Clinical trials: Gastroparesis
Diabetes Mellitus, Gastroparesis
Drug Trial of Lixisenatide on Gastric Emptying and Blood Pressure Drops in Type 2 Diabetics and Healthy People
The purpose of this study is to determine the effects of the drug lixisenatide on blood sugar levels, stomach emptying, blood pressure and heart rate, release of gut hormones and blood flow in the gut after a glucose drink in…
- Trial name
- Lixi (NCT02308254)
- Testing
- Lixisenatide
- Where
- Australia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Royal Adelaide Hospital
Gastroparesis
Placebo Controlled Trial of Botulinum Toxin for Gastroparesis
It is hypothesized that in some patients with gastroparesis increased pyloric tone may be a contributing feature. Botox relaxes the pylorus so that food can empty the stomach more rapidly.
- Trial name
- NCT00372970
- Testing
- Botulinum toxin A
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Temple University
Gastroparesis
Clinical Management With SPM System and Validation of the SPM 5 Hour Cutoff in Patients With Symptoms of Gastroparesis
This protocol is designed to validate use of the SPM for diagnosis of delayed gastric emptying in patients with symptoms of gastroparesis and assess impact of a SmartPill study on patient management in the gastroparetic…
- Trial name
- NCT02022826
- Testing
- SmartPill Monitoring System
- Where
- 11 sites in United States
- Volunteers
- 167 people
- Sponsor
- Medtronic - MITG
Gastroparesis Nondiabetic
Effect of Gastric Electrical Stimulation on Serum Insulin Levels
The goal of this study is to determine how much effect turning off an individual's Gastric Electrical Stimulator (GES) for up to four hours will have on levels of insulin, C-peptide, GLP-1 and glucose levels.
- Trial name
- NCT07635576
- Testing
- Gastric Electrical Stimulator
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Indiana University
Gastroparesis
Methylnaltrexone vs Erythromycin for Facilitating Gastric Emptying Time in Critically Ill Patients
42 patients admitted in ICU with intolerance to enteral feeding (GRV more than 250 ml) are recruited. All patients enter a primary acetaminophen absorption test study as baseline.
- Trial name
- NCT01117376
- Testing
- Erythromycin, Methylnaltrexone
- Where
- Iran
- Volunteers
- 42 people
- Sponsor
- Shiraz University of Medical Sciences
Gastroparesis
GI-Challenge Study for Gastroparesis Patients and Healthy Controls
Gastroparesis Patients and Healthy Controls ages 20-49 will be asked to participate in an observational study measuring vagal activity following food ingestion in order to establish parameters of autonomic nerve/vagal function in…
- Trial name
- NCT03896126
- Testing
- Observational
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Stanford University
Gastroparesis
ABCA2 GIRMS Analytical Validation Clinical Performance Study
The purpose of this study is to collect human breath samples for use in a validation study intended to demonstrate equivalent clinical performance measures of new ABCA2 GIRMS (Automated Breath Carbon Analyzer-2 Gas Isotope Ratio…
- Trial name
- NCT04607304
- Testing
- ABCA2 GIRMS
- Where
- United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Cairn Diagnostics
Cirrhosis, Hypertension
Modified Vagus Nerve-preserving Laparoscopic Splenectomy and Azygoportal Disconnection
This study aimed to evaluate whether vagus nerve-preserving laparoscopic splenectomy and azygoportal disconnection is effective and safe, and to determine whether a reduction in the incidence of postoperative complications of the…
- Conditions
- Cirrhosis, Hypertension, Splenectomy, Laparoscopy
- Trial name
- ESVLSD (NCT03396796)
- Testing
- Vagus nerve-preserving group
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Yangzhou University
Type 1 Diabetic
Efficacy of Domperidone (a Prokinetic Agent) on Time in Range in Digestively Asymptomatic Type I Diabetic Patients With Delayed Gastric Emptying (Gastro-TIR)
Patients living with type 1 diabetes (PwT1D) still have trouble controlling their blood sugar, even with the latest treatments. PwT1D may have slow stomach emptying influencing blood glucose level.
- Trial name
- Gastro-TIR (NCT06695962)
- Testing
- Domperidone 10mg, gastric emptying test
- Where
- 6 sites in France
- Volunteers
- 70 people
- Sponsor
- University Hospital, Rouen
Postprocedural Delayed Gastric Emptying
The Effect of Oxytocin on the Gastric Emptying
The investigators are going to examine whether oxytocin has a prokinetic effect on gastric emptying in patients suffering from gastro paresis. Oxytocin infusion will be compared with sodium chloride infusion.
- Trial name
- NCT00776360
- Testing
- oxytocin
- Volunteers
- 12 people
- Sponsor
- Skane University Hospital
Gastroparesis
Use of EndoFLIP and Manometry Prior to G-POEM
The purpose of this study is to assess physiologic response of therapy in patients with refractory gastroparesis undergoing Gastric per-oral endoscopic myotomy (G-POEM) using endoscopic functional lumen imaging probe (EndoFLIP)…
- Trial name
- NCT04844190
- Testing
- EndoFLIP, Antroduodenal Manometry
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Northwestern University
Gastroparesis
Predicting Outcomes of GPOEM Using Gastric Electrical Mapping
Gastric peroral endoscopic myotomy (GPOEM) is a minimally-invasive procedure that involves dividing the pylorus, to enhance gastric emptying in gastroparesis patients.
- Trial name
- GPOEM-GEMS (NCT06381349)
- Testing
- Gastric Alimetry test
- Where
- New Zealand
- Volunteers
- 300 people
- Sponsor
- Chris Varghese
Idiopathic Gastroparesis
Effects of Global Osteopathic Manual Treatments in Patients With Idiopathic Gastroparesis
Global osteopathic manual treatments will decrease the severity score of the Gastroparesis Cardinal Symptom Index tool of patients with idiopathic gastroparesis.
- Trial name
- NCT02232334
- Testing
- Global Osteopathic Manual Treatment
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Kathleen Brannan Brown, Inc.
Gastroparesis
Domperidone Expanded Access Treatment Program
To allow the use of domperidone by patients with gastrointestinal disorders who have failed standard therapy.
- Trial name
- NCT04996134
- Testing
- Domperidone Oral Product
- Where
- United States
- Sponsor
- Wake Forest University Health Sciences
Achalasia, Gastroparesis
Disposable Endoscope Platform in Third Space Endoscopic Procedures
This is a prospective, single-arm unblinded study performed at a single tertiary center in the United States. All subjects will receive standard medical care and no experimental interventions are going to be performed.
- Trial name
- NCT06738628
- Testing
- (Esophageal or Gastric) Per-Oral Endoscopic Myotomy
- Where
- United States
- Sponsor
- Baylor College of Medicine
PGS
Clinical Study of Electroacupuncture for Postoperative Gastroparesis in Patients With Digestive Tract Tumors
This study aims to design and conduct a prospective, multicenter, randomized, parallel-controlled, sham-controlled clinical trial to evaluate the clinical efficacy of electroacupuncture for postsurgical gastroparesis syndrome…
- Trial name
- NCT07546175
- Testing
- Electroacupuncture
- Volunteers
- 76 people
- Sponsor
- First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
Intra Abdominal Pressure, Abdominal Compartment Syndrome
Intra-abdominal Hypertension and Abdominal Compartment Syndrome in Patients After Pancreatic Procedures.
This study investigates the development of intra-abdominal hypertension and compartment syndrome in patients undergoing elective pancreatic procedures.
- Conditions
- Intra Abdominal Pressure, Abdominal Compartment Syndrome, Pancreatic Surgery, Pancreatic Fistula After Pancreaticoduodenectomy
- Trial name
- HYPA (NCT06672601)
- Where
- Czechia
- Volunteers
- 150 people
- Sponsor
- Charles University, Czech Republic
Gastroparesis, Functional Dyspepsia
Transauricular Vagal Nerve Stimulation; Functional Dyspepsia and Gastroparesis
The goal of this study is to establish parameters of gastric myoelectrical activity and heart rate variability in healthy human subjects and compare and contrast them to those with gastroparesis and functional dyspepsia, at…
- Conditions
- Gastroparesis, Functional Dyspepsia, Healthy, Digestive System Disease
- Trial name
- AVNS (NCT05405842)
- Testing
- Transauricular Vagal Nerve Stimulation
- Volunteers
- healthy volunteers welcome
- Sponsor
- Stanford University
Gastroesophageal Reflux Disease, GERD
Treatment Use of Domperidone for Gastroparesis
Domperidone is a drug that may be of benefit to individuals with gastroesophageal reflux disease (GERD), with upper GI symptoms, gastroparesis, and chronic constipation.
- Conditions
- Gastroesophageal Reflux Disease, GERD, Gastroparesis
- Trial name
- NCT02227927
- Testing
- Domperidone
- Where
- 2 sites in United States
- Sponsor
- Scott Gabbard, MD
Gastroparesis
Endoscopic Clips Versus Overstich Suturing System Device for Closure of Mucosotomy After G-POEM
Gastric per-oral endoscopic pyloromyotomy (G-POEM) has been assessed as new modality for treatment of refractory gastroparesis. G-POEM is promising method, which is still under investigation as its safety and efficacy has not…
- Trial name
- NCT03679104
- Testing
- Closure of mucosotomy using endoscopic clips, Closure of mucosotomy using OverStitch™ suturing device
- Where
- Czechia
- Volunteers
- 40 people
- Sponsor
- Institute for Clinical and Experimental Medicine