy (BQT) versus a personalized H.
- Trial name
- VA EradicateHP (NCT07104318)
- Testing
- Bismuth quadruple therapy with optimized proton pump inhibitor (PPI), Bismuth quadruple therapy with standard proton pump inhibitor (PPI), Clarithromycin triple therapy with optimized proton pump inhibitor (PPI)
- Where
- United States
- Volunteers
- 360 people
- Sponsor
- VA Office of Research and Development
Gastric Cancer, H Pylori Infection
H. Pylori Screen-and-treat Study in a Population of Young Adults
Gastric cancer remains a major challenge to public health on a global scale. H. pylori related cancer burden contributes to the largest proportion of cancer cases attributable to infections in Europe.
- Conditions
- Gastric Cancer, H Pylori Infection, H Pylori Eradication, H-pylori
- Trial name
- NCT06275204
- Testing
- Bismuth-based quadruple therapy, Levofloxacin-based quadruple therapy, Standard triple therapy
- Where
- 7 sites in Croatia, Ireland and 4 more
- Volunteers
- 6,800 people, healthy volunteers welcome
- Sponsor
- University of Latvia
Helicobacter Pylori Infection
Helicobacter Pylori First-line Treatment Containing Tetracycline in Patients Allergic to Penicillin
The purpose of this study is to assess and compare the effectiveness of levofloxacin-tetracycline -containing and metronidazole-tetracycline-containing quadruple regimens for the primary treatment of Helicobacter pylori infection…
- Trial name
- NCT05129176
- Testing
- Levofloxacin, Metronidazole
- Where
- China
- Volunteers
- 106 people
- Sponsor
- Shandong University
GASTRITIS
Levofloxacin-Doxycycline for Helicobacter Pylori Eradication in Saudi Arabia
Helicobacter pylori (H. pylori) eradication is achieved in 60-80% with first-line therapy. Different second-line therapeutic options are available.
- Trial name
- NCT02884713
- Testing
- Levofloxacin, Doxycycline, Esomeprazole
- Volunteers
- 55 people
- Sponsor
- King Faisal Specialist Hospital & Research Center
Helicobacter Pylori Infection
Standardize Communication With General Practitioner & Patient for Improved Eradication of Helicobacter Pylori
Patients who test Helicobacter pylori positive, are treated with antibiotics. However, due to a number of factors (such as unknown treatment compliance, no standardized follow-up, ...), a relative low eradication-percentage was…
- Trial name
- Helipro (NCT02873247)
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Algemeen Ziekenhuis Maria Middelares
Helicobacter Pylori, Gut Microbiota
Helicobacter Pylori Eradication Therapy in Portugal
Helicobacter pylori (H. pylori) infection remains a major public health problem, with an estimated prevalence of over 50% worldwide and 60-86% for Portugal. H.
- Conditions
- Helicobacter Pylori, Gut Microbiota, Immunology
- Trial name
- NCT05449028
- Testing
- H. pylori eradication scheme A, H. pylori eradication scheme B, H. pylori eradication scheme C
- Where
- Portugal
- Volunteers
- 230 people
- Sponsor
- Unidade Local de Saúde de Coimbra, EPE
Helicobacter Pylori, Eradication
The Preventive Effect of Helicobacter Pylori Eradication on the Development of Gastric Cancer
Recently, the preventive effect of Helicobacter pylori (Hp) eradication treatment on the incidence of gastric cancer has been reported.
- Conditions
- Helicobacter Pylori, Eradication, Gastric Cancer, Medical Care Cost
- Trial name
- NCT00596401
- Where
- Japan
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Showa Inan General Hospital
Helicobacter Pylori Infection
Telephone-Based Re-education for Hp Eradication
It was suggested that the patient compliance plans an important role in the Hp eradication. However, data on whether re-education could improve the eradication rate are lacking.
- Trial name
- NCT03193450
- Testing
- telephone-based re-education, First education at the clinic
- Where
- China
- Volunteers
- 162 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Helicobacter Pylori Infection, Obesity, Morbid
THE EFFECT OF HELICOBACTER PYLORI ERADICATION THERAPY TO GASTRIC WALL THICKNESS BEFORE THE LAPAROSCOPIC SLEEVE GASTRECTOMY
Laparoscopic sleeve gastrectomy is one of the most popular bariatric surgery in the world. The most important complication about this surgery that the leakage from the stapler line because of the inconvenient stapler choice..The…
- Trial name
- NCT03757650
- Testing
- Bismuth Subsalicylate
- Where
- Turkey (Türkiye)
- Volunteers
- 3 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Helicobacter Pylori Infection
Safety, Efficacy of Pylera BID Dosing in Eradication of H. Pylori
The purpose of this study is to evaluate the effect of Pylera when given twice a day. Pylera approved treatment schedule is 3 pills taken 4 times daily, in addition to omeprazole given twice daily.
- Trial name
- NCT00712413
- Testing
- OBMT
- Where
- 3 sites in United States, Canada
- Sponsor
- Forest Laboratories
Helicobacter Pylori Infected Patients, Thyroid Cancer Patients
The Effect of Radioactive Iodine Administration for Thyroid Diseases on H.Pylori Eradication
Because of the high iodine uptake in the stomach, radioactive iodine treatment for thyroid diseases (cancer or hyperthyroidism) or radioactive iodine administered for thyroid scan may be able to eradicate H.pylori infection from…
- Conditions
- Helicobacter Pylori Infected Patients, Thyroid Cancer Patients, Hyperthyroidism
- Trial name
- NCT00822289
- Volunteers
- 120 people
- Sponsor
- Rabin Medical Center
Helicobacter Pylori Infection
Clarithromycin Triple Therapy Plus Bismuth for Helicobacter Pylori First-line Treatment
Standard triple therapy including a proton pump inhibitor (PPI) and clarithromycin with either amoxicillin or metronidazole are no longer recommended as empirical first-line therapy to treat Helicobacter pylori infection because…
- Trial name
- NCT02732249
- Testing
- Esomeprazole, Bismuth Potassium Citrate, Clarithromycin
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Increase the Eradication Rate of Helicobacter Pylori
The Effect of Berry Extract on Helicobacter Pylori Eradication
Helicobacter pylori (HP) is the major risk factors of gastritis, gastric ulcers, duodenal ulcers, mucosa associated lymphoid tissue lymphoma and gastric cancer.
- Trial name
- NCT01045408
- Testing
- Berry extract
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Shin Kong Wu Ho-Su Memorial Hospital
Helicobacter Pylori
7-Day Vonoprazan, High-Dose Amoxicillin, and Bismuth Therapy
The 2024 American College of Gastroenterology (ACG) Clinical Guideline recommends a 14-day vonoprazan-amoxicillin (VA) regimen, consisting of vonoprazan 20 mg twice daily with amoxicillin 1000 mg three times daily, as a…
- Trial name
- JSHERO4 (NCT07232095)
- Testing
- VAB-7, VA-14
- Where
- China
- Volunteers
- 316 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Gastritis H Pylori
14-day Quadruple Therapy Versus Triple Therapy in HP Eradication
In this prospective randomized-controlled study, treatment-naive H. pylori-infected patients are randomized to receive either standard triple therapy or sequential therapy.
- Trial name
- HEPRA (NCT04769583)
- Testing
- metronidazole based quadriple therapy
- Where
- Tunisia
- Volunteers
- 121 people
- Sponsor
- mohamed bouchoucha
Helicobacter Pylori Eradication
Potassium Copetitive Acid Blockers Efficacy in H.Pylori Eradication
This trial assessed the efficacy of potassium competetor acid blocker (P-CAB) in the eradication of H.pylori
- Trial name
- P-CABs (NCT06101420)
- Testing
- Vonoprazan
- Where
- Egypt
- Volunteers
- 232 people
- Sponsor
- Ain Shams University
Helicobacter Pylori Infection
Study the Effect of Probiotics Combined With Bismuth Quadruple Rescue Therapy on H Pylori Infective Patients
Retrospectivly follow-up the outpatients for H pylori eradication failures more than 2 times in the digestive department of Changhai hospital from 2015-2017,analyse the eradication rates and adverse effects of the therapy with…
- Trial name
- NCT03297242
- Volunteers
- 30 people
- Sponsor
- Changhai Hospital
H. Pylori Infection
Optimization of Keverprazan-amoxicilli Dual Therapy for Helicobacter Pylori
The purpose of this study was to evaluate the efficacy and safety of keverprazan with different doses of amoxicillin for Helicobacter Pylori.
- Trial name
- NCT06412640
- Testing
- Keverprazan, Amoxicillin
- Volunteers
- 268 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Helicobacter Infection
The Efficacy of the Tailored Therapy Based on Antimicrobial Susceptibility for 2nd Eradication of H. Pylori
As increasing the antibiotics resistance, the effectiveness of traditional Helicobacter pylori (H. pylori) therapies has been declined coincidently. In this study, the investigators evaluated the efficacy of H.
- Trial name
- NCT02349685
- Testing
- H. pylori culture and antimicrobial susceptibility test, 14 day PBMT group, 14 day MEA group
- Volunteers
- 219 people, healthy volunteers welcome
- Sponsor
- Seoul National University Bundang Hospital