Clinical trials: Gingivitis; Chronic
Periodontitis
PerioWave Re-Treatment Protocol Compared to Scaling and Root Planing (SRP) and a Single Treatment With PerioWave
This is a pivotal, prospective, randomized, blinded, multicenter study to evaluate two treatments of photodynamic disinfection in adults with chronic periodontal disease.
- Trial name
- NCT00336661
- Testing
- PerioWave
- Where
- 2 sites in China
- Volunteers
- 105 people
- Sponsor
- Ondine Research Laboratories
Periodontal Diseases, Periodontitis
HALP Score, Blood-Based Inflammatory Indices, and Salivary MMP-8 in Periodontal Disease and Healing After Non-Surgical Therapy
This observational clinical study aims to investigate the relationship between the HALP score (Hemoglobin × Albumin × Lymphocyte / Platelet), several blood-based inflammatory indices (including NLR, PLR, LMR, and SII), and…
- Conditions
- Periodontal Diseases, Periodontitis, Gingivitis; Chronic
- Trial name
- NCT07312045
- Testing
- Non-surgical Periodontal Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Ömer Faruk Okumuş
Gingival Diseases, Gingivitis
Acquired Chronic Erosive Gingivitis: Clinical Relevance of Papillary Gingival Biopsy
Chronic erosive gingivitis is a syndrome (CEGS) that combines severe gingival inflammation and gingival erosion. The term "desquamative gingivitis" is often used in the literature to define chronic erosive gingivitis.
- Conditions
- Gingival Diseases, Gingivitis, Autoimmune Diseases, Oral Lichen Planus
- Trial name
- NCT04293718
- Testing
- papillary gum biopsies
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Gingivitis; Chronic
Zinc Stents for the Treatment of Gingivitis
Background This study investigates the effects of zinc-containing stents on gingival inflammation, bleeding, and plaque regrowth in gingivitis patients.
- Trial name
- NCT06888440
- Testing
- scaling and zinc stents
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Cukurova University
Chronic Peridontitis Patients, Chronic Gingivitis
Effect of Non-surgical Periodontal Therapy on Gingival Crevicular Fluid Interleukin-21 Levels
Human IL-21 is present in gingival crevicular fluid in periodontal health, gingivitis and chronic periodontitis. A significant increase in the concentration of IL-21 in gingival crevicular fluid is observed with an increase in…
- Conditions
- Chronic Peridontitis Patients, Chronic Gingivitis, Healthy
- Trial name
- NCT02861937
- Testing
- non surgical periodontal therapy
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Krishnadevaraya College of Dental Sciences & Hospital
Gingivitis; Chronic, Oxidative Stress
Efficacy of Green and White Tea Extract Mouthwashes in the Management of Plaque-induced Gingivitis: A Clinical and Biochemical Study
Background and objective: Tea is the second most consumed drink in the world after water. Gingivitis is among the most common infectious diseases.
- Conditions
- Gingivitis; Chronic, Oxidative Stress, Inflammation
- Trial name
- NCT05861206
- Testing
- GT-MW group (5% Green tea), WT-MW group (5% White tea),EO-MW group (Listerine mouthrinse), CHX-MW group (0.12% CHX, as a positive control group)
- Where
- Turkey (Türkiye)
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Yağmur Saraç Gül
Gingivitis; Chronic
Effects of Using Miswak in Addition to Oral Hygiene Products in Patients With Gingivitis
This pilot study aims to evaluate the effects of miswak use on the oral biological environment by comparing biochemical parameters obtained from saliva and dental plaque samples collected from individuals who use miswak and…
- Trial name
- NCT07689786
- Testing
- Miswak, Toothpaste
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Mustafa Kemal University
Gingivitis, Gingivitis; Chronic
A Multicentre Randomised Controlled Trial Evaluating the Efficacy of the SMILE™ Module for Improving Short-term Periodontal Outcomes, Compliance, and Acceptability Among Clinical Dental Students
This multicentre randomised controlled trial aims to evaluate the efficacy and safety of the SMILETM (Siwak Method for Integrated Lifestyle Enhancement) module in improving short-term periodontal outcomes, oral hygiene behaviour…
- Trial name
- SMILE (NCT07702383)
- Testing
- SMILE Module, Conventional Toothbrushing Module
- Where
- 4 sites in Malaysia
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- National University of Malaysia
Gingivitis; Chronic
The Effect of Probiotics on Gingivitis
The aim of the study is to assess the effect of oral probiotics containing Streptococcus salivarius M18 on gingivitis and oral hygiene in young adults.
- Trial name
- NCT05727436
- Testing
- Dentoblis
- Where
- Russia
- Volunteers
- 61 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Gingivitis; Chronic, Gingivitis and Periodontal Diseases
Comparision of Enzymatic and Active Salt Toothpaste
Dental plaque is a major etiological factor in the development of gingivitis. Mechanical plaque control through toothbrushing is essential for maintaining oral hygiene, while toothpaste formulations containing active ingredients…
- Conditions
- Gingivitis; Chronic, Gingivitis and Periodontal Diseases, Dental Plaque
- Trial name
- Enzyme T/P (NCT07880483)
- Testing
- Enzyme toothpaste, active salt toothpaste, standard fluoridated toothpaste
- Where
- India
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Uttar Pradesh University of medical sciences
Gingivitis; Chronic, Smoking
Synbiotic as an Adjunct to Mechanical Treatment of Gingivitis
The aim of this study is to evaluate the efficacy of oral administration of synbiotic tablets on the clinical parameters and the levels of selected inflammatory mediators in gingival crevicular fluid (GCF) in smokers and…
- Trial name
- NCT03455192
- Testing
- Synbiotic Supplement
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Kırıkkale University
Periodontal Diseases
Periostin and Non-Surgical Periodontal Treatment
A total of 90 subjects, 30 patients with chronic periodontitis, 30 with gingivitis and 30 periodontally healthy subjects were included. Patients with periodontal disease received non-surgical periodontal treatment.
- Trial name
- NCT04332965
- Testing
- Non-Surgical Periodontal Treatment
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Kırıkkale University
Periodontal Inflammation
Saliva Levels of S100A12, CRP, Fetuin-A in Periodontal Disease Patients
Hs-CRP, Fetuin-A and S100A12 are acute phase proteins associated with many systemic diseases and conditions. The aim of this study was to determine the clinical parameters and salivary Hs-CRP, Fetuin-A and S100A12 levels before…
- Trial name
- NCT03345745
- Testing
- salivary samples
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Ordu University
Gingivitis; Chronic
Hyaluronic Acid Mouthwash as Adjunct
Patients were instructed to use 2 different mouthwashes after performing professional tooth cleaning. The effect of each of the 2 mouthwashes was detected.
- Trial name
- NCT07366398
- Testing
- Hyaluoric acid mouthwash, Chlorhexidine 0,12%
- Where
- Egypt
- Volunteers
- 16 people
- Sponsor
- Cairo University
Chronic Gingivitis, Plaque Induced
Efficacy of a Plaque Disclosing Toothpaste on Home Oral Hygiene Procedures
Plaque accumulation on tooth and gingival surfaces is a causative factor for oral diseases such as demineralization, dental caries, gingivitis, and periodontitis.
- Trial name
- NCT03287011
- Testing
- Shoplaq toothpaste, Colgate toothpaste
- Where
- Malaysia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Segi University
Chronic Gingivitis, Chronic Gingivitis, Plaque Induced
Efficacy of a Rinse Containing Sea Salt and Lysozyme on Biofilm and Gingival Health
This study evaluates the addition of a mouth rinse containing sea salt, xylitol and lysozyme to standardized oral health practices on biofilm formation and gingival health in a group of young adults.
- Trial name
- NCT03329105
- Testing
- Sea Salt Mouth Rinse, Standardized Oral Health Practices
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Saskatchewan
Chronic Periodontitis
Plaque Formation Rate and Toothpaste
This 12-week prospective, randomized, double-blind, two-center trial evaluated the impact of a microcrystalline zinc-hydroxyapatite (mHA) dentifrice on plaque formation rate (PFR) in periodontitis patients.
- Trial name
- PFR (NCT02697539)
- Testing
- AmF/SnF2, mHA
- Volunteers
- 74 people
- Sponsor
- University Hospital Muenster
Chronic Gingivitis
Efficacy of Cuminum Cyminum Herbal =Preparation in Inhibition of Plaque and Gingivitis.
Present work was to investigate the possible efficacy of 0.2% cuminum cyminum herbal preparation as an antiplaque and antigingivitis agent when compared with chlorhexidine.
- Trial name
- NCT04767269
- Testing
- Cuminum Cyminum, herbal Mouthwash
- Where
- India
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Maharishi Markendeswar University (Deemed to be University)
Periodontal Diseases, Periodontitis
Home Use of Dual-light Photodynamic Therapy for Chronic Periodontitis
This early-stage research is designed to determine the efficacy of the Lumoral method in chronic periodontitis patients. Improved supragingival plaque control can help to also sustain the subgingival plaque management in the long…
- Conditions
- Periodontal Diseases, Periodontitis, Plaque, Dental, Plaque Induced Gingivitis
- Trial name
- NCT05425784
- Testing
- Lumoral treatment, Standard oral hygiene self care
- Where
- 3 sites in Finland
- Volunteers
- 41 people
- Sponsor
- Koite Health Oy
Mild and Moderate Chronic Periodontitis
Effect of Probiotic Lozenge on Gingivitis and Periodontitis
The oral cavity is mostly influenced by general health. The oral microbiota which is as complex as the gastro-intestinal or vaginal microbiota are considered to be difficult therapeutic targets.
- Trial name
- NCT02203812
- Testing
- Probiotic Arm
- Where
- India
- Volunteers
- 32 people
- Sponsor
- CD Pharma India Pvt. Ltd.