Clinical trials: Glaucoma and Ocular Hypertension
Glaucoma
SENSIMED Triggerfish Safety and Tolerability
The purpose of this investigation is to study the safety and tolerability of SENSIMED Triggerfish, a soft contact lens-based device intended to continuously record relative changes in intraocular pressure (IOP).
- Trial name
- NCT01319617
- Testing
- SENSIMED Triggerfish
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Sensimed AG
Glaucoma
Study of AR-12286 Versus Latanoprost in Patients With Elevated Intraocular Pressure
A 28 day study of the safety and efficacy of two concentrations of topical AR-12286 in treating ocular hypertension and open-angle glaucoma compared to latanoprost.
- Trial name
- NCT01060579
- Testing
- AR-12286 0.5% ophthalmic solution, AR-12286 0.25% Ophthalmic solution, Latanoprost ophthalmic solution
- Where
- 18 sites in United States
- Volunteers
- 217 people
- Sponsor
- Aerie Pharmaceuticals
Intraocular Pressure, Open Angle Glaucoma
A FIH Trial of the STREAMLINE™ SURGICAL SYSTEM
The purpose of this study is to evaluate the safety and Intraocular pressure lowering effectiveness of the Streamline™ Surgical System.
- Trial name
- NCT04700189
- Testing
- ab interno canaloplasty
- Where
- Mexico
- Volunteers
- 42 people
- Sponsor
- New World Medical, Inc.
Open Angle Glaucoma, Narrow Angles
Comparison of Gonioscopy With Cirrus and Visante
The aim of this study is to analyze similarities and evaluate interchangeability of Visante and Cirrus OCT (optical coherent tomography)and to compare agreement between gonioscopy and the two systems for evaluation of anterior…
- Conditions
- Open Angle Glaucoma, Narrow Angles, Angle Closure Glaucoma
- Trial name
- ASOCT (NCT01895686)
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Wills Eye
Glaucoma
Human Optokinetic Contrast Device (HOCD) to Measure Visual Function and Identify Patients With and Without Glaucoma
The purpose of this study is to determine if an optokinetic contrast detection device is sufficient to measure contrast sensitivity and to distinguish between patients with and without glaucoma.
- Trial name
- HOCD (NCT02014597)
- Testing
- HOCD
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Benjamin Frankfort, MD, PhD
Glaucoma
Bleb Function and Morphology With Intratendon Injection of MMC Compared With Standard Method
Patients with advanced glaucoma that are candidates for trabeculectomy will be included. Thorough ophthalmic examination including best corrected visual acuity, slit lamp examination, intraocular pressure (IOP) measurement…
- Trial name
- conj mmc (NCT02385370)
- Testing
- MMC
- Where
- Iran
- Volunteers
- 126 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
Open-Angle Glaucoma, Ocular Hypertension
Efficacy of Changing to TRAVATAN® From Prior Therapy
The purpose of this study was to assess the efficacy and tolerability of TRAVATAN® Solution without benzalkonium chloride (BAK) in patients previously on latanoprost 0.005% or bimatoprost 0.01% ophthalmic solution monotherapy.
- Trial name
- NCT01493427
- Testing
- Travoprost 0.004%
- Volunteers
- 202 people
- Sponsor
- Alcon Research
Glaucoma
Blood Flow of Ophthalmic Artery and Glaucoma
The main purpose of this project is to investigate the blood flow of the ophthalmic artery (OA) in patients with ocular hypertension, high tension glaucoma and normal tension glaucoma.
- Trial name
- NCT02656979
- Testing
- Latanoprost
- Where
- Sweden
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Umeå University
Glaucoma
Use of Ranibizumab With Mitomycin C During Trabeculectomy
The purpose of the study is to study the safety of the combination of ranibizumab and MMC vs monotherapy MMC vs intravitreal ranibizumab injection in patients with glaucoma.
- Trial name
- OCTOPUS (NCT00661583)
- Testing
- Ranibizumab, Ranibizumab and MMC, MMC
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Colorado, Denver
Glaucoma, Glaucoma, Open-Angle
Dresden Glaucoma and Treatment Study (DGTS)
To assure the quality of follow-up and treatment, data of glaucoma patients are stored and evaluated after anonymisation.
- Conditions
- Glaucoma, Glaucoma, Open-Angle, Glaucoma, Angle-Closure, Glaucoma, Low Tension
- Trial name
- NCT02959242
- Where
- Germany
- Volunteers
- 10,000 people
- Sponsor
- Technische Universität Dresden
Glaucoma
Comparative Study of Ologen Collagen Matrix Versus Mitomycin-C in Glaucoma Filtering Surgery
The objective of this prospective randomised study is to compare the efficacy and safety of ologen CM (Collagen matrix) and Mitomycin-C (MMC) as adjuncts to filtration surgery in uncontrolled treated glaucoma cases, the efficacy…
- Trial name
- MCToCM (NCT01440751)
- Testing
- Use of ologen Collagen Matrix in trabeculectomy (ologen), Use of Mitomycin-C (MMC) in trabeculectomy
- Where
- 8 sites in United States
- Volunteers
- 99 people
- Sponsor
- Aeon Astron Europe B.V.
Glaucoma
Intraluminal Stenting Versus External Ligation of Ahmed Glaucoma Valve
Objectives: To compare the intraluminal stenting and external ligation of Ahmed Glaucoma Valve (AGV) regarding refractory glaucoma management and postoperative hypotony prevention.
- Trial name
- NCT04508881
- Testing
- Ahmed Glaucoma Valve
- Where
- Egypt
- Volunteers
- 1 people
- Sponsor
- Menoufia University
Primary Congenital Glaucoma, Developmental Glaucoma
Comparison of Surgical Treatment Options for Primary Congenital and Developmental Glaucomas
Newborn and children can be affected by two subgroups of this disease: (1) primary congenital glaucoma (PCG) or (2) developmental glaucoma (DG).
- Trial name
- STOP-Glaucoma (NCT04647929)
- Testing
- Santen PRESERFLO MicroShunt, Trabeculectomy
- Sponsor
- University of Zurich
Primary Open Angle Glaucoma
Surgical Approaches in Treating Uncontrolled Glaucoma in Black African and African-Caribbeans
The aim is to perform a randomised feasibility trial preceding a large prospective randomised controlled trial (RCT) comparing three surgical methods - trabeculectomy with Mitomycin C (MMC), primary Baerveldt tube with MMC and…
- Trial name
- PEACE (NCT02989207)
- Testing
- Trabeculectomy, Baerveldt tube surgery, mitomycin-C
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Glaucoma, Open-Angle, Ocular Hypertension
Safety And Efficacy Of Xalatan Delivered Using Either A Conventional Dropper Bottle or A Delivery Device
Compare the antihypertensive efficacy of two methods for instilling Xalatan eyedrops
- Trial name
- NCT00283764
- Testing
- Xalatan
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Glaucoma, Ocular Hypertension
Efficacy and Tolerability of AZARGA® as Replacement Therapy in Patients on COMBIGAN® Therapy in Canada
The purpose of this study was to assess the efficacy and tolerability of changing to AZARGA® from prior brimonidine 0.2%/timolol 0.5% fixed combination (COMBIGAN®) therapy in patients with open-angle glaucoma or ocular…
- Conditions
- Glaucoma, Ocular Hypertension, Open-angle Glaucoma
- Trial name
- NCT01415401
- Testing
- Brinzolamide 1% / timolol 0.5% maleate fixed combination
- Volunteers
- 57 people
- Sponsor
- Alcon Research
Glaucoma
Effect of Kron (Citicoline and Nicotinamide Oral Solution) on Patients With Open-angle Glaucoma
Aim of this study is to investigate the administration effects of the combination of citicoline 40mg/ml and nicotinamide 15mg/ml oral solution (Kron®) on short term improvement in inner retinal function, bioelectrical activity of…
- Trial name
- NCT06333236
- Testing
- Food for Special Medical Purposes: Kron®
- Where
- 2 sites in Italy
- Volunteers
- 30 people
- Sponsor
- ASST Santi Paolo e Carlo
Open-angle Glaucoma, Ocular Hypertension
Examination of Ocular Surface Effects With Administration of Travatan Z and XALATAN
The purpose of this study is to compare two ophthalmic solutions in patients with open-angle glaucoma or ocular hypertension.
- Trial name
- NCT00798759
- Testing
- Travoprost ophthalmic solution 0.004% with SofZia® preservative system (TRAVATAN Z®), Latanoprost ophthalmic solution 0.005% (XALATAN®)
- Volunteers
- 236 people
- Sponsor
- Alcon Research
Retinal Disease, Glaucoma
Optos P200TE Agreement and Precision Study
This study is a prospective comparative, randomized, single center study to assess agreement and precision of the Optos P200TE in comparison to the predicate device in normal subjects, subjects with glaucoma, and subjects with…
- Trial name
- NCT03868462
- Testing
- Optos P200TE, Predicate Device
- Where
- United States
- Volunteers
- 137 people, healthy volunteers welcome
- Sponsor
- Optos, PLC
Glaucoma, Glaucoma, Open-Angle
Prevalence of Glaucoma and Normative Data of Ocular Biometry in Elderly Population in Bangkok
The BANMOP eye study is an ophthalmic subproject of the Bangkoknoi Model Project (BANMOP), a community-based initiative integrating electronic health databases with population surveys to sup-port context-specific health promotion…
- Conditions
- Glaucoma, Glaucoma, Open-Angle, Glaucoma, Suspect, Glaucoma, Angle-Closure
- Trial name
- BANMOP (NCT07763288)
- Where
- Thailand
- Volunteers
- 1,470 people, healthy volunteers welcome
- Sponsor
- Siriraj Hospital
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