Clinical trials: Generalized Severe Chronic Periodontitis
Periodontitis Chronic Generalized Severe, Intrabony Periodontal Defect
Clinical and Radiograhic Evaluation of NIPSA With and Without Allograft Plus Platelet Rich Fibrin in the Treatment of Intraosseous Defects in Stage III Periodontitis Patients
Several minimal invasive techniques have been proposed since the last decade aiming to enhance and provide adequate environment for periodontal regeneration.
- Trial name
- NCT04444063
- Testing
- Non-Incised Papilla Surgical Approach
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cairo University
Periodontitis Chronic Generalized Severe
Hyaluronic Acid Versus Red Injectable Platelet Rich Fibrin in Treatment of Periodontitis
the aim of this clinical trial is to compare the efficacy of hyaluronic acid (HA) used as an adjunctive to scaling and root planing (SRP) and red injectable platelet rich-fibrin (i-PRF) in the non-surgical treatment of stage III…
- Trial name
- NCT05768243
- Testing
- Hyaluronic acid, red injectable platelet rich fibrin (i-prf)
- Where
- Lebanon
- Volunteers
- 75 people
- Sponsor
- Beirut Arab University
Periodontitis Chronic Generalized Moderate, Periodontitis Chronic Generalized Severe
Clinical Evaluation of Laser Therapy Used as an Adjunct to Non-Surgical Treatment of Gum Disease
The use of lasers to treat various problems in dentistry is growing as it has in medicine. One application is the use of lasers to treat periodontal disease.
- Trial name
- NCT04027686
- Testing
- Laser Therapy, Non-surgical Scaling and Root Planing
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Periodontitis Chronic Generalized Severe, Hyperlipidemia
Effects of Non-surgical Periodontal Therapy on Severe Periodontitis and Hyperlipidemia
This study was a single-center, non-randomized, parallel-group design clinical trial, and each group was assigned a 1:1 ratio with or without hyperlipidemia.
- Conditions
- Periodontitis Chronic Generalized Severe, Hyperlipidemia, Gingival Crevicular Fluid, Serum
- Trial name
- NCT05548933
- Testing
- non-surgical periodontal therapy
- Where
- China
- Volunteers
- 64 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Periodontitis Chronic Generalized Moderate, Periodontitis Chronic Generalized Severe
Regular Home-use of Dual-light Photodynamic Therapy in the Management of Chronic Stage III-IV Periodontitis
This study is designed to determine the efficacy of the Lumoral method in chronic periodontitis with a targeted group of stage III and IV periodontitis.
- Trial name
- NCT05698823
- Testing
- Lumoral Treatment
- Where
- Lithuania
- Volunteers
- 56 people
- Sponsor
- Koite Health Oy
Periodontitis Chronic Generalized Severe
Contribution of an Antiviral Drug (Valaciclovir) in the Treatment of Generalized Periodontitis (Stage III or IV and Grade A, B or C): Prospective, Randomized and Double Blind Clinical Trial
Periodontitis is an inflammatory pathology that destroys periodontitis and causes tooth loosening. Its high incidence, combined with very high oral and systemic morbidity, places this pathology at the heart of global public…
- Trial name
- HERPARO (NCT05902208)
- Testing
- Antiviral treatment with conventional non-surgical treatment
- Where
- 3 sites in France
- Volunteers
- 142 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Periodontitis Chronic Generalized Severe, Periodontitis Chronic Generalized Moderate
Scaling and Root Planning With Localized Delivery of Autogenous Growth Factors- Platelet Rich Fibrin (PRF)
The purpose of this research study is to find out about the effect of growth factors extracted from blood on improving healing of periodontal pockets (Gum pockets) after deep gum cleaning.
- Trial name
- NCT04978324
- Testing
- leukocyte platelet rich fibrin (L-PRF), Scaling and Root Planing
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Generalized Chronic Periodontitis
Activated MMP-8 as Diagnostic Test for Periodontitis
Background: Untreated periodontal disease may influence general health. However, how may a physician who is not trained in periodontal probing detect untreated periodontitis? Activated matrix metalloproteinase-8 (aMMP-8) in…
- Trial name
- MMP-8 (NCT02280122)
- Testing
- no intervention provided
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Goethe University
Periodontitis, Periodontitis Chronic Generalized Severe
Effect of Non-surgical Treatment of Periodontitis Patients Focusing on Inflammatory Mediators in Gingival Crevicular Fluid
This study investigates inflammatory biomarkers in gingival crevicular fluid (GCF) from smokers and non-smokers with severe periodontitis, before and during non-surgical periodontal therapy (NSPT).
- Trial name
- NONSURG (NCT07503041)
- Testing
- Collecting fluid for biomarker analyses, Hygiene instruction, tooth cleaning, plaque removal
- Where
- Norway
- Volunteers
- 30 people
- Sponsor
- Oral Health Centre of Expertise in Western Norway
Periodontitis Chronic Generalized Severe, Gingivitis
Evaluation of Macrophage Inflammatory Protein-1α as a Periodontal Disease Biomarker
Periodontal disease is a chronic progressive state of inflammation pertaining to supporting tissues of the dentition that culminates in loss of the affected teeth.
- Conditions
- Periodontitis Chronic Generalized Severe, Gingivitis, Inflammatory Response
- Trial name
- NCT06016023
- Where
- India
- Volunteers
- 120 people
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Generalized Moderate Chronic Periodontitis, Generalized Severe Chronic Periodontitis
Treatment of Periodontitis With Er:YAG Laser
The purpose of this research project is to gain information on the best and most comfortable way to treat the periodontal disease.
- Conditions
- Generalized Moderate Chronic Periodontitis, Generalized Severe Chronic Periodontitis, Periodontal Diseases
- Trial name
- NCT03628872
- Testing
- Scaling and root planing, Er:YAG Laser, Hand instruments
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Columbia University
Periodontal Diseases
Quantification of Proteomes: L-plastin , Lipocalin and Adiponectin in Chronic Periodontitis and Diabetic Subjects
The quantification of the proteomes : L-plastin, lipocalin and adiponectin was analysed in the subgingival tissue samples of generalized severe chronic periodontitis patients with and without diabetes mellitus.The demographic and…
- Trial name
- NCT03391349
- Volunteers
- 70 people
- Sponsor
- Meenakshi Ammal Dental College and Hospital
Periodontitis Stage II, Periodontitis Stage III
3-Month Clinical Trial of Liquid S-PRF in Periodontal Debridement for Periodontitis Stages II-IV
What is the purpose of this study? This study is to investigate the effect of a processed blood product in healing after treatment for gum disease.
- Conditions
- Periodontitis Stage II, Periodontitis Stage III, Periodontitis (Stage 3), Periodontitis
- Trial name
- NCT07293962
- Testing
- Normal saline irrigation, Platelet rich fibrin
- Where
- Malaysia
- Volunteers
- 14 people
- Sponsor
- Mahsa University
Periodontitis Chronic Generalized Severe
Flurbiprofen Versus Aloe Vera Gel in the Treatment of Chronic Periodontitis in Smoking Patients.
This study aims to evaluate clinically the efficacy of flurbiprofen gel in comparison to Aloe Vera gel as adjunctive to SRP in the reduction of periodontal pockets in patients with chronic periodontitis in smoking patients.
- Trial name
- NCT06041178
- Testing
- 2.5% flurbiprofen, 98% aloe vera
- Where
- Lebanon
- Volunteers
- 60 people
- Sponsor
- Beirut Arab University