Clinical trials: Granulosa Cell Tumour of the Ovary
Ovarian Granulosa Cell Tumor, Ovarian Gynandroblastoma
Paclitaxel and Carboplatin or Bleomycin Sulfate, Etoposide Phosphate, and Cisplatin in Treating Patients With Advanced or Recurrent Sex Cord-Ovarian Stromal Tumors
This randomized phase II trial studies paclitaxel and carboplatin to see how well they work compared with bleomycin sulfate, etoposide phosphate, and cisplatin in treating patients with sex cord-ovarian stromal tumors that have…
- Conditions
- Ovarian Granulosa Cell Tumor, Ovarian Gynandroblastoma, Ovarian Sertoli-Leydig Cell Tumor, Ovarian Sex Cord Tumor With Annular Tubules
- Trial name
- NCT01042522
- Testing
- Bleomycin Sulfate, Carboplatin, Cisplatin
- Where
- 219 sites in United States
- Volunteers
- 63 people
- Sponsor
- GOG Foundation
Adult Ovarian Granulosa Cell Tumor
Study to Test the Drug Darolutamide Along With the Drugs Leuprolide Acetate and Exemestane in Patients With Recurrent Ovarian Granulosa Cell Tumors
This phase II trial tests how well darolutamide in combination with leuprolide acetate and exemestane works in treating patients with ovarian granulosa cell tumors that have come back after a period of improvement (recurrent).
- Trial name
- NCT06169124
- Testing
- Biospecimen Collection, Chest Radiography, Computed Tomography
- Where
- 66 sites in United States
- Volunteers
- 17 people
- Sponsor
- National Cancer Institute (NCI)
Ovarian Granulosa-Stromal Tumor, Ovarian Granulosa Cell Tumor
Nirogacestat in Ovarian Granulosa Cell Tumors
This phase 2 clinical trial will study the effectiveness of nirogacestat in ovarian granulosa cell tumors (OvGCTs). Nirogacestat is a gamma secretase inhibitor (GSI) which is hypothesized to decrease the growth and activity of…
- Conditions
- Ovarian Granulosa-Stromal Tumor, Ovarian Granulosa Cell Tumor, Ovarian Cancer
- Trial name
- NCT05348356
- Testing
- Nirogacestat
- Where
- 21 sites in United States, Canada and 1 more
- Volunteers
- 53 people
- Sponsor
- SpringWorks Therapeutics, Inc., a healthcare company of Merck KGaA, Darmstadt, Germany
Granulosa Cell Tumour of the Ovary
Ketoconazole as Inhibitor of the Enzyme CYP17 in Locally Advanced or Disseminated Granulosa Cell Tumour of Ovary
Our proposal is to conduct an open phase II clinical trial that allows us to explore the activity of ketoconazole, an inhibitor of the enzyme CYP17, in ovarian granulosa tumors similar to what has been done in prostate cancer.
- Trial name
- GreKo (NCT01584297)
- Testing
- Ketoconazole
- Where
- 10 sites in Spain
- Volunteers
- 6 people
- Sponsor
- Grupo Español de Tumores Huérfanos e Infrecuentes
Malignant Ovarian Epithelial Tumor, Ovarian Granulosa Cell Tumor
Bevacizumab in Treating Patients With Recurrent Sex Cord-Stromal Tumors of the Ovary
This phase II trial studies how well bevacizumab works in treating patients with sex cord-stromal tumors of the ovary that have come back.
- Conditions
- Malignant Ovarian Epithelial Tumor, Ovarian Granulosa Cell Tumor, Ovarian Gynandroblastoma, Ovarian Sertoli-Leydig Cell Tumor
- Trial name
- NCT00748657
- Testing
- Bevacizumab, Laboratory Biomarker Analysis
- Where
- 36 sites in United States
- Volunteers
- 36 people
- Sponsor
- National Cancer Institute (NCI)
Adult Granulosa Cell Tumor of the Ovary
Luspatercept in Metastatic AGCT of the Ovary
This is a single participant study of luspatercept for the treatment of a patient with dult granulosa cell tumor (AGCT) of the ovary.
- Trial name
- NCT06254781
- Testing
- Luspatercept
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- University Health Network, Toronto