Clinical trials: Glutathione
Busulfan Pharmacokinetic Analysis, Busulfan Dosing
26DT052; Scaling Busulfan Dose to Body Surface Area in Children
The goal of this pilot study is to determine if scaling the first busulfan dose to Body Surface Area (BSA) in children with a BSA ≥0.5 m2 and using a BSA-banded dosing table for infants (BSA <0.5 m2) increases the fraction of…
- Conditions
- Busulfan Pharmacokinetic Analysis, Busulfan Dosing, Hematopoietic Stem Cell Transplant (HSCT), Busulfan
- Trial name
- NCT07792369
- Testing
- Busulfan (BU)
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Children's Hospital of Philadelphia
Type 2 Diabetes
Glutathione-rich Foods for Type 2 Diabetes
The purpose of this research study is to find out whether certain plant-based foods may be beneficial for individuals with type 2 diabetes. To meet the goal, study participants will be fed known amounts of foods and nutrients.
- Trial name
- GSH (NCT04386187)
- Testing
- GSH Foods, Nutrition education about glutathione sources in the diet, Standard of care nutrition education for type 2 diabetes
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of California, San Diego
Parkinson's Disease
Vitamin B6, B12, Folic Acid and Exercise in Parkinson's Disease
This experiment seeks to determine whether individuals with PD will benefit from vitamin B6 (pyridoxine hydrochloride), B12 (cyanocobalamin), and Folic Acid supplementation, whether they will benefit from a 6-week circuit…
- Trial name
- NCT01238926
- Testing
- PD vitamin supplementation, PD exercise intervention, PD vitamin + exercise
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- New York Institute of Technology
Myelodysplastic Syndrome (MDS)
Phase 2 Study Comparing Two Dose Schedules of Telintra™ in Myelodysplastic Syndrome (MDS)
This is a randomized, open label, multicenter, Phase 2 study comparing two dose schedules of Telintra in patients with Low or Intermediate-1 risk MDS.
- Trial name
- NCT00700206
- Testing
- Ezatiostat Hydrochloride
- Where
- 36 sites in United States
- Volunteers
- 86 people
- Sponsor
- Telik
Gaucher Disease Type 1
Role of Oxidative Stress and Inflammation in Type 1 Gaucher Disease (GD1)
The purpose of this study is to measure levels of blood and brain chemicals related to oxidative stress and inflammation in healthy volunteers and individuals with Type 1 Gaucher disease (GD1) to see if these levels are altered…
- Trial name
- NCT02583672
- Testing
- N-acetylcysteine
- Where
- 2 sites in United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
COVID-19
The Role of Glutathione Deficiency and MSIDS Variables in Long COVID-19
The purpose of this research study is to assess if glutathione, along with NAC (N-acetyl cysteine) and Alpha lipoic acid (ALA), can help reverse some of the COVID long-haul symptoms.Subjects will be randomized in to one of two…
- Trial name
- NCT05371288
- Testing
- NAC (N-acetyl cysteine), Alpha lipoic acid (ALA), liposomal glutathione (GSH)
- Where
- United States
- Sponsor
- University of California, Irvine
Myelodysplastic Syndrome (MDS)
Study of (Telintra®) in Non-Del(5q) Myelodysplastic Syndrome
This is a multicenter, single arm open label Phase 2b Study of oral ezatiostat (Telintra®) in Patients who are RBC tranfusion dependent, Low to INT-1 IPSS risk, non-del (5q) Myelodysplastic Syndrome (MDS).
- Trial name
- NCT01459159
- Testing
- ezatiostat hydrochloride (Telintra®)
- Where
- 7 sites in United States
- Volunteers
- 162 people
- Sponsor
- Telik
Non-Small Cell Lung Cancer, Chemotherapy
Randomized Trial of Glutathione With Anti-PD-1 and Chemotherapy in Advanced NSCLC
Chemotherapeutic agents exert significant immunomodulatory effects by influencing tumor-infiltrating immune cells. However, the sequence and combination of chemotherapy regimens differentially modulate immune cell dynamics…
- Conditions
- Non-Small Cell Lung Cancer, Chemotherapy, PD1 Antibody, Glutathione
- Trial name
- NCT06896422
- Testing
- Glutathione, PD1 Inhibitor, Chemotherapy
- Where
- China
- Volunteers
- 80 people
- Sponsor
- The First Affiliated Hospital of Zhengzhou University
Discoloration, Tooth
Effect of Glutathione vs KI in Reducing SDF Staining When Used in Treatment of Primary Carious Teeth
Although black staining is considered a drawback that is clinically observed following SDF application and is the main primary barrier for its use clinically .
- Trial name
- NCT04816487
- Testing
- Potassium Iodide or Glutathione
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Effects of High Altitude, Hypoxia
Induced Changes in Ventilatory Responsiveness and Altitude Exposure
The main purpose of this study is to determine if a drug (acetyl-cysteine or ACCY) can increase the amount of oxygen in your body at a high altitude of 11,500 feet.
- Conditions
- Effects of High Altitude, Hypoxia, Inadequate or Impaired Breathing Pattern or Ventilation, Abnormal Blood Oxygen Pressure
- Trial name
- NCT01241513
- Testing
- NAC
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Assay Muscle, Liver Glutathione in Healthy Human
Non-invasive Quantification of Muscle and Liver Glutathione GSH-MRS
Glutathione (glutamyl-cysteinyl-glycine) is the main intracellular compound. It participates also in the detoxification of electrophiles molecules of which paracetamol.
- Trial name
- NCT02662816
- Testing
- Proton magnetic resonance spectroscopy (1H MRS), a protein rich breakfast at home, a protein rich lunch at the Clinical Investigation Center
- Where
- France
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Periodontitis
Does Hyaluronic Acid Affect Periodontal Treatment?
Objective: The aim of this study is to evaluate the effect of HA as an adjunct to scaling and root planning (SRP) on clinical parameters, periodontal inflamed surface area (PISA) and adenosine deaminase (ADA), catalase (CAT), and…
- Trial name
- NCT03754010
- Testing
- Scaling and root planning, Hyaluronic acid gel (HA) and SRP, HA mouthrinse and SRP
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people
- Sponsor
- Yuzuncu Yil University
CBS Deficiency
Effect of Acetaminophen and N-Acetylcysteine on Liver Metabolism on Homocystinuria
In homocystinuria due to cystathionine beta synthase (CBS) deficiency or classical homocystinuria, decreased blood cysteine levels are observed.
- Trial name
- NCT04015557
- Testing
- Acetaminophen, N-acetylcysteine
- Where
- Brazil
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
Aging, Erythrocyte Glutathione Deficiency
Energetics and Function in Older Humans
The investigators have previously reported that older patients with HIV are deficient in glutathione (GSH) due to decreased availability of cysteine and glycine, and that oral supplementation with cysteine (as n-acetylcysteine)…
- Conditions
- Aging, Erythrocyte Glutathione Deficiency, Muscle Weakness
- Trial name
- NCT02348762
- Testing
- Cysteine (as n-acetylcysteine) and Glycine
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Parkinson's Disease
Phase IIb Study of Intranasal Glutathione in Parkinson's Disease
Glutathione is an important nutrient for brain function and loss of glutathione has been implicated in Parkinson's disease. Glutathione is an antioxidant made in the body out of three amino acids, the nutrients that make up…
- Trial name
- (in)GSH (NCT02424708)
- Testing
- Reduced Glutathione 100mg, Reduced Glutathione 200mg
- Where
- 2 sites in United States
- Volunteers
- 45 people
- Sponsor
- Bastyr University
Parkinson Disease
Intranasal Insulin and Glutathione as an Add-On Therapy in Parkinson's Disease
This study will be evaluating the safety and efficacy of insulin and glutathione in subjects with Parkinson's Disease compared to placebo.
- Trial name
- NOSE-PD (NCT05266417)
- Testing
- INS-GSH
- Where
- 4 sites in United States
- Volunteers
- 56 people
- Sponsor
- Gateway Institute for Brain Research
Stress, Psychological
Meditation Practice in Pediatric Healthcare Professionals
Rationale: Healthcare professionals face a growing burden of responsibilities and work overload which may cause psychological suffering expressed by burnout, depression and other negative psychological variables.
- Trial name
- NCT02947074
- Testing
- Yoga Meditation
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Danilo Forghieri Santaella
Skin Condition, Anti-Oxidative Stress
Efficacy Evaluation Study of Vitamin C and Glutathione Liquid Sachet
The objective of this study is to evaluate the effect of liquid vitamin C and glutathione supplements on human skin condition improvement and anti-oxidation.
- Trial name
- NCT07379216
- Testing
- Vitamin C and Glutathione Liquid Sachet
- Where
- Taiwan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- TCI Co., Ltd.
Cystic Fibrosis
Inhaled Glutathione (GSH) Versus Placebo in Cystic Fibrosis
Cystic fibrosis (CF) is the most common inherited disease among the Caucasian population with considerable morbidity and reduced life expectancy.
- Trial name
- NCT01450267
- Testing
- Inhaled Reduced Glutathione, Physiological solution
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Serafino A. Marsico
HIV Infection, Erythrocyte Glutathione Deficiency
Role of HIV on Glutathione Synthesis and Oxidative Stress
HIV infection is associated the development of increased oxidative stress and deficiency of glutathione (GSH), the dominant endogenous antioxidant protein, but the underlying mechanisms contributing to GSH deficiency are hitherto…
- Trial name
- NCT01355198
- Testing
- Cysteine (as n-acetylcysteine) and glycine, Cysteine/glycine
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Baylor College of Medicine