Clinical trials: Globus, active
Parkinson Disease
Continuous Electrical Neuromodulation of the Globus Pallidus Intern in Parkinson's Disease by the Directional Electrode CARTESIA™
Many patients have benefited from the implantation of brain stimulation electrodes for the treatment of various motor signs of Parkinson's disease in the phase of motor fluctuations.
- Trial name
- NEC-Parkinson (NCT05626608)
- Testing
- Classical ring stimulation, Stimulation in directional mode
- Where
- France
- Volunteers
- 10 people
- Sponsor
- University Hospital, Montpellier
Parkinson Disease
Intrapatient Comparison of STN and GPi tTIS in PD
The goal of this clinical trial is to investigate the therapeutic efficacy of tTIS in patients with Parkinson's disease and to evaluate the immediate effects and conduct intrapatient comparisons of individualized 130 Hz…
- Trial name
- NCT07018388
- Testing
- NervioX-2400
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Ruijin Hospital
Dystonia, Dystonia, Focal
Local Field Potentials in Dystonia
The goal of this clinical trial is to learn whether local field potential (LFP) signals recorded from the globus pallidus interna (GPi) using the Medtronic Percept™ deep brain stimulation (DBS) device can help optimize DBS…
- Conditions
- Dystonia, Dystonia, Focal, Dystonia, Primary
- Trial name
- LFP-DYT (NCT07309133)
- Testing
- Deep Brain Stimulation System
- Where
- United Kingdom
- Volunteers
- 25 people
- Sponsor
- Newcastle-upon-Tyne Hospitals NHS Trust
Tourette Syndrome
Observational Database on Deep Brain Stimulation in Tourette Syndrome
Within an ongoing deep brain stimulation (DBS) program for Tourette syndrome (TS) at the Department of Neurology, Pitié-Salpêtrière Hospital, Paris/France, the investigator team plans to evaluate patients pre-operatively and then…
- Trial name
- POSTSTIC (NCT04449068)
- Testing
- Neurological and neuropsychological Follow-up after deep brain stimulation, EEG recordings
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cervical Dystonia
Comparison of Pallidal With Subthalamic Deep Brain Stimulation for Cervical Dystonia
Cervical dystonia (CD), also known as spasmodic torticollis, is a type of focal dystonia, mainly manifesting as involuntary head turning or tilting, or holding a twisted posture.
- Trial name
- NCT05715138
- Testing
- GPi-DBS, STN-DBS, GPi-DBS devices
- Where
- China
- Volunteers
- 98 people
- Sponsor
- Chinese PLA General Hospital
Parkinson Disease
Asymmetric DBS for PD : A Multicenter, Prospective, Single Arm, Open Label Study
Deep brain stimulation (DBS) is an efficacious neurosurgical treatment for moderate-to-late stage Parkinson's disease (PD). The subthalamic nucleus (STN) and globus pallidus interna (GPi) are two targets extensively studied and…
- Trial name
- ADP (NCT04616521)
- Testing
- Deep brain stimulation
- Volunteers
- 1,000 people
- Sponsor
- Ruijin Hospital
Parkinson Disease
Globus Pallidus Stimulation to Treat Insomnia
Researchers are to determine if turning on an additional unilateral DBS (deep brain stimulation) electrode with stimulation to the globus pallidus externa (GPe) region of the brain will improve insomnia (sleep).
- Trial name
- GPS-I (NCT04116996)
- Testing
- DEEP BRAIN STIMULATION
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Mayo Clinic
PD - Parkinson's Disease
Subthalamic Nucleus Versus Globus Pallidal Internus Deep Brain Stimulation for Parkinson Disease
The primary objective of this prospective, multicenter, double-blind, randomized, crossover clinical trial is to evaluate whether Subthalamic Nucleus-Deep Brain Stimulation (STN-DBS) is more effective than Globus Pallidus…
- Trial name
- Superior PD (NCT07250685)
- Testing
- STN-DBS stimulation, GPi-DBS stimulation, STN&GPi-DBS stimulation
- Where
- 8 sites in China
- Volunteers
- 86 people
- Sponsor
- Zhang Jianguo
Huntington Disease
Optimizing Parameters of Low-Intensity Focused Ultrasound for Pallidal Modulation in Huntington's Disease
The purpose of this research study is to determine the optimal pulse repetition frequency of low-intensity focused ultrasound that is safe and effective in improving motor symptoms in patients with Huntington's disease.
- Trial name
- NCT07513844
- Testing
- Low-Intensity Focused Ultrasound Stimulation（LIFU）
- Where
- China
- Volunteers
- 24 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Parkinson Disease, Essential Tremor
Effects of Stimulation Patterns of Deep Brain Stimulation
The purpose of this study is to measure the effects of non-regular temporal patterns of deep brain stimulation (DBS) on motor symptoms and neural activity in persons with Parkinson's disease (PD), essential tremor (ET), dystonia…
- Conditions
- Parkinson Disease, Essential Tremor, Multiple Sclerosis, Dystonia
- Trial name
- NCT02553525
- Testing
- Therapeutic Stimulation Patterns, Symptogenic Stimulation Patterns
- Where
- 3 sites in United States
- Volunteers
- 180 people
- Sponsor
- Duke University
Parkinson&Amp;#39;s Disease, Freezing of Gait
Understanding Freezing of Gait Using Brain Signals and Virtual Reality
Freezing of gait - the inability to start or continue walking - is a particularly disabling problem in Parkinson's disease that has few treatment options.
- Conditions
- Parkinson&Amp;#39;s Disease, Freezing of Gait, Freezing of Gait Symptoms in Parkinson&Amp;#39;s Disease
- Trial name
- NCT07092995
- Testing
- VR Freezing Task, Dual Task, External Cueing
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of California, Los Angeles
Parkinson Disease
ExAblate Pallidotomy for Medically-Refractory Dyskinesia Symptoms or Motor Fluctuations of Advanced Parkinson's Disease
Evaluate the safety and efficacy of unilateral focused ultrasound pallidotomy using the ExAblate 4000 System in the management of dyskinesia symptoms or motor fluctuations for medication refractory, advanced idiopathic…
- Trial name
- NCT03319485
- Testing
- ExAblate Pallidotomy
- Where
- 20 sites in United States, Canada and 6 more
- Volunteers
- 92 people
- Sponsor
- InSightec
Temporal Interference Stimulation, Parkinson's Disease
The Efficacy and Safety of Transcranial Temporal Interference Stimulation (tTIS) Targeting the Right Globus Pallidus Internus (GPi) for Motor Symptoms in Patients With PD
To demonstrate that intervention targeting the right globus pallidus internus (GPi) using transcranial temporal interference stimulation can improve motor symptoms in patients with Parkinson's disease.
- Conditions
- Temporal Interference Stimulation, Parkinson's Disease, the Right Globus Pallidus Internus, Motor Symptoms
- Trial name
- NCT06931483
- Testing
- Transcranial temporal interference stimulation (tTIS)
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Yanghua Tian
Craniofacial Dystonia, Deep Brain Stimulation
Deep Brain Stimulation for Idiopathic Craniofacial Dystonia: GPi or STN
MEIGES is a prospective, multicenter, randomized controlled clinical trial with the primary hypothesis that, STN-DBS is non-inferior to GPi-DBS for motor symptoms improvements at 365 days postoperatively in patients with…
- Trial name
- MEIGES (NCT05416905)
- Testing
- STN-DBS, GPi-DBS
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Beijing Tiantan Hospital
Parkinson Disease, Dystonia
Towards Noninvasive DBS of the Basal Ganglia in Parkinson's Disease Using TUS
Transcranial Ultrasound Stimulation (TUS) is an emerging non-invasive brain stimulation technique capable of targeting both superficial and deep brain areas with high spatial resolution, down to a few cubic millimeters.
- Trial name
- NCT06232629
- Testing
- TUS Active
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- University Health Network, Toronto
Globus Pharyngeus
Bump the Lump - Intervention for the Treatment of Globus Pharyngeus
To develop a standardized speech-language pathology treatment protocol to systematically address Globus pharyngeus (GP) as a proof of concept
- Trial name
- NCT06762444
- Testing
- Speech-language pathologist (SLP) protocol
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Wake Forest University Health Sciences