Clinical trials: Gastrointestinal Motility Disorders in Children
Gastroesophageal Reflux in Children
Study on the Efficacy and Tolerance of a New Anti-regurgitation Infant Formula (STELLAR)
The aim of the study is to assess the effectiveness of this new formula on regurgitations and secondarily its effect on digestive tolerance through a randomized, controlled, double-blind trial against a comparator.
- Trial name
- STELLAR (NCT04358146)
- Testing
- Experimental Infant formula, Infant formula thickened with locust bean gum
- Where
- 12 sites in Belgium, France and 2 more
- Volunteers
- 346 people
- Sponsor
- United Pharmaceuticals
Dyspepsia, Malabsorption Syndrome
Evaluation of Topical Lidocaine Spray as Adjuvant to Upper Gastrointestinal Endoscopy in Children
There is some controversy in the medical literature regarding the effectiveness of topical lidocaine in children as an adjuvant drug to upper gastrointestinal endoscopy.
- Conditions
- Dyspepsia, Malabsorption Syndrome, Gastroesophageal Reflux Disease, Abdominal Pain
- Trial name
- NCT00521703
- Testing
- Lidocaine, Tannic acid
- Where
- Brazil
- Volunteers
- 78 people
- Sponsor
- Hospital Infantil Cândido Fontoura
Gastroesophageal Reflux
Pre and Post-gastrostomy Evaluation of GER in Children Using 24-hour pH Monitoring
The aim of this study was to evaluate 24-hour pH monitoring results before and after gastrostomy in neurological impaired (NI) children who underwent gastrostomy or Nissen fundoplication (NF) concurrently with gastrostomy.
- Trial name
- NCT04454112
- Testing
- 24-hour esophageal pH monitoring using an ambulatory system (Ohmega, MMS, Enschede, The Netherlands).
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Fatma Demirbaş
Eosinophilic Esophagitis
Comparing Anesthetic Techniques in Children Having Esophagogastroduodenoscopies
The purpose of this research study is to compare the safety and effectiveness of three commonly used techniques for delivering anesthesia during a procedure known as esophagogastroduodenoscopy.
- Trial name
- NCT02038894
- Testing
- Intubated with Sevoflurane (IS), Intubated with Propofol (IP), Zofran - no intubation
- Where
- United States
- Volunteers
- 179 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Autism, Gastrointestinal Symptoms
A Study to Assess the Role of a Gluten Free-dairy Free (GFCF) Diet in the Dietary Management of Autism Associated Gastrointestinal Disorders
Doctors at MassGeneral Hospital for Children (MGHfC) are doing a research study to learn if a gluten free-dairy free (GFCF) diet is helpful in improving gastrointestinal symptoms associated with autism.
- Trial name
- GFCF (NCT01116388)
- Testing
- GFCF product with GFCF diet, product containing gluten and casein (milk protein) with GFCF diet
- Where
- 2 sites in United States
- Volunteers
- 65 people
- Sponsor
- Massachusetts General Hospital
Gastroesophageal Reflux
A Study of Cisapride in Patients With Symptomatic Gastro-Oesophageal Reflux Disease
The purpose of this study is to compare the efficacy and tolerability of cisapride with placebo in infants and children with gastro-oesophageal reflux disease (GORD).
- Trial name
- NCT01281553
- Testing
- Cisapride
- Volunteers
- 6 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Gastroesophageal Reflux
Is Laparoscopic Fundoplication Better Than Open Fundoplication in Children ?
The aim of the study was to compare short- and longterm outcomes after laparoscopic and open Nissen fundoplication in children.
- Trial name
- NCT01551134
- Testing
- Fundoplication
- Where
- Norway
- Volunteers
- 88 people
- Sponsor
- Oslo University Hospital
Gastroesophageal Reflux
Natural History of Gastroesophageal Reflux (GER) in Children < 12 Years of Age
The goal of this project is to determine the long-term health outcome of children diagnosed with gastroesophageal reflux (GER). We are inviting subjects that were previously followed in the Pediatric GI programs at Massachusetts…
- Trial name
- NCT01048840
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Gastro Esophageal Reflux
Prevalence of Symptomatic Gastroesophageal Reflux Disease in Czech Children (Czech GERDKids)
This study aims to determine the prevalence of symptomatic gastroesophageal reflux disease (GERD) in children aged 8-9 years and 12-13 years in the Czech Republic.
- Trial name
- Czech GERDKids (NCT07482969)
- Where
- Czechia
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Motol
Esophageal Atresia
Respiratory Complications of Operated Esophageal Atresia in Children
The respiratory complications of esophageal atresia have already been identified. They are mainly related to tracheomalacia linked to the esophageal malformation, and are aggravated by frequently associated gastroesophageal…
- Trial name
- ATRESIA (NCT05527873)
- Where
- France
- Volunteers
- 67 people
- Sponsor
- University Hospital, Strasbourg, France
Gastroesophageal Reflux Disease
Comparison of Laparoscopic Nissen Versus Thal Fundoplication in Children
Laparoscopic fundoplication is increasingly performed in paediatric surgery. Many types of fundoplication are performed, each has advantages and disadvantages.
- Trial name
- NCT01027975
- Testing
- laparoscopic Nissen/laparoscopic Thal
- Where
- United Kingdom
- Sponsor
- Oxford University Hospitals NHS Trust
Gastroesophageal Reflux Disease, Hiatal Hernia
Necessity of Esophageal Dissection During Laparoscopic Fundoplication
This study compares complete dissection of the tissue around the lower esophagus to no dissection of these tissues during laparoscopic fundoplication in children.
- Trial name
- NCT00287612
- Testing
- Lap. Fundo. with Mobilization of the Esophageal Junction, Lap. Fundo. without Mobilization of the Esophageal Junction
- Where
- 2 sites in United States
- Volunteers
- 177 people
- Sponsor
- Children's Mercy Hospital Kansas City
Gastro-oesophageal Reflux
A Validation Study of the Dx-pH Probe in Children for the Detection of Extra-oesophageal Reflux
Gastro-oesophageal reflux (GORD) and its extraoesophageal manifestations present with a variety of symptoms in both adult and paediatric populations.
- Trial name
- NCT02457429
- Testing
- Experiemental diagnostic procedure: Dx-pH measurement system, Peptest assay, GORD symptom questionnaire
- Where
- United Kingdom
- Volunteers
- 16 people
- Sponsor
- Manchester University NHS Foundation Trust
Gastro-Oesophageal Reflux
Laparoscopy in Children: Does it Decrease the Metabolic, Endocrine and Inflammatory Stress Response to Surgery
The aim of this trial was to characterise the intra and post operative metabolic, endocrine and inflammatory response to laparoscopic fundoplication in children.
- Trial name
- NCT00231543
- Testing
- Laparoscopic fundoplication, open Nissen fundoplication
- Where
- United Kingdom
- Sponsor
- Institute of Child Health
Gastroesophageal Reflux Disease
PK Study With Pantoprazole in Obese Children and Adolescents
Multicenter, comparative single-dose pharmacokinetic (PK) study
- Trial name
- PAN01 (NCT02186652)
- Testing
- Pantoprazole
- Where
- 4 sites in United States
- Volunteers
- 41 people
- Sponsor
- Phillip Brian Smith
Otitis Media With Effusion, Laryngopharyngeal Reflux
Three Methods Used in the Diagnosis of EER in Children With OME
Detection of extraesophageal reflux (EER) in children with chronic otitis media with effusion (OME) using three different diagnostic methods and selection of the group of patients with severe EER who could potentially benefit…
- Trial name
- NCT02183961
- Testing
- Restech, Peptest, Detection of pepsin in adenoid specimen
- Where
- Czechia
- Volunteers
- 24 people
- Sponsor
- University Hospital Ostrava
GERD in Children, GERD
The Study of Nutrition of Children and Adolescents With GERD
This trial is to study the aspects of nutrition in children and adolescents with GERD compared to the sex and age-matched control group
- Trial name
- NCT04202276
- Testing
- diet assessment
- Where
- Russia
- Volunteers
- 219 people, healthy volunteers welcome
- Sponsor
- Federal State Budgetary Scientific Institution
Asthma, Gastroesophageal Reflux
Importance of Non-Acid Reflux in Asthma in Children
The purpose of the study is to follow the medical course of children with moderate to severe asthma and see how this relates to whether they have acid of non-acid gastroesophageal reflux
- Trial name
- NCT00200980
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Nemours Children's Clinic
Gastroesophageal Reflux, Nervous System Diseases
Comparative Anti-Reflux Procedures in Neurologically Impaired Children
This trial is a randomized controlled trial of two standard anti-reflux procedures, Nissen fundoplication versus gastrojejunal feeding tubes (GJ tubes), in children and adolescents with functional and intellectual impairment who…
- Conditions
- Gastroesophageal Reflux, Nervous System Diseases, Fundoplication, Enteral Nutrition
- Trial name
- CARPNIC (NCT01307982)
- Testing
- Fundoplication, Gastrojejunal (GJ) feeding tube
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Utah
Asthma, Gastroesophageal Reflux
Genotype-tailored Treatment of Symptomatic Acid-Reflux in Children With Uncontrolled Asthma
This study will evaluate the effect of CYP2C19 and ABCB1 genes on pharmacokinetics of lansoprazole in children with mild gastroesophageal reflux (GER) and uncontrolled asthma.
- Trial name
- GenARA (NCT03015610)
- Testing
- commercially available lansoprazole
- Where
- 2 sites in United States
- Volunteers
- 41 people
- Sponsor
- Jason Lang, M.D., M.P.H.