Clinical trials: General Anesthesia With Propofol
General Anesthesia
Safety and Efficacy of Maintenance of Etomidate in General Anesthesia
This study was designed to use etomidate combined with sevoflurane intravenously to maintain anesthesia process under the monitoring of BIS. Propofol was used as the controls.
- Trial name
- NCT05223907
- Testing
- Etomidate, Propofol
- Where
- China
- Volunteers
- 1,080 people
- Sponsor
- Henan Provincial People's Hospital
Surgery With General Anesthesia
Validation of the Effect of Propofol and Opiates Closed-loop Administration Device During Anesthesia and Sedation
Sleeping medication and analgesia are standard administered during anesthesia. Sleeping medication, Propofol (Diprivan, AstraZeneca), and analgesia, Remifentanil (GlaxoSmithKline), are most frequently used In the University…
- Trial name
- NCT00764855
- Testing
- Automatic administration of propofol and opiates during routine clinical practice
- Where
- Belgium
- Volunteers
- 180 people
- Sponsor
- University Hospital, Ghent
General Anaesthesia
Evaluation of Equivalent Minimum Alveolar Concentration (eMAC) During Propofol/Remifentanil Anesthesia
The aim of this study is to verify the accuracy of eMAC compared to Bispectral Index (BIS) for depth and nociceptive stimulation monitoring of anesthesia during general anesthesia.
- Trial name
- eMAC (NCT05789992)
- Testing
- Propofol, Low Remifentanil, Heigh Remifentanil
- Where
- China
- Volunteers
- 62 people
- Sponsor
- Zhang Haopeng
Target Controlled Infusion (TCI), Thoracic Epidural Anesthesia
The Effect of Thoracic Epidural Anesthesia With Different Block Level on Propofol Induction
It is a prospective, randomized, placebo-controlled study to investigate the effect of TEA with different block level on propofol concentration during general anesthesia induction.
- Conditions
- Target Controlled Infusion (TCI), Thoracic Epidural Anesthesia, Block Level, Gastrointestinal Surgery
- Trial name
- NCT02135016
- Testing
- 1% lidocaine, 2% lidocaine, 0.9% normal saline
- Where
- China
- Volunteers
- 45 people
- Sponsor
- First Hospital of China Medical University
General Anesthesia
Population Pharmacokinetics and Clinical Individual Dosage Regimen of Propofoll Injection
Propofol is a widely used sedative anesthetic, but there are large individual differences, which making different patients with different sensitivity to propofol.
- Trial name
- NCT03422315
- Testing
- Propofol
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Zhongyuan Xu
General Anesthesia
Continuous and Discontinuous Determination of Propofol Concentration in Breathing Gas
This study should compare the propofol concentration in breathing gas and in plasma (before and) after lung passage. Propofol concentrations in breathing gas are continuously measured by a sensor.
- Trial name
- NCT00532402
- Where
- 2 sites in Germany
- Volunteers
- 16 people
- Sponsor
- University of Luebeck
Analgesia
Correlation Between qNOX and Analgesia Nociception Index (ANI) Values During General Anesthesia
qNOX and ANI are two indexes evaluting the analgesia conduction during general anesthesia. No trials have compared them, so with this trial authors want to explore the correlations between them.
- Trial name
- ANI (NCT06351072)
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- University of Padova
Anesthesia, General
Comparison of Sugammadex With Neostigmine During Laparoscopic Cholecystectomy or Appendectomy (P05699)
The current trial was designed to demonstrate faster recovery from a neuromuscular blockade (NMB) induced by rocuronium after reversal at 1-2 Post Tetanic Count (PTC) by 4.0 mg.kg-1 sugammadex compared to 50 µg.kg-1 neostigmine…
- Trial name
- NCT00724932
- Testing
- Rocuronium, Sugammadex, Neostigmine
- Volunteers
- 140 people
- Sponsor
- Merck Sharp & Dohme LLC
Eye Diseases
Correlation Between Exhaled Propofol Concentration With Plasma Concentration in Children
Children due for elective eye surgery in propofol based anesthesia will be kept at steady state propofol infusion for maintenance, ventilation via endotracheal tube.
- Trial name
- NCT04150432
- Testing
- Edmon
- Where
- Norway
- Volunteers
- 32 people
- Sponsor
- Oslo University Hospital
Neuromuscular Block
Can Adequacy of Anesthesia Depth and Quality of Recovery be Influenced by the Level of Neuromuscular Blockade?
The investigators hypothesize that an anesthetic protocol maintaining deep neuromuscular block throughout the entire surgical procedure followed by sugammadex reversal, would suppress EMG activity and result in improved…
- Trial name
- NCT02484651
- Testing
- Sugammadex, Rocuronium
- Where
- Portugal
- Volunteers
- 70 people
- Sponsor
- Centro Hospitalar do Porto
Anesthesia, General
The Effect of BIS-guided Propofol Induction on Hemodynamic Response in Patients With Cardiac Risk.
Anesthesia induction will be started by monitoring ECG, non-invasive artery monitoring, peripheral oxygen saturation and BIS for all patients who are taken to the operating room without sedation.
- Trial name
- NCT04729465
- Testing
- Propofol, Bispectral Index Monitor
- Volunteers
- 60 people
- Sponsor
- Istanbul University - Cerrahpasa
General Anesthesia
Effect of Etomidate and Propofol on Electroencephalography
Electroencephalography (EEG) monitoring reflect the brain electro-activity. Different anesthetics may show different changes in EEG during anesthesia. Etomidate and propofol are widely used for general anesthesia.
- Trial name
- CHAPE (NCT04369014)
- Testing
- etomidate anesthesia, propofol anesthesia
- Where
- China
- Volunteers
- 68 people
- Sponsor
- Air Force Military Medical University, China
Pediatric Anesthesia, Airway Management
Effective Dose of Alfentanil Combined With Propofol for Laryngeal Mask Airway Insertion in Children
This study uses a prospective, up-and-down sequential allocation method to determine the median effective dose (ED50) and 95% effective dose (ED95) of alfentanil combined with propofol for successful laryngeal mask airway (LMA)…
- Conditions
- Pediatric Anesthesia, Airway Management, General Anesthesia, LMA
- Trial name
- NCT07581665
- Testing
- Alfentanil
- Where
- China
- Volunteers
- 23 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
General Anesthesia, Elective Surgery
Therapeutic Equivalence (TE) Study of Propofol 2% MCT Fresenius (MCT=Medium-Chain Triglycerides) Compared With Diprivan® in Patients Undergoing Elective Surgery
The purpose of this study is to evaluate the therapeutic equivalence, based on pharmacodynamic parameters of Propofol 2% (20 mg/mL) MCT Fresenius and Diprivan® 20 mg/mL (AstraZeneca), administered by target controlled infusion…
- Trial name
- PropofolTE (NCT01856998)
- Testing
- Propofol, Diprivan
- Where
- France
- Volunteers
- 71 people
- Sponsor
- Fresenius Kabi
Tumor of Ear, Nose and Throat
Conditions of Diagnostic Panendoscopy of the Upper Airway Under Propofol Remifentanil General Anesthesia
The most important considerations for the general anesthesia in diagnostic panendoscopy of the upper airway is the maintenance of a patient's airway for optimal surgical exposure, adequate ventilation and sufficient depth of…
- Trial name
- ENDOTANIL (NCT02093143)
- Testing
- Remifentanil
- Where
- 2 sites in France
- Volunteers
- 256 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Uterine Fibroids (UF)
Ultrasound-Guided Stellate Ganglion Block Plus Propofol for Perimenopausal Insomnia With Anxiety
Laparoscopic myomectomy is a commonly performed minimally invasive gynecologic procedure. However, surgical trauma, tracheal intubation, and pneumoperitoneum may induce pronounced perioperative stress responses, resulting in…
- Trial name
- SGB-PROP-PIA (NCT07384468)
- Testing
- Ultrasound-Guided Stellate Ganglion Block
- Where
- China
- Volunteers
- 233 people
- Sponsor
- Xiaochen Ji
Smooth Extubation
Smooth Extubation With Ketofol for Induction of General Anesthesia in Laparoscopic Drilling of Polycystic Ovary
the effect of ketofol, a combination of propofol and ketamine, on hemodynamics and airway response during induction of general anesthesia has been studied before.
- Trial name
- NCT04365686
- Testing
- Ketofol as induction agent, Propofol as induction agent
- Where
- Egypt
- Volunteers
- 106 people
- Sponsor
- Fayoum University Hospital
Anesthesia With Use of LMA (Laryngeal Mask Airway)
Emergence Times and Airway Reactions in General Laryngeal Mask Airway Anesthesia
The aim of this study is first to assess if desflurane is superior in order to achieve a faster emergence from anesthesia.
- Trial name
- NCT02322502
- Testing
- Desflurane, Sevoflurane, propofol
- Where
- 4 sites in Germany
- Volunteers
- 352 people
- Sponsor
- RWTH Aachen University
Used to Induce and Implement General Anesthesia in Combination With Sedative Anesthetics (Such as Propofol)
Pharmacokinetics, Safety and Efficacy of HR020602 Injection in Children Undergoing General Anesthesia
This study is divided into two stages: the first stage is a dose verification trial, with a multicenter, open, single arm trial design, which is planned to enroll 10 children with general anesthesia surgery (all using HR020602…
- Trial name
- NCT04867343
- Testing
- HR020602 injection, fentanyl injection ； remifentanil injection
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Anesthesia Brain Monitoring
Describe Relations Between qCON and qNOX Indicies During Propofol-Remifentanil General Anesthesia
CONOX is a neuromonitoring EEG- device for sedation (qCON) and analgesia (qNOX) monitoring during general anesthesia. It is unknown on how the indicies can differentiate themselves so aim of this study is to determine the…
- Trial name
- NCT06349681
- Where
- Italy
- Volunteers
- 14 people
- Sponsor
- University of Padova