Clinical trials: Gerd
Gastroesophageal Reflux Disease
Study to Evaluate the Influence of Tegoprazan on the Pharmacokinetics of Proguanil in Healthy Volunteers
The aim of this study is to evaluate the influence of tegoprazan on the pharmacokinetics of proguanil in healthy volunteers.
- Trial name
- NCT04568772
- Testing
- Atovaquone / Proguanil 250/100 mg, Tegoprazan 50 mg, Esomeprazole 40 mg
- Where
- South Korea
- Volunteers
- 19 people
- Sponsor
- Seoul National University Hospital
Laryngopharyngeal Reflux
Efficacy of Reza Band for the Treatment of Laryngopharyngeal Reflux
We hypothesize that tissue and salivary pepsin will resolve after 12 weeks use of Reza Band, but not following standard of care alone.
- Trial name
- NCT03463395
- Testing
- Reza band
- Where
- United States
- Sponsor
- Medical College of Wisconsin
Systemic Sclerosis (SSc), GERD (Gastroesophageal Reflux Disease)
PPI Refractory - GERD Mechanisms in Systemic Sclerosis
The goal of this observational study is to learn about the mechanisms of gastroesophageal reflux disease (GERD) in patients with systemic sclerosis (SSc) who continue to experience reflux symptoms despite treatment with proton…
- Trial name
- NCT07022912
- Testing
- educational healthcare intervention, Objective assessment of GI motility, Evaluation of GERD severity
- Volunteers
- 147 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Non-erosive Gastroesophageal Reflux Disease, Functional Dyspepsia
Functional Gastrointestinal Disorder Screening Program - A Randomized Controlled Trial
Background: Functional gastrointestinal disorder (FGID) is the most common gastrointestinal disease in daily clinical practice. The disease is symptomatic but has no identifiable cause by standard diagnostic tests such as…
- Conditions
- Non-erosive Gastroesophageal Reflux Disease, Functional Dyspepsia, Irritable Bowel Syndrome
- Trial name
- FGISP-RCT (NCT01047800)
- Testing
- Counseling
- Where
- Hong Kong
- Volunteers
- 200 people
- Sponsor
- Chinese University of Hong Kong
Obesity and Obesity-related Medical Conditions
Management of Obese Patients With Gastroesophageal Reflux Disease .
The aim of this study is to evaluate the efficacy Sleeve gastrectomy with cruroplasty with or without ligamentum teres wrapping for management of morbidly obese patients with concomitant reflux symptoms.
- Trial name
- NCT06599489
- Testing
- surgery ..operation
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hossam Mahmoud Ibrahim
Gastroesophageal Reflux
Study Evaluating Pantoprazole in Children With GERD
The purpose of this study is to characterize the PK profile, safety and tolerability of single and multiple doses of pantoprazole in children aged 1 through 11 years with endoscopically proven GERD.
- Trial name
- NCT00141817
- Testing
- pantoprazole for approximately 9 weeks.
- Where
- 23 sites in United States
- Volunteers
- 41 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Barrett's Esophagus, Gastroesophageal Reflux Disease
Reflux-Induced Oxidative Stress in Barrett's Esophagus: Response, Repair, and Epithelial-Mesenchymal-Transition
The purpose of this study is to elucidate mechanisms whereby oxidative stress induced by acute reflux esophagitis: 1) activates p38 to regulate proteins that control the G1/S cell cycle checkpoint, and 2) activates HIFs (hypoxia…
- Trial name
- NCT02579460
- Testing
- Cessation of Acid Suppressing Medications
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Dallas VA Medical Center
Reflux Esophagitis (RE), Non-erosive Reflux Disease (NERD)
Analysis of GERD Symptoms Using Gastroesophageal Reflux Impact Score Questionnaire for Quality of Life
Even the patients complain GERD symptoms such as heartburn and acid regurgitation the final diagnosis could be reflux esophagitis (RE), non-erosive reflux disease (NERD) and even functional heartburn (FH).
- Conditions
- Reflux Esophagitis (RE), Non-erosive Reflux Disease (NERD), Functional Heartburn (FH)
- Trial name
- NCT01536080
- Where
- South Korea
- Volunteers
- 207 people
- Sponsor
- Seoul National University Bundang Hospital
Non-erosive Reflux Disease (NERD)
Effect of Inspiratory Muscle Training on Symptom Severity and Quality of Life in Non-Erosive Reflux Disease
The goal of this clinical trial is to learn if inspiratory muscle training (IMT) works to treat on clinical symptom severity and quality of life in patients with Non-erosive reflux disease (NERD).
- Trial name
- NCT07584096
- Testing
- Inspiratory Muscle Training (IMT)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Izmir University of Economics
Obesity, Weight Loss
Endoscopic Bariatric Therapies (EBTs): A Retrospective and Prospective Multicenter Registry
The purpose of this registry study is to collect data through medical chart review and in patient visits on the efficacy and safety of various Endoscopic Bariatric therapies (EBTs).
- Conditions
- Obesity, Weight Loss, Gastro Esophageal Reflux, Bariatric Surgery Candidate
- Trial name
- EBT (NCT04494048)
- Testing
- Endoscopic Bariatric Therapies
- Where
- United States
- Volunteers
- 9,999 people
- Sponsor
- Weill Medical College of Cornell University
Constipation, Diarrhea
Efficacy of a Dietary Supplementation With Lactobacillus Reuteri for Digestive Health in an Elderly Population
The purpose of this study is to investigate the effect of a daily supplement consisting of the probiotic bacteria, Lactobacillus reuteri, on the digestive health among persons 65 years and older.
- Conditions
- Constipation, Diarrhea, Indigestion, Reflux
- Trial name
- NCT01837940
- Testing
- Lactobacillus reuteri DSM 17938
- Where
- Sweden
- Volunteers
- 290 people, healthy volunteers welcome
- Sponsor
- Örebro University, Sweden
Airway Disease, Barrett Esophagus
Biomarkers of Airway Disease, Barrett's and Underdiagnosed Reflux Noninvasively (BADBURN)
A majority of Fire Department of New York (FDNY) World Trade Center (WTC) exposed rescue and recovery workers developed gastroesophageal reflux disease (GERD), a risk factor for Barrett's Esophagus (BE) and subsequent esophageal…
- Conditions
- Airway Disease, Barrett Esophagus, Gastroesophageal Reflux Disease
- Trial name
- NCT05216133
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- NYU Langone Health
Allergic Rhinitis, Asthma
Integrating Targeted MedlinePlus Health Prescriptions Into Clinic Practice Workflow
The specific aim of this proposed project is to implement a standard process for integrating MedlinePlus health information prescriptions into the clinic workflow.
- Conditions
- Allergic Rhinitis, Asthma, Back Pain, Benign Prostatic Hypertrophy
- Trial name
- NCT00634608
- Testing
- Health Information Prescription
- Where
- United States
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Barretts Esophagus With Dysplasia
The Impact of Adjuvant Liquid Alginate on Endoscopic Ablation Therapy of Complicated Barrett's Esophagus
This study evaluates the addition of an alginate based solution to twice daily proton pump inhibitor therapy (PPI) in patients undergoing ablative therapy for dysplastic Barrett's esophagus.
- Trial name
- NCT03193216
- Testing
- Alginates
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Gastroesophageal Reflux Disease, Functional Bowel Disorders
Temple Registry for the Investigation of African American Gastrointestinal Disease Epidemiology
DESCRIPTION: Minimal data exists on the prevalence of gastroesophageal reflux disease in minority populations. Specific objectives of this K24 research project are to: (1) Provide an estimate of the prevalence of gastroesophageal…
- Trial name
- TRIAGE (NCT01262755)
- Testing
- Structured Interview
- Where
- United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Temple University
Gastro-esophageal Reflux
Post Prandial High Resolution Impedance- Manometry
Nine to 30% of the population suffers from gastro-esophageal reflux disease (GERD) - suggestive symptoms (heartburn, regurgitation, chest pain, chronic couch, sore throat).
- Trial name
- NCT03306485
- Testing
- Correlating the number of reflux episodes detected on 1-h post prandial esophageal high resolution manometry combined and those detected on ambulatory 24-h pH-impedance monitoring performed on PPI
- Where
- France
- Volunteers
- 9 people
- Sponsor
- Hospices Civils de Lyon
Gastroesophageal Reflux Disease, Systemic Sclerosis
Gastroesophageal Reflux Treatment in Scleroderma
The investigators purposes are to define the prevalence of omeprazole resistance gastroesophageal reflux disease (GERD) in systemic sclerosis (SSc), to compare the efficacy of omeprazole in combination with algycon versus…
- Conditions
- Gastroesophageal Reflux Disease, Systemic Sclerosis, Scleroderma
- Trial name
- GERD-SSc (NCT01878526)
- Testing
- Alginic acid, Domperidone
- Where
- Thailand
- Volunteers
- 80 people
- Sponsor
- Khon Kaen University
Infant Nutrition Disorders, Gastrointestinal Dysfunction
Management of Infant Digestive Disorders and Quality of Life
The objective of the study is to measure the evolution of the quality of life in infants between 0 and 5 months old, not breastfed and suffering from regurgitation or colic.
- Trial name
- NCT04462640
- Testing
- Management of Infant Digestive Disorders and Quality of Life
- Where
- France
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Gastroesophageal Reflux Disease
Symptomatic Gastroesophageal Reflux Disease: Double Blind Randomized Controlled Study of On-demand Therapy Versus Maintenance Therapy
Maintenance treatment with proton pump inhibitor (PPI) is the most widely recommended modality of treatment for long-term management of gastroesophageal reflux disease (GERD).
- Trial name
- NCT00164840
- Testing
- Esomeprazole
- Where
- China
- Volunteers
- 244 people
- Sponsor
- Chinese University of Hong Kong
Gastroesophageal Reflux, Sleeve Gastrectomy
The Use of EndoFlip as a Clinical Tool for the Prediction of Postoperative GERD After Sleeve Gastrectomy
This study aims to determine if preoperative EndoFlip measurement can effectively predict postoperative GERD-related quality of life and lower esophageal acid exposure.
- Conditions
- Gastroesophageal Reflux, Sleeve Gastrectomy, Bariatric Surgery Complication
- Trial name
- NCT05690022
- Testing
- sleeve gastrectomy
- Volunteers
- 100 people
- Sponsor
- Laval University