Clinical trials: Gynecologic Cancer, active
Cervical Cancer, Gynecologic Cancer
Radiotherapy for Gynecologic Cancer With Up to 10 Active Metastatic Lesions
OLIGYNE-10 RT is an international registry of adults with gynecologic cancer and a limited number of active sites of cancer spread who receive radiotherapy (RT) to at least one metastatic lesion during routine care.
- Conditions
- Cervical Cancer, Gynecologic Cancer, Endometrial Cancer, Uterine Cancer
- Trial name
- OLIGYNE-10 RT (NCT07883798)
- Testing
- Routine-care metastasis-directed radiotherapy
- Where
- Poland
- Volunteers
- 500 people
- Sponsor
- Affidea Nu-med Center of Oncological DIagnostics and Therapy
Gynecologic Cancer, Radiotherapy Side Effect
Advanced Radiotherapy (ART) in Gynecological Cancer Patients (GYN-ART)
This is an observational mono-institutional study. Patients with gynecologic tumors treated with advanced radiotherapy- Image Guided Radiotherapy (IGRT), Intensity Modulated Radiotherapy (IMRT), Stereotactic Body Radiotherapy…
- Conditions
- Gynecologic Cancer, Radiotherapy Side Effect, Radiotherapy; Complications, Survivorship
- Trial name
- GYN-ART (NCT06306170)
- Testing
- Image Guided Radiotherapy
- Where
- Italy
- Volunteers
- 1,000 people
- Sponsor
- IRCCS San Raffaele
Sexual Wellness, Gynecologic Cancers
Assessment of Sexual Well-being in Patients With Gynecologic Cancer and Their Partners: the ONCOSEX Study
Study type and design This is an observational, exploratory, prospective, longitudinal (cohort), multicenter, non-profit study. Its purpose is to observe changes in sexual function over time without modifying standard clinical…
- Trial name
- ONCOSEX (NCT07557342)
- Testing
- Questionnaire and Physical Exam
- Where
- 6 sites in Italy
- Volunteers
- 200 people
- Sponsor
- Casa di Cura Dott. Pederzoli
Prostate Cancer, Gynecologic Cancers
Quality and Safety of Real-Time Brachytherapy Treatments: Clinical Implementation of a Multipoint Scintillation Detector for Treatment Monitoring
This project addresses a key safety gap in High-Dose-Rate (HDR) brachytherapy, where very high, localized radiation doses mean that small geometric deviations in catheter placement or radioactive source positioning can cause…
- Trial name
- (CurieInVivo) (NCT07580651)
- Testing
- Brachytherapy treatment monitoring using a plastic scintillation detector
- Volunteers
- 25 people
- Sponsor
- CISSS de Chaudière-Appalaches
Head and Neck Cancer, Head and Neck Tumor
A Study Evaluating the Integrative Medicine at Home (IM@HOME) Program in People With Cancer
The overarching long-term goal of the Integrative Medicine for Patient-reported Outcomes Values and Experience (IMPROVE) research program is to evaluate whether integrating a virtual mind-body programming, Integrative Medicine at…
- Conditions
- Head and Neck Cancer, Head and Neck Tumor, Thoracic Tumor, Thoracic Cancer
- Trial name
- IMPROVE (NCT05053230)
- Testing
- IM@Home, Enhanced usual care
- Where
- 7 sites in United States
- Volunteers
- 324 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Recurrent Gynecologic Cancer, Recurrent Uterine Cancer
Reirradiation and Total Ablative Strategies for Recurrent Gynecologic Cancer
REGYNERA(dia)TION is an international, multicenter, ambispective observational patient registry of adults with recurrent gynecologic malignancies after prior radiotherapy who are treated or planned for reirradiation and/or total…
- Conditions
- Recurrent Gynecologic Cancer, Recurrent Uterine Cancer, Recurrent Cervical Cancer, Recurrent Vaginal Cancer
- Trial name
- Regynera-RT (NCT07667192)
- Testing
- Reirradiation, Total Ablative Strategy
- Where
- Poland
- Volunteers
- 500 people
- Sponsor
- Affidea Nu-med Center of Oncological DIagnostics and Therapy
Postoperative Delirium (POD), Gynecologic Cancers
Immunonutrition and Neuromonitoring for Postoperative Delirium in Gynecologic Oncology
Early postoperative delirium (POD) is a common and distressing neuropsychiatric complication frequently observed in elderly patients undergoing major surgical interventions, including radical and cytoreductive gynecologic…
- Conditions
- Postoperative Delirium (POD), Gynecologic Cancers, Malnutitrion
- Trial name
- NCT07877285
- Testing
- Preoperative Immunonutritional Scoring and Intraoperative Neuromonitoring
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Elazıg Fethi Sekin Sehir Hastanesi
Gynecologic Neoplasm, Brachytherapy
Using Reiki Therapy to Improve Symptoms Associated With Brachytherapy in Patients With Gynecological Malignancies
The goal of this open label, randomized, controlled clinical trial is to assess the benefits of providing Reiki therapy to subjects receiving their first brachytherapy treatment for gynecological malignancies.
- Conditions
- Gynecologic Neoplasm, Brachytherapy, Therapeutic Touch, Endometrial Cancer
- Trial name
- Reiki-Brachy (NCT05979610)
- Testing
- Reiki therapy
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Utah
Head and Neck Cancer, Pelvic Cancer
Health Oriented Protocol for Epidermal Radiodermatitis
Radiation therapy is a standard treatment for malignant tumors of the head and neck and pelvic regions, used alone or in combination with chemotherapy.
- Conditions
- Head and Neck Cancer, Pelvic Cancer, Radiation Skin Injury, Gynecologic Cancer
- Trial name
- HOPE (NCT07129525)
- Testing
- Radiation therapy
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Gynecologic Cancers
A Prospective Study of a Lifestyle Medicine Survivorship Program for Patients With Gynecologic Cancer
This study will examine the effects of an 8-week intervention called the Healthy Eating Active Lifestyle (HEAL)-GYN program on participants' 1) self-efficacy 2) lifestyle factors, including physical activity and diet, as well as…
- Trial name
- HEAL-GYN (NCT07121738)
- Testing
- Healthy Eating Active Lifestyle (HEAL): Gyn Cancer Program
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- AdventHealth
Mesonephric Gynecologic Cancer
A Study of Avutometinib (VS-6766) and Defactinib in People With Mesonephric Gynecologic Cancer
This study will test if Avutometinib (VS-6766) in combination with Defactinib is an effective treatment for advanced or recurrent mesonephric gynecologic cancer.
- Trial name
- NCT05787561
- Testing
- Avutometinib (VS-6766), Defactinib
- Where
- 7 sites in United States
- Volunteers
- 40 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Gynecologic Cancers, Breast Cancer
Virtual Mindful After Cancer (MAC) Intervention to Promote Sexual Health for Breast and Gynecologic Cancer Survivors
The goal of this study is to plan for a large scale evaluation of a program called Mindful After Cancer, or MAC. The MAC Program provides training in mindfulness, educational material about sexual health after cancer, and support…
- Trial name
- MAC (NCT07055854)
- Testing
- Mindful After Cancer Program
- Where
- 3 sites in United States
- Volunteers
- 60 people
- Sponsor
- Oregon State University
Gynecologic Cancers, Advanced Breast Cancer
Phase II, Prospective, Randomized, Proof-of-concept Study to Evaluate the Effects of a Personalized Dietary Intervention in Women With Advanced Gynecologic or Breast Tumors Treated With Antibody-Drug Conjugates (ADCs).
The objective of the study is to evaluate the effect of a personalized dietary intervention (cohort A), compared with a standard nutritional intervention based on general recommendations for following a Mediterranean diet (cohort…
- Trial name
- LUMInova (NCT07406789)
- Testing
- Personalised dietary intervention., General recommendations
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- TNC Nutrición Terapéutica S.L.
Gynecologic Cancer
Follow-up in Gynecological Cancer Survivors
A cross-sectional prospective study of follow-up in gynecologic cancer patients after primary treatment
- Trial name
- NCT03515993
- Where
- 21 sites in Austria, Belgium and 7 more
- Volunteers
- 1,100 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Disorders of Sex Development (DSD), Pediatric and Adolescent Cancers of the Genital Tract
Data Collection Study of Pediatric and Adolescent Gynecology Conditions
Background: Gynecologic conditions are those that are related to the reproductive system. They can be reproductive gland disorders or reproductive system tumors. They can also be inborn anomalies of the reproductive tract.
- Conditions
- Disorders of Sex Development (DSD), Pediatric and Adolescent Cancers of the Genital Tract, Reproductive Endocrine Conditions in Puberty, Structural Gynecologic Conditions Including Vulvar and Vaginal Conditions
- Trial name
- NCT04717349
- Where
- United States
- Volunteers
- 11,000 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Gynecologic Cancer, Chemotherapy-induced Peripheral Neuropathy
Cryocompression to Reduce Chemotherapy-induced Peripheral Neuropathy in Gynecologic Cancer - COHORT 2
The investigators aim to determine the effect of cryotherapy wraps plus compression therapy (henceforth referred to as cryocompression) versus cryotherapy wraps alone on the incidence and degree of chemotherapy-induced peripheral…
- Trial name
- NCT06139458
- Testing
- Cryotherapy, Compression
- Where
- 4 sites in United States
- Volunteers
- 190 people
- Sponsor
- Duke University
Gynecologic Cancers, Platinum-Sensitive Ovarian Cancer
A Study to Assess Change in Disease Activity and Adverse Events in Adult Participants With Gynecologic Cancers Receiving Intravenous Infusion of IMGN151 as Monotherapy or in Combination With Other Therapies
Cancer is a condition where cells in a specific part of body grow and reproduce uncontrollably. The purpose of this study is to assess safety and tolerability of IMGN151 when given as monotherapy and in combination with other…
- Conditions
- Gynecologic Cancers, Platinum-Sensitive Ovarian Cancer, Fallopian Tube Cancer, Primary Peritoneal Cancer (PSOC)
- Trial name
- NCT07024784
- Testing
- IMGN151, Carboplatin, Bevacizumab
- Where
- 21 sites in United States, Israel and 1 more
- Volunteers
- 377 people
- Sponsor
- AbbVie
Advanced Gynecologic Malignancies
To Evaluate the Safety and Efficacy of RNK08954 in Patients With Advanced Gynecological Tumors.
This is a multicenter, open-label, phase II clinical study to evaluate the safety and preliminary efficacy of RNK08954 in patients with advanced gynecological tumors
- Trial name
- NCT07848893
- Testing
- RNK08954
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Ranok Therapuetics Co. Ltd.
Gynecologic Cancer, Remission
Impact of a Multidisciplinary Assessment in Day Hospitalization Versus Standard Care on the Deployment of Supportive Oncology Care Recommended by the Personalized Post-cancer Plan in Patients at the End of Initial Treatment for Gynecological Ovarian and Endometrial Cancer Endometrial Cancer
This project proposes a structuring of supportive oncology care for the recovery phase after gynecological cancer (ovarian/trope/peritoneum or endometrium).
- Trial name
- AFTERGYN2 (NCT06553612)
- Testing
- Multidisciplinary assessment, Standard assesment, Observational cohort
- Where
- 13 sites in France
- Volunteers
- 268 people
- Sponsor
- Centre Francois Baclesse
Breast Cancer, Lung Cancer
Investigating the Effects of Atezolizumab in People Whose Tumour DNA or RNA Indicates Possible Sensitivity
This study will investigate the effects of atezolizumab on select cancer types in people whose analysis of tumour DNA and RNA indicates they may be sensitive to atezolizumab.
- Conditions
- Breast Cancer, Lung Cancer, Gastrointestinal Cancer, Genitourinary Cancer
- Trial name
- CAPTIV-8 (NCT04273061)
- Testing
- Atezolizumab
- Where
- 2 sites in Canada
- Volunteers
- 50 people
- Sponsor
- British Columbia Cancer Agency