Clinical trials: Glaucoma and Ocular Hypertension
Glaucoma
Clinical Effectiveness of Low Vision Rehabilitation in Glaucoma Patients
Our team is interested in what can be done to improve the functioning of patients who suffer from glaucoma, a chronic and irreversible eye disease.
- Trial name
- LOVIT (NCT01262209)
- Testing
- portable CCTV, Telescopes, telemicroscopes and microscopes, Absorptive filters
- Where
- Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Glaucoma
This Study Examines Whether Personality Traits Influence the Frequency or Severity of Ocular Adverse Effects Reported by Patients Using Glaucoma Medications. The Findings May Identify Patients at Greater Risk of Intolerance and Support More Personalized Treatment and Counselling.
The goal of this observational study is to learn whether personality traits are related to eye side effects from glaucoma medications in adults who currently use or previously used these medications.
- Trial name
- Adverse Events (NCT07739784)
- Testing
- No Interventions
- Where
- Canada
- Volunteers
- 352 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Glaucoma, Ocular Hypertension
Comparing Refractive and Visual Outcomes of MIGS and Traditional Surgeries
The primary goal of this study is to evaluate refractive and visual outcomes in glaucoma patients who will be having either traditional glaucoma surgery or minimally invasive glaucoma surgery, also known as MIGS.
- Trial name
- NCT03584958
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Wills Eye
Glaucoma, Congenital Cataract
Glaucoma After Congenital And Infantile Cataract Surgery
Pediatric patients who have undergone surgery for congenital or infantile cataracts have a risk of developing suspected glaucoma and glaucoma, but the current evidence does not address our understanding of the incidence and…
- Trial name
- NCT04131114
- Where
- China
- Volunteers
- 241 people
- Sponsor
- Sun Yat-sen University
Glaucoma
Efficacy and Safety of Non-resorbable Uveoscleral Implant Versus Absorbable Collagen Matrix in Non-perforating Deep Sclerectomy
The aim of the study is to evaluate and compare the hypotensive efficacy at 24 months between non-perforating deep sclerectomy surgery with non-resorbable uveoscleral implant associated with absorbable collagen matrix versus…
- Trial name
- NCT04586738
- Testing
- non-perforating deep sclerectomy surgery
- Where
- 2 sites in Spain
- Volunteers
- 120 people
- Sponsor
- Germans Trias i Pujol Hospital
Graft vs Host Disease, Congenital Aniridia
Safety and Performance Study of the ARGOS-IO System in Patients Undergoing Boston Keratoprosthesis Implantation
The ARGOS-IO pressure sensor is intended to be implanted in the human eye in combination with Boston Keratoprosthesis (BKPro) surgery and to remain in place indefinitely.
- Conditions
- Graft vs Host Disease, Congenital Aniridia, Chemical Burns, Stevens-Johnson Syndrome
- Trial name
- NCT02945176
- Testing
- ARGOS-IO system
- Where
- 2 sites in Germany
- Volunteers
- 13 people
- Sponsor
- Implandata Ophthalmic Products GmbH
Glaucoma
Macular Damage in Early Glaucoma and Progression
Glaucoma is the leading cause of irreversible blindness worldwide. This study aims to test a new method that may allow earlier diagnosis of glaucoma and better ways to monitor if it is getting worse.
- Trial name
- NCT02547740
- Where
- United States
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Columbia University
Open-angle Glaucoma, Ocular Hypertension
Phase 4 Study Comparing IOP Lowering in OAG or OH in Caucasian or Japanese Subjects C-02-32
The purpose of this study is to evaluate safety and efficacy of two different IOP lowering medications after six weeks of treatment in Caucasian and Japanese subjects.
- Trial name
- NCT00047606
- Testing
- IOP Lowering Medications
- Volunteers
- 84 people
- Sponsor
- Alcon Research
Open-angle Glaucoma, Pseudoexfoliation Glaucoma
Vitamin Mix (B6, B9, B12, And Choline) For Glaucoma Patients
This study aims to determine whether a combination of vitamins (B6, B9, B12, and choline) can help protect the eyes of people with glaucoma and slow vision loss.
- Trial name
- IVMGS (NCT06885827)
- Testing
- Vitamin B-mix, Standard Care
- Where
- 2 sites in Sweden
- Volunteers
- 80 people
- Sponsor
- Karolinska Institutet
Glaucoma, Open-Angle
Study of an Interposition Supraciliary Implant in Patients With Open Angle Glaucoma
The purpose of this study is to prolong observational follow-up up to 36 months of patients already implanted with a novel interposition supraciliary implant.
- Trial name
- SAFARI FU (NCT05159817)
- Where
- Armenia
- Volunteers
- 19 people
- Sponsor
- Ciliatech
Open-angle Glaucoma
Safety and Efficacy of the GTS400 Stent in Conjunction With Cataract
To evaluate the safety and efficacy of the Glaukos Trabecular Micro-Bypass Stent Model GTS400 in conjunction with cataract surgery, compared to cataract surgery only, in subjects with mild to moderate open angle glaucoma.
- Trial name
- NCT00721968
- Testing
- Glaucoma Stent Surgery (GTS400 Stent), cataract surgery alone
- Volunteers
- 62 people
- Sponsor
- Glaukos Corporation
Cataract, Glaucoma
Evaluation of the Safety and Efficacy of the Bimatoprost Implant System Used in Combination With the SpyGlass IOL Compared to Timolol Ophthalmic Solution (Rhone)
This trial is a randomized study to evaluate the Bimatoprost Implant System used in combination with the SpyGlass IOL to Timolol Ophthalmic Solution in participants with mild to moderate open-angle glaucoma or ocular hypertension…
- Conditions
- Cataract, Glaucoma, Ocular Hypertension
- Trial name
- NCT07218796
- Testing
- Bimatoprost Implant System, SpyGlass IOL, Timolol Maleate Ophthalmic Solution, 0.5%
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- SpyGlass Pharma, Inc.
Primary Open Angle Glaucoma, Primary Angle Closure Glaucoma
Malay Glaucoma Eye Study II Navigation, Mobility and Reading Ability in Primary Glaucoma
With the improvement of health system, the life span of Asians has increased tremendously especially in Malaysia. As an early preparation to be an 'aging country' in 2023, Malaysia needs to prepare infrastructure and policy to…
- Trial name
- MaGESII (NCT04736264)
- Testing
- Visual rehabilitation module: navigation and mobility, Visual rehabilitation module: exercise, Visual rehabilitation module: reading
- Where
- Malaysia
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia
Glaucoma, Canaloplasty
Trabeculectomy Versus Canaloplasty
Study aims for comparison of trabeculectomy and canaloplasty, in order to find out if one operation is superior to the other. Both procedures are performed in patients with medically uncontrolled open-angle glaucoma.
- Conditions
- Glaucoma, Canaloplasty, Trabeculectomy
- Trial name
- TVC (NCT01228799)
- Testing
- trabeculectomy, Canaloplasty
- Where
- Germany
- Volunteers
- 64 people
- Sponsor
- University Eye Hospital, Würzburg
Healthy Eyes, Eye Diseases
Triton Agreement and Precision Study
To Compare the agreement and precision between the Topcon DRI OCT Triton and the 3D OCT-1 Maestro with RDB.
- Trial name
- NCT03080714
- Testing
- Topcon DRI OCT Triton (plus), 3D OCT-1 Maestro
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Topcon Medical Systems, Inc.
Cataract, Glaucoma, Open-Angle
Phaco-UCP Versus Phaco Alone for OAG and Cataract
This study was carried out to evaluate the safety and efficacy of combined phacoemulsification and Ultrasound ciliary plasty (Phaco-UCP) as a first-line surgical treatment of coexisting cataract and op /en angle glaucoma compared…
- Trial name
- NCT04430647
- Testing
- combined phacoemulsification and ultrasound ciliary plasty (Phaco-UCP), Phacoemulsification alone
- Where
- Egypt
- Volunteers
- 61 people
- Sponsor
- Ameera Gamal Abdelhameed
Retinitis Pigmentosa, Maculopathy, Age Related
Bimodal and Coaxial High Resolution Ophtalmic Imaging
The knowledge of the pathogenesis of retinal affections, a major cause of blindness, has greatly benefited from recent advances in retinal imaging.
- Conditions
- Retinitis Pigmentosa, Maculopathy, Age Related, Macular Dystrophy, Macular Edema
- Trial name
- AOSLO-OCT (NCT04620876)
- Testing
- Bimodal high resolution imaging of the retina
- Where
- France
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts
Glaucoma
Serum Citrate in Diagnosis and Follow-up for Glaucoma
Glaucoma might be a mitochondria associated disease. Since citrate is a major component in mitochondrial metabolism its determination in blood might serve as a biomarker.
- Trial name
- NCT00804063
- Testing
- drawing blood sample
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Open-Angle Glaucoma, Ocular Hypertension
To Investigate the Safety and Efficacy of DE-104 Ophthalmic Solution to Treat Open-Angle Glaucoma or Ocular Hypertension
To investigate the intraocular pressure (IOP)-lowering effect and safety of DE-104 ophthalmic solution in patients with Primary Open-Angle Glaucoma or Ocular Hypertension
- Trial name
- NCT00656240
- Testing
- DE-104 ophthalmic solution, DE-104 vehicle
- Where
- Japan
- Sponsor
- Santen Pharmaceutical Co., Ltd.
Glaucoma
Ologen (OculusGen)-Glaucoma MMC Control Trial in India
The purpose of this study is to compare the safety and effectiveness of the ologen (OculusGen) Biodegradable Collagen Matrix Implant and the MMC group in filtration surgery.
- Trial name
- NCT00449098
- Testing
- OculusGen Biodegradable Collagen Matrix Implant, Trabeculectomy with MMC
- Where
- India
- Volunteers
- 40 people
- Sponsor
- Pro Top & Mediking Company Limited
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