Clinical trials: Gingivitis
Dental Plaque, Gingivitis
A Clinical Study to Evaluate the Efficacy of a Cetylpyridinium Chloride Mouthwash in Improving Gingival Health and Reducing Plaque Accumulation
The aim of this 12-week clinical study is to evaluate the ability of an experimental mouthwash, containing 0.085 percent (%) Cetylpyridinium chloride (CPC) as an adjunct to toothbrushing with a regular fluoride toothpaste, to…
- Trial name
- NCT06933368
- Testing
- Crest Cavity Protection Toothpaste, Experimental Mouthwash
- Where
- United States
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- HALEON
Periodontal Health, Gingivitis
Salivary and GCF Biomarkers in Periodontal Health, Gingivitis and Periodontitis
This observational cross-sectional study aims to compare the levels of irisin, interleukin-6 (IL-6), interleukin-10 (IL-10), and tumor necrosis factor-alpha (TNF-α) in saliva and gingival crevicular fluid (GCF) among individuals…
- Conditions
- Periodontal Health, Gingivitis, Periodontitis
- Trial name
- NCT07881406
- Testing
- Clinical periodontal examination, ELISA-based biomarker analysis
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Yuzuncu Yil University
Gingivitis
Effectiveness of Oil Pulling Using Oils in Comparison With Mouthwash for Gingivitis
The goal of this clinical trial is to learn if daily oil pulling with coconut oil or sesame oil works as effectively as a standard mouthwash to treat gum swelling and redness (gingivitis) in adults aged 18 to 55 years.
- Trial name
- NCT07892235
- Testing
- virgin coconut oil (VCO), Sesame Oil, 0.2% Chlorhexidine Digluconate Mouthwash
- Where
- Pakistan
- Volunteers
- 45 people
- Sponsor
- Bahria University
Gingival Inflammation and Loss the Orthodontic Mini-screws
Strontium-Hydroxyapatite Coated Mini-Screws: Antibacterial Effect and Stability
This randomized controlled clinical trial aims to evaluate the antibacterial efficacy and stability of strontium-incorporated hydroxyapatite (Sr-HA) coated orthodontic mini-screws (OMSs) used for maxillary canine retraction.
- Trial name
- NCT07105969
- Testing
- Strontium Incorporated Hydroxyapatite [Sr-HA] coated mini-screws purchased from Dentarum company
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Gingivitis; Chronic, Gingivitis and Periodontal Diseases
Comparision of Enzymatic and Active Salt Toothpaste
Dental plaque is a major etiological factor in the development of gingivitis. Mechanical plaque control through toothbrushing is essential for maintaining oral hygiene, while toothpaste formulations containing active ingredients…
- Conditions
- Gingivitis; Chronic, Gingivitis and Periodontal Diseases, Dental Plaque
- Trial name
- Enzyme T/P (NCT07880483)
- Testing
- Enzyme toothpaste, active salt toothpaste, standard fluoridated toothpaste
- Where
- India
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Uttar Pradesh University of medical sciences
Dental Plaque, Gingivitis
The Study to Evaluate the Plaque Control and Anti-Gingivitis Efficacy of a Toothpaste in Chinese Population
The aim of this study is to evaluate the efficacy of the test toothpaste compared to a regular fluoride toothpaste in the reducing gingivitis and plaque accumulation in Chinese participants with plaque-induced gingivitis.
- Trial name
- NCT07816406
- Testing
- Test Toothpaste, Regular Fluoride Toothpaste
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- HALEON
Gingivitis and Periodontal Diseases
Alpha-Lipoic Acid as an Adjunct to Non-Surgical Periodontal Treatment in Gingivitis
Gingivitis is an early and reversible form of periodontal disease characterized by an increased inflammatory response to dental biofilm.
- Trial name
- NCT07882394
- Testing
- Alpha-Lipoic Acid 200 mg, Alpha-Lipoic Acid 600 mg
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Biruni University
Plaque-Induced Gingivitis
Individualized Management of Plaque-Related Gingival Inflammation in Routine Dental Practice
Gingival inflammation is common and can often be reversed with effective daily oral hygiene. However, preventive care is not always delivered consistently in dental practices, and patients may not receive sufficient…
- Trial name
- NCT07882459
- Testing
- Structured Preventive Care Workflow (iMGi)
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- Curaden AG
Gingivitis, Maxillary Transversal Deficiency
St. John's Wort Oil Versus Chlorhexidine Mouthwash for Gingival Problems After Rapid Maxillary Expansion
The goal of this clinical trial was to learn whether St. John's wort (Hypericum perforatum) oil helps gum healing in children and adolescents aged 11 to 16 years after treatment with a rapid maxillary expansion appliance.
- Trial name
- SJW-CHX-RME (NCT07882771)
- Testing
- St. John's Wort Oil, Chlorhexidine
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Yuzuncu Yil University
Gingivitis, Healthy Adult
Comparative Evaluation of the Anti-Plaque and Anti-Gingivitis Effects of Nanobiofusion Gingival Gel (NBF), Placebo Gel, and Commercial Toothpaste
The goal of this clinical trial is to learn if Nanibiofusion Gingival Gel (NBF) is able to reduce dental plaque and gum inflammation in adults.
- Trial name
- NCT07850232
- Testing
- Nano Bio-Fusion (NBF) Gingival Gel, Commercial fluoride toothpaste
- Where
- Jordan
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- King Abdullah University Hospital
Diabete Mellitus, Dyslipidaemia
Prevalence and Associated Factors of High BMI and Periodontitis in Thai Adults Aged Under 60 Years
Overweight and obesity, as well as periodontitis, are common public health problems with increasing prevalence. Both conditions may be linked through shared mechanisms involving chronic low-grade systemic inflammation.
- Conditions
- Diabete Mellitus, Dyslipidaemia, Chronic Kidney Disease, Psychiatric Disorder
- Trial name
- NCT07880717
- Testing
- Periodontal Examination, Questionnaire interview, Anthropometric measurements
- Where
- Thailand
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Gingivitis
Efficacy of SALI-10 Oral Probiotics in Experimental Gingivitis
Gingivitis is among the most prevalent oral diseases worldwide, affecting an estimated 50-90% of adults. It is a reversible condition primarily caused by microbial plaque accumulation on teeth and gingival surfaces, which…
- Trial name
- NCT07256743
- Testing
- SALI-10 lozenge
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ostia Sciences
Gingivitis Infection
Chlorhexidine (CHX) Mouthwash With or Without an Anti-Discoloration System (ADS) During Experimental Gingivitis
Recently, a chlorhexidine product with an anti-discoloration system (ADS) was launched in the market. A comparative study was done to confirm the effectiveness of 0.2% chlorhexidine with ADS. The study was single-blinded.
- Trial name
- NCT07696364
- Testing
- Experimental gingivitis model
- Where
- Switzerland
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of Bern
Plaque Induced Gingival Disease
Taste Acceptance and Effectiveness of Hyaluronic Acid and Chlorhexidine Mouthwashes in Children With Gingivitis
This randomized controlled clinical trial aims to compare the taste acceptance and clinical effectiveness of hyaluronic mouthwash and chlorhexidine mouthwash in children with plaque-induced gingivitis.
- Trial name
- NCT07662226
- Testing
- Hyaluronic Acid mouthwash, Chlorohexidine 0.12% mouthwash
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Cairo University
Gingivitis
Variation in Gingival Inflammatory Responses
The aim of this NIH National Institute of Dental and Craniofacial Research (NIDCR) funded study is to identify molecular mechanisms underlying observed variations in human responses to natural accumulation and maturation of…
- Trial name
- NCT05968742
- Testing
- Abstinence of oral hygiene on select teeth
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of Washington
Dental Plaque, Gingivitis
A Study Investigating Gingival Crevicular Fluid Biomarkers Following Use of a Commercially Available Toothpaste Containing Stannous Fluoride
The aim of this study is to evaluate the feasibility, sensitivity, and interpretability of gingival crevicular fluid (GCF) cytokine biomarkers as early indicators of tissue recovery following use of commercial dentifrice compared…
- Trial name
- NCT07842042
- Testing
- Test Toothpaste, Regular Fluoride Toothpaste
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- HALEON
Gingivitis, Dental Health
CHEER Oral Health in Pregnancy Study
Many pregnant people don't get the dental care they need, even though it's safe and important. The CHEER Study offers free dental check-ups, cleanings, and supplies to help participants take care of their teeth and gums during…
- Conditions
- Gingivitis, Dental Health, Pregnancy, Pregnancy Outcomes
- Trial name
- CHEER (NCT07377344)
- Testing
- Enhanced Care, Enhanced Care +
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- University of California, San Francisco
Plaque-Induced Gingivitis, Orthodontic Treatment
Clinical Outcomes of Different Mouth Rinses During Clear Aligner Orthodontic Therapy
This pilot randomized controlled clinical trial will evaluate the feasibility and preliminary clinical effects of three mouth rinses-alum, Triphala-based herbal mouth rinse, and 0.2% chlorhexidine-in adults undergoing clear…
- Trial name
- NCT07865416
- Testing
- Alum Mouth Rinse, Triphala-based Herbal Mouth Rinse, Chlorhexidine mouth rinse
- Where
- India
- Volunteers
- 30 people
- Sponsor
- Manav Rachna International Institute of Research and Studies
Dental Plaque, Gingivitis
A Study to Investigate the Efficacy of an Experimental Dentifrice Containing Stannous Fluoride in Improving Gingival Health
The aim of this study will be to evaluate the ability of using an experimental dentifrice containing 0.454 percent (%) weight for weight (w/w) Stannous Fluoride (SnF2) to reduce gingivitis and plaque accumulation, compared with a…
- Trial name
- NCT07704905
- Testing
- Test Dentifrice, Reference Dentifrice (Colgate Cavity Protection Dentifrice)
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- HALEON
Autism Disorder, Autism Spectrum Disorder (ASD
Effectiveness of Interactive Techniques on Oral Hygiene Skills in a Group of Autistic Egyptian Children
The present study will be performed to evaluate the effectiveness of peer modeling and audiovisual peer modeling video on toothbrushing skills in comparison to the visual pedagogical method at home.
- Conditions
- Autism Disorder, Autism Spectrum Disorder (ASD, Autism, Plaque Reduction
- Trial name
- Autism ASD (NCT07859696)
- Testing
- Peer model, Pre-recorded video of peer modeling, Pedagogical method
- Volunteers
- 90 people
- Sponsor
- Faculty of Dental Medicine for Girls