Skin ConditionNCT07379216
Efficacy Evaluation Study of Vitamin C and Glutathione Liquid Sachet
A study testing Vitamin C and Glutathione Liquid Sachet in people with Skin Condition and Anti-Oxidative Stress, run by TCI Co., Ltd. at 1 site in Taiwan.
Trial summary
The objective of this study is to evaluate the effect of liquid vitamin C and glutathione supplements on human skin condition improvement and anti-oxidation. Read more about this study
- Who is it for?
- Ages 18 to 65 yearsHealthy volunteers can take part
- Conditions the study is for
- Skin Condition, Anti-Oxidative Stress
- What is being tested?
- Vitamin C and Glutathione Liquid Sachet
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 30 participants
- Where
- 1 siteTaiwan
- Study dates
- 24 Jan 2026to 1 Jun 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 65 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Healthy male or female adults, aged 18-65 years old;
- Commitment not to use products having activity comparable with that of the product to be tested during the study period;
- Free of any dermatological or systemic disorder that would interfere with results.
Who cannot join
- Subject with obvious skin surface damage;
- Subject who had oral or topical medication which may affect skin condition within 1 month;
- Individuals with known allergies to cosmetics, medications, or foods (especially those allergic to legumes/soy);
- Pregnant or breastfeeding individuals;
- Received facial laser therapy, chemical peeling in the past 2 months.
- Individuals unwilling to allow publication or public disclosure of photographs taken as part of the study results
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Taiwan1 site, 1 recruiting
- Recruiting
Chia Nan University of Pharmacy & Science
Pingtung City, 928
Chia-Hua Liang, Ph.D., +886-06-2664911 ext. 2441, tinna_ling@mail.cnu.edu.tw
Chia-Hua Liang, Ph.D.
About this study
The objective of this study is to evaluate the effect of liquid vitamin C and glutathione supplements on human skin condition improvement and anti-oxidation.
Read the detailed description
This study is a single-center, placebo-controlled, double-blinded, parallel human trial designed to evaluate the skin beauty and anti-oxidant effect of liquid vitamin C and glutathione supplements.
Healthy adult participants aged 18-65 years will be enrolled. Participants will be informed to consume test samples daily for 12 consecutive weeks. Skin measurement and self-assessment questionnaires will be conducted at baseline (before intake), after 4, 8 weeks, and 12 weeks of consumption. Fasting blood samples will be collected at baseline and after 12 weeks of consumption.
- Conditions
- Skin Condition, Anti-Oxidative Stress
- Being tested
- Placebo sachet, Vitamin C and Glutathione Liquid Sachet
- Keywords
- Vitamin C supplement, Glutathione supplement
- Medical subject headings
- Skin Diseases
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Placebo sachetDietary supplement
consume 1 sachet of the test samples daily for 12 consecutive weeks
Vitamin C and Glutathione Liquid SachetDietary supplement
Also called Lipo GLUTA-C
consume 1 sachet of the test samples daily for 12 consecutive weeks
| Study group | Role | What they receive |
|---|---|---|
| Placebo sachet | Placebo comparator | Not described Receives: Dietary Supplement: Placebo sachet |
| Vitamin C and Glutathione Liquid Sachet | Experimental | Not described Receives: Dietary Supplement: Vitamin C and Glutathione Liquid Sachet |
What is being measured
The primary outcome is the main question the study is designed to answer.
The change of skin tone
Chroma Meter MM500 was utilized to measure face skin tone. Units: Individual Typology Angle (ITA°)
Measured: Change from Baseline skin tone at 12 weeks
The change of visible spots
VISIA Complexion Analysis was utilized to measure visible spots on face. Units: the amount of detectable visible spots
Measured: Change from Baseline visible spots at 12 weeks
The change of UV spots
VISIA Complexion Analysis was utilized to measure UV spots on face. Units: the amount of detectable UV spots
Measured: Change from Baseline UV spots at 12 weeks
Secondary outcomes (12)
The change of skin hydration
Corneometer® CM825 (CK, Germany) was utilized to measure skin surface hydation. Units: arbitrary Corneometer® units 0-120.
Measured: Change from Baseline skin hydration at 12 weeks
The change of skin redness
Chroma Meter MM500 was utilized to measure face skin redness. Units: a* value
Measured: Change from Baseline skin redness at 12 weeks
The change of skin melanin index
Mexameter® MX18 (CK, Germany) was utilized to measure face skin melanin level. Units: arbitrary units
Measured: Change from Baseline skin melanin index at 12 weeks
The change of skin elasticity
Skin elasticity (Softplus, Italy) was utilized to measure face skin elasticity. Units: arbitrary units
Measured: Change from Baseline skin elasticity at 12 weeks
The change of brown spots
VISIA Complexion Analysis was utilized to measure brown spots on face. Units: the amount of detectable brown spots
Measured: Change from Baseline brown spots at 12 weeks
The change of wrinkles around the eyes
VISIA Complexion Analysis was utilized to measure wrinkles around the eyes. Units: the amount of detectable wrinkles
Measured: Change from Baseline wrinkles around the eyes at 12 weeks
The change of skin texture
VISIA Complexion Analysis was utilized to measure skin texture. Units: arbitrary units
Measured: Change from Baseline skin texture at 12 weeks
The change of skin collagen density
DermaLab® Series SkinLab Combo was utilized to measure skin collagen density. Units: arbitrary units
Measured: Change from Baseline skin collagen density at 12 weeks
The change of total antioxidation capacity (TAC)
A fasting blood sample will be collected for TAC testing.
Measured: Change from Baseline TAC at 12 weeks
The change of Superoxide Dismutase (SOD)
A fasting blood sample will be collected for SOD testing.
Measured: Change from Baseline SOD at 12 weeks
The change of Glutathione S-transferase-Red Blood Cells (GST-RBC)
A fasting blood sample will be collected for GST-RBC testing.
Measured: Change from Baseline GST-RBC at 12 weeks
The change of Malondialdehyde (MDA)
A fasting blood sample will be collected for MDA testing.
Measured: Change from Baseline MDA at 12 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted30 Jan 2026
- Study start24 Jan 2026
- Primary completion18 May 2026 (estimated)
- Study completion1 Jun 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Skin ConditionStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind
- Who is masked
- Participant, Investigator
- Enrolment
- 30 participants (estimated)
Sponsor and investigators
- Lead sponsor
- TCI Co., Ltd.
- Sponsor type
- Industry (pharma, biotech, devices)
- Responsible party
- Sponsor
- Investigators
- Chia-Hua Liang, Ph.D., Principal investigator, Chia Nan University of Pharmacy ＆ Science
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07379216
- Sponsor's protocol ID
- 25-103-A
- Status last verified
- Feb 2026
- First submitted
- 23 Jan 2026
- Last updated
- 4 Feb 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 4 Feb 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Efficacy Evaluation Study of Vitamin C and Glutathione Liquid Sachet
- ClinicalTrials.gov ID
- NCT07379216
- Acronym / sponsor ID
- 25-103-A
- Conditions
- Skin Condition, Anti-Oxidative Stress
- Keywords
- Vitamin C supplement, Glutathione supplement
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 30 participants (estimated)
- Lead sponsor
- TCI Co., Ltd.Industry (pharma, biotech, devices)
- Study start
- 24 Jan 2026 (actual)
- Primary completion
- 18 May 2026 (estimated)
- Study completion
- 1 Jun 2026 (estimated)
- First posted
- 30 Jan 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The objective of this study is to evaluate the effect of liquid vitamin C and glutathione supplements on human skin condition improvement and anti-oxidation.
Detailed description
This study is a single-center, placebo-controlled, double-blinded, parallel human trial designed to evaluate the skin beauty and anti-oxidant effect of liquid vitamin C and glutathione supplements.
Healthy adult participants aged 18-65 years will be enrolled. Participants will be informed to consume test samples daily for 12 consecutive weeks. Skin measurement and self-assessment questionnaires will be conducted at baseline (before intake), after 4, 8 weeks, and 12 weeks of consumption. Fasting blood samples will be collected at baseline and after 12 weeks of consumption.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, investigator)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Placebo sachet | Placebo comparator | Dietary Supplement: Placebo sachet |
| Vitamin C and Glutathione Liquid Sachet | Experimental | Dietary Supplement: Vitamin C and Glutathione Liquid Sachet |
Who may qualify
- Ages
- 18 to 65 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (3 listed)
- Healthy male or female adults, aged 18-65 years old;
- Commitment not to use products having activity comparable with that of the product to be tested during the study period;
- Free of any dermatological or systemic disorder that would interfere with results.
Key exclusion criteria (6 listed)
- Subject with obvious skin surface damage;
- Subject who had oral or topical medication which may affect skin condition within 1 month;
- Individuals with known allergies to cosmetics, medications, or foods (especially those allergic to legumes/soy);
- Pregnant or breastfeeding individuals;
- Received facial laser therapy, chemical peeling in the past 2 months.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Placebo sachetconsume 1 sachet of the test samples daily for 12 consecutive weeks | Dietary supplement | Placebo sachet |
| Vitamin C and Glutathione Liquid SachetAlso: Lipo GLUTA-Cconsume 1 sachet of the test samples daily for 12 consecutive weeks | Dietary supplement | Vitamin C and Glutathione Liquid Sachet |
Primary outcome
The change of skin tone
Time frame: Change from Baseline skin tone at 12 weeks
Chroma Meter MM500 was utilized to measure face skin tone. Units: Individual Typology Angle (ITA°)
The change of visible spots
Time frame: Change from Baseline visible spots at 12 weeks
VISIA Complexion Analysis was utilized to measure visible spots on face. Units: the amount of detectable visible spots
The change of UV spots
Time frame: Change from Baseline UV spots at 12 weeks
VISIA Complexion Analysis was utilized to measure UV spots on face. Units: the amount of detectable UV spots
12 secondary outcomes
The change of skin hydration
Time frame: Change from Baseline skin hydration at 12 weeks
The change of skin redness
Time frame: Change from Baseline skin redness at 12 weeks
The change of skin melanin index
Time frame: Change from Baseline skin melanin index at 12 weeks
The change of skin elasticity
Time frame: Change from Baseline skin elasticity at 12 weeks
The change of brown spots
Time frame: Change from Baseline brown spots at 12 weeks
The change of wrinkles around the eyes
Time frame: Change from Baseline wrinkles around the eyes at 12 weeks
The change of skin texture
Time frame: Change from Baseline skin texture at 12 weeks
The change of skin collagen density
Time frame: Change from Baseline skin collagen density at 12 weeks
The change of total antioxidation capacity (TAC)
Time frame: Change from Baseline TAC at 12 weeks
The change of Superoxide Dismutase (SOD)
Time frame: Change from Baseline SOD at 12 weeks
The change of Glutathione S-transferase-Red Blood Cells (GST-RBC)
Time frame: Change from Baseline GST-RBC at 12 weeks
The change of Malondialdehyde (MDA)
Time frame: Change from Baseline MDA at 12 weeks
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 4 Feb 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Chia-Hua Liang, Ph.D. principal investigator
Chia Nan University of Pharmacy ＆ Science
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Vitamin C and Glutathione Liquid Sachet in people with Skin Condition and Anti-Oxidative Stress, run by TCI Co., Ltd. at 1 site in Taiwan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 4 Feb 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Taiwan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Chia-Hua Liang, Ph.D. (+886-06-2664911 ext. 2441, tinna_ling@mail.cnu.edu.tw), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
The change of skin tone (time frame: Change from Baseline skin tone at 12 weeks). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 4 Feb 2026.