Clinical trials: Goals
Gaucher Disease, Type 1
A Study of Eliglustat Tartrate (Genz-112638) in Patients With Gaucher Disease Who Have Reached Therapeutic Goals With Enzyme Replacement Therapy (ENCORE)
This Phase 3 study was designed to confirm the efficacy and safety of eliglustat tartrate (Genz-112638) in participants with Gaucher disease type 1 who had reached therapeutic goals with enzyme replacement therapy (ERT).
- Trial name
- ENCORE (NCT00943111)
- Testing
- Eliglustat tartrate, Imiglucerase
- Where
- 34 sites in United States, Argentina and 10 more
- Volunteers
- 160 people
- Sponsor
- Genzyme, a Sanofi Company
Palliative Care, Generative Artificial Intelligence
Patient Aid for Theory-Driven Health Communication (PATH): Translating Goal-Power Theory Into an Instrument and Generative AI Support for Palliative Care Communication
The goal of this clinical trial is to learn whether an artificial intelligence (AI)-supported communication tool can help improve communication between people receiving palliative care and their healthcare providers.
- Conditions
- Palliative Care, Generative Artificial Intelligence, Natural Language Processing (NLP)
- Trial name
- NCT07692711
- Testing
- NurseChat+
- Where
- Taiwan
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Care Delivery, Geriatrics
Understanding the Preferences and Views of Older Adults on the Use of Geriatric and Objective Functional Assessments for Cancer Treatment Planning.
This Interventional clinical study aims to explore how receiving information about their health and physical abilities affects the treatment decisions of older adults.
- Conditions
- Care Delivery, Geriatrics, Geriatric Assessment
- Trial name
- NCT06652347
- Testing
- Cancer care delivery
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Fox Chase Cancer Center
Chronic Pain
Defense Health Agency- Development of a Medical Device Utilizing an EEG-Based Algorithm for the Objective Quantification of Pain
PainQx, with the support of the Department of Defense (Contract #W81XWH-21-C-0034), is conducting a study to collect electroencephalography (EEG) data from people with chronic pain in order to develop algorithms than will…
- Trial name
- PQXDOD1 (NCT05215184)
- Testing
- Zeto WR19 EEG Recording
- Where
- 5 sites in United States
- Volunteers
- 278 people, healthy volunteers welcome
- Sponsor
- PainQx, Inc
Sepsis, Critical Illness
Indirect Calorimetry Usage and Effect in Ventilator-free Days and Muscle Thickness in Septic Ventilated Patients
Patients admitted to the ICU with diagnosis of sepsis and requiring mechanical ventilation for at least 24-hours and receiving enteral or parenteral nutrition will be prospectively randomized to one of two arms.
- Conditions
- Sepsis, Critical Illness, Respiratory Failure, Nutrition Disorders
- Trial name
- NCT03440593
- Testing
- Caloric delivery will target results of IC measurement.
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Baylor Research Institute
Copd, Acute Exacerbation of Chronic Obstructive Pulmonary Disease
The Individualized Accurate Diagnosis and Treatment of Chronic Objective Pulmonary Disease(COPD) Patients Based on Multidimensional Data
Chronic obstructive pulmonary disease (COPD) is known as progressive lung disease and the fourth leading cause of death worldwide.
- Trial name
- COPD (NCT04183530)
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Spinal Muscular Atrophy (SMA), Neuromuscular Disease
Ultrasonographic Muscle Assessment and Functional Scales in Spinal Muscular Atrophy
This study aims to investigate the relationship between ultrasonographic muscle thickness measurement and echogenicity assessment with functional scales in children with spinal muscular atrophy (SMA).
- Trial name
- NCT06599606
- Testing
- Ultrasonographic Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Hernia, Inguinal, Convalescence
Objective Measure of Recovery After Outpatient Surgery
This is a study using wearable monitoring devices, patient activity and sleep patterns to monitor pre and post operative following outpatient inguinal hernia surgery to determine when these parameters return to baseline.
- Trial name
- NCT02616406
- Testing
- GENEactiv
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Mayo Clinic
Epilepsy, Absence
Objective EEG Bed Side Assessment of Impaired Conscious Awareness in Epilepsy
In this project EEG recordings between healthy participants and those with a diagnosed Absence-epilepsy will be compared. The investigators suggest differences in EEG microstate analysis and neuropsychological parameters related…
- Trial name
- NCT04799795
- Where
- Germany
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University Hospital Schleswig-Holstein
End Stage Renal Disease
Research Study Evaluating Cinacalcet for Patients With End Stage Renal Disease (ESRD)
The purpose of this study is to observe the effects of a treatment strategy that incorporates cinacalcet HCl into the management of secondary hyperparathyroidism (HPT) in subjects with ESRD receiving hemodialysis, on bio-intact…
- Trial name
- NCT00113945
- Testing
- Cinacalcet
- Volunteers
- 360 people
- Sponsor
- Amgen
Bladder Cancer
A Prospective Randomized Controlled Clinical Trial of Standard Versus Goal-Directed Perioperative Fluid Management (GDT) for Patients Undergoing Radical Cystectomy
The purpose of this study is to help us learn what is the best amount of fluid to give to patients during bladder surgery in order to avoid delayed bowel function after surgery, which could prolong hospital stay.
- Trial name
- NCT02145871
- Testing
- standard fluid management, fluid management guided by the EV1000
- Where
- 5 sites in United States
- Volunteers
- 282 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Cancer
Pre-operative Prehabilitation in Cancer Surgery - Objective Recovery Assessment
To compare prehabilitation with physical exercise, psychological support, nutritional support and smoke/alchol stop to "standard of care" before canceer surgery.
- Trial name
- Popcorn (NCT05270577)
- Testing
- Prehabilitation, Standard care
- Volunteers
- 90 people
- Sponsor
- Linkoeping University
Dental Fear
The Effect of Parental Presence on Dental Fear
150 children aged between five and seven years presenting for the first dental visit, whose parents consented to participate in the study were selected from patients reporting to the dental clinics Riyadh Colleges of Dentistry…
- Trial name
- NCT02619981
- Testing
- Restorative procedure, Maxillary infiltration anesthesia with 2%Lidocaine
- Where
- Saudi Arabia
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Riyadh Colleges of Dentistry and Pharmacy
Tinnitus
Cognitive Speed as an Objective Measure of Tinnitus
Tinnitus, commonly referred to as "ringing in the ears", affects 50 million people in the United States and is recognized as a major public health concern.
- Trial name
- COMeT (NCT01395368)
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- Washington University School of Medicine
Insomnia
Study of Trazodone & Cognitive Behavioral Therapy to Treat Insomnia
The purpose of this study is to evaluate the effect of a 3 month medication trial of Trazodone versus 3 months of Cognitive Behavioral Therapy (CBT) in patients with chronic insomnia.
- Trial name
- NCT01348542
- Testing
- Trazodone, Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Milton S. Hershey Medical Center
Coronary Artery Disease, Dyslipidemias
Lipid Efficacy of the Extended Release Niacin/Laropiprant Combination in Patients With Cardiovascular Disease
Clinical studies with statins have shown that patients that suffered a cardiovascular event have a high residual risk. Residual risk decreases with the attaining of progressive lower LDL-C levels.
- Trial name
- NCT01308203
- Testing
- Extended release niacin/laropiprant
- Where
- Argentina
- Volunteers
- 32 people
- Sponsor
- Daniel A. Siniawski
Physical Activity, Child
Arkansas Active Kids! -Objective 3
This is a cross-sectional study aiming to identify how daily activities affect children's body fitness and general health. Also, the study will address how specific behaviors (such as diet and sleep) as well as neighborhood and…
- Trial name
- AAK (NCT03221673)
- Where
- United States
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Arkansas Children's Hospital Research Institute
Erectile Dysfunction (ED)
Evaluation of the Rigicon Infla10® Inflatable Penile Prosthesis (IPP) for Erectile Dysfunction
This study evaluates the long-term safety and effectiveness of the Rigicon Infla10® Inflatable Penile Prosthesis in patients with erectile dysfunction.
- Trial name
- UNITED (NCT07273773)
- Testing
- Rigicon Infla10® Inflatable Penile Prosthesis (IPP)
- Where
- 4 sites in United States
- Volunteers
- 182 people
- Sponsor
- Rigicon, Inc.
Uremia, Complication of Hemodialysis
Probing the Dry Weight (DW) by Bioimpedance (BIA): Which is the Gold Standard Between Clinical DW and BIA DW?
Background Very recently, a test aimed at assessing dry weight (DW) in hemodialysis (HD) patients has been developed, the "resistance stabilization test" (REST) Aim of the study To verify if BIA-based DW (BIA DW) control is truly…
- Trial name
- REST (NCT02446535)
- Testing
- achievement of the DW by means of the BIA DW (RE.S.T.)
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Miulli General Hospital
Auditory Perceptual Disorders, Age-related Hearing Loss
Objective Measurement of Hearing Aid Benefit
Hearing loss is a critical health concern in the rapidly aging population, affecting approximately 22 million older individuals in the United States.
- Trial name
- NCT04431622
- Testing
- Hearing aid amplification algorithms
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Maryland, College Park
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