Clinical trials: Genetic Testing
Polycystic Kidney Disease, Assisted Reproductive Technology
Descriptive Analysis of Preimplantation Genetic Test (PGT)in Couples With Polycystic Kidney Disease (PKD). In the ADPKD Subgroup Evaluation of Outcomes and Complications Comparing Couples in Which the Father is Affected With Couples in Which the Mother is Affected
The goal of this observational study is to evaluate the outcomes of assisted reproductive technology (ART) combined with preimplantation genetic testing for monogenic diseases (PGT-M) in couples affected by or carriers of…
- Conditions
- Polycystic Kidney Disease, Assisted Reproductive Technology, Preimplantation Genetic Testing (PGT)
- Trial name
- PGT-M PKD (NCT07310641)
- Testing
- Assisted reproductive technology and preimplantation diagnosis for monogenic diseases
- Where
- Italy
- Volunteers
- 44 people
- Sponsor
- Azienda Sanitaria Universitaria Integrata del Trentino
Ovarian Stimulation, Quality of Life
PPOS (Progestin Primed Ovarian Stimulation) and Corifollitropin Alfa (CFA) Cross-over Study
P-CCROSS is a randomized, prospective monocentric phase 4 study with a crossover study design. The aim of the study is to compare patient satisfaction (by means of questionnaires) and treatment compliance with IVF treatment with…
- Conditions
- Ovarian Stimulation, Quality of Life, Preimplantation Genetic Testing, Fertility Preservation
- Trial name
- P-CCROSS (NCT06175832)
- Testing
- Elonva®, Puregon®, Orgalutran®
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- University Hospital, Ghent
Hereditary Cancer, Genetic Testing
Addressing Genomic Disparities in Cancer Survivors
The goal of this observational study is to increase genetic education and genetic testing for hereditary cancer risk among Black cancer survivors. The study will: 1.
- Trial name
- NCT06073626
- Testing
- Relational agent (RA) / Chatbot, Enhanced Usual Care (EUC)
- Where
- 2 sites in United States
- Volunteers
- 428 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Age-Related Macular Degeneration, Genetic Testing
The Moran AMD Genetic Testing Assessment Study
The goals of this study are: To assess the impact of genetic testing for Age-related Macular Degeneration (AMD) on lifestyle behaviors as measured by systemic and ocular carotenoid status.
- Conditions
- Age-Related Macular Degeneration, Genetic Testing, Nutritional Biomarkers
- Trial name
- MAGENTA (NCT05265624)
- Testing
- Early disclosure of genetic testing results, Late disclosure of genetic testing results
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Paul S. Bernstein
Pregnant Women, Mobile Applications
Impact of a Mobile App on Pregnant Women's Prenatal Genetic Testing Decision-making
Determine the effect of a culturally sensitive prenatal genetic testing (PGT) education intervention delivered via a mobile application on pregnant women's perceptions, knowledge, and uptake of PGT.
- Conditions
- Pregnant Women, Mobile Applications, Genetic Testing, Prenatal Care
- Trial name
- NCT05055700
- Testing
- Mobile app with prenatal genetic testing information
- Where
- United States
- Volunteers
- 178 people
- Sponsor
- Texas A&M University
Preimplantation Genetic Testing, Progestin-primed Ovarian Stimulation
Comparison of the Euploid Rate of Blastocyst Between PPOS and GnRH Antagonist Protocol in Patients Undergoing PGT-A
This randomized trial aims to compare the euploid rate of blastocysts between PPOS and GnRH antagonist protocols in patients undergoing PGT-A.
- Conditions
- Preimplantation Genetic Testing, Progestin-primed Ovarian Stimulation, Euploid Rate, GnRH Antagonist
- Trial name
- NCT04414748
- Testing
- GnRH antagonist, oral Duphaston
- Where
- China
- Volunteers
- 400 people
- Sponsor
- ShangHai Ji Ai Genetics & IVF Institute
Preimplantation Genetic Testing, Growth Hormone
Effect of GH on the Blastocyst Euploid Rate in AMA Patients
This randomized trial aims to compare the euploid rate of blastocysts in AMA patients undergoing PGT-A (preimplantation genetic testing for aneuploidy) with or without growth hormone supplement.
- Conditions
- Preimplantation Genetic Testing, Growth Hormone, Age, Parental
- Trial name
- NCT05447208
- Testing
- Growth Hormone, GnRH antagonist
- Where
- China
- Volunteers
- 400 people
- Sponsor
- ShangHai Ji Ai Genetics & IVF Institute
The Focus is to Validate the Accuracy of a Non-invasive Artificial Intelligence Model for the Prediction of the Human Blastocyst Ploidy, Preimplantation Genetic Testing (PGT)
Evaluation of an Artificial Intelligence Model for the Prediction of Human Blastocyst Ploidy Without Invasive Procedures
The goal of this clinical trial is to evaluate an artificial intelligence model for the prediction of human blastocyst ploidy without invasive procedures in couples that receive preimplantation genetic testing.
- Trial name
- NCT06762704
- Testing
- Video recording
- Where
- 5 sites in China
- Volunteers
- 1,408 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Hypercholesterolemia, Familial, Hypercholesterolemia, Familial, 1
Genetic Testing and Motivational Counseling for FH
To date, there are highly effective lipid-lowering drugs, the combination of which makes it possible to achieve the target level of LDL-C in most patients with familial hypercholesterolemia (FH).
- Conditions
- Hypercholesterolemia, Familial, Hypercholesterolemia, Familial, 1, Hypercholesterolemia, Familial, 2, Hypercholesterolemia, Familial, 3
- Trial name
- GENMOTIV-FH (NCT04656028)
- Testing
- Genetic Testing, Motivational Counseling, Lipid analysis
- Where
- Russia
- Volunteers
- 180 people
- Sponsor
- National Medical Research Center for Therapy and Preventive Medicine
De Novo Mutation, Preimplantation Genetic Testing
Optimized PGT-M Strategy for Patients With No Proband
The clinical practice of PGT-M for monogenetic disease usually adopted a double-checking strategy, which detect the mutation by Sanger sequencing and meantime construct haplotypes using the DNA sample of the proband so as to…
- Conditions
- De Novo Mutation, Preimplantation Genetic Testing, Without Proband
- Trial name
- NCT06722313
- Testing
- Gametes (sperm or second polar bodies, MI eggs) or arrested embryos were reserved for identification of a proband
- Where
- China
- Volunteers
- 5 people
- Sponsor
- ShangHai Ji Ai Genetics & IVF Institute
Genetic Testing
Access to Genetic Information Leveraging Innovative Technology (AGILITY)
AGILITY is a type 1 hybrid trial that will test the effectiveness of a chatbot to provide pre-test information about genetic screening for tier 1 conditions.
- Trial name
- AGILITY (NCT05159011)
- Testing
- AGILITY (Access to Genetic Information Leveraging Innovative TechnologY)
- Sponsor
- RTI International
Genetic Testing
Development and Implementation of Electronic Decision Aids for Genetic Testing in Inherited Cancer Syndromes
An electronic decision aid will be used to assist individuals in choosing a multi-gene panel with their medical oncologist instead of a genetic counselor.
- Trial name
- NCT04704193
- Testing
- Survey of Decision Aid
- Where
- United States
- Volunteers
- 93 people
- Sponsor
- Massachusetts General Hospital
Genetic Testing
Clinical Application of Non-invasive PGT-A
The study aims to investigate the difference of in vitro fertilization (IVF) outcomes among non-invasive PGT-A, PGT-A and combined non-invasive PGT-A and PGT-A.
- Trial name
- NCT04856696
- Testing
- PGT-A, non-invasive PGT-A
- Where
- Taiwan
- Volunteers
- 22 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Candidates for Hereditary Pancreatic Cancer Testing
Familial Pancreatic Cancer PROPHilation Program in Italy
The goal of the PROPH-ITA Study is to perform genetic testing in family members of pancreatic cancer patients who may have a genetic predisposition.
- Trial name
- PROPH-ITA (NCT05724992)
- Testing
- Saliva swab testing
- Where
- Italy
- Volunteers
- 3,000 people
- Sponsor
- Associazione Italiana per lo Studio del Pancreas
Breast Cancer, Genetic Testing
Health-promoting Lifestyle in a Genetic Counseling Clinic
This was a cross-seThis was a cross-sectional study, which aimed to describe the health-promoting lifestyle of breast cancer patients and family members in a Chinese genetic counseling clinic, and to explore its various levels…
- Trial name
- NCT05545254
- Testing
- genetic testing
- Where
- China
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Fudan University
Candidates for BRCA 1/2 Genetic Testing
A Study of the Communication of Genetic Test Results By Telephone: A Multi-Center Study
The overall goal of the proposed research is to evaluate psychosocial and behavioral outcomes (i.e.risks and benefits) of an innovative and efficient delivery model for genetic testing, telephone communication, as an alternative…
- Trial name
- NCT01736345
- Testing
- Genetic Providers, Visual Aids, Post-Disclosure Asessments
- Where
- 5 sites in United States
- Volunteers
- 289 people, healthy volunteers welcome
- Sponsor
- Abramson Cancer Center at Penn Medicine
Genotype, Pain
Genetics and Pain Severity in Sickle Cell Disease
Background: Pain is the most common symptom of sickle cell disease. Episodes of severe sickle cell pain are known as "crises." High rates of pain crises are associated with a higher risk of early death.
- Conditions
- Genotype, Pain, Genetic Variation, Quantitative Sensory Testing (QST)
- Trial name
- NCT01441141
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Preimplantation Genetic Testing (PGT), ICSI
Noninvasive Preimplantation Genetic Testing for Aneuploidy
The study is conducted to evaluate the sensitivity and specificity of non-invasive preimplantation genetic testing for aneuploidy (NiPGT-A) using cell free DNA into spent culture medium (SCM).
- Trial name
- NCT04490889
- Testing
- NiPGT-A
- Where
- 2 sites in Vietnam
- Volunteers
- 218 people
- Sponsor
- Mỹ Đức Hospital
Genetic Testing, Quality of Life
Impact of Predictive Genetic Testing
Analysing Impact of preemptive genetic testing on quality of life, physical activity and eating behavior at baseline and 3 months after testing.
- Conditions
- Genetic Testing, Quality of Life, Physical Activity
- Trial name
- NCT03988504
- Testing
- Routine check up including genetic testing
- Volunteers
- 241 people, healthy volunteers welcome
- Sponsor
- Robert Bosch Medical Center
Genetic Testing
Evaluation of the Implementation of Expanded Carrier Screening Before Pregnancy in Hong Kong
The objectives are to: 1. Assess patient's views and preferences in receiving expanded carrier screening 2. Perform qualitative study on post testing counselling on screen positive individuals and at risk couples
- Trial name
- NCT02742116
- Testing
- DNA screening before Pregnancy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong