Clinical trials: Granulomatous Enteritis
Crohn Disease, Absorption; Disorder, Protein
Impact of an Oligomeric Diet in Intestinal Absorption and Inflammatory Markers in Patients With Crohn Disease
This is a randomized, multicenter, translational, triple-blind, clinical trial in patients with Crohn's disease, who will be prescribed an oral nutritional supplement to control symptoms in the acute phase and to recover in the…
- Conditions
- Crohn Disease, Absorption; Disorder, Protein, Absorption; Disorder, Absorption; Disorder, Fat
- Trial name
- NCT04305535
- Testing
- Peptidic+Probiotic
- Where
- Spain
- Volunteers
- 162 people
- Sponsor
- Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz
Healthy
Safety, Pharmacodynamics, Pharmacokinetics, and Immunogenicity of Ascending Doses BCD-261 in Healthy Subjects
The goal of this clinical trial is to investigate the safety, tolerability, pharmacodynamics, pharmacokinetics, and immunogenicity of BCD-261 after single subcutaneous injection at ascending doses and proposed therapeutic doses…
- Trial name
- NCT06715540
- Testing
- BCD-261, dose 1, BCD-261, dose 2, BCD-261, dose 3
- Where
- Russia
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Biocad
Ulcerative Colitis (UC), Crohn's Disease
A Study to Evaluate the Effect of Intravenous (IV) Infusions of Risankizumab on Pharmacokinetics of Cytochome P450 Substrates in Adult Participants With Moderately to Severely Active Ulcerative Colitis or Crohn's Disease
Ulcerative colitis (UC) is a type of inflammatory bowel disease that causes inflammation and bleeding from the lining of the rectum and colon (large intestine).Crohn's disease (CD) is a long-lasting condition causing inflammation…
- Trial name
- NCT04254783
- Testing
- Risankizumab, Cytochrome P450 (CYP) Substrates
- Where
- 6 sites in United States, Germany and 1 more
- Volunteers
- 20 people
- Sponsor
- AbbVie
Crohn's Disease
Efficacy Study of T2 Versus AZA to Maintain Clinical and Endoscopic Remission in Postoperative Crohn's Disease
The purpose of this study is to see whether T2 versus Azathioprine is able to maintain the clinical and endoscopic remission in subjects with Crohn's disease after surgery-induced remission.
- Trial name
- T2 (NCT01015391)
- Testing
- T2, Azathioprine
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Jinling Hospital, China
Inflammatory Bowel Disease
The EDICT Trial - Therapy for Inflammatory Bowel Disease Flares
Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), are chronic inflammatory conditions of the gastrointestinal tract that affect millions of people in the United States of America.
- Trial name
- EDICT (NCT07143188)
- Testing
- elemental diet (ED)
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Wake Forest University Health Sciences
Crohn Disease (CD)
The Microbial Impact on Intestinal Fibrosis and the Associated Immune Microenvironment in Crohn's Disease
The goal of this study is to find out if there is a direct connection between an imbalance of gut bacteria and the development of scar tissue in the gut by identifying important bacterial proteins found in scarred gut tissue.
- Trial name
- NCT06720961
- Testing
- Collection of surgical specimen, Collection of stool sample
- Where
- Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Inflammatory Bowel Diseases, Treatment
Vedolizumab Study With Inflammatory Bowel Disease Patients in Germany
This study on biologics (Vedolizumab/anti-TNF) in the treatment of inflammatory bowel disease (IBD) patients in Germany extends the prospective documentation of efficacy in induction and maintenance therapy of anti-TNF to the use…
- Trial name
- VEDOibdI (NCT03375424)
- Testing
- vedolizumab
- Where
- Germany
- Volunteers
- 2,500 people
- Sponsor
- Ced Service GmbH
Crohn Disease
Post-operative CRP Trend After Ileocolic Resection in Crohn's Disease Patients.
Our aim is to analyze C-Reactive Protein trends during the post-operative course in Crohn's Disease patients having undergone ileocolic resection and primary anastomosis, for the purpose of anastomotic leak early diagnosis.
- Trial name
- NCT04739579
- Testing
- C-Reactive Protein
- Where
- France
- Volunteers
- 59 people
- Sponsor
- Central Hospital, Nancy, France
Ulcerative Colitis, Crohn's Colitis
Chromoendoscopy for Dysplasia Detection in Chronic Inflammatory Bowel Disease
Patients with longstanding ulcerative colitis or crohn's disease in the large bowel have an increased risk of developing cancer.
- Trial name
- NCT01505842
- Testing
- Colonoscopy with Indigo-Carmine chromoendoscopy, Conventional white-light colonoscopy
- Where
- Sweden
- Volunteers
- 304 people
- Sponsor
- Karolinska University Hospital
Crohn's Disease
Cimzia Versus Cimzia Plus Azathioprine in the Treatment of Active Crohn's Disease
This is a randomized, double blind trial of combination therapy (Cimzia plus Azathioprine) versus mono therapy (Cimzia alone) and the improvement in mean SES-CD (Simple Endoscopic Scoring in Crohn's Disease) score.
- Trial name
- NCT01817972
- Testing
- Certolizumab pegol, Azathioprine
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Gastroenterology Research of America
Crohn Disease (CD), Ulcerative Colitis (UC)
Food Limitations In Crohn's Disease and Ulcerative coliTis
The goal of this clinical trial is to increase the knowledge on what type of diet affects inflammation and how to better convay that information in patients with inflammatory bowel disease (IBD) and decrease selective eating in…
- Conditions
- Crohn Disease (CD), Ulcerative Colitis (UC), IBD (Inflammatory Bowel Disease)
- Trial name
- FLIT (NCT07289672)
- Testing
- Diet, education
- Where
- Sweden
- Volunteers
- 140 people
- Sponsor
- Region Skane
Crohn's Disease
A Study of Oral Foralumab in Participants With Moderate to Severely Active Crohn's Disease
The primary objective of this study is to establish the safety and tolerability of multiple ascending doses (MAD) of foralumab enteric coated capsules administered orally, once daily for 5 days per week over 2 weeks in…
- Trial name
- NCT05028946
- Testing
- Foralumab
- Sponsor
- Tiziana Life Sciences LTD
Perianal Fistula in Patients With Crohn's Disease
Safety of Injection of Placental Mesenchymal Stem Cell Derived Exosomes for Treatment of Resistant Perianal Fistula in Crohn's Patients
Study aim: Safety of Human Placenta Mesenchymal Stem Cells Derived Exosomes for treatment of perianal fistula in patients with Crohn's disease 2.
- Trial name
- NCT05499156
- Testing
- placenal MSC derived exosomes
- Where
- Iran
- Volunteers
- 80 people
- Sponsor
- Tehran University of Medical Sciences
HELICOBACTER PYLORI INFECTIONS, Inflammatory Bowel Disease (Crohn's Disease and Ulcerative Colitis)
Prevalence of Helicobacter Pylori on Patients With Chronic Inflammatory Bowel Disease (IBD) at the CHU of Guadeloupe
Clinical and experimental data suggest that dysbiosis may play a pivotal role in the pathogenesis of intestinal bowel disease (IBD).
- Trial name
- HP-MICI (NCT07292454)
- Testing
- Biopsies
- Where
- Guadeloupe
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire de la Guadeloupe
Crohn Disease in Remission, Crohn Disease
Lengthening Adalimumab Dosing Interval in Quiescent Crohn's Disease Patients
Crohn's disease is a chronic inflammatory bowel disease. This disease can be treated with, among other things, biologicals such as adalimumab.
- Trial name
- LADI (NCT03172377)
- Testing
- Lengthening adalimumab dosing interval
- Where
- 22 sites in Netherlands
- Volunteers
- 174 people
- Sponsor
- Radboud University Medical Center
Crohn Disease, Ultrasound
Validation and Interobserver Reliability of a Simple Ultrasound Score for Crohn's Disease
Crohn's disease (CD) is a chronic inflammatory disease in the gastrointestinal (GI) tract. It is characterized by an alternating course between remission and relapse, which necessitates subsequent adjustments in medical therapy.
- Trial name
- NCT03481751
- Testing
- Diagnostic test: Ultrasound
- Where
- 3 sites in Norway
- Volunteers
- 124 people
- Sponsor
- Haukeland University Hospital
Crohn Disease
Treatment of Crohn's Complex Perianal Fistulas With Tissue Transplantation by Local Injection of Micro-fragmented Autologous Adipose Tissue.
multicentre randomized controlled prospective study aimed at evaluating the efficacy of the infiltration of microfractured adipose tissue in the healing of perianal fistulas not-responding to treatment with biologics, in order to…
- Trial name
- ATTIC (NCT05594862)
- Testing
- Lipogems
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Lipogems International spa
Crohn Disease
An Efficacy and Safety Study of Anti-TNF Monoclonal Antibody in Patients With Fistulizing Crohn's Disease
The purpose of this study is to evaluate the effectiveness and safety of anti-TNF chimeric monoclonal antibody (cA2) compared to placebo in the treatment of patients with fistulizing Crohn's disease.
- Trial name
- NCT00269841
- Testing
- Infliximab 10 mg/kg, Infliximab 5 mg/kg
- Volunteers
- 94 people
- Sponsor
- Centocor, Inc.
Crohn Disease
The Effects of Parenteral ω-3 Polyunsaturated Fatty Acid on Postoperative Complications of Patients With Crohn's Disease
This study is intended to investigate the safety and efficacy of ω-3 polyunsaturated fatty acid-based parenteral nutrition (PN) for patients with Crohn's disease.
- Trial name
- ω3CD (NCT03901937)
- Testing
- ω-3 polyunsaturated fatty acid, Intestinal surgery for Crohn's Disease
- Where
- China
- Volunteers
- 158 people
- Sponsor
- Sir Run Run Shaw Hospital
Inflammatory Bowel Diseases, Psychosocial Impairment
Evaluation of Quality of Life and Psychosocial Status in Children With Inflammatory Bowel Disease
Inflammatory bowel disease (IBD) is a chronic condition that affects the psychosocial status and physical activities of children and their parents in many ways.
- Trial name
- NCT06270277
- Testing
- Pediatric Quality of Life Inventory (PedsQL), Strengths and Difficulties Questionnaire (SDQ)
- Where
- Turkey (Türkiye)
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
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