Clinical trials: Glaucoma; Drugs
Glaucoma
This Study Examines Whether Personality Traits Influence the Frequency or Severity of Ocular Adverse Effects Reported by Patients Using Glaucoma Medications. The Findings May Identify Patients at Greater Risk of Intolerance and Support More Personalized Treatment and Counselling.
The goal of this observational study is to learn whether personality traits are related to eye side effects from glaucoma medications in adults who currently use or previously used these medications.
- Trial name
- Adverse Events (NCT07739784)
- Testing
- No Interventions
- Where
- Canada
- Volunteers
- 352 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Graft vs Host Disease, Congenital Aniridia
Safety and Performance Study of the ARGOS-IO System in Patients Undergoing Boston Keratoprosthesis Implantation
The ARGOS-IO pressure sensor is intended to be implanted in the human eye in combination with Boston Keratoprosthesis (BKPro) surgery and to remain in place indefinitely.
- Conditions
- Graft vs Host Disease, Congenital Aniridia, Chemical Burns, Stevens-Johnson Syndrome
- Trial name
- NCT02945176
- Testing
- ARGOS-IO system
- Where
- 2 sites in Germany
- Volunteers
- 13 people
- Sponsor
- Implandata Ophthalmic Products GmbH
Open-angle Glaucoma, Ocular Hypertension
Phase 4 Study Comparing IOP Lowering in OAG or OH in Caucasian or Japanese Subjects C-02-32
The purpose of this study is to evaluate safety and efficacy of two different IOP lowering medications after six weeks of treatment in Caucasian and Japanese subjects.
- Trial name
- NCT00047606
- Testing
- IOP Lowering Medications
- Volunteers
- 84 people
- Sponsor
- Alcon Research
Glaucoma; Drugs
Evaluation of Adherence to Clinical Treatment of Glaucoma
Evaluation of adherence to clinical treatment of glaucoma in patients of a Reference Ophthalmological Hospital in Goiânia using Morisky Adhesion scale as a validated questionary.
- Trial name
- NCT03338088
- Where
- 2 sites in Brazil
- Volunteers
- 150 people
- Sponsor
- Instituto de Olhos de Goiania
Glaucoma
Effects of Anti-Glaucoma Medications on the Ocular Surface
The purpose of the study is to compare the efficacy of FDA-approved Travoprost (Travatan Z) and Latanoprost (Xalatan)as anti-glaucoma treatment.
- Trial name
- BAK (NCT01315574)
- Testing
- Travoprost, Latanoprost
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Massachusetts Eye and Ear Infirmary
Glaucoma, Ocular Surface Disease
Ocular Surface Disease in Glaucoma Patients on Long-Term Therapy
This cross-sectional study aims to determine the prevalence and severity of ocular surface disease among adult patients with glaucoma receiving long-term topical antiglaucoma medications.
- Conditions
- Glaucoma, Ocular Surface Disease, Dry Eye
- Trial name
- NCT07841912
- Volunteers
- 55 people
- Sponsor
- Assiut University
Glaucoma, Dry Eye Syndrome
Eye Drop Use in Glaucoma Patients Through Patient Surveys and Video Observations
This study will be used to evaluate how patients put eye drops in their eyes and any problems that may arise from this activity.
- Conditions
- Glaucoma, Dry Eye Syndrome, Conjunctivitis
- Trial name
- NCT00522600
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Robin, Alan L., M.D.
Open-Angle Glaucoma, Ocular Hypertension
Safety and Efficacy of a New Ophthalmic Formulation of Bimatoprost in Patients With Open Angle Glaucoma and Ocular Hypertension
This study will evaluate the safety and efficacy of new ophthalmic formulations of bimatoprost in patients with open angle glaucoma and ocular hypertension.
- Trial name
- NCT01157364
- Testing
- bimatoprost 20 µg generation 2, bimatoprost 15 µg generation 2, bimatoprost 10 µg generation 2
- Where
- 57 sites in United States, Australia and 8 more
- Volunteers
- 109 people
- Sponsor
- Allergan
Glaucoma
Steroids and/ or Non-steroidal Anti-inflammatory Drugs in the Postoperative Regime After Trabeculectomy.
PURPOSE: Glaucoma is the leading cause of non-curable blindness globally. Patients with glaucoma will get a gradual narrowing of the visual fields caused by compression at the optic nerve head due to increased intraocular…
- Trial name
- SNAP (NCT04054830)
- Testing
- Voltaren Ophtha 1 mg/ml, GSK, Monopex 1 mg/ml, Théa
- Where
- Denmark
- Volunteers
- 70 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Primary Open Angle Glaucoma (POAG)
iStent Inject in OAG Subjects on 2 Pre-op Topical Ocular Hypotensive Medications
The purpose of this study is to evaluate the intraocular pressure (IOP) lowering effect of iStent inject in eyes of subjects with primary open-angle glaucoma previously on two anti-glaucoma medications.
- Trial name
- NCT03478293
- Testing
- iStent inject surgery
- Where
- Brazil
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Glaukos Corporation
Glaucoma, Open Angle or Ocular Hypertension
Therapeutic Equivalence Study of Generic Brinzolamide vs Azopt
The main purpose of this prospective study is to demonstrate the therapeutic equivalence of topical brinzolamide compared with AzoptTM
- Trial name
- NCT03896633
- Testing
- brinzolamide 1% ophthalmic suspension, Azopt 1%
- Where
- United States
- Volunteers
- 637 people
- Sponsor
- Bausch & Lomb Incorporated
Glaucoma
Compliance and Administration Technique in Topical Drug Therapy of Glaucoma
Clinic-based evaluation of patients compliance with topical medications in the treatment of glaucoma. Also assessing effectiveness of delivery techniques among these patients.
- Trial name
- NCT00303121
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- University of Toronto
Glaucoma, Ocular Hypertension
Survey of Patients Taking IOP-Lowering Eye Drops
Survey to assess perspectives of patients prescribed IOP-lowering eye drops at a single office visit.
- Trial name
- NCT02384772
- Testing
- Survey
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- ForSight Vision5, Inc.
Glaucoma, Ocular Surface Disease
Treatment of Ocular Discomfort in Glaucoma Patients Using Multiple Topical Medications
To evaluate glaucoma patients' response to treatment with Xiidra, an FDA-approved drug for ocular surface discomfort, which will be prescribed as standard of care treatment.
- Trial name
- NCT04354545
- Testing
- Xiidra (Lifitegrast ophthalmic solution) 5%
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Drug Effect (Glaucoma Drugs)
Pupillary Response After Glaucoma Medication
Investigation of the effect on the pupillary constriction by latanoprost, dorzolamide,timolol in healthy subjects. The pupillary constriction is compared to no drug.
- Trial name
- pupil (NCT02522039)
- Testing
- Latanoprost, Timolol, Dorzolamide
- Where
- Denmark
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Glostrup University Hospital, Copenhagen
Glaucoma
The Effect of Education on Patient Compliance
With patient education, the compliance with glaucoma medications will increase.
- Trial name
- NCT00376974
- Testing
- American Academy of Ophthalmology Glaucoma Educational Tape
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Michael E. DeBakey VA Medical Center
Glaucoma and Ocular Hypertension, Diabetic Macular Edema
Effect of Dexamethasone Implant on Optic Disc
This study evaluates the effect of dexamethasone implant which is an intraocular corticosteroid on the optic nerve fibers. Retinal nerve fiber thicknesses and optic nerve head pitting rates were measured before and 6 months after…
- Conditions
- Glaucoma and Ocular Hypertension, Diabetic Macular Edema, Intravenous Drug Usage, Optic Disk Disorders
- Trial name
- NCT03927118
- Testing
- intravitreal dexamethasone implant application
- Where
- Turkey (Türkiye)
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Bulent Ecevit University
Glaucoma
Development and Implementation of an Educational Program to Enhance Adherence to Glaucoma Treatment
This study evaluates the addition of an educational intervention program in order to improve medication adherence in glaucoma patients.
- Trial name
- NCT04245163
- Testing
- Educational program
- Where
- Cyprus
- Volunteers
- 40 people
- Sponsor
- Cyprus University of Technology
Open-angle Glaucoma
Two Trabecular Micro-bypass Stents & Postoperative Travoprost to Treat Glaucoma Subjects on Two Hypotensive Agents
The study objective was to evaluate the intraocular pressure (IOP) lowering effect of two iStent devices in eyes of subjects with primary open-angle glaucoma, washed out of two anti-glaucoma medications (one a Prostaglandin)…
- Trial name
- NCT02873806
- Testing
- Implantation of two iStent inject micro-bypass stents, Topical travoprost, Two iStent inject micro-bypass stents
- Where
- Armenia
- Volunteers
- 53 people
- Sponsor
- Glaukos Corporation
Glaucoma, Open-Angle, Ocular Hypertension
Safety and Efficacy of a Glaucoma Drug Delivery System
The purpose of this study is to evaluate the ocular safety and efficacy of a glaucoma drug delivery system in open-angle glaucoma or ocular hypertension.
- Trial name
- NCT00824720
- Testing
- High Dose Device, Low Dose Device
- Where
- 4 sites in United States
- Volunteers
- 55 people
- Sponsor
- Vistakon Pharmaceuticals