Clinical trials: Gingivitis
Gingivitis, Plaque
A Twelve Week Study of Experimental Mouth Rinses
The purpose of this study is to evaluate the safety and efficacy of experimental mouth rinse formulations compared to a hydroalcohol control mouth rinse and a positive control mouth rinse for the reduction of gingivitis and…
- Trial name
- NCT05120141
- Testing
- Colgate Cavity Protection Toothpaste, American Dental Association (ADA) Ref Toothbrush, Prototype 1 Mouth Rinse
- Where
- Canada
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Consumer Inc. (J&JCI)
Dental Plaque
Plaque Removal Efficacy of a U-Shaped Sonic Power Toothbrush in Children
The objective of this single-use, examiner blinded, randomized, two-period, cross-over, IRB-approved clinical study is to evaluate the safety and plaque removal efficacy of AutoBrush®, a new children's 360° sonic toothbrush…
- Trial name
- NCT06300073
- Testing
- Experimental: U-shaped Power Toothbrush
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Lander Enterprises, LLC
Dental Plaque
Effect of Enzymes on Dental Biofilm Accumulation in Healthy Individuals
The purpose of the study is to assess the effect of enzyme containing lozenges on dental plaque accumulation in healthy adults.
- Trial name
- NCT05082103
- Testing
- Enzyme lozenge 1, Enzyme lozenge 2
- Where
- Denmark
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Novozymes A/S
Gingivitis, Plaque
Six Week Study of Experimental Mouth Rinses: Effect on Gingivitis and Plaque
The purpose of this study is to evaluate the safety and efficacy of experimental mouth rinse formulations compared to a positive control mouth rinse and a hydroalcohol control mouth rinse for the reduction of gingivitis and…
- Trial name
- NCT04921371
- Testing
- Colgate® Cavity Protection Toothpaste, Listerine® Cool Mint®, Concept Curve Winter Series Toothbrush
- Where
- United States
- Volunteers
- 157 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Consumer Inc. (J&JCI)
Dental Plaque, Gingivitis
A Study to Evaluate the Efficacy of a Stannous Fluoride Toothpaste With a Cetylpyridinium Chloride Mouthwash in Improving Gingival Health and Reducing Plaque Accumulation
The aim of this study is to assess the ability of a marketed Cetylpyridinium Chloride (CPC) mouthwash alongside a marketed Stannous Fluoride (SnF2) toothpaste in improving gingival health and reducing plaque accumulation…
- Trial name
- NCT06660069
- Testing
- Stannous Fluoride Toothpaste (Parodontax Complete Protection Toothpaste), CPC Mouthwash (Parodontax Active Gum Health Mouthwash), Regular Fluoride Toothpaste (Crest Cavity Protection)
- Where
- United States
- Volunteers
- 199 people, healthy volunteers welcome
- Sponsor
- HALEON
Gingivitis, Plaque, Dental
Investigation of Clinical Efficacy of a New Mouthwash on Reducing Dental Plaque and Helping Prevent Gum Problems as Compared to a Control Mouthwash
Qualified subjects will be enrolled and randomized to either one of the two study groups described above based on their initial modified gingivitis and plaque scores.
- Trial name
- NCT07263698
- Testing
- cetylpyridinium chloride (CPC), zinc lactate and sodium fluoride Mouthwash, sodium fluoride Mouthwash
- Where
- Italy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Gingivitis
An Efficacy Study of Chlorhexidine Mouthwashes
The aim of this study is to compare subject gingival health after 6 weeks of twice daily use of a non-alcohol or alcohol containing mouthrinse and brushing compared to brushing only.
- Trial name
- NCT01751178
- Testing
- Chlorhexidine Digluconate Mouthwash with Alcohol, Chlorhexidine Digluconate Mouthwash without Alcohol
- Where
- 3 sites in United Kingdom
- Volunteers
- 324 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Dental Calculus
Testing if Tartarase Can Remove Dental Tartar
This study was designed to find our whether a novel toothpaste containing safe digestive enzymes (Tartarase) was able to remove pre-existing dental tartar when compared to a well-known toothpaste (Crest).
- Trial name
- NCT06139835
- Testing
- Tartarase
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Pontis Biologics, Inc.
Plaque, Gingivitis
Determination of the Safety and Efficacy of a Novel Oral Rinse on Oral Health
Since over 50% of the US population have gingivitis, mouthrinses serve as a valuable adjunct to brushing and flossing. The primary objective is to determine the effectiveness of the oral rinse in reducing plaque and gingivitis…
- Trial name
- NCT04197427
- Testing
- Experimental Oral Rinse
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- You First Services
Dental Plaque, Gingivitis
A Study to Investigate the Efficacy of an Experimental Dentifrice Containing Stannous Fluoride in Improving Gingival Health
The aim of this study will be to evaluate the ability of using an experimental dentifrice containing 0.454 percent (%) weight for weight (w/w) Stannous Fluoride (SnF2) to reduce gingivitis and plaque accumulation, compared with a…
- Trial name
- NCT07704905
- Testing
- Test Dentifrice, Reference Dentifrice (Colgate Cavity Protection Dentifrice)
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- HALEON
Plaque, Gingivitis
A Pilot Study to Evaluate a Molecular Method for Plaque
This study is to evaluate the sensitivity of the molecular method and its ability to split a stannous fluoride toothpaste versus a negative control.
- Trial name
- NCT02574221
- Testing
- stannous fluoride toothpaste, cavity protection toothpaste
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Procter and Gamble
Gingivitis, Plaque
Self-selection Study of the Toothwave Toothbrush
This study objective is to test the Silk'n Toothwave self-selection, by potential end users. Additionally, this study will evaluate if contraindicated subjects will self-exclude from use of the device and the ability to…
- Conditions
- Gingivitis, Plaque, Calculus, Tooth Discoloration
- Trial name
- NCT04023097
- Testing
- Toothwave toothbrush
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Home Skinovations Ltd.
Gingivitis, Plaque, Dental
Gingivitis Reduction After Use of 0.45% Stannous Fluoride Toothpaste
The 6-month clinical study was designed to investigate clinical efficacy on plaque and gingivitis for the stannous fluoride containing toothpaste (SNAP) compared to Colgate Cavity Protection Toothpaste after 3 and 6 months of…
- Trial name
- NCT06300866
- Testing
- Test, Control
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Plaque, Gingivitis
Clinical Evaluation of the Efficacy of a Marketed Dentifrice on Plaque and Gingivitis
Parallel, double blind, randomized, Institutional Review Board (IRB) -approved study involving approximately 160 subjects to complete.
- Trial name
- NCT03214406
- Testing
- Arm & Hammer Advance White Brilliant Sparkle (Test product), Crest Cavity Protection Regular Toothpaste (Negative Control)
- Where
- Canada
- Volunteers
- 181 people, healthy volunteers welcome
- Sponsor
- Church & Dwight Company, Inc.
Plaque, Gingivitis
Study to Investigate Toothpaste on Antibacterial Effects in the Different Regions of the Mouth
The clinical study will examine the effects of brushing with randomly assigned test toothpaste on the bacteria on the dental plaque, tongue, cheek, gum surface, and in saliva
- Trial name
- NCT07458464
- Testing
- stannous fluoride toothpaste, 0.76% Sodium Monofluorophosphate (Na MFP) toothpaste
- Where
- 2 sites in Thailand
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Gingivitis
Clinical Investigation of a Toothpaste Containing Stannous Fluoride as Compared to Colgate Fluoride Toothpaste
The objective of this study is to evaluate the clinical efficacy of a toothpaste containing stannous fluoride as compared to Colgate Fluoride Toothpaste in reducing plaque and gingivitis - a three- month study.
- Trial name
- CP_Total (NCT04033575)
- Testing
- Colgate Total SF, Colgate Cavity Protection toothpaste
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Gingivitis, Periodontal Disease
Rapid Point-of-Care Salivary Diagnostic for Periodontal Health
The purpose of this study is to learn if a chair-side testing device will accurately measure levels of a salivary biomarker and thus indicate if a patient has periodontal health, gingivitis or periodontal disease.
- Trial name
- NCT02403297
- Testing
- Quik Check PD
- Where
- United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Innovative Diagnostics Inc
Dental Plaque, Gingivitis
A Study Investigating Gingival Crevicular Fluid Biomarkers Following Use of a Commercially Available Toothpaste Containing Stannous Fluoride
The aim of this study is to evaluate the feasibility, sensitivity, and interpretability of gingival crevicular fluid (GCF) cytokine biomarkers as early indicators of tissue recovery following use of commercial dentifrice compared…
- Trial name
- NCT07842042
- Testing
- Test Toothpaste, Regular Fluoride Toothpaste
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- HALEON
Dental Plaque and Gingivitis
The Clinical Investigation of a Zinc Based Toothpaste in Reducing Plaque and Gingivitis
This is a six (6) month, double-blind, parallel, controlled clinical trial utilizing one hundred and sixty (160) adults to evaluate the reduction of dental plaque and gingivitis.
- Trial name
- NCT02243046
- Testing
- Control toothpaste, Experimental toothpaste, Active Comparator
- Where
- Dominican Republic
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Gingivitis, Dental Plaque
A Clinical Study Investigating the Effects of a Dentifrice Containing 67% Sodium Bicarbonate When Used Twice Daily for 12 Weeks on Gingivitis Treatment and Plaque Removal
The main goal of this study is to evaluate and compare the efficacy of an on-market dentifrice containing 67 percent (%) sodium bicarbonate and 0.31% sodium fluoride to a reference regular fluoride dentifrice on treating gingival…
- Trial name
- NCT05654662
- Testing
- Corsodyl Original Dentifrice, Colgate Cavity Protection Dentifrice
- Where
- United Kingdom
- Volunteers
- 197 people, healthy volunteers welcome
- Sponsor
- HALEON