Clinical trials: Gynecologic Cancer
Advanced Solid Tumor, Gynecologic Cancer
A Study to Evaluate Lucitanib in Combination With Nivolumab in Patients With a Solid Tumor
This is an open-label, Phase 1b/2 study to determine the recommended dose of lucitanib in combination with nivolumab in patients with an advanced solid tumor (Phase 1b); followed by evaluation of the safety and efficacy of…
- Trial name
- NCT04042116
- Testing
- Lucitanib, Nivolumab
- Where
- 27 sites in United States, Austria and 4 more
- Volunteers
- 227 people
- Sponsor
- Clovis Oncology, Inc.
Stage III Gynecologic Cancer, Stage IV Gynecologic Cancer
A Self-Directed Mindfulness Meditation Intervention in Gynecologic Cancer Patients
The current study examines the effects of a 3-week, at-home mindfulness mediation intervention (MMI) to address psychological and physical distress in patients with gynecologic cancer.
- Trial name
- NCT04072406
- Testing
- Mindfulness meditation, Usual care packet
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Washington University School of Medicine
Gynecologic Cancer, Hereditary Cancer Syndrome
Chatbot to Maximize Hereditary Cancer Genetic Risk Assessment
In this study, the investigators aim to compare a mobile health platform, known as a 'chatbot,' that leverages artificial intelligence and natural language processing to scale communication, to 'usual care' that patients would…
- Trial name
- NCT05562778
- Testing
- Chatbot
- Where
- 4 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Endometrium Cancer, Gynecologic Cancer
The Surveillance, Epidemiology, and End Results Database Program on Endometrial Cancer in the Italian Population
The aim of this study is to lay the bases for an ambitious project that reports and records all the epidemiological-clinical information of the cases of endometrial carcinoma diagnosed and treated in the reference oncology…
- Trial name
- ENDOCancerDATA (NCT07558889)
- Where
- Italy
- Volunteers
- 10,000 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Malignant Female Reproductive System Neoplasm, Malignant Hepatobiliary Neoplasm
Acceptance and Commitment Therapy in Improving Well-Being in Patients With Stage III-IV Cancer and Their Partners
This pilot clinical trial studies how well acceptance and commitment therapy works in improving well-being in patients with stage III-IV cancer and their partners.
- Conditions
- Malignant Female Reproductive System Neoplasm, Malignant Hepatobiliary Neoplasm, Partner, Stage III Breast Cancer
- Trial name
- NCT03112668
- Testing
- Cognitive Behavior Therapy, Quality-of-Life Assessment, Questionnaire Administration
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Malignant Female Reproductive System Neoplasm
Optimizing Screening for Cervical Cancer Among Women Living With HIV in the Dominican Republic
This study compares different screening approaches to detect abnormal cell growth on the cervix that could be an early sign of cervical cancer. The lesions are caused by an infection of human papillomavirus, also called HPV.
- Trial name
- NCT05556772
- Testing
- Biospecimen Collection, Interview
- Where
- Dominican Republic
- Volunteers
- 619 people
- Sponsor
- Fred Hutchinson Cancer Center
Frailty, Neuromuscular Blockade
Incidence of Residual Neuromuscular Blockade in Fraility in OncoGynae Surgery
Frailty among patients undergoing surgery is strongly associated with an elevated risk of adverse perioperative outcomes, heightened incidence of postoperative complications, increased mortality rates, and prolonged hospital…
- Conditions
- Frailty, Neuromuscular Blockade, General Anesthetic Drug Adverse Reaction, Gynecologic Cancer
- Trial name
- FIGO (NCT06216002)
- Testing
- Train of four nerve stimulator
- Where
- Thailand
- Volunteers
- 356 people
- Sponsor
- Mahidol University
Malignant Female Reproductive System Neoplasm
Liposomal Bupivacaine With or Without Hydromorphone for the Improvement of Pain Control After Laparotomy in Patients With Gynecological Malignancies
This phase IV trial studies how well liposomal bupivacaine with or without hydromorphone works in improving pain control during the first 24 hours after surgery in patients with gynecological malignancies undergoing laparotomy.
- Trial name
- NCT04258631
- Testing
- Hydromorphone, Laparotomy, Liposomal Bupivacaine
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- Mayo Clinic
Endometrial Cancer, Sarcoma
Thalidomide in Treating Patients With Gynecologic Sarcomas
RATIONALE: Thalidomide may stop the growth of gynecologic sarcomas by stopping blood flow to the tumor. PURPOSE: Phase II trial to study the effectiveness of thalidomide in treating patients who have recurrent or persistent…
- Trial name
- NCT00006005
- Testing
- thalidomide
- Where
- 10 sites in United States
- Sponsor
- New York University Cancer Institute
Cervix Cancer
Hyaluronic Acid-based Gel Spacers in Gynecologic Malignancies
This pilot feasibility study evaluates the use of a hyaluronic acid-based spacing gel (Barrigel) in participants with cervical cancer undergoing chemoradiotherapy (chemoRT), including brachytherapy, as part of standard care.
- Trial name
- NCT07292818
- Testing
- Barrigel gel spacer
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Gynecologic Cancer, Cervical Cancer
A Pilot Study of Quantitative Tumor Oxygen Measurements in Cervical Cancer
This research is studying the level of oxygen in tumors during the brachytherapy procedure.
- Trial name
- NCT03970083
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Brigham and Women's Hospital
Head and Neck Cancer, Prostate Cancer
Improving Evidence-Based Care for Cancer Patients
The purpose of this study is to improve cancer care and the delivery of cancer care. Researchers are interested in studying patient reported information and examining how different factors may impact cancer care.
- Conditions
- Head and Neck Cancer, Prostate Cancer, Breast Cancer, Lung Cancer
- Trial name
- NCT03207594
- Testing
- Survey, Saliva sample, Smoking Status questions
- Where
- United States
- Volunteers
- 128 people
- Sponsor
- Medical University of South Carolina
Medical Education, Ovarian Cancer
Ultrasound Training Program for Gynecologic Cancer Staging in Residents
This is a prospective, interventional study aiming to develop and validate an ultrasound training program for gynecology and obstetrics residents, focused on the staging of gynecologic cancers, including ovarian, endometrial, and…
- Conditions
- Medical Education, Ovarian Cancer, Endometrial Cancer, Cervix Cancer
- Trial name
- Ultra-teaching (NCT07028229)
- Testing
- Training Group
- Where
- Italy
- Volunteers
- 6 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Gynecologic Cancers
Interest in Nighttime Day Hospital Chemotherapy Infusions Among Gynecologic Cancer Patients
This observational study aims to assess the interest of patients with gynecologic cancers in a nighttime Day Hospital service for the administration of long-duration chemotherapy infusions.
- Trial name
- CHeMoON (NCT07483905)
- Testing
- online survey
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Breast Cancer, Gynecologic Cancer
Effectiveness of Lay Navigators in Meeting Cancer Patients' Non-Clinical Needs: A Pilot Study
The Stanford Cancer Center is undertaking a Transformation Initiative in order to improve the quality of care and care coordination across the continuum of care.
- Conditions
- Breast Cancer, Gynecologic Cancer, Neck Cancer, Head and Neck Cancer
- Trial name
- NCT03245788
- Testing
- Lay Navigation
- Where
- United States
- Volunteers
- 1,053 people
- Sponsor
- Stanford University
Gastrointestinal Cancer, Urologic Cancer
Palliative Radiotherapy in Symptomatic Pelvic Soft Tissue Tumors
PALLSOFT is a randomized, open-label, non-inferiority phase III, multicenter, national trial that will investigate whether the patient-reported symptomatic effect of palliative radiotherapy delivered in 1-2 fractions is…
- Conditions
- Gastrointestinal Cancer, Urologic Cancer, Gynecologic Cancer
- Trial name
- PALLSOFT (NCT06398314)
- Testing
- Palliative radiotherapy
- Where
- 11 sites in Norway
- Volunteers
- 200 people
- Sponsor
- Sykehuset Telemark
Malignant Female Reproductive System Neoplasm, Malignant Solid Neoplasm
Testing the Use of Neratinib or the Combination of Neratinib and Palbociclib Targeted Treatment for HER2+ Solid Tumors (A ComboMATCH Treatment Trial)
This phase II ComboMATCH treatment trial compares the effect of neratinib to the combination of neratinib and palbociclib in treating patients with HER2 positive solid tumors.
- Conditions
- Malignant Female Reproductive System Neoplasm, Malignant Solid Neoplasm, Recurrent Malignant Female Reproductive System Neoplasm, Recurrent Malignant Solid Neoplasm
- Trial name
- NCT06126276
- Testing
- Biopsy Procedure, Biospecimen Collection, Computed Tomography
- Where
- 194 sites in United States, Puerto Rico
- Volunteers
- 70 people
- Sponsor
- National Cancer Institute (NCI)
Anal Carcinoma, Cervical Carcinoma
Vaginal DHEA to Improve Vaginal Health After Radiation for Women With Gynecologic, Anal or Rectal Cancer
This phase II trial tests the feasibility and side effects of vaginal DHEA to improve vaginal health after radiation for women with gynecologic, anal or rectal cancer.
- Conditions
- Anal Carcinoma, Cervical Carcinoma, Malignant Female Reproductive System Neoplasm, Rectal Carcinoma
- Trial name
- NCT07407647
- Testing
- Biospecimen Collection, Prasterone, Survey Administration
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Postoperative Delirium (POD), Gynecologic Cancers
Immunonutrition and Neuromonitoring for Postoperative Delirium in Gynecologic Oncology
Early postoperative delirium (POD) is a common and distressing neuropsychiatric complication frequently observed in elderly patients undergoing major surgical interventions, including radical and cytoreductive gynecologic…
- Conditions
- Postoperative Delirium (POD), Gynecologic Cancers, Malnutitrion
- Trial name
- NCT07877285
- Testing
- Preoperative Immunonutritional Scoring and Intraoperative Neuromonitoring
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Elazıg Fethi Sekin Sehir Hastanesi
Fear of Cancer Recurrence
The Effect of Metacognition-based, Manualized Intervention on Fear of Cancer Recurrence
The primary aim of this study is to assess the effect of ConquerFear, a metacognition-based manualized intervention on fear of cancer recurrence, using the randomized controlled trial approach, among Chinese patients newly…
- Trial name
- NCT04568226
- Testing
- ConquerFear Intervention, Active control: Basic Cancer Care
- Where
- 6 sites in Hong Kong
- Volunteers
- 177 people
- Sponsor
- The University of Hong Kong