Clinical trials: Genetic Screening
Sickle Cell, Diabetes
Developing the Family Map: Looking at Communal Coping
Background: Knowing one s family medical history is a part of staying healthy. Some health risks run in families, and knowing these risks can promote more healthy behavior.
- Conditions
- Sickle Cell, Diabetes, Cancer, Cardiovascular Disease
- Trial name
- NCT01633021
- Where
- 3 sites in United States
- Volunteers
- 1,061 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Genetic Screening, Adolescent
Engaging Adolescents in Decisions About Return of Genomic Research Results
Recent recommendations to return children's results for adult-onset conditions to parents anytime whole exome or genome sequencing is performed, as well as growing expectations to return research results to participants on a…
- Conditions
- Genetic Screening, Adolescent, Genetic Change, Shared Decision Making
- Trial name
- NCT04481061
- Testing
- Electronic Decision Tool
- Where
- 2 sites in United States
- Volunteers
- 787 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Breast Cancer Screening, Colon Cancer Screening
Bundled Cancer Screening and Genetic Services Navigation
The goal of this study is to test bundled familial cancer risk assessment + multicancer (colorectal + breast) vs. single (breast) cancer navigation, using a wait list control for colorectal cancer screening referral and…
- Conditions
- Breast Cancer Screening, Colon Cancer Screening, Genetics Predisposition
- Trial name
- NCT07228000
- Testing
- Breast cancer screening navigation, Multicancer screening navigation, Usual care genetics referral
- Where
- 2 sites in United States
- Volunteers
- 820 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Genetic Screening, Hereditary Disease
Study on Early Genetic Screening and Precise Strategy of Neonatal Critical Illness
The researchers hope to establish an overall program of early genetic screening for neonatal critical illness in China, and to develop precise intervention strategies to assist clinical diagnosis and treatment of hereditary…
- Conditions
- Genetic Screening, Hereditary Disease, Newborn, Stillbirth
- Trial name
- NCT04905537
- Testing
- No intervention
- Where
- China
- Volunteers
- 4,000 people
- Sponsor
- Children's Hospital of Fudan University
Miscarriage, Frozen Embryo Transfer
Natural Cycle Versus Hormone Replacement Therapy Cycle for a Frozen-thawed Embryo Transfer in PGT Patients
The aim of the current study is to compare miscarriage rates (before 8 weeks) between a true natural cycle (awaiting spontaneous LH surge) and a hormone replacement therapy cycle prior to blastocyst transfer in preimplantation…
- Conditions
- Miscarriage, Frozen Embryo Transfer, Natural Cycle, Hormone Replacement Therapy Cycle
- Trial name
- NCT03976544
- Testing
- Estradiol Valerate, Micronized progesterone
- Where
- Belgium
- Volunteers
- 362 people
- Sponsor
- CRG UZ Brussel
Infertility, Preimplantation Genetic Screening
Investigating the Cryopreserved Blastocyst's ImplantatiOn Potential After Genetic Screening
This is a two-arm parallel group randomized controlled trial at the Department of Reproductive Medicine at Ghent University Hospital.
- Trial name
- BIOPS (NCT03173885)
- Testing
- Preimplantation Genetic Screening
- Where
- Belgium
- Volunteers
- 56 people
- Sponsor
- University Hospital, Ghent
Prenatal Screening, Pregnancy Related
Fetal Cell Analysis From Maternal Blood
The aim of this clinical study is the evaluation of clinical performance of a cell-based non-invasive test technology for fetal aneuploidies and segmental imbalances detection in a high-risk pregnancies population.
- Conditions
- Prenatal Screening, Pregnancy Related, Genetic Disease
- Trial name
- NCT05671744
- Testing
- Cell-based non-invasive prenatal testing
- Where
- Italy
- Volunteers
- 1,500 people
- Sponsor
- Menarini Biomarkers Singapore
Preimplantation Genetic Screening
The Effects of Miminal Stimulation Protocol on Preimplantation Genetic Screening
PGS has been the most effective method for embryo selection in IVF cycles. Euploidy rates decrease significantly with advancing maternal age (AMA).
- Trial name
- NCT05220995
- Testing
- protocol
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Gokalp Oner
Screening, Aortic Aneurysm and Dissection
A Study to Evaluate the Feasibility of Screening Relatives of Patients Affected by Non-Syndromic Thoracic Aortic Diseases
The primary hypothesis is that a tailored programme of genetic and imaging screening of first- and second-degree relatives of patients affected by non-syndromic forms of thoracic aortic diseases will identify individuals at risk…
- Conditions
- Screening, Aortic Aneurysm and Dissection, Genetic Disease
- Trial name
- ReST (NCT03861741)
- Testing
- WES, MRI, TTE
- Where
- United Kingdom
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Leicester
Recurrent Pregnancy Loss, Preimplantation Genetic Screening
Live Birth Rate in Patients With Unexplained Recurrent Pregnancy Loss
STUDY AIM: to study the pregnancy outcomes and offspring development of patient with Unexplained Recurrent Pregnancy Loss Treated by PGS and spontaneous pregnancy, and to compare the health economic indicators and patient…
- Trial name
- NCT04621773
- Testing
- Preimplantation Genetic Screening(exposure)
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Peking University Third Hospital
Infertility, Preimplantation Genetic Diagnosis/Screening
Estradiol, Progesterone and Endometrial Thickness in Frozen Euploid Embryo Transfer
The development and improvement in Preimplantation genetic diagnosis/screening (PGS) in association with the efficacy and security of vitrification and trophectoderm biopsy, more efficient stimulation schemes and laboratory…
- Conditions
- Infertility, Preimplantation Genetic Diagnosis/Screening, Miscarriage
- Trial name
- NCT03395665
- Testing
- Estradiol level, Progesterone level, Endometrial thickness
- Where
- Spain
- Volunteers
- 299 people
- Sponsor
- Fundacion Dexeus
Infertility, Preimplantation Genetic Screening
The Transition From Blastomere to Trophectoderm Biopsy: Comparing Two PGS Strategies
Shortly after the implementation of Comprehensive Chromosome Screening (CCS) techniques for Preimplantation Genetic Screening (PGS) came the transition in biopsy timing.
- Trial name
- NCT03062969
- Testing
- Cleavage stage biopsy group, Trophectoderm biopsy group
- Volunteers
- 383 people
- Sponsor
- Fundacion Dexeus
Infertility, Preimplantation Genetic Screening
Cumulative Live Birth Rates in Patients With Repeated Implantation Failure (RIF) Undergoing Preimplantation Genetic Screening (PGS )
This is a single centre retrospective study in repeated implantation failure patients: < 39 years old, at least 4 D3 good quality embryos or 2 good quality blastocysts transferred without implantation, absence of known causes of…
- Trial name
- NCT03001648
- Testing
- PGS (Preimplantation Genetic Screening) with trophectoderm biopsy
- Where
- Spain
- Volunteers
- 80 people
- Sponsor
- Fundacion Dexeus
Preimplantation Gentic Screening (PGS), In Vitro Fertilization (IVF)
Impact of Parental Support on Pregnancy Outcomes (IPSO) Trial- Day 3 Preimplantation Genetic Screening (PGS) With Day 5 Fresh Transfer
Natera is recruiting patients for a research study evaluating pregnancy and implantation rates in women undergoing In Vitro Fertilization (IVF) and Preimplantation Genetic Screening (PGS).
- Conditions
- Preimplantation Gentic Screening (PGS), In Vitro Fertilization (IVF), Preimplantation Genetic Diagnosis (PGD)
- Trial name
- IPSO (NCT01194531)
- Testing
- 24 Chromosome Aneuploidy Screening with Parental Support
- Where
- 9 sites in United States
- Volunteers
- 59 people
- Sponsor
- Natera, Inc.
Spinal Muscular Atrophy (SMA), Carrier Screening
Multi-disease Carrier Screening Test Validation
The purpose of this study is to collect blood samples to enable validation of genetic testing for diseases within a multi-disease carrier screening panel.
- Conditions
- Spinal Muscular Atrophy (SMA), Carrier Screening, Genetic Testing
- Trial name
- NCT01663584
- Testing
- Blood draw
- Where
- United States
- Sponsor
- Natera, Inc.