Clinical trials: Goal Directed Fluid Therapy
Hemodynamic
Three Different GHDT ( Goal Hemodynamic Directed Therapy) Strategies for Intraoperative Fluid Management Optimization During Major Abdominal Surgery: A Randomized Controlled Trial
Major oncological surgery is among the most complex procedures, involving patients with a combination of high-risk factors that can significantly influence immediate postoperative outcomes and quality of life.
- Trial name
- SMART FLUID (NCT06871150)
- Testing
- Flotrac sensor, HPI, HPI-AFM
- Where
- 3 sites in Italy
- Volunteers
- 150 people
- Sponsor
- ASST Sette Laghi
Goal-directed Fluid Therapy
Goal Directed Fluid Therapy Guided Fluid Management in Pneumoresection
Perioperative fluid management is a key component of anesthetic management during thoracic surgery. On one hand, fluid restriction could compromise perfusion of vital organs and surgical anastomosis.
- Trial name
- NCT03237351
- Testing
- Fluid therapy
- Where
- China
- Volunteers
- 60 people
- Sponsor
- ZhiHeng Liu
Septic Shock, Hyperlactatemia
Early Goal Directed Therapy Using a Physiological Holistic View. The ANDROMEDA-SHOCK Study
Septic shock is a highly lethal condition associated with a mortality risk of 30 to 60%. Optimizing tissue perfusion and oxygenation is the aim to decrease mortality and morbidity in septic shock patients.
- Conditions
- Septic Shock, Hyperlactatemia, Peripheral Perfusion
- Trial name
- ANDROMEDA (NCT03078712)
- Testing
- Peripheral Perfusion guided resuscitation, Lactate guided resuscitation
- Where
- Chile
- Volunteers
- 424 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Septic Shock
Pilot Study for the SQUEEZE Trial
The purpose of the SQUEEZE Trial is to determine which fluid resuscitation strategy results in the best outcomes for children treated for suspected or confirmed septic shock.
- Trial name
- SQUEEZE (NCT01973907)
- Testing
- Fluid Sparing Resuscitation Strategy
- Where
- Canada
- Volunteers
- 53 people
- Sponsor
- McMaster Children's Hospital
Blood Pressure, Low
Goal-Directed Fluid Therapy for Patients Undergoing Oro-Maxillofacial Surgery
Orthognathic surgery, one kind of Oro-maxillofacial surgery, is a complicate surgery that undergoes several hours with nasotracheal intubation general anesthesia.
- Trial name
- NCT03086694
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Goal-Directed Fluid Therapy, Hemodynamic Monitoring
Comparison of Goal-directed and Liberal Fluid Management
Background: The investigators aim is to indicate that the "goal directed fluid management" is more effective for open abdominal surgeries by performing perioperative hemodynamic monitorisation using a minimal invasive pulse…
- Conditions
- Goal-Directed Fluid Therapy, Hemodynamic Monitoring, Fluid Management
- Trial name
- NCT04265014
- Testing
- Goal-directed fluid treatment, Liberal Fluid Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- healthy volunteers welcome
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Delayed Graft Function, End Stage Renal Disease
Norepinephrine Infusion Combined With Goal-directed Fluid Therapy in Patients Undergoing Kidney Transplantations
Delayed graft function (DGF), delineated by the necessity for dialytic intervention within the initial week post-transplantation, afflicts approximately 20%-50% of recipients.
- Conditions
- Delayed Graft Function, End Stage Renal Disease, Kidney Transplantation
- Trial name
- NCT06367205
- Testing
- Goal-Directed Fluid Therapy (GDFT), Regular Fluid Therapy
- Where
- 3 sites in China
- Volunteers
- 380 people
- Sponsor
- RenJi Hospital
Arthroplasty, Replacement, Hip, Anesthesia, Spinal
Goal Directed Fluid Therapy Versus Liberal Fluid Regimen in Primary Elective Hip Artrhoplasty
Patients undergoing elective primary total hip replacement and spinal anesthesia may encounter significant hemodynamic instability.
- Conditions
- Arthroplasty, Replacement, Hip, Anesthesia, Spinal, Hemodynamic Monitoring, Crystalloid Solutions
- Trial name
- NCT04996420
- Testing
- Clearsight non invasive hemodynamic monitoring
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Istituto Ortopedico Rizzoli
Head and Neck Cancer
Goal Directed Fluid Therapy in Free Flap Reconstructive Surgery
Wide excision of head and neck cancer with microsurgical free flap's reconstruction (FFR) results to a high cancer cure rate and a good functional recovery.
- Trial name
- NCT01129037
- Testing
- Goal directed fluid management based on continuous monitoring of stroke volume
- Where
- Canada
- Volunteers
- 78 people
- Sponsor
- University Health Network, Toronto
Obesity
Obesity and Goal-directed Intraoperative Fluid Therapy
The purpose of the study is to compare non-obese patients (BMI≤ 30 kg/m2)versus obese patients (BMI> 30 kg/m2) in regard of their respective needs for intraoperative fluid therapy during laparoscopic surgery.
- Trial name
- NCT01052519
- Testing
- Goal directed fluid therapy
- Where
- Austria
- Volunteers
- 90 people
- Sponsor
- Medical University of Vienna
Acute Abdomen, Abdominal Trauma
Enhanced Recovery After Surgery (ERAS) in Patients Undergoing Emergency Laparotomy
The goal of this clinical trial is to test the safety and effectiveness of the ERAS protocols compared to a conventional care protocols in patients who received emergency laparotomy.
- Conditions
- Acute Abdomen, Abdominal Trauma, Emergency Surgery
- Trial name
- ERAS (NCT06182488)
- Testing
- ERAS protocols, Conventional protocols
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Tianjin Medical University
Free Flap Post Mastectomy
Goal Directed Fluid Therapy in Free Flap Patients
Fluid management of surgical patients has changed dramatically in recent years. Recent studies have shown that so called 'restrictive' fluid strategies can improve outcomes such as length of stay and time to fitness for…
- Trial name
- NCT00869297
- Testing
- Goal Directed Fluid Administration, Control
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of Manitoba
Surgery--Complications
Goal-directed Therapy in Neurosurgery.
The purpose of the study is to assess feasibility of future large randomised controled study aimed on assessment of effect of goal-directed therapy on incidence of complications in neurosurgery compared to standard care.
- Trial name
- NCT04754295
- Testing
- Goal-Directed Therapy, STANDARD
- Where
- Czechia
- Volunteers
- 34 people
- Sponsor
- Brno University Hospital
Anesthesia, ERAS
Goal-Directed Fluid Therapy in Patients Undergoing Lower Limb Surgeries
Controlling the amount of fluids given to patients in perioperative setting can significantly influence their outcomes.
- Conditions
- Anesthesia, ERAS, Fluid Overload, Hypovolemia; Surgical Shock
- Trial name
- NCT06133257
- Testing
- Goal-Directed Fluid Therapy guided by Inferior Vena Cava Collapsibility Index, standard fluid management
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Severe Sepsis, Emergency
Impact of Early Goal-directed Fluid Therapy in Septic Patients Undergoing Emergency Surgery
This study wants to compared the safety and efficacy of GDTs using standard pressure-related parameters vs. dynamic hemodynamic indices associated with fluid compartment monitoring, in septic patients requiring emergency surgery.
- Conditions
- Severe Sepsis, Emergency, Surgery
- Trial name
- NCT01654003
- Testing
- CONTROL, OPTIMIZED
- Where
- 2 sites in Switzerland
- Volunteers
- 20 people
- Sponsor
- University Hospital, Geneva
Pancreaticoduodenectomy, Stroke Volume Variation
Goal-directed Fluid Therapy on Complications After Pancreaticoduodenectomy
Optimal fluid balance is critical to minimize anastomotic edema in patients undergoing pancreaticoduodenectomy. This study examined the effects of decreased fluid administration on rates of postoperative pancreatic leak and…
- Trial name
- NCT03699917
- Where
- 2 sites in United States
- Volunteers
- 64 people
- Sponsor
- Wake Forest University Health Sciences
Perioperative Fluid Management
Comparison of Perioperative Standard Fluid Management and Goal-Directed Fluid Management
To compare the goal-directed fluid therapy based on the data obtained from the hemodynamic monitoring system, which provides continuous CO, SV and SVV measurements through arterial pressure wave with standard fluid therapy in…
- Trial name
- NCT04728178
- Testing
- Crystalloid solution, Colloid solution
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Istanbul University
Other Complications of Esophagostomy
Outcome Study of Restrictive vs. Liberal Intraoperative Fluid Management Guided by PPV in Esophagectomy
The purpose of this study is to determine whether intraoperative restrictive fluid management guided by pulse pressure variation produces a better effect on the postoperative lung function, kidney function, inflammatory response…
- Trial name
- PPV (NCT01933451)
- Testing
- Intraoperative fluid therapy
- Where
- Taiwan
- Volunteers
- 7 people
- Sponsor
- National Taiwan University Hospital
Therapy Adverse Effect
Preoperative Goal-directed Fluid Therapy and Physiological Changes Following One-lung Ventilation
Intraoperative goal-directed fluid therapy (GDFT) is proposed to improve the outcomes of patients undergoing major surgery. In the GDFT algorithm, the employment of fluid bolus plays a crucial role.
- Trial name
- NCT03064880
- Testing
- SV maximization
- Volunteers
- 60 people
- Sponsor
- National Taiwan University Hospital
Complication, Postoperative
Perioperative Fluid Management: Goal-directed Versus Restrictive Strategy
There is no ideal "cookbook recipe" for fluid prescription that would fit every surgical patient. In this study, the investigators working hypothesis is that the adoption of an integrative algorithm for perioperative fluid and…
- Trial name
- NCT02625701
- Testing
- Goal-directed therapy, Restrictive fluid therapy
- Where
- Switzerland
- Volunteers
- 400 people
- Sponsor
- University Hospital, Geneva