Clinical trials: Glaucoma Secondary
Primary Open Angle Glaucoma, Secondary Open Angle Glaucoma
Early Diagnosis, Pathogenesis and Progression of Open Angle Glaucoma
The Erlangen Glaucoma Registry is a clinical registry for cross sectional and longitudinal observation of patients with open angle glaucoma (OAG) or glaucoma suspect, founded in 1991.
- Conditions
- Primary Open Angle Glaucoma, Secondary Open Angle Glaucoma, Ocular Hypertension
- Trial name
- NCT00494923
- Where
- Germany
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Primary Open Angle Glaucoma, Secondary Open Angle Glaucoma
Protective Effect of Phenytoin on Glaucoma
since glaucoma is considered an optic neuropathy, new treatments for glaucoma are being continuously investigated, including neuroprotection.
- Conditions
- Primary Open Angle Glaucoma, Secondary Open Angle Glaucoma, Narrow-Angle Glaucomas, Normal Tension Glaucoma
- Trial name
- NCT00739154
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Rabin Medical Center
Glaucoma, Open-Angle
A Prospective Evaluation of Glaucoma Subjects Treated With Two Second Generation iStents and One iStent Supra
Prospective Evaluation of Open-Angle Glaucoma Subjects treated with two second generation iStents and one iStent Supra
- Trial name
- GCF-041 (NCT03255798)
- Testing
- G2 and G3
- Where
- Germany
- Volunteers
- 7 people
- Sponsor
- Glaukos Corporation
Open Angle Glaucoma
Comparison of Efficacy Between Silicone Ahmed Glaucoma Valves and Second Trabeculectomy in Glaucoma Patients
In the management of open angle glaucoma, frequently more then one procedure is necessary to control the intra ocular pressure. There is still no consensus whether this second intervention should be a second trabeculectomy or a…
- Trial name
- NCT00665756
- Testing
- second Trabeculectomy, Ahmed Implant
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Federal University of São Paulo
Intraocular Pressure, Neovascular Glaucoma
Aflibercept as Adjunctive Treatment for Filtration Surgery in Neovascular Glaucoma
Purpose: To investigate intravitreal aflibercept (IVA) injection as an adjunctive treatment to trabeculectomy with mitomycin C (TMC) and panretinal photocoagulation (PRP) for neovascular glaucoma (NVG).
- Conditions
- Intraocular Pressure, Neovascular Glaucoma, Vascular Endothelial Growth Factor Overexpression, Glaucoma Secondary to Eye Inflammation
- Trial name
- NCT04970251
- Testing
- Aflibercept Ophthalmic
- Where
- Thailand
- Volunteers
- 5 people
- Sponsor
- Siriraj Hospital
Lens Implantation, Intraocular
Incidence of Glaucoma-related Adverse Events in Pediatric Secondary Intraocular Lens Implantation
To compare the incidence of glaucoma-related adverse events of in-the-bag versus ciliary-sulcus-fixed secondary intraocular lens (IOL) implantation in pediatric aphakia
- Trial name
- NCT05136950
- Testing
- Secondary in-the-bag IOL fixation, Secondary ciliary sulcus IOL fixation
- Where
- China
- Volunteers
- 228 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Glaucoma, Open-Angle, Glaucoma Secondary
The Outcome of Ahmed Glaucoma Valve in Difficult Glaucoma Cases
The clinical difference (mean IOP, success rate, and complications) on using S2 and FP7 models of Ahmed Glaucoma Valve that had similar dimensions and different materials used for their construction in one year follow up was…
- Conditions
- Glaucoma, Open-Angle, Glaucoma Secondary, Glaucoma, Neovascular
- Trial name
- NCT04214847
- Testing
- Ahmed Glaucoma Valve surgery
- Volunteers
- 1 people
- Sponsor
- Ain Shams University
Glaucoma Secondary
Pars Plana Ex-Press Shunt in Vitrectomized Eyes
Implantation of Ex-Press Minishunt via the pars plana in treatment of secondary glaucoma in vitrectomized eyes achieves promising results avoiding complications of other surgical modalities.
- Trial name
- NCT03605823
- Testing
- Express Mini shunt
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Cairo University
Glaucoma, Open-Angle, Glaucoma Secondary
Baerveldt (BGI) Valve Versus Ahmed(AGV) Valve in Management of Difficult Glaucoma Cases
Refractory glaucoma is a difficult subject as many glaucoma devices attempt to reduce IOP. Baerveldt implant is considered as a large implant, and, on the contrary, Ahmed implant is considered a small implant as many comparisons…
- Conditions
- Glaucoma, Open-Angle, Glaucoma Secondary, Glaucoma, Neovascular, Glaucoma, Angle-Closure
- Trial name
- NCT04215575
- Testing
- glaucoma implant procedure (Baerveldt), glaucoma implant procedure (Ahmed)
- Volunteers
- 81 people
- Sponsor
- Ain Shams University
Glaucoma, Open-Angle, Glaucoma, Angle-Closure
Keratometric Change After XEN, Trabeculectomy and Tube Shunts
The main goal of this study is to assess the severity of postoperative corneal astigmatism induced by implantation of the XEN Gel Stent compared to that induced by traditional filtering surgery (trabeculectomy and GDDs).
- Conditions
- Glaucoma, Open-Angle, Glaucoma, Angle-Closure, Glaucoma Secondary, Glaucoma Eye
- Trial name
- Topo-XEN (NCT04602923)
- Testing
- Corneal topography: OPD-Scan, Corneal topography: Pentacam
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Open Angle Glaucoma
Two Second-Generation Trabecular Micro-bypass Stents to Treat Glaucoma Subjects on One Hypotensive Medication
This study objective is to evaluate the intraocular pressure (IOP) lowering effect of two trabecular micro-bypass stents (iStent inject) in eyes of subjects with primary open-angle glaucoma on one topical hypotensive medication
- Trial name
- NCT02868190
- Testing
- Two trabecular micro-bypass stents (iStent inject)
- Where
- Armenia
- Volunteers
- 57 people
- Sponsor
- Glaukos Corporation
Glaucoma, Primary Open Angle Glaucoma
Ahmed Glaucoma Valve Surgery With Mitomycin-C
This study will determine the effectiveness of Mitomycin-C use in the glaucoma surgery Ahmed valve implantation. Approximately 100 patients will be enrolled, with half receiving the Mitomycin-C treatment and the other half…
- Conditions
- Glaucoma, Primary Open Angle Glaucoma, Secondary Glaucoma, Neovascular Glaucoma
- Trial name
- AMCT (NCT02805257)
- Testing
- Mitomycin-C, Balanced Salt Solution, Ahmed Glaucoma Valve Implant
- Where
- 4 sites in United States, China and 2 more
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Glaucoma Following Pediatric Cataract Surgery, Glaucoma Secondary
Glaucoma Following Pediatric Cataract Surgery
The purpose of this study is to report the incidence and related risk factors glaucoma following cataract surgery (GFCS). and to provide evidence-based evidence for the development of standardized follow-up methods or diagnosis…
- Conditions
- Glaucoma Following Pediatric Cataract Surgery, Glaucoma Secondary, Congenital Cataract
- Trial name
- NCT05451745
- Volunteers
- 819 people
- Sponsor
- Sun Yat-sen University
Glaucoma Secondary
Treatment of Malignant Glaucoma by Anterior Vitrectomy From Two Different Approaches
To compare the surgical outcomes of treating phacoemulsification with intraocular lens implantation combined with goniosynechialysis (Phaco-IOL-GSL) associated malignant glaucoma (MG), using different incision sites in anterior…
- Trial name
- NCT04172857
- Testing
- anterior vitrectomy combined with hyaloidotomy, zonulectomy and iridectomy
- Volunteers
- 9 people
- Sponsor
- Wenzhou Medical University
Refractory Primary Open Angle Glaucoma
Re-Trabeculectomy Versus Ahmed Glaucoma Valve Implantation in Secondary Surgical Management of Patients With Refractory Glaucoma
The purpose of this study is to compare three-year outcomes of re-trabeculectomy with those of Ahmed glaucoma valve implantation in secondary surgical management of patients with primary open angle glaucoma (POAG) and a history…
- Trial name
- NCT01633775
- Testing
- Implantation of Ahmed glaucoma tube shunt, and Trabeculectomy with MMC
- Where
- 3 sites in Iran
- Volunteers
- 100 people
- Sponsor
- Vanak Eye Surgery Center
Glaucoma Open-Angle, Glaucoma Eye
INTEGRAL Study: A Longitudinal Study of Surgeries and Lasers in Glaucoma: Long-term Results and Success Predictors Analysed From a Large-scale Retrospective and Prospective Glaucoma Register
The study is an observational analysis of patients' medical data recorded in a large-scale register, both retrospective (for patients operated and data recorded before 2018) and prospective (for data collected after 2018) in…
- Conditions
- Glaucoma Open-Angle, Glaucoma Eye, Glaucoma; Drugs, Glaucoma, Angle-Closure
- Trial name
- NCT04381611
- Where
- Switzerland
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- Dr. Kaweh Mansouri
Glaucoma Secondary, Congenital Cataract
Quantitatively Analysis of Fundus Structure Characteristics in Glaucoma Following Congenital Cataract Surgery
To quantitatively analyze the fundus structure and microvascular characteristics of GFCS and non-GFCS (NGFCS) using optical coherence tomography angiography (OCTA), to explore the vascular-structural association, and to assess…
- Trial name
- NCT05446077
- Where
- China
- Volunteers
- 129 people
- Sponsor
- Sun Yat-sen University
Primary Open Angle Glaucoma, Secondary Open Angle Glaucoma Due to PEX
Contrast Sensitivity in Glaucoma
The primary aim of the Erlangen´s Glaucoma Contrast Sensitivity-Study (EGCS-Study) is the evaluation of the diagnostic and prognostic validity of a diagnostic procedure, measuring contrast sensitivity.
- Trial name
- NCT00947869
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg
Glaucoma, Angle-Closure
Outcome of GATT Combined With Goniosynechiolysis in Glaucoma Patients With Secondary Synechial Angle Closure.
To evaluate the intraocular pressure reduction effect of combined gonioscopy-assisted transluminal trabeculotomy (GATT) with goniosynechialysis in eyes with secondary synechial angle closure glaucoma.
- Trial name
- NCT06445634
- Testing
- Gonioscopy-Assisted Transluminal Trabeculotomy Combined with Goniosynechiolysis
- Where
- Egypt
- Volunteers
- 23 people
- Sponsor
- Kasr El Aini Hospital
Coronary Artery Disease, Glaucoma
Prospective Electronic Polygenic Risk Study - Second Phase
This study will investigate the role of polygenic risk scores (PRS) in preventive health.
- Trial name
- PEPRS2 (NCT05175651)
- Testing
- Genetic risk assessment
- Volunteers
- 10,000 people
- Sponsor
- Scripps Translational Science Institute